Pancreatic Duct Obstruction: Causes & Reasons

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Possible Causes for Pancreatic Duct Obstruction

Cystic Fibrosis

Obstruction of the pancreatic ducts severely damages the pancreas and results in reduced capacity to make the enzymes required to digest proteins and fat. [nationaljewish.org]

The secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production which causes obstruction of passageways (including pancreatic and bile ducts [icd9data.com]

Manifesting with excessively viscous mucus production, patients typically experience obstruction of passageways (e.g., pancreatic and bile ducts, intestines, and bronchi). [nature.com]

Choledocholithiasis

Other indicators include raised indicators of ampulla of vater (pancreatic duct obstruction) such as lipases and amylases. [en.wikipedia.org]

Obstruction of the common bile duct may also lead to obstruction of the pancreatic duct because these ducts are usually connected. [mountsinai.org]

If the pancreatic duct is also obstructed, pancreatitis will likely develop. The liver produces bile which aids in the digestion of fats. [mountsinai.org]

Cholestatic Jaundice

[…] connecting the pancreas to the intestines Swelling of lymph glands near the bile duct Pancreatic cysts Other pancreatic duct obstructions such as scarring What Causes Obstructive [nyp.org]

Imaging revealed distal bile duct obstruction and a mass in the head of the pancreas suspicious for cancer. [ncbi.nlm.nih.gov]

Bile Duct Stone or obstruction Pancreatic head mass Hepatocellular carcinoma (may obstruct the ducts within the liver and hinder the flow) So to summarize, if the bilirubin [examrefresh.com]

Ampulla of Vater Obstruction Syndrome

• Cholangiocarcinoma • Pancreatic adenocarcinoma • Duodenal adenoma or adenocarcinoma • Abdominal US to identify biliary and pancreatic duct dilatation • ERCP to identify [accesssurgery.mhmedical.com]

duct obstruction Gastrointestinal bleeding Acute pancreatitis Courvoisier’s law – distended and Palpable gall bladder Diagnosis Electrolyte panel measures the level of electrolytes [thegastrosurgeon.com]

Pancreatic stricture: Chronic pancreatitis 3. Portal lymphadenopathy 4. Bile duct obstruction due to ascaris 5. [epomedicine.com]

Pancreatitis

Treatment for chronic pancreatitis is designed to reduce pain and to limit pancreatic duct obstruction in the hope of limiting destruction of the gland. [montefiore.org]

pancreatic duct, biliary or duodenal obstruction, haemorrhage, or accumulation of fluid in the abdomen (ascites) or chest (pleural effusion) significantly increases the risk [gpnotebook.co.uk]

When the pancreas is hyperstimulated (alcohol or excessive eating) or when the bile-pancreatic duct is obstructed (gall stones), it increases pancreatic duct pressure and [naturalnews.com]

Chronic Pancreatitis

Association with chronic pancreatitis is rare and usually due to pancreatic duct obstruction by the tumor. [ncbi.nlm.nih.gov]

Chronic obstructive pancreatitis results from partial or complete obstruction of the pancreatic duct. [merckmanuals.com]

[…] conductance regulator gene (CFTR) Other genetic disorders Obstructive Pancreatic duct stricture (traumatic, iatrogenic, anastomotic, or malignant) Mass effect due to a tumor [merckmanuals.com]

Pancreatic Atrophy

[…] collection Pancreatic duct calculus Pancreatic duct leakage Pancreatic duct obstruction Pancreatic duct obstruction by calculus Pancreatic duct stricture Pancreatic exocrine [icd9data.com]

duct obstruction; biliary dilatation; pancreatic atrophy; liver metastases; peritoneal nodules; ascites; lymph node enlargement; and invasion of adjacent structures. [ncbi.nlm.nih.gov]

[…] head tumor obstructing the common bile duct and pancreatic duct. [radiologyassistant.nl]

Pancreatic Insufficiency

However, many other causes and conditions may be implicated, including cystic fibrosis, pancreatic duct obstruction, gastric and pancreatic surgery, diabetes mellitus and [ncbi.nlm.nih.gov]

Physical and biochemical causes of EPI include decreased production and secretion of lipase, increased lipase destruction, pancreatic duct obstruction, decreased lipase stimulation [ncbi.nlm.nih.gov]

Pancreatic Duct Obstruction

A 65-year-old Japanese male was referred to our hospital for evaluation of a main pancreatic duct obstruction. [ncbi.nlm.nih.gov]

Although fibrosis is a major characteristic of chronic pancreatitis (CP) induced by pancreatic duct obstruction, it is unclear whether pancreatic duct obstruction itself activates [ncbi.nlm.nih.gov]

The effects of preoperative pancreatic duct obstruction on exocrine pancreatic function were also investigated. [ncbi.nlm.nih.gov]

Pancreatic Ductal Stone

duct was more effective than endoscopic treatment in patients with obstruction of the pancreatic duct due to chronic pancreatitis. [nejm.org]

In this the pancreatic duct obstruction resulting in ductal dilatation, ductal hypertension and parenchymal hypertension is thought to be the cause of pain. [clinicaltrials.gov]

[…] can obstruct the pancreatic duct. [kjpbt.org]

Cystic Duct Obstruction

Pancreatic stricture: Chronic pancreatitis 3. Portal lymphadenopathy 4. Bile duct obstruction due to ascaris 5. [epomedicine.com]

We report the successful management of acute cholecystitis using cystic duct stent placement in 3 patients with inoperable malignant cystic duct obstruction (2 cholangiocarcinoma [ncbi.nlm.nih.gov]

In addition, blockage of the duodenal papilla (of Vater), distal to the juncture of the bile duct with the pancreatic duct, can lead to complicating pancreatitis. [usmleforum.com]

Duodenal Diverticulum

Most of duodenal diverticula (75%) are located within 2 cm of the ampulla of Vater, which is the reason why they may be associated with biliary and pancreatic duct obstruction [eurorad.org]

[…] malignancies, development of symptoms from biliary and pancreatic duct obstruction often occurs when the ampullary tumors are still very small. [revistagastroenterologiamexico.org]

[…] types are adenoma and adenocarcinoma, but other tumors such as lipoma, leiomyoma, carcinoid, hemangioma, fibroma and neurogenic tumors have been reported.1 In contrast to pancreatic [revistagastroenterologiamexico.org]

Pancreas Divisum

Pancreatic duct obstruction and pancreas divisum as congenital anomaly may be consider potential etiologies for pancreatic cancer. 2. [ncbi.nlm.nih.gov]

In pancreas divisum, longstanding pancreatic duct obstruction caused by relative stenosis of the minor duodenal papilla might be a factor promoting oncogenesis. [ncbi.nlm.nih.gov]

obstruction of the pancreatic duct both by mucus secretion and intraductal tumor growth [ 22 ]. [omicsonline.org]

Biliary Tree Disease

[…] fluid, deposition of inspissated protein plugs in pancreatic ducts - Contraction of sphincter of Oddi - Direct toxic effect o Pancreatic duct obstruction (impaction of gallstones [medschool.lsuhsc.edu]

Parasites may also lead to pancreatic duct obstruction or dilatation [41]. [saudijgastro.com]

Neoplasia obstructing the bile duct: Within the gall bladder. Within the biliary tree. At the duodenal papilla. Pancreatic. Duodenal foreign body obstruction. [vetstream.com]

Accessory Pancreas

Obstruction of the pancreatic duct, commonly due to gallstones can lead to acute pancreatitis. [anatomyzone.com]

pancreatic duct may lead to acute pancreatitis. [en.wikipedia.org]

It is named for Giovanni Domenico Santorini. [5] [6] Clinical significance Compression, obstruction or inflammation of the pancreatic duct may lead to acute pancreatitis. [ipfs.io]

Pancreatic Lipase Deficiency

Chronic obstructive pancreatitis results from partial or complete obstruction of the pancreatic duct. [merckmanuals.com]

Lipase levels may also be increased with pancreatic duct obstruction, pancreatic cancer, and other pancreatic diseases, as well as with gallbladder inflammation or kidney [labtestsonline.org]

Sphincter of Oddi disorders Duct obstruction (pancreatic or ampullary tumors, posttraumatic pancreatic duct fibrosis) Pathophysiology Most studies of the pathophysiology [aafp.org]

Congenital Pancreatic Cyst

Main-duct IPMN is characterized by a dilated pancreatic duct (>5 mm) that is ectactic and mucin-filled (in the absence of pancreatic duct obstruction). [surgery.wisc.edu]

Mucinous cystic neoplasms do not communicate with the pancreatic duct but can cause partial pancreatic duct obstruction, resulting in symptoms of pancreatitis. [massgeneral.org]

Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. [profiles.umassmed.edu]

Acute Pancreatitis

Prolonged dilation of the pancreatic duct following secretin administration may suggest obstruction at the level of the pancreatic duct orifice. [doi.org]

Possible pathways of enzyme activation: (1) Pancreatic duct obstruction Increased intrapancreatic ductal pressure results in accumulation of enzyme-rich interstitial fluid [medical-dictionary.thefreedictionary.com]

[…] or pancreatic duct obstructions MRCP is noninvasive but less sensitive than ERCP ERCP can be combined with sphincterotomy and stone extraction; but may worsen pancreatitis [amboss.com]

Pancreatic Heterotopia

Review of the literature and report of three cases, one of which produced common and pancreatic duct obstruction. [ncbi.nlm.nih.gov]

Keywords Excretory Duct Heterotopic Pancreas Pyloric Obstruction Ectopic Pancreatic Tissue Intralobar Sequestration These keywords were added by machine and not by the authors [link.springer.com]

Review of the literature and report of three cases, one of which produced common and pancreatic duct obstruction. AMA Arch Surg 1951;63:168-86. 3. [sjmms.net]

Postoperative Pancreatitis

A Japanese study[ 7 ] reported similar findings, and the authors speculated that ENBD itself may prevent pancreatic duct obstruction caused by residual stones or papillary [wjgnet.com]

The injury healing may result in a narrowing of the main pancreatic duct, causing obstructive pancreatitis in the gland downstream from the stricture. [intechopen.com]

It is thought that acinar cell injury occurs secondary to increasing pancreatic duct pressures caused by obstructive biliary stones at the ampulla of Vater, although this [emedicine.medscape.com]

Cholelithiasis

Occasional biliary duct or common bile duct obstruction may be present. Obstruction of the common bile duct can cause gallstone pancreatitis. [clinicaladvisor.com]

An elevated amylase suggests gallstone pancreatitis. Jaundice or elevated total bilirubin suggests obstruction of the common bile duct. [clinicaladvisor.com]

Progression from cholelithiasis to duct obstruction, and also development of pancreatitis are potential complications with conservative management. [clinicaladvisor.com]

Pancreatic Cyst

Similar to bile ducts and the urinary system, calculi may form inside pancreatic ducts, obstruct them and provoke retention cysts. [symptoma.com]

Main-duct IPMN is characterized by a dilated pancreatic duct (>5 mm) that is ectactic and mucin-filled (in the absence of pancreatic duct obstruction). [surgery.wisc.edu]

Pure pancreatic stones are rare. However, when present, they are the main cause of acute obstruction of the main pancreatic duct. [websurg.com]

Pancreatic Phlegmon

pancreatic duct. [intechopen.com]

Increased circulating cholecystokinin in obstruction induced acute pancreatitis. Pancreatic duct obstruction with and without bile duct obstruction. [tmj.ro]

Alcohol can dehydrate pancreatic fluid, making it more viscous and liable to obstruct the pancreatic duct. Other causes also induce pancreatitis in this fashion. [histocutup.co.uk]

Tropical Pancreatitis

Age above 40 years, short duration of symptoms, mass lesions on ultrasonography and main pancreatic duct obstruction on endoscopic retrograde pancreatography were associated [ncbi.nlm.nih.gov]

Acute suppuration of the pancreatic duct (ASPD) in the setting of chronic calcific pancreatitis and pancreatic ductal obstruction with septicemia is a rare complication that [karger.com]

The pathogenesis of this pain is not understood but pancreatic duct obstruction from one of the complications of chronic pancreatitis may be one cause. [ 17 ] Usually the [patient.info]

Ascending Cholangitis

Pancreatic carcinoma obstructing common biliary duct and leading to hepatic abscesses, appearing as rounded collections of contrast agent in dome of liver (arrows). [med-ed.virginia.edu]

Obstruction of the bile duct by pancreatic cancer can cause bile stasis and infection, a condition known as acute ascending cholangitis (AAC). [ncbi.nlm.nih.gov]

These stones cause biliary colic, biliary obstruction, gallstone pancreatitis, or cholangitis (bile duct infection and inflammation). [merckmanuals.com]

Partial Pancreatic Agenesis

[…] system are not observed Top Differential Diagnoses Pancreatic ductal carcinoma Abrupt, irregular obstruction of pancreatic duct seen on ERCP Pancreatic duct dilated upstream [radiologykey.com]

Some individuals experience no symptoms, while others may develop hyperglycemia, diabetes mellitus, bile duct obstruction, abdominal pain, pancreatitis, or other conditions [rarediseases.info.nih.gov]

The underlying cause of recurrent acute pancreatitis is hypothesized to be obstruction of the pancreatic duct by viscous mucus secretions, ulcer bleeding or biliary sludge [kjronline.org]

Bile Duct Disease

Complete obstruction of bile duct can cause cholangitis or can lead to an obstruction of the pancreatic duct, which may cause pancreatitis. [froedtert.com]

An obstruction of the common bile duct can also lead to an obstruction of the pancreatic duct, which may cause pancreatitis. [digestivedisease.uthscsa.edu]

Obstruction of the common bile duct may also lead to obstruction of the pancreatic duct because these ducts are usually connected. [virginiamason.org]

Neoplasm of Ampulla of Vater

Pancreatic cholera: Diarrhea is due to the absence of lipase within the gut caused by pancreatic duct obstruction. [oncology-articles.blogspot.com]

[…] or pancreatic ducts Dilatation of these ducts is essentially diagnostic for extrahepatic obstruction Biliary or pancreatic ductal dilatation can explain abdominal pain, even [emedicine.medscape.com]

DIFFERENTIALS Ascariasis Bile Duct Strictures Bile Duct Tumors Biliary Disease Biliary Obstruction Cholangiocarcinoma Choledocholithiasis Duodenal Ulcers Gallbladder Cancer [oncology-articles.blogspot.com]

Carcinoma of Ampulla of Vater

Pancreatic cholera: Diarrhea is due to the absence of lipase within the gut caused by pancreatic duct obstruction. [oncology-articles.blogspot.com]

Pancreatic Pseudocyst

Pseudocysts are a frequent complication of both acute and chronic pancreatitis, pancreatic trauma or a result of pancreatic duct obstruction. [karger.com]

Pancreatic duct disruption and pancreatic duct obstruction secondary to calculus, protein plug or localized stricture also play a major role in the formation of chronic pseudocyst [academic.oup.com]

The mechanism is pancreatic duct obstruction during injury, inflammation or anatomic anomaly. [sages.org]