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211 Possible Causes for Painful Neuropathy, Progressive Polyneuropathy, Pruritus

  • Diabetes Mellitus

    But for others, diabetic neuropathy can be quite painful and disabling. Diabetic neuropathy is a common and serious complication of diabetes.[mayoclinic.org] […] outweighed by the benefits of reducing cardiovascular risk. [ 8 ] Presentation Patients with all types of diabetes may present with polyuria, polydipsia, lethargy, boils, pruritus[patient.info] Symptoms develop 30 min to 2 h after injection and include urticaria, angioedema, pruritus, bronchospasm, and anaphylaxis.[msdmanuals.com]

  • Chronic Alcoholism

    Alcoholism can cause peripheral neuropathy, often because many alcoholics also have a thiamine deficiency, which can cause painful neuropathy of the extremities.[disabilitysecrets.com] Generalised pruritus Generalised skin itching ( pruritus ) may occur due to the build up of poorly metabolised substances that stimulate nerve endings in the skin.[dermnetnz.org] Too much vitamin B6, however, may worsen peripheral neuropathy Pain medication Physical therapy Use of orthopedic appliances, such as orthotic devices, which may be covered[foundationforpn.org]

  • Vasculitis

    Neuropathic pain due to vasculitic neuropathy can be treated with anti-seizure medications, antidepressants, or analgesics including opiate drugs.[hopkinsmedicine.org] Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] The lesions may be asymptomatic or associated with burning, pruritus, or pain.[clinicaladvisor.com]

  • Paraneoplastic Syndrome

    neuropathy.[cancercompass.com] We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.[doi.org] This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer.[ncbi.nlm.nih.gov]

  • Multiple Myeloma

    For patients who have neuropathy, pain can be a debilitating symptom.[cancer.ucsf.edu] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Her pruritus resolved, but the lesions persisted. Footnotes Competing interests: None declared. This article has been peer reviewed.[cmaj.ca]

  • Diabetic Polyneuropathy

    Sixty-one patients with type 2 diabetes and painful neuropathy, 19 patients with painless DPN, 25 patients with type 2 diabetes but no clinical evidence of neuropathy, and[ncbi.nlm.nih.gov] Ms Q is a 52-year-old woman who has had progressive polyneuropathy in the setting of diabetes for the past 8 years.[ncbi.nlm.nih.gov] […] urinary tract infection, urinary frequency or dribbling, erectile dysfunction, loss of libido, dyspareunia, vaginal dryness, anorgasmia Sudomotor (sweat glands) symptoms: pruritus[aafp.org]

  • Systemic Amyloidosis

    A 51-year-old female was diagnosed with AL amyloidosis after 20 months of investigation of small painful deformities of the feet.[ncbi.nlm.nih.gov] Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] This case demonstrates an unusual presentation of primary systemic amyloidosis consisting of arthritis and intense debilitating pruritus without primary skin lesions for a[ncbi.nlm.nih.gov]

  • Thiamine Deficiency

    Anorexia, nausea, vomiting, abdominal pain. Later features Paraesthesia, peripheral neuropathy, depressed tendon reflexes, loss of vibration sense.[patient.info] Nerve conduction studies were consistent with axonal, length-dependent polyneuropathy.[ncbi.nlm.nih.gov] There was no history of fever, pruritus of hand and feet, headache, hypertension, oliguria, edema, and visual disturbances.[ijnpnd.com]

  • Waldenstrom Macroglobulinemia

    Fatigue Unexplained weight loss Enlarged lymph nodes or spleen Numbness, weakness or other nervous system problems, pain in the hands or feet, sometimes called peripheral[cancer.net] Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] This can lead to numbness or a painful “pins and needles” sensation in the feet and legs, which is called neuropathy.[cancer.org]

  • Beriberi

    Individuals who have undergone bariatric surgery for weight loss and do not take the required vitamin supplements may develop symptoms of beriberi (painful neuropathy due[health24.com] The essential feature is a polyneuropathy. b. The muscles become progressively more wasted and weak, and walking becomes increasingly difficult. c.[biologydiscussion.com] There was no history of fever, pruritus of hand and feet, headache, hypertension, oliguria, edema, and visual disturbances.[ijnpnd.com]

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