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15 Possible Causes for Pancytopenia, Pleural Effusion, Polyclonal Hyperglobulinemia

  • Multicentric Castleman's Disease

    Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[] Nevertheless, his general condition, including pleural effusion and ascites, worsened, and C-reactive protein and interleukin-6 levels showed marked increases.[] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[]

  • Primary Myelofibrosis

    This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[] The condition may result in spinal cord compression, focal seizures, symptoms related to brain tumours, ascites, haematuria, pericardial effusion, pleural effusion, haemoptysis[] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[]

  • Castleman Disease

    There is often significant anemia which may be hemolytic, often reflecting pancytopenia or hemophagocytic syndrome (Stebbing 2009).[] A thoracic radiography can show a wide mediastinum or pleural effusions.[] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[]

  • Angioimmunoblastic Lymphadenopathy

    Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ...[] Occasionally, pulmonary involvement, including pleural effusion, has also been observed. Two cases of AILD accompanied by pleural effusion are reported here.[] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[]

  • Posthemorrhagic Anaemia of the Newborn

    […] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia[] effusion\n","Infection of TB spreading - to other body sites.[] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[]

  • MALT Lymphoma

    In the entire collective, three cases (6%) of prolonged pancytopenia including manifest myelodysplastic syndrome in one patient (2%), three cases (6%) of secondary lymphoid[] Less than 10% of patients have bilateral diffuse reticulonodular opacities, atelectasia or pleural effusion [ 9, 10, 12 ].[] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[]

  • Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

    […] lymphoproliferative syndrome (ALPS) is a rare, newly recognized, chronic lymphoproliferative disorder in children and is characterized by lymphadenopathy, splenomegaly, pancytopenia[] […] and pleural effusion.[] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[]

  • Pediatric Chronic Granulomatous Disease

    He developed pancytopenia, hypofibrinogenemia, transaminitis, and elevated ferritin of 11 783 ng/mL.[] Effusions 941 941 Causes of FalsePositive Dipstick Reactions for Table 73 Normal Ranges for Gonadotropin and Sex Steroid 947 Glasgow Coma Scale GCS for Adults and Children[] Polyclonal hyperglobulinemia 3. Elevated acute phase reactants such as ESR or CRP 4. Normal studies of T and B lymphocyte immunity Diagnostic test 1.[]

  • Polycythemia Neonatorum

    Excludes1: pancytopenia (due to) (with): aplastic anemia (D61.-) bone marrow infiltration (D61.82) congenital (pure) red cell aplasia (D61.01) drug induced (D61.1) hairy[] Chest X-rays showed mild cardiomegaly, pulmonary congestion and edema, and pleural effusions.[] pancytopenia D61.82 Myelophthisis Includes: Leukoerythroblastic anemia Myelophthisic anemia Panmyelophthisis Excludes 1: idiopathic myelofibrosis (D47.1) myelofibrosis NOS[]

  • Idiopathic Cryoglobulinemia

    . • However, a high rate of hematologic side effects (mainly grade 3 and 4 pancytopenia) was recorded. 1. Saadoun D, et al.[] Chest computed tomography (CT) showed a bilateral pleural effusion and alveolointerstitial infiltrates (Figures 2 a-b).[] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[]

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