Painless Jaundice: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Painless Jaundice

Pancreatic Adenocarcinoma

This patient initially presented with painless jaundice and computed tomography (CT) revealed a mass in the head of the pancreas. [ncbi.nlm.nih.gov]

jaundice The majority of pancreatic cancer is incurable at presentation 1 2 Whether or not pancreatic cancer is deemed curable, current surgical, endoscopic, and oncological [bmj.com]

jaundice and enlarged gallbladder Trousseau syndrome: migratory thrombophlebitis new-onset diabetes mellitus lipase hypersecretion syndrome (10-15%) 9 polyarthralgia and [radiopaedia.org]

Adenocarcinoma of the Ampulla of Vater

The patient initially developed painless jaundice about 1 year previously, and was found to have a cancer of the ampulla. [medicorcancer.com]

Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. [journals.sjp.ac.lk]

SYMPTOMS: The usual symptoms are painless jaundice, intermittent or constant; fatigue, pruritis, fever, and nonspecific abdominal pain. [ralphmoss.com]

Malignant Neoplasm of the Pancreas

Another symptom is painless jaundice (yellowish discoloration of the eyes) associated with passage of tea-colored urine and grayish white (alcoholic) stools when imme3diately [themedicalcityclark.com]

CASE REPORT A 55-year-old female was hospitalized for the problem of painless obstructive jaundice. [pancreas.imedpub.com]

Therefore, a painless jaundice that becomes worse is often the first sign of pancreatic cancer. [patient.info]

Gallbladder Carcinoma

Of note, Courvoisier's law states that in the presence of a palpably enlarged gallbladder which is nontender and accompanied with mild painless jaundice, the cause is unlikely [en.wikipedia.org]

Symptoms and Signs of Gallbladder and Bile Duct Tumors Most patients with cholangiocarcinomas present with pruritus and painless obstructive jaundice, typically at age 50 [merckmanuals.com]

Toxic Hepatitis

Johnson, 62-Year-Old Man With Painless Jaundice and Hyponatremia, Mayo Clinic Proceedings, 10.1016/j.mayocp.2012.09.009, 88, 6, (e49-e53), (2013). [doi.org]

Metastatic Liver Carcinoma

Ultrasound The most striking clinical symptom leading to diagnostic imaging is painless obstructive jaundice, which is caused by compression or ingrowth of the distal common [radiologyassistant.nl]

Syphilitic Liver Cirrhosis

[…] sores) genital warts, possibly no symptoms Sores, flu-like symptoms, possibly no symptoms Painful urination, discharge, possibly no symptoms Jaundice (yellow skin), fatigue [quizlet.com]

[…] represent one type of infection but a whole group of infections that are spread through intimate contact. painful urination, discharge, possibly no symptoms skin rash, chancre (painless [quizlet.com]

Cholestatic Jaundice

[…] usually due to stones or tumor ROS: Painless jaundice suggests malignancy whereas choledocholithiasis often p/w colicky abdominal pain PE: jaundice, abd ttp. [errolozdalga.com]

Painful obstructive jaundice is usually related to gallstones, while painless obstructive jaundice tends to be related to tumours. [singhealth.com.sg]

Fig. 4: Fig 4Pancreatic carcinoma A 59 years old men presented with painless jaundice... Know the place of imaging techniques in the exploration of cholestatic jaundice. [posterng.netkey.at]

Cryptogenic Cirrhosis

Abstract Some patients diagnosed with cryptogenic cirrhosis may have "burned-out" nonalcoholic fatty liver disease (NAFL). To test this hypothesis, we used our liver transplant database (November 1984 to November 1998) to assess the incidence of NAFL in patients with cryptogenic cirrhosis after orthotopic liver[…] [ncbi.nlm.nih.gov]

Viral Hepatitis

Abstract The commonest causes of acute pancreatitis are cholelithiasis and alcohol. Rare causes include various viral infections, among which mumps is the commonest. Hepatitis A, hepatitis B and, recently, hepatitis E have been reported to cause acute but mild pancreatitis in patients with acute viral hepatitis. This[…] [ncbi.nlm.nih.gov]

Hepatitis B

Hepatitis B is a form of viral hepatitis, caused by the hepatitis B virus, a member of the Hepadnavirus family. It is estimated that worldwide, more than 350 million people have chronic hepatitis B virus infection. The course of the disease may be extremely variable, depending on the patient’s age and immune status.[…] [symptoma.com]

Malignant Neoplasm of the Gallbladder

A 65-year-old man with prior cholecystectomy presented with painless jaundice, vomiting, and weight loss. CA19-9 and alpha-fetoprotein (AFP) were elevated. [hindawi.com]

Painless jaundice (yellow/orange coloring of the skin and eyes) may be the only initial clue. [medicinenet.com]

Of note, Courvoisier's law states that in the presence of a palpably enlarged gallbladder which is nontender and accompanied with mild painless jaundice, the cause is unlikely [en.wikipedia.org]

Autoimmune Hepatitis

Autoimmune hepatitis Micrograph showing a lymphoplasmacytic interface hepatitis -- the characteristic histomorphologic finding of autoimmune hepatitis. Liver biopsy. H&E stain. Specialty Gastroenterology, hepatology Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that[…] [en.wikipedia.org]

Primary Biliary Cirrhosis

Primary biliary cholangitis Other names Primary biliary cirrhosis Micrograph of PBC showing bile duct inflammation and injury. H&E stain. Specialty Gastroenterology Symptoms Cholestasis, pruritus, fatigue Complications Cirrhosis, hepatic failure, portal hypertension Usual onset Usually middle-aged women Causes Autoimmune[…] [en.wikipedia.org]

Neoplasm of Ampulla of Vater

Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice. [ncbi.nlm.nih.gov]

jaundice which may have waxing and waning nature because at times the sloughing of the tumor tissue relieves the obstruction partially. [ citation needed ] Notes [ edit ] [en.wikipedia.org]

The patient initially developed painless jaundice about 1 year previously, and was found to have a cancer of the ampulla. [medicorcancer.com]

Hepatitis A

Hepatitis A is a form of viral hepatitis, caused by the hepatitis A virus, a single-stranded, positive-sense, linear RNA enterovirus of the Picornaviridae family. The virus spreads by the fecal-oral route and infections often occur in conditions of poor sanitation. The incubation period usually lasts 2 to 6 weeks.[…] [symptoma.com]

Hepatitis E

Hepatitis E is a viral infection caused by the hepatitis E virus. In children, Hepatitis E infection does not produce symptoms. It mostly affects adults as this disease mimics hepatic illness with features such as fatigue, jaundice, nausea, emesis, fever, anorexia, hepatomegaly, and abdominal pain. The duration is 1 to 2[…] [symptoma.com]

Indian Childhood Cirrhosis

Abstract We previously demonstrated decreased metallothionein (MT) synthesis in cultured fibroblasts obtained from an American boy with findings typical of Indian Childhood Cirrhosis (ICC). We now report normal basal, copper-induced, and zinc-induced MT synthesis in the fibroblasts of two Indian boys and one Irish[…] [ncbi.nlm.nih.gov]

Weil Disease

Abstract Leptospirosis is characterised by a broad spectrum of clinical manifestations varying from inapparent infection to fulminant fatal disease. Severe leptospirosis characterised by profound jaundice is referred to as Weil's disease. In the present study 20 patients of leptospirosis, of which 7 belonged to[…] [ncbi.nlm.nih.gov]

Leptospirosis

Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. World J Clin Infect Dis. Nov 25, 2016; 6(4): 61-66 Published online Nov 25, 2016. doi: 10.5495/wjcid.v6.i4.61 Leptospirosis: A clinical review of evidence based diagnosis, treatment and prevention Alison B Lane, Walter Reed[…] [doi.org]

Carcinoma of Ampulla of Vater

The patient initially developed painless jaundice about 1 year previously, and was found to have a cancer of the ampulla. [medicorcancer.com]

Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. [journals.sjp.ac.lk]

jaundice, a tumor of the ampulla of Vater was detected by means of PTC. de Wenn die Verfassung nicht kommt, wird der Zwang entstehen, eine Verteidigungsunion außerhalb des [de.glosbe.com]

Yellow Fever

Note: This travel notice was updated on April 13, 2017, to include additional information about areas affected by the outbreak. What is the current situation? The Brazilian Ministry of Health has reported an ongoing outbreak of yellow fever. The first cases were reported in the State of Minas Gerais in December[…] [web.archive.org]

Biliary Tree Disease

Note: If tumor is obstructing the common bile duct, painless jaundice may develop gradually over weeks prior to onset of infection. [cram.com]

It most commonly presents with painless jaundice or acute pancreatitis. Biliary tract cysts Cystic dilatation of the biliary tree is an uncommon abnormality. [emedicine.medscape.com]

Pancreatic Disorders Carcinoma of the head of the pancreas can manifest with painless jaundice caused by obstruction of the bile duct as it passes through the head of the [clevelandclinicmeded.com]

Riedel Thyroiditis

Painless jaundice with serial multi-organ dysfunction. Lancet. 2009 Apr 25. 373(9673):1494. [Medline]. Drieskens O, Blockmans D, Van den Bruel A, et al. [emedicine.medscape.com]

Ampulla of Vater Obstruction Syndrome

Painless jaundice (yellow/orange coloring of the skin and eyes) may be the only initial clue. [medicinenet.com]

Case report Here, we report the case of a 68-year-old man who presented with painless obstructive jaundice, general fatigue, loss of appetite and weight loss. [pancreas.imedpub.com]

CASE REPORT A 68-year-old man was admitted because of painless obstructive jaundice of 10-day duration when he noticed yellow colored scleras, dark colored urine and stool [pancreas.imedpub.com]

Undifferentiated Carcinoma of Liver and Intrahepatic Biliary Tract

jaundice. [radiopaedia.org]

A 69-year-old man was admitted for painless jaundice and a 2-week history of pruritus, dark urine, and acholic stools, and represents the third case of an intracholedochal [acgcasereports.gi.org]

Thirty-four patients (73.9%) presented with painless jaundice. [cancerindex.org]

Stauffer Syndrome

Ann Hematol. 2012, 91:1325-1326. 10.1007/s00277-011-1396-8 Jangouk P, Hashash J: An unusual case of painless jaundice. Gastroenterology. 2014, 146:4. [cureus.com]

jaundice, pruritus, urinary hyperpigmentation, and hepatomegaly. [ncbi.nlm.nih.gov]

Puga M, Gonzalez-Ballina E, Rivas-Moral L: Stauffer’s syndrome variant as an unusual case of painless jaundice. Clin Gastroenterol Hepatol. 2015, 13:A25-A26. [cureus.com]

Mirizzi Syndrome

jaundice Caption: Long axis view of the gallbladder and common hepatic duct | Description: There is a small gallbladder with stones.There is a stone in the cystic duct. [123sonography.com]

Pelaez-Luna M, Levy MJ, Arora AS, et al: Mirizzi syndrome presenting as painless jaundice: a rare entity diagnosed by EUS. [karger.com]

Mirizzi syndrome presenting as painless jaundice: a rare entity diagnosed by EUS. Gastrointest Endosc. 2008 May. 67(6):974-5; discussion 975. [Medline]. [emedicine.medscape.com]

Pancreatic Disease

Around 1 in 10 people (10%) have painless jaundice. Jaundice is yellowing of the skin and whites of the eyes. [cancerresearchuk.org]

The classic presentation of pancreatic cancer is referred to as painless jaundice, a yellowish skin discoloration with no other symptoms. [pancreasfoundation.org]

Many people with pancreatic cancer have jaundice when they first go to their doctors. Most of these people will have pain as well. [cancerresearchuk.org]

Pancreatic Carcinoma

The coexistence of painless jaundice and a space-occupying lesion in the head of the pancreas usually signifies a diagnosis of pancreatic cancer. [ncbi.nlm.nih.gov]

jaundice, pruritus, and weight loss. [ncbi.nlm.nih.gov]

A 28-year old patient presented with painless jaundice and was subsequently diagnosed as pancreatic adenocarcinoma with liver metastases. [ncbi.nlm.nih.gov]