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800 Possible Causes for Pancytopenia, Splenomegaly, Vasculitis

  • Paroxysmal Nocturnal Hemoglobinuria

    PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[] Blood tests, coagulation study, search for thrombophilic disorders and small vessel vasculitis. Stool culture and virology. Test for autoantibodies. Abdominal CT scan.[] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[]

  • Brucellosis

    The most frequent admission symptoms and findings of the patients with pancytopenia were fever (75%), fatigue (50%), splenomegaly (75%), and hepatomegaly (41%).[] […] arthralgia and rash on legs, diagnosed with brucellosis through brucellosis tube agglutination test and found to have splenic infarct upon examination and leukocytoclastic vasculitis[] Tender hepatomegaly or splenomegaly was striking in seven patients. Other characteristics included epistaxis, arthralgia, myalgia, and weight loss.[]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[] Hairy cell leukemia typically presents with pancytopenia and often mimics aplastic anemia.[] We present a 37-year-old man with paraneoplastic leukocytoclastic vasculitis complicating newly diagnosed HCL.[]

  • Malignant Histiocytosis

    The long duration of massive splenomegaly suggests that this patient could represent a chronic form of MH.[] […] pancreas at initial presentation is exceptional, this entity should be included in the differential diagnosis of acute pancreatitis, especially when hepatosplenomegaly and pancytopenia[] We report a case of malignant histiocytosis that presented initially as a cutaneous vasculitis without malignant features.[]

  • Felty's Syndrome

    Computed tomography of the pelvis led to an incorrect diagnosis of malignancy, while radionuclide imaging using Tc-99m sulfur colloid confirmed the diagnosis of ectopic splenomegaly[] One of the latter 2 patients developed pancytopenia and died.[] We address the issue of "adding fuel to the fire" and review reported implications of GCSF in induction of vasculitis.[]

  • Chronic Lymphocytic Leukemia

    In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[] Wegener's granulomatosis is a systemic vasculitis of the small- and medium-sized vessels, produced by the action of ANCA, which involves the respiratory tract, kidneys, and[]

  • Disseminated Tuberculosis

    Splenic tuberculosis leads to splenomegaly, nausea, vomiting and abdominal pain.[] The purpose of this paper is to record a case of pancytopenia due to disseminated tuberculosis, and again to draw attention to the difficulties encountered in diagnosis.[] He was compatible with systemic vasculitis, Henoch-Schönlein purpura(HSP), based on the cutaneous leukocytoclastic vasculitis and mesangial Ig A, Ig G and C3 deposits revealed[]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[] The outcome was rapidly marked by febrile pancytopenia and ataxia leading to the diagnosis of pernicious anemia.[] ., autoimmune hemolytic anemia, anti-phospholipid antibody syndrome, arthritis, myasthenia gravis, necrotizing vasculitis, and vitiligo); the pernicious anemia in our two[]

  • Systemic Lupus Erythematosus

    […] relapsing illness, with a variety of different presentations. [ 5 , 6 ] Symptoms and signs are often nonspecific - eg, fatigue (can be severe and debilitating), malaise, fever, splenomegaly[] We report four cases of CNS vasculitis that occurred 5 to 16 years after the diagnosis of SLE.[] Evaluation revealed pancytopenia with normocellular marrow, hypocomplementaemia and Coomb's positive haemolytic anaemia.[]

  • Gaucher Disease

    HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[] […] w/ severe thrombocytopenia is seen; - splenectomy offers temporary relief but pancytopenia may recur w/ depletion of the normal marrow elements; - Radiographs: - fusiform[] Cutaneous leukocytoclastic vasculitis (CLV) is a necrotizing inflammation of the small vessels in the dermis.[]

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