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130 Possible Causes for Pallor, Splenomegaly, Uric Acid Increased

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old.[ncbi.nlm.nih.gov] He had been suffering from repeated attacks of jaundice, pallor, and splenomegaly since he was 10 years old.[ncbi.nlm.nih.gov]

  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] acid. 21 Immunosuppression from chemotherapy, hematopoietic stem cell transplantation, or the leukemia itself may increase the risk of serious infections.[aafp.org] […] leukemia (T-PLL) is the most common type of mature T-cell leukemia and is characterized by a rapidly rising peripheral blood lymphocyte count, bone marrow involvement, and splenomegaly[web.archive.org]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Abstract Pernicious anemia (PA) is an entity initially described in 1849 as a condition that consisted of pallor, weakness, and progressive health decline.[ncbi.nlm.nih.gov] Hepatomegaly and splenomegaly may be present.[patient.info]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] stupor from leukostasis Left upper quadrant and left shoulder pain as a consequence of splenic infarction and perisplenitis Clinical symptoms can include the following: Pallor[emedicine.com] The unusual case of myeloproliferative disease described here is characterized by the following features: (1) a clinically completely silent course for 11 years without splenomegaly[ncbi.nlm.nih.gov]

  • Acute Myelocytic Leukemia

    Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] The main clinical picture consists of a short time period with pallor, fatigue, fever, infections and hemorrhages. Presence of all these features is not compulsory.[orpha.net] Hyperleukocytosis also increases the odds of spontaneous TLS and the number of blasts contributing to the uric acid load.[clinicaladvisor.com]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] Increased uric acid Presence of the JAK2 mutation Hypercellular bone marrow 5.[slideshare.net] The symptoms are burning pain in the feet, hands, toes and fingers, sometimes associated with pallor, erythema, or cyanosis. Occasionally, it progresses to gangrene.[symptoma.com]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] […] insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually giving way to accelerated or blast phases with more ominous signs, such as splenomegaly, pallor[msdmanuals.com] Gout – increased cell turnover excess purines broken down to uric acid Increased susceptibility to infections – functional immune cells Shortness of breath/fatigue – anaemia[geekymedics.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    Those complaints are generally associated with anemia and splenomegaly.[symptoma.com] With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com] acid – gout/uropathy Histamine increase with basophil 90% In normal cells, two red and two green signals indicate the location of the normal ABL and BCR genes, respectively[slideshare.net]

  • Autoimmune Hemolytic Anemia

    Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] The diagnosis of HLH after SOT is especially difficult, as several of the diagnostic criteria, including fever, splenomegaly, and cytopenias, are nonspecific and can be seen[ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia

    Splenomegaly and thrombocytopenia were frequently observed more in CD200 patients. Increased frequency of CD34 was associated with CD200 and CD56 patients.[ncbi.nlm.nih.gov] […] leukemia that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor[merriam-webster.com] This is done to maintain good flow through the kidneys to prevent renal damage from tumor lysis and to increase the solubility of uric acid that is excreted in the urine.[clinicaladvisor.com]

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