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1,044 Possible Causes for Pallor, Splenomegaly, Weakness

  • Heart Failure

    […] report is intended to sensitise pediatricians to consider systemic vasculitis with pulmonary hemorrhage in children with pulmonary hypertension even in the absence of severe pallor[ncbi.nlm.nih.gov] There are many causes of congestive heart failure including: (1) coronary artery disease leading to heart attacks and heart muscle weakness, (2) primary heart muscle weakness[medterms.com] Increased adrenergic activity is manifested by tachycardia, diaphoresis, pallor, peripheral cyanosis with pallor and coldness of the extremities, and obvious distention of[emedicine.medscape.com]

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] CASE REPORT A 51-year-old Korean man was admitted to our hospital with general weakness and left-side abdominal pain.[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] stupor from leukostasis Left upper quadrant and left shoulder pain as a consequence of splenic infarction and perisplenitis Clinical symptoms can include the following: Pallor[emedicine.com] The resulting fibrous scar tissue formation leads to severe anemia, weakness, fatigue and an enlarged spleen and liver.[llscanada.org]

  • Childhood Acute Lymphoblastic Leukemia

    The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop.[ncbi.nlm.nih.gov] Anemia may manifest as pallor, headache, fatigue, dizziness, decreased energy or exercise tolerance, and sometimes syncope.[clinicaladvisor.com] […] comparison to the GSK-3β immunohistochemistry results of the bone marrow samples, showed significant differences between positive and negative cases (p 0.001) and between weak-positive[ncbi.nlm.nih.gov]

  • Thalassemia

    Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] Abstract We report a case of a thalassemia major male patient with back pain associated to severe weakness in lower extremities resulting in the ability to ambulate only with[ncbi.nlm.nih.gov] Clinical description Onset is during infancy with severe anemia, failure to thrive and progressive pallor.[orpha.net]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Symptoms are referable to the specific cell line most affected and may include fatigue, weakness, pallor (secondary to anemia), increased infections and fever (secondary to[msdmanuals.com] We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and[ncbi.nlm.nih.gov]

  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] It can cause arthralgias and weakness in intrinsic muscles of the hand.[ncbi.nlm.nih.gov] A 59-year-old man presented with a 10-day history of right-sided frontal headache and a 7-day history of subacute left-sided weakness. He had no history of RA.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] We describe a case of a 77-year-old man who presented with fatigue, pallor and lower limb pain and weakness.[ncbi.nlm.nih.gov] Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, characterized by fatigable weakness of the extraocular, bulbar, and limb musculature; prevalence[ncbi.nlm.nih.gov]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] The symptoms are burning pain in the feet, hands, toes and fingers, sometimes associated with pallor, erythema, or cyanosis. Occasionally, it progresses to gangrene.[symptoma.com] Painful swelling of one joint, often the big toe Shortness of breath Numbness, tingling, burning or weakness in your hands, feet, arms or legs A feeling of fullness or bloating[mayoclinic.org]

  • Gaucher Disease

    CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] […] reactions, occurring in 2 or more patients, included abdominal pain, agitation, fever, chills, diarrhea, eczema, edema, hypertension, irritability, laryngeal edema, nausea, pallor[aetna.com] However, there is weak correlation between GD/cancer phenotype and the systemic burden of glucocerebroside-laden macrophages.[ncbi.nlm.nih.gov]

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