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658 Possible Causes for Pancytopenia, Petechiae

  • Hypersplenism

    Pancytopenia can be limited by reducing the volume of the functional spleen.[ncbi.nlm.nih.gov] Figure 67-8 Petechiae and ecchymoses in a patient with idiopathic thrombocytopenic purpura. (Courtesy of Sidney Sussman, MD.)[5minuteconsult.com] He was initially asymptomatic though there was mild pancytopenia.[ncbi.nlm.nih.gov]

  • Aplastic Anemia

    Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.[ncbi.nlm.nih.gov] We report a case of 6-year-old South Asian girl presenting with bruises, petechiae, and recent history of loose stools.[ncbi.nlm.nih.gov] Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[merckmanuals.com]

  • Leukemia

    Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[merckmanuals.com] "Petechiae usually appears on the lower extremities," Wadleigh adds.[prevention.com] […] familial exposure to radiation during cancer treatment and strategies to help limit incidental contact with potentially harmful byproducts. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Primary Myelofibrosis

    Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia.[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Myelodysplasia

    An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[ncbi.nlm.nih.gov] ., bruising and/or petechiae) may cause patient distress.[ncbi.nlm.nih.gov] […] manifests usually in childhood with neurologic disorder (cerebellar ataxia or atrophy) and/or hematologic disorder (marrow hypoplasia, myelodysplasia, acute myeloid leukemia, or pancytopenia[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov] Mucocutaneous bleeding and/or petechiae may be due to thrombocytopenia.[emedicine.medscape.com] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] […] of splenic infarction and perisplenitis Clinical symptoms can include the following: Pallor (except in patients with polycythemia vera) Plethora secondary to polycythemia Petechiae[emedicine.medscape.com] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Acute Leukemia

    Pancytopenia in her secondary MF phase responded well to the therapy of corticosteroids, which indicated that the immune mechanism was involved in the pathogenesis of MF.[ncbi.nlm.nih.gov] The early symptoms and signs of acute leukemia may be similar to the flu, and include fatigue, fever, dyspnea, weight loss, bony pain and petechiae (flat pinpoint spots under[secure.ssa.gov] Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[merckmanuals.com]

  • Severe Aplastic Anemia

    Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[ncbi.nlm.nih.gov] An 8-year-old girl was admitted with fever, myalgia and petechiae. Dengue virus IgM antibodies were positive.[ncbi.nlm.nih.gov] The intraoral examination identified bleeding gums; petechiae of the palate, tongue and cheek mucosa; and an atrophic, smooth and shining dorsal surface of the tongue.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov] […] include: Bruising Excessive sweating (night sweats) Fatigue Fever Pressure under the lower left ribs from a swollen spleen Rash -- small pinpoint red marks on the skin ( petechiae[nlm.nih.gov] As a result of bone marrow infiltration, one or all series are suppressed, generating pancytopenia (anemia, neutropenia and thrombocytopenia).[pathologyatlas.ro]

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