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99 Possible Causes for Paracrystalline Inclusions

  • Hypervitaminosis E

    The theoretical pathogenesis of muscle damage and the possible origin of paracrystalline inclusion bodies are discussed.[link.springer.com] Bardosi A & Dickmann U (1987) Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E. Acta Neuropathologica 75 (2), 166-172 PubMed .[vetstream.com] Summary A necrotizing, nonprogressive myopathy with unusual paracrystalline inclusion bodies is described in a patient who underwent long-term treatment with megadoses of[link.springer.com]

  • Mitochondrial Myopathy and Sideroblastic Anemia

    Irregular and enlarged mitochondria with paracrystalline inclusions were also seen on electron microscopy of the patients' muscle specimen.[unboundmedicine.com] Electron microscopy revealed paracrystalline inclusions in most mitochondria. Southern blot of the mitochondrial DNA did not show any large-scale rearrangements.[ncbi.nlm.nih.gov] Muscle biopsy shows a low activity of complexes 1 and 4 of the respiratory chain and the possibility of paracrystalline inclusions in most mitochondria, observable by electron[bloodgenetics.com]

  • MELAS Syndrome

    Paracrystalline inclusions were found only in damaged mitochondria of skeletal muscle.[ncbi.nlm.nih.gov] Axonal degeneration, relative loss of large myelinated fibers and paracrystalline inclusion bodies in the Schwann cells were noted.[ncbi.nlm.nih.gov] There were no ragged-red fibers, but paracrystalline inclusion bodies were shown in the muscle biopsies under electron microscopic examination.[ncbi.nlm.nih.gov]

  • Acute Fatty Liver of Pregnancy

    Studies by electron microscopy showed megamitochondria with paracrystalline inclusions in four samples. All the mothers survived, but fetal mortality was 58.3%.[ncbi.nlm.nih.gov]

  • Mitochondrial Myopathy

    Electron microscopy was also performed which demonstrated abnormal, hyperplastic, pleomorphic, and hypertrophic mitochondria, characterized by paracrystalline inclusions arranged[ncbi.nlm.nih.gov] Diagnostic methods Muscle biopsy demonstrates low activity of complexes 1 and 4 of the respiratory chain and paracrystalline inclusions can be revealed in most mitochondria[orpha.net] Six ultrastructural abnormalities were identified including i) paracrystalline inclusions, ii) linearization of cristae and abnormal angular features, iii) concentric layering[ncbi.nlm.nih.gov]

  • Chronic Progressive External Ophthalmoplegia

    Electron microscopy revealed a number of abnormal mitochondria which contain paracrystalline inclusion bodies.[ncbi.nlm.nih.gov] Electron microscopy revealed paracrystalline inclusions. Mitochondrial genetic analysis demonstrated a large-scale mtDNA deletion of m.8470_13446del4977.[ncbi.nlm.nih.gov] Ultrastructurally, abnormal mitochondria with disoriented cristae and paracrystalline inclusions were seen.[ncbi.nlm.nih.gov]

  • Subependymal Giant Cell Astrocytoma

    Immunohistochemically, tumors exhibited features of glial differentiation, while ultrastructural studies identified the characteristic paracrystalline inclusions within the[ncbi.nlm.nih.gov] Interestingly, tumour cells containing unusual paracrystalline inclusions, infrequently described in SEGA, were identified ultrastructurally.[ncbi.nlm.nih.gov]

  • MERRF Syndrome

    Muscle biopsy from two affected siblings revealed ragged-red fibers and abundant subsarcolemmal mitochondria with paracrystalline inclusions.[ncbi.nlm.nih.gov] On electron microscopy these fibres contained subsarcolemnal aggregations of abundant abnormal mitochondria with proliferation of inner membranes or paracrystalline inclusions[ncbi.nlm.nih.gov]

  • Leydig Cell Tumor of the Testis

    Other structures also identified in this tumor are Reinke crystalloids, cytoplasmic microbodies, myelin figures, gap-type junctional complexes and paracrystalline inclusions[ncbi.nlm.nih.gov]

  • Hypercarotinemia

    Most of mitochondria is deformitied and swollen, though some mitochondria shows paracrystalline inclusion.[jstage.jst.go.jp]

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