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287 Possible Causes for Pallor, Refractory Anemia, Splenomegaly

  • Gastrointestinal Hemorrhage

    This is often due to pre-existing liver disease and splenomegaly.[geekymedics.com] Seek immediate medical care (call 911) for serious symptoms, pale skin or pallor and difficulty breathing, severe abdominal pain , vomiting blood or black material, or change[healthgrades.com] Other signs to look for are ascites and erythema (chronic liver disease) and splenomegaly and dilated abdominal wall veins (portal hypertension).[uspharmacist.com]

  • Primary Myelofibrosis

    […] frequency of leukemic blast cells (its degree of leukemicness) and, therefore, its course, than to clonal sideroblastic anemia (‘refractory sideroblastic anemia in the WHO[doi.org] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net]

  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] anemia with ring sideroblasts associated with marked thrombocytosis 9982/3 Myelodysplastic syndromes Refractory anemia 9980/3 Refractory neutropenia 9991/3 Refractory thrombocytopemia[atlasgeneticsoncology.org] […] leukemia (T-PLL) is the most common type of mature T-cell leukemia and is characterized by a rapidly rising peripheral blood lymphocyte count, bone marrow involvement, and splenomegaly[web.archive.org]

  • Chronic Lymphocytic Leukemia

    One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] Refractory: CLL does not respond to standard treatments.[rarediseases.org] We describe a case of a 77-year-old man who presented with fatigue, pallor and lower limb pain and weakness.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    The presence of a subclinical PNH population in myelodysplastic bone marrow disorders, such as aplastic anemia or refractory anemia, may correlate with a positive immunotherapeutic[ltd.aruplab.com] PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com]

  • Acute Myelocytic Leukemia

    Cytogenetic investigation of the bone marrow cells of an 88-year-old woman with refractory anemia with an excess of blasts in transformation with progression to acute myelocytic[ncbi.nlm.nih.gov] Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] The main clinical picture consists of a short time period with pallor, fatigue, fever, infections and hemorrhages. Presence of all these features is not compulsory.[orpha.net]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] anemia with excess blasts in transformation [RAEB T] Type 1 Excludes acute exacerbation of chronic myeloid leukemia ( C92.10 ) refractory anemia with excess of blasts not[icd10data.com] […] insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually giving way to accelerated or blast phases with more ominous signs, such as splenomegaly, pallor[msdmanuals.com]

  • Sickle Cell Disease

    Two of the patients had sickle cell anemia [Hb S (HBB: c.20A   T) (β(S)/β(S))] with refractory leg ulcers that required amputations.[ncbi.nlm.nih.gov] In two mouse SCD models, Berkeley and SAD, inhibition of red blood cell dehydration and sickling was achieved with correction of hematological parameters, splenomegaly, and[ncbi.nlm.nih.gov] ASS: Inquire about noticeable increase in weakness or pallor, syncope, and sudden abdominal distention.[web.archive.org]

  • Chronic Phase of Chronic Myeloid Leukemia

    Those complaints are generally associated with anemia and splenomegaly.[symptoma.com] With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com] A 55-year-old man presented with splenomegaly (10 cm below left costal margin) and leucocytosis (145 10(9)/L).[ncbi.nlm.nih.gov]

  • Myelodysplasia

    anemia (RA) 1 10-20 30-65 10-40 Refractory anemia with ringed sideroblasts (RARS) 1 10-35 34-83 10-35 Refractory anemia with excess blasts (RAEB) 5-20 50 8-18 25-30 Refractory[web.archive.org] Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Symptoms are referable to the specific cell line most affected and may include fatigue, weakness, pallor (secondary to anemia), increased infections and fever (secondary to[msdmanuals.com]

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