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22 Possible Causes for Palmar Hyperlinearity, Skin Thickening, Xeroderma

  • Ichthyosis Vulgaris

    Symptoms may include any of the following: Dry skin, severe Scaly skin ( scales ) Possible skin thickening Mild itching of the skin The dry, scaly skin is usually most severe[nlm.nih.gov] The main characteristics of IV are fine-scale on the arms and legs, palmar hyperlinearity, and keratosis pilaris.[ncbi.nlm.nih.gov] As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[wederm.com]

  • Atopic Dermatitis

    Skin thickening and plaque formation is dependent on habitual scratching.[emedicine.medscape.com] Particularly, xeroderma pigmentosum patients are characterized by a 1,000-fold increased susceptibility to sunlight-induced skin cancer ( 4 ).[doi.org] Among patients, reduced level of monomeric filaggrin and NMF correlated with the presence of FLG mutations and clinical phenotypes such as xerosis, palmar hyperlinearity and[ncbi.nlm.nih.gov]

  • Ichthyosis

    As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[wederm.com] Ichthyosis, also called fish-skin disease, or xeroderma, a hereditary condition involving dryness and scaliness of the skin brought about by excessive growth of the horny[britannica.com] Palms and soles show accentuated creases and when affecting the palms this sign is referred to as palmar hyperlinearity or as “ichthyosis palms”.[medizin.uni-muenster.de]

  • Inherited Ichthyosis

    As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[wederm.com] Genetic Disorder Ichthyosis, Disease, Disorder, Emedicine, Ichthyosis Genetics, Information, Types Home Disease & Condition I Ichthyosis Ichthyosis (Fish Scale Disease, Xeroderma[knowyourdisease.com] […] keratoderma in LK ( LOR ). ( f ) Palmar hyperlinearity in IV ( FLG ). ( g ) Generalized fine scaling phenotype with concomitant severe erythema in NS ( SPINK5 ). ( h ) Onychoschisis[nature.com]

  • X-Linked Ichthyosis

    Dermatological examination revealed that the skin over the patient's entire body was dry and coarse, with thickening and scaling of the skin in the extensor side of the extremities[ncbi.nlm.nih.gov] Ichthyosis can also be much more severe than xeroderma.[merckmanuals.com] The proband (ǁǀ5) is a 9 year-old boy with generalized dry and grey brown scales, without involvement of the palms, soles and face, and no palmar hyperlinearity, accompanied[ijdvl.com]

  • Acquired Ichthyosis

    Symptoms Symptoms may include any of the following: Dry skin, severe Scaly skin ( scales ) Possible skin thickening Mild itching of the skin The dry, scaly skin is usually[mountsinai.org] X-linked ichthyosis xeroderma of eyelid Zunich Neuroectodermal Syndrome[rgd.mcw.edu] The phenotypic characteristics of ichthyosis vulgaris include palmar hyperlinearity, keratosis pilaris, and dry, scaly skin.[flipper.diff.org]

  • Peeling Skin Syndrome Type A

    Palms and soles are spared or may show redness and mild skin thickening or hyperlinearity. Underlying erythroderma is present.[orpha.net] […] pigmentosum, group A XPA Xeroderma pigmentosum, group C XPC Xeroderma pigmentosum, group D ERCC2 Xeroderma pigmentosum, group E, DDB-negative subtype DDB2 Xeroderma pigmentosum[centogene.com] Palmar and plantar areas are spared or present erythema, slight thickening of the skin or palmar hyperlinearity. An underlying erythroderma is present.[sites.uclouvain.be]

  • Parana Hard-Skin Syndrome

    […] syndrome is a rare genetic skin disorder characterized by very early-onset of progressive skin thickening over the entire body (except for eyelids, neck and ears), progressively[malacards.org] WITH HYPOLIPOPROTEINEMIA AND ACANTHOCYTOSIS 278150 : WOOLLY HAIR, AUTOSOMAL RECESSIVE 278200 : WOOLLY HAIR, HYPOTRICHOSIS, EVERTED LOWER LIP, AND OUTSTANDING EARS 278810 : XERODERMA[www5.geometry.net] […] of their palmar skin and xerotic fish scale on their legs * Many genetic conditions, such as the large family of ichthyoses (including X-linked ichthyoses, Netherton\'s disease[checkorphan.org]

  • Pityriasis Circinata

    Toyama A skin disease marked by the appearance of localized and circumscribed patches of thickened skin with lichenification, becoming scaly, without inflammatory changes,[whonamedit.com] Blue diaper syndrome, ataxia-telangiectasia, hydroa vacciniforme, pityriasis alba, and xeroderma pigmentosum (see these terms) should be excluded. Symp...[findzebra.com] The skin is not thickened and its surface is unbroken.[medical-dictionary.thefreedictionary.com]

  • Congenital Ankyloblepharon

    ., extension of lesions onto the dorsal aspect of the foot) of blisters, erosions, and subsequent skin thickening is possible and may be secondary to trauma, edema, or secondary[dermatologyadvisor.com] […] pigmentosum ERCC4 Fanconi anemia, Xeroderma pigmentosum ERCC5 Xeroderma pigmentosum, Xeroderma pigmentosum/Cockayne syndrome ERCC6 De Sanctis-Cacchione syndrome, Xeroderma[genda.com.ar] Increased numbers and depth of skin lines on the palms may also occur (hyperlinearity). Hyperkeratosis may also affect the knees and elbows.[rarediseases.org]

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