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1,367 Possible Causes for Pallor, Splenomegaly

  • Upper Respiratory Infection

    Approximately half of EBV mononucleosis cases involve generalized adenopathy or splenomegaly. An enlarged liver may also be palpable.[emedicine.medscape.com] Although it commonly affects the face, circumoral pallor is present. During recovery, the skin on the fingers and toes peels.[emedicine.medscape.com] Pallor and edema may be associated with underlying allergic rhinitis. The presence of unilateral signs suggests sinus involvement rather than uncomplicated rhinitis.[emedicine.medscape.com]

  • Pharyngitis

    It is characterised by : Sore throat Fever Enlarged cervical lymph nodes Enlarged tonsils and fatigue Other clinical manifestations are splenomegaly (enlarged spleen), hepatomegaly[singhealth.com.sg] , lethargy, malaise, weakness,Pallor, lethargy, malaise, weakness, anorexia, headache and dull back painanorexia, headache and dull back pain – Fever not prominentFever not[de.slideshare.net] Splenomegaly and/or hepatomegaly can be present in more than 50% of patients.[infectiousdiseaseadvisor.com]

  • Thalassemia

    The presence of splenomegaly and the elevation of Hb A(2) and Hb F and the exclusion of a defect of protein of red blood cell (RBC) membranes defined a clinical picture of[ncbi.nlm.nih.gov] Clinical description Onset is during infancy with severe anemia, failure to thrive and progressive pallor.[orpha.net] Clinical description Patients present with moderate to severe anemia, jaundice and splenomegaly.[orpha.net]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old.[ncbi.nlm.nih.gov] He had been suffering from repeated attacks of jaundice, pallor, and splenomegaly since he was 10 years old.[ncbi.nlm.nih.gov]

  • Malaria

    We report the case of a 12-year-old child who was admitted to our Department, with 7 days' history of high fever and splenomegaly.[ncbi.nlm.nih.gov] Infant presented with pallor, jaundice and massive spleen. Laboratory tests revealed anaemia, thrombocytopenia and bilirubinemia.[ncbi.nlm.nih.gov] Hyperreactive malarial splenomegaly (also called “tropical splenomegaly syndrome”) occurs infrequently and is attributed to an abnormal immune response to repeated malarial[cdc.gov]

  • Pyruvate Kinase Deficiency

    Significant hyperbilirubinaemia, anemia, and splenomegaly are common features in patients with severe haemolysis due to pyruvate kinase (PK) deficiency.[ncbi.nlm.nih.gov] Symptoms of this condition include pale skin (pallor), jaundice, a yellowing of the white of the eyes (icterus), fatigue, and recurrent gallstones.[wohproject.org] She is doing well with mild splenomegaly.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] Although SI provided a high rate of palliation for patients with symptomatic splenomegaly, the responses were transient.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] […] insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually giving way to accelerated or blast phases with more ominous signs, such as splenomegaly, pallor[msdmanuals.com] With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] […] disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor[medical-dictionary.thefreedictionary.com] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[symptoma.com] We describe a case of a 77-year-old man who presented with fatigue, pallor and lower limb pain and weakness.[ncbi.nlm.nih.gov] […] examination In addition to localized or generalized lymphadenopathy, patients may manifest the following: Splenomegaly (30-54% of cases) Hepatomegaly (10-20% of cases) Petechiae Pallor[emedicine.medscape.com]

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