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25 Possible Causes for Pancytopenia, Polyclonal Hyperglobulinemia, Weight Loss

  • Multicentric Castleman's Disease

    A 49-year-old man with superficial lymphadenopathy presented with symptoms of low-grade fever, general fatigue and weight loss.[ncbi.nlm.nih.gov] Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org]

  • Primary Myelofibrosis

    Constitutional symptoms, such as night sweats, pruritus, weight loss and fever may be treated with Jakafi.[mpnresearchfoundation.org] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • HIV Infection

    loss .[medicinenet.com] […] osteomalacia* Protease inhibitors with statins: myopathy Hematologic or oncologic Anemia of chronic disease Lymphoma, multiple myeloma Bone marrow infiltration (leading to pancytopenia[aafp.org] Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened[hivinsite.ucsf.edu]

  • Castleman Disease

    The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] There is often significant anemia which may be hemolytic, often reflecting pancytopenia or hemophagocytic syndrome (Stebbing 2009).[hivbook.com] Symptoms include: High fever Anemia Weight loss Loss of appetite Low white blood cell counts Castleman’s disease can also be defined as hyaline vascular or plasma cell type[uamshealth.com]

  • Chronic Active Hepatitis

    A 27-year-old woman, para 0-1-2-1, presented at 36 weeks' gestation with a 2-week history of malaise, nausea, emesis, diarrhea, and an 18-lb weight loss.[ncbi.nlm.nih.gov] Abstract A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] hyperglobulinemia.[hepatitiscentral.com]

  • MALT Lymphoma

    It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia.[ncbi.nlm.nih.gov] In the entire collective, three cases (6%) of prolonged pancytopenia including manifest myelodysplastic syndrome in one patient (2%), three cases (6%) of secondary lymphoid[ncbi.nlm.nih.gov] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[ncbi.nlm.nih.gov]

  • Angioimmunoblastic Lymphadenopathy

    Patients typically have generalized lymphadenopathy, fever, weight loss, skin rash, polyclonal hypergammaglobulinemia and autoimmune phenomena, and are susceptible to infections[ncbi.nlm.nih.gov] Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ...[citeulike.org] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com]

  • Congenital Intrinsic Factor Deficiency

    A 58-year-old female presents in the clinic presenting with fatigue, weight loss, and tingling in her fingers.[studyblue.com] Gene GIF (AR) Diagnostic Test Plasma Vitamin B12, Folate Neurological Ataxia, dystonia Non-Neurological Megaloblastic anemia, pancytopenia Treatment HydroxyCobalamin Level[treatable-id.org] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Posthemorrhagic Anaemia of the Newborn

    loss\n","Malnutrition\n","Coughing\n","Breathlessness\n","Lung infection\n","Pneumonia\n","Pulmonary infection\n\nSee also the symptoms of Achalasia and Acha","Sudden death[webhealthnetwork.com] […] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia[theodora.com] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Chronic Active Hepatitis B

    PAN is a necrotizing vasculitis of medium-sized arteries; its most prominent clinical manifestations include variable signs such as MM, weight loss, livedo reticularis, hypertension[synapse.koreamed.org] A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] hyperglobulinemia.[hepatitiscentral.com]

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