Possible Causes for painless jaundice Pancreatic Adenocarcinoma This patient initially presented with painless jaundice and computed tomography (CT) revealed a mass in the head of the pancreas. [ncbi.nlm.nih.gov] jaundice The majority of pancreatic cancer is incurable at presentation 1 2 Whether or not pancreatic cancer is deemed curable, current surgical, endoscopic, and oncological [bmj.com] jaundice and enlarged gallbladder Trousseau syndrome: migratory thrombophlebitis new-onset diabetes mellitus lipase hypersecretion syndrome (10-15%) 9 polyarthralgia and [radiopaedia.org] Malignant Neoplasm of the Pancreas Another symptom is painless jaundice (yellowish discoloration of the eyes) associated with passage of tea-colored urine and grayish white (alcoholic) stools when imme3diately [themedicalcityclark.com] Therefore, a painless jaundice that becomes worse is often the first sign of pancreatic cancer. [patient.info] In some cases, painless jaundice may be a symptom of early pancreatic cancer that can be cured with surgery. [medicinenet.com] Cryptogenic Cirrhosis Abstract Some patients diagnosed with cryptogenic cirrhosis may have "burned-out" nonalcoholic fatty liver disease (NAFL). To test this hypothesis, we used our liver transplant database (November 1984 to November 1998) to assess the incidence of NAFL in patients with cryptogenic cirrhosis after orthotopic liver[…] [ncbi.nlm.nih.gov] Gallbladder Carcinoma Of note, Courvoisier's law states that in the presence of a palpably enlarged gallbladder which is nontender and accompanied with mild painless jaundice, the cause is unlikely [en.wikipedia.org] Symptoms and Signs of Gallbladder and Bile Duct Tumors Most patients with cholangiocarcinomas present with pruritus and painless obstructive jaundice, typically at age 50 [msdmanuals.com] Adenocarcinoma of the Ampulla of Vater The patient initially developed painless jaundice about 1 year previously, and was found to have a cancer of the ampulla. [medicorcancer.com] SYMPTOMS: The usual symptoms are painless jaundice, intermittent or constant; fatigue, pruritis, fever, and nonspecific abdominal pain. [ralphmoss.com] Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. [journals.sjp.ac.lk] Viral Hepatitis Abstract The commonest causes of acute pancreatitis are cholelithiasis and alcohol. Rare causes include various viral infections, among which mumps is the commonest. Hepatitis A, hepatitis B and, recently, hepatitis E have been reported to cause acute but mild pancreatitis in patients with acute viral hepatitis. This[…] [ncbi.nlm.nih.gov] Toxic Hepatitis Johnson, 62-Year-Old Man With Painless Jaundice and Hyponatremia, Mayo Clinic Proceedings, 10.1016/j.mayocp.2012.09.009, 88, 6, (e49-e53), (2013). [dx.doi.org] Cholestatic Jaundice […] usually due to stones or tumor ROS: Painless jaundice suggests malignancy whereas choledocholithiasis often p/w colicky abdominal pain PE: jaundice, abd ttp. [errolozdalga.com] Fig. 4: Fig 4Pancreatic carcinoma A 59 years old men presented with painless jaundice... Know the place of imaging techniques in the exploration of cholestatic jaundice. [posterng.netkey.at] Malignant neoplasms should be suspected in older patients ( 50 years old) presenting with painless jaundice. In newborn patients, biliary atresia must be suspected. [link.springer.com] Metastatic Liver Carcinoma Ultrasound The most striking clinical symptom leading to diagnostic imaging is painless obstructive jaundice, which is caused by compression or ingrowth of the distal common [radiologyassistant.nl] Hepatitis B Tenofovir disoproxil fumarate (TDF) is a potent nucleotide analogue that is recommended as first-line therapy for patients with chronic hepatitis B. The results of a longitudinal study of TDF treatment demonstrated no development of resistance. We observed one treatment-naïve chronic hepatitis B (CHB) patient[…] [ncbi.nlm.nih.gov] Autoimmune Hepatitis Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease involving many organs; it includes IgG4-related sclerosing cholangitis and inflammatory pseudotumor in the hepatobiliary system. Two types of hepatic parenchymal involvement have been reported in IgG4-RD: IgG4-related autoimmune hepatitis (AIH) and[…] [ncbi.nlm.nih.gov] Primary Biliary Cirrhosis A 34-year-old woman showed liver dysfunction for the first time at 3 months after delivery. Two years later, she was referred to our department with continued liver dysfunction. She fulfilled the criteria for primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap. Liver dysfunction improved after[…] [ncbi.nlm.nih.gov] Hepatitis A Hepatitis A virus (HAV) and hepatitis E virus (HEV) infections are endemic in most developing countries, including Nepal and Afghanistan, and may cause outbreaks in military personnel. Previously, more than 99% of new British Gurkha recruits were already immune to HAV because of prior infection, but this may be[…] [ncbi.nlm.nih.gov] Hepatitis E Hepatitis E virus (HEV) infection is an emerging autochthonous disease in industrialized countries. Extra-hepatic manifestations, in particular neurologic manifestations, have been reported in HEV infection. Only a few cases of hepatitis E-associated Parsonage-Turner syndrome have been reported, and HEV genotypes[…] [ncbi.nlm.nih.gov] Indian Childhood Cirrhosis Abstract We previously demonstrated decreased metallothionein (MT) synthesis in cultured fibroblasts obtained from an American boy with findings typical of Indian Childhood Cirrhosis (ICC). We now report normal basal, copper-induced, and zinc-induced MT synthesis in the fibroblasts of two Indian boys and one Irish[…] [ncbi.nlm.nih.gov] Weil Disease Abstract Leptospirosis is characterised by a broad spectrum of clinical manifestations varying from inapparent infection to fulminant fatal disease. Severe leptospirosis characterised by profound jaundice is referred to as Weil's disease. In the present study 20 patients of leptospirosis, of which 7 belonged to[…] [ncbi.nlm.nih.gov] Leptospirosis Abstract Leptospirosis is a zoonosis caused by the spirochete Leptospira interrogans. Most cases of leptospirosis are mild to moderate, and self-limited. The course of disease, however, may be complicated by multiorgan dysfunction such as in Weil's disease. We present a case of Weil's disease with pancreatitis in a[…] [ncbi.nlm.nih.gov] Syphilitic Liver Cirrhosis […] sores) genital warts, possibly no symptoms Sores, flu-like symptoms, possibly no symptoms Painful urination, discharge, possibly no symptoms Jaundice (yellow skin), fatigue [quizlet.com] […] represent one type of infection but a whole group of infections that are spread through intimate contact. painful urination, discharge, possibly no symptoms skin rash, chancre (painless [quizlet.com] Neoplasm of Ampulla of Vater Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice. [ncbi.nlm.nih.gov] jaundice which may have waxing and waning nature because at times the sloughing of the tumor tissue relieves the obstruction partially. [ citation needed ] Notes [ edit ] [en.wikipedia.org] The patient initially developed painless jaundice about 1 year previously, and was found to have a cancer of the ampulla. [medicorcancer.com] Malignant Neoplasm of the Gallbladder A 65-year-old man with prior cholecystectomy presented with painless jaundice, vomiting, and weight loss. CA19-9 and alpha-fetoprotein (AFP) were elevated. [hindawi.com] Painless jaundice (yellow/orange coloring of the skin and eyes) may be the only initial clue. [medicinenet.com] Of note, Courvoisier's law states that in the presence of a palpably enlarged gallbladder which is nontender and accompanied with mild painless jaundice, the cause is unlikely [en.wikipedia.org] Yellow Fever The first case of yellow fever in French Guiana since 1902 was reported in March 1998. The yellow fever virus genome was detected in postmortem liver biopsies by seminested polymerase chain reaction. Sequence analysis showed that this strain was most closely related to strains from Brazil and Ecuador. [ncbi.nlm.nih.gov] Carcinoma of Ampulla of Vater The patient initially developed painless jaundice about 1 year previously, and was found to have a cancer of the ampulla. [medicorcancer.com] Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. [journals.sjp.ac.lk] jaundice, a tumor of the ampulla of Vater was detected by means of PTC. de Wenn die Verfassung nicht kommt, wird der Zwang entstehen, eine Verteidigungsunion außerhalb des [de.glosbe.com] Riedel Thyroiditis Painless jaundice with serial multi-organ dysfunction. Lancet. 2009 Apr 25. 373(9673):1494. [Medline]. Drieskens O, Blockmans D, Van den Bruel A, et al. [emedicine.medscape.com] Ampulla of Vater Obstruction Syndrome Painless jaundice (yellow/orange coloring of the skin and eyes) may be the only initial clue. [medicinenet.com] More than two thirds occur in the head of the pancreas and classically present with painless, progressive, obstructive jaundice. [patient.info] Carcinoma of the head of the pancreas can manifest with painless jaundice caused by obstruction of the bile duct as it passes through the head of the pancreas. [aimisrobotics.com] Duodenal Diverticulum Melena, occult blood in the stool with anemia and painless jaundice with dilatation of the gall bladder is a common triad. Blood loss and anemia are not common. [revistagastroenterologiamexico.org] Undifferentiated Carcinoma of Liver and Intrahepatic Biliary Tract jaundice. [radiopaedia.org] A 69-year-old man was admitted for painless jaundice and a 2-week history of pruritus, dark urine, and acholic stools, and represents the third case of an intracholedochal [acgcasereports.gi.org] Thirty-four patients (73.9%) presented with painless jaundice. [cancerindex.org] Cholelithiasis See also[edit] Courvoisier's law – when the gallbladder is palpable, painless jaundice is unlikely to be related to gallstones. [en.wikipedia.org] Choledocholithiasis jaundice • Both pain and jaundice • Fever • Asymptomatic • Nausea • Vomiting • Anorexia • Conjugated hyperbilirubinemia (for choledocholithiasis) • Elevated alkaline phosphatase [accesssurgery.mhmedical.com] Jaundice, fever with chills Painless jaundice Biliary colic usually lasting 6 hours, nausea Abdominal pain Signs Jaundice,abdominal tenderness Fever, right upper quadrant [clinicaladvisor.com] […] annually of patients who are asymptomatic • Average age generally 10 years older than those affected by cholelithiasis (eg, 40-50 years of age) • Right upper quadrant pain • Painless [accesssurgery.mhmedical.com] Jaundice Many people with obstruction due to gallstones experience abdominal pain, while those with obstruction due to tumours usually have painless jaundice. [medbroadcast.com] Painless jaundice in elderly patients with weight loss and a mass but with minimal pruritus suggests biliary obstruction caused by cancer. [msdmanuals.com] Suspect biliary obstruction due to cancer in elderly patients with painless jaundice, weight loss, an abdominal mass, and minimal pruritus. [msdmanuals.com] Biliary Tree Disease Note: If tumor is obstructing the common bile duct, painless jaundice may develop gradually over weeks prior to onset of infection. [cram.com] It most commonly presents with painless jaundice or acute pancreatitis. Biliary tract cysts Cystic dilatation of the biliary tree is an uncommon abnormality. [emedicine.medscape.com] Pancreatic Disorders Carcinoma of the head of the pancreas can manifest with painless jaundice caused by obstruction of the bile duct as it passes through the head of the [clevelandclinicmeded.com]
