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19 Possible Causes for Paroxysmal Activity - Spikes, Variable Psychomotor Retardation

  • Myoclonic-Astatic Epilepsy

    - or polyspike-wave activity at more than 2.5 Hz without generalized paroxysmal fast activity or focal spikes.[jamanetwork.com] retardation mainly affecting speech.[ipfs.io] […] myoclonic, myoclonic-atonic, absence, and generalized tonic-clonic seizures and nonconvulsive status epilepticus. 1 , 2 The electroencephalogram (EEG) shows generalized spike[jamanetwork.com]

  • West Syndrome

    […] clinical manifestations such as hypotonia, psychomotor retardation, and feeding difficulties.[ncbi.nlm.nih.gov] Leigh syndrome (LS) (sub-acute necrotizing encephalomyelopathy) is characterized by symmetric brain lesions occurring mainly in the basal ganglia and associated with variable[ncbi.nlm.nih.gov]

  • Early Infantile Epileptic Encephalopathy Type 2

    .  EEG with paroxysms of fast activity and slow (less than 2.5 Hz) generalised spike-wave discharges (GSWD). 17.[slideshare.net] […] degree of psychomotor delay and cognitive impairment, ranging from mild to severe mental retardation [23].[journals.plos.org] paroxysms and generalized slow spike-and-wave discharges Affected LGS patients have different degrees of developmental delay and they often develop autism and intellectual[centogene.com]

  • Severe Neonatal-Onset Encephalopathy with Microcephaly

    paroxysms and generalized slow spike-and-wave discharges Affected LGS patients have different degrees of developmental delay and they often develop autism and intellectual[centogene.com] Rarely it is an etiology of psychomotor retardation of childhood. Lens dislocation outside of the neonatal period is a common finding but of variable onset.[clinicaladvisor.com] […] tonic–clonic seizures The onset of LGS is mostly between 3-5 years of age 43 The incidence of LGS is estimated to be 1-10% of all childhood-onset epilepsies 43 EEG shows fast activity[centogene.com]

  • Neuronal Ceroid Lipofuscinosis 2

    EEGs revealed progressive disorganization of background activity with either focal paroxysms or diffuse bursts of slow waves and spikes.[scielo.br] […] mild to moderate mental retardation/learning disabilities/variable www.mpssociety.org Mucolipdosis IV (Sialolipidosis) Ganglioside sialidase (neuraminidase) AR infancy psychomotor[ntsad.org] retardation/mental retardation Saposin Deficiencies Saposins A, B, C or D AR infancy - adulthood neurological deterioration, variable B.[ntsad.org]

  • Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

    paroxysms and generalized slow spike-and-wave discharges Affected LGS patients have different degrees of developmental delay and they often develop autism and intellectual[centogene.com] retardation, retinal dystrophy, infantile onset, cerebellar atrophy [ 73 , 74 ] SCAR16 STUB1 615768 Pyramidal signs, neuropathy, occasional hypogonadism, variable age at[cerebellumandataxias.biomedcentral.com] […] tonic–clonic seizures The onset of LGS is mostly between 3-5 years of age 43 The incidence of LGS is estimated to be 1-10% of all childhood-onset epilepsies 43 EEG shows fast activity[centogene.com]

  • Ring Chromosome 10

    EEG tended to show slow background activity with paroxysmal spike-waves often during sleep.[omim.org] The clinical variability of fourteen r(Jeny6) individuals when reviewed was shown to include growth failure, psychomotor retardation, eye and facial abnormalities and abnormal[tp.amegroups.com]

  • Ring Chromosome 11 Syndrome

    EEG tended to show slow background activity with paroxysmal spike-waves often during sleep.[omim.org] The clinical variability of fourteen r(Jeny6) individuals when reviewed was shown to include growth failure, psychomotor retardation, eye and facial abnormalities and abnormal[tp.amegroups.com]

  • Sialidosis Type 2

    Electrophysiological studies showed paroxysmal activities in the EEG, consistent temporal relationship between the EEG spikes and myoclonic jerks demonstrated by jerk-locked[kyushu-u.pure.elsevier.com] […] mild to moderate mental retardation/learning disabilities/variable www.mpssociety.org Mucolipdosis IV (Sialolipidosis) Ganglioside sialidase (neuraminidase) AR infancy psychomotor[ntsad.org] Electrophysiological studies showed paroxysmal activities in the EEG, consistent temporal relationship between the EEG spikes and myoclonic jerks demonstrated by jerk-blocked[eurekamag.com]

  • Pachygyria-Mental Retardation-Seizures

    Interictal electroencephalography (EEG) showed occipital spikes and diffuse polyspike-wave paroxysms predominantly in the posterior region.[pubmed.cn] A classic type lissencephaly associated with psychomotor retardation and seizures.[nectarmutation.org] His EEG showed almost continuous 2 to 2.5Hz spike and wave paroxysmal activity, which was of greater amplitude on the left side.[vdocuments.net]

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