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13 Possible Causes for Pallor, Pancytopenia, Polyclonal Hyperglobulinemia

  • Primary Myelofibrosis

    Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • Posthemorrhagic Anaemia of the Newborn

    NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org] […] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia[theodora.com] Pallor persists in spite of administration of oxygen. Under such conditions immediate re-expansion of blood volume is imperative and lifesaving.[pediatrics.aappublications.org]

  • Multicentric Castleman's Disease

    Physical examination was significant for mild pallor, left axillary lymphadenopathy, diffuse abdominal tenderness, mild hepatosplenomegaly and 2 pitting edema involving the[bmcinfectdis.biomedcentral.com] Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org]

  • Congenital Intrinsic Factor Deficiency

    CASE DESCRIPTION A 2 year old male (Figure 1) presented with daily persistent emesis, pallor and perioral cyanosis.[epostersonline.com] Gene GIF (AR) Diagnostic Test Plasma Vitamin B12, Folate Neurological Ataxia, dystonia Non-Neurological Megaloblastic anemia, pancytopenia Treatment HydroxyCobalamin Level[treatable-id.org] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Anemia due to Glutathione Metabolism Disorder

    NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org] Individuals with hemolytic anemia can present with fatigue, pallor, irregular heartbeats, lightheadedness, and shortness of breath.[emedicine.medscape.com] Pallor of anaemia. During a crisis jaundice occurs. Back or abdominal pain (usually occurs when 50% haemolysis occurs). Splenomegaly may occur.[patient.info]

  • Castleman Disease

    The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] There is often significant anemia which may be hemolytic, often reflecting pancytopenia or hemophagocytic syndrome (Stebbing 2009).[hivbook.com] Examination revealed pallor; generalized edema; axillary, cervical, and inguinal lymphadenopathy; hypertension; and hepatomegaly.[ncbi.nlm.nih.gov]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    All hemolytic anemias feature varying degrees of fatigue, pallor, and weakness (from asymptomatic disease to life-threatening hemolytic crisis ), although some diseases have[amboss.com] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org] Symptoms of this condition include pale skin (pallor), jaundice, a yellowing of the white of the eyes (icterus), fatigue, and recurrent gallstones.[wohproject.org]

  • Chronic Active Hepatitis

    […] with autoimmune hepatitis recorded the following clinical findings and their prevalence [1] : Jaundice (58%) Nonspecific weakness (57%) Anorexia (47%) Abdominal pain (38%) Pallor[emedicine.medscape.com] Abstract A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] hyperglobulinemia.[hepatitiscentral.com]

  • Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

    NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[icd10coded.com] […] lymphoproliferative syndrome (ALPS) is a rare, newly recognized, chronic lymphoproliferative disorder in children and is characterized by lymphadenopathy, splenomegaly, pancytopenia[ncbi.nlm.nih.gov] On physical examination, he had pallor, petechial and oral haemorrhagic bullae.[casereports.bmj.com]

  • Polycythemia Neonatorum

    Continue reading RHESUS DISEASE Haemolytic anaemia in neonatal period is typified by rhesus disease in which there is rapid onset of jaundice within first 24 hours with pallor[atulchoube.wordpress.com] Excludes1: pancytopenia (due to) (with): aplastic anemia (D61.-) bone marrow infiltration (D61.82) congenital (pure) red cell aplasia (D61.01) drug induced (D61.1) hairy[en.wikisource.org] Pallor Anemia Hepatosplenomegaly Extravascular hemolysis occurs in the spleen and liver, which sequesters damaged RBCs.[pathophys.org]

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