Partial Thromboplastin Time Prolonged: Causes & Reasons

Possible Causes for Partial Thromboplastin Time Prolonged

An isolated abnormal prothrombin time (PT) suggests FVII deficiency, whereas a prolonged activated partial thromboplastin time (aPTT) indicates most commonly hemophilia or [accessmedicine.mhmedical.com]

[…] of partial thromboplastin time and decrease in prothrombin activity. [ncbi.nlm.nih.gov]

Activated partial thromboplastin time was prolonged in47 (57.31 % ) patients, while35 (42.68 % ) patients had normal APTT which was less than 40 seconds (mean + SD = 33.05 [pacificejournals.com]

Factor XII Deficiency

On admission, the patient's activated partial thromboplastin time (aPTT) was prolonged (271 s), and activated clotting time was 500 s. His factor XII level was <3%. [ncbi.nlm.nih.gov]

In the majority of cases, patients remain asymptomatic, with the only pathologic finding being the prolonged activated partial thromboplastin time (aPTT) detected via laboratory [symptoma.com]

The patient eventually was found to have AIL and a prolonged partial thromboplastin time. There was no evidence of a circulating anticoagulant. [ncbi.nlm.nih.gov]

Acquired Hemophilia

The laboratory revealed isolated activated partial thromboplastin time prolongation with low FVIII activity and a presence of FVIII inhibitor. [ncbi.nlm.nih.gov]

Prothrombin time was within normal range, but activated partial thromboplastin time was prolonged. [ncbi.nlm.nih.gov]

Her activated partial thromboplastin time was prolonged (80.0 s). [ncbi.nlm.nih.gov]

Factor V Deficiency

The D-dimer, prothrombin time, and partial thromboplastin time prolongation persisted from admission until 24 hours after coronary stenting. [ncbi.nlm.nih.gov]

On preliminary investigations her prothrombin time and activated partial thromboplastin time were prolonged. [ncbi.nlm.nih.gov]

Normal Normal or prolonged Prothrombin time Normal Normal Activated partial thromboplastin time Prolonged Normal or prolonged Test Haemophilia VWD Platelet count Normal Normal [academic.oup.com]

Factor X Deficiency

Hematologic tests showed prolonged prothrombin time, partial thromboplastin time, and a factor X level of 5%. [ncbi.nlm.nih.gov]

Factor X deficiency was diagnosed on the basis of prolonged prothrombin time and prolonged partial thromboplastin time with kaolin, which were corrected by addition of aged [ncbi.nlm.nih.gov]

Symptoms Bleeding into joints Muscle bleeding Mucus membrane bleeding Nosebleeds (epitaxis) Exams and Tests Low factor X activity Normal thrombin time Prolonged partial thromboplastin [indiatoday.in]

Acquired Hemophilia A

The laboratory revealed isolated activated partial thromboplastin time prolongation with low FVIII activity and a presence of FVIII inhibitor. [ncbi.nlm.nih.gov]

Prothrombin time was within normal range, but activated partial thromboplastin time was prolonged. [ncbi.nlm.nih.gov]

Her activated partial thromboplastin time was prolonged (80.0 s). [ncbi.nlm.nih.gov]

Factor II Deficiency

prolonged prothrombin time (PT) and prolonged partial thromboplastin time (PTT). [1] FX antigen and its coagulant activity can be used to classify the severity of the condition [en.wikipedia.org]

LA-HPS is to be suspected when a patient presents with bleeding and a prolonged activated partial thromboplastin and prothrombin time, in combination with a lupus anticoagulant [ncbi.nlm.nih.gov]

Hereditary Factor X Deficiency

The propositus had a markedly prolonged prothrombin time, a mild prolongation of activated partial thromboplastin time and a clotting time activated by Russell's viper venom [ncbi.nlm.nih.gov]

However, a high index of suspicion should follow an abnormal clotting profile with prolonged PT (prothrombin time) and APTT (activated partial thromboplastin time). [symptoma.com]

prolonged prothrombin time (PT) and prolonged partial thromboplastin time(PTT).[1] FX antigen and its coagulant activity can be used to classify the severity of the condition [en.wikipedia.org]

Hereditary Factor XI Deficiency

Severe Factor XI (FXI) deficiency is defined when the activated partial thromboplastin time is prolonged and its activation is <1-15 UdL(-1) in plasma. [ncbi.nlm.nih.gov]

During 1 year of post-transplant follow-up, his activated partial thromboplastin time (aPTT) remained prolonged, but he did not develop bleeding complications. [ncbi.nlm.nih.gov]

A 42-year-old-women with sigmoid colon adenocarcinoma was found to have isolated prolonged activated partial thromboplastin time (aPTT 102.5 s, normal range 24-36 s) preoperatively [ncbi.nlm.nih.gov]

Disseminated Intravascular Coagulation

Prothrombin time (PT) – normal or prolonged Activated partial thromboplastin time (aPTT) – normal or prolonged (may be normal in early or chronic DIC) Thrombin time (TT) [arupconsult.com]

Prothrombin and activated partial thromboplastin times are prolonged. [stago-us.com]

[…] prothrombin time (PT) prolonged international normalized ratio (INR) prolonged activated partial thromboplastin time (aPTT) schistocytes on blood smear due to microangiopathic [radiopaedia.org]

Hereditary Factor I Deficiency

Bleeding time (BT) was prolonged beyond 15 minutes. prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) were prolonged infinitely. [jpma.org.pk]

Diagnostic methods Diagnosis is based on prolonged activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin and reptilase times and on fibrinogen levels [orpha.net]

Laboratory studies showed prolongation of prothrombin time, activated partial thromboplastin time, and undetectably low level of fibrinogen. [ncbi.nlm.nih.gov]

Hereditary Coagulopathy

Prothrombin time Partial thromboplastin time Inherited Acquir Prolonged Normal Factor VII deficiency Acquired factor VII deficiencyFactor VII inhibitorVitamin K deficiencyLiver [clinicaladvisor.com]

Patients referred due to a prolonged activated partial thromboplastin time with bleeding more frequently (41.7%) present coagulopathy with a real risk of bleeding. [analesdepediatria.org]

Haemostasis tests in bleeding disorders [ 1, 21 ] Platelet count Prothrombin time Activated partial thromboplastin time Bleeding time Thrombin time Additional tests Haemophilia [patient.info]

Hemophilia B

The diagnosis of hemophilia B is typically suspected by significantly prolonged activated partial thromboplastin time (aPTT) on screening tests, but aPTT may be normal or [ncbi.nlm.nih.gov]

The patient was diagnosed with hemophilia B based on the results of a detailed inquiry, a mildly prolonged activated partial thromboplastin time, and low factor IX activity [ncbi.nlm.nih.gov]

Clotting analysis performed in both twins revealed a markedly prolonged partial thromboplastin time (> 100 s). The factor IX levels were below 2%. [ncbi.nlm.nih.gov]

Bleeding Diathesis

The partial thromboplastin time and prothrombin time were markedly prolonged. [ncbi.nlm.nih.gov]

Studies revealed prolonged prothrombin time and activated partial thromboplastin time. [ncbi.nlm.nih.gov]

Plasma from affected family members had prolonged prothrombin times and activated partial thromboplastin times, low to below normal factor X coagulant activity, and normal [ncbi.nlm.nih.gov]

Anticardiolipin Antibody Syndrome

[…] dilute Russell viper venom time (DRVVT) test prolonged partial thromboplastin time (PTT) anti-β 2 glycoprotein (IgG and IgM) anticardiolipin (IgG and IgM) coagulation studies [medbullets.com]

The lupus anticoagulant will prolong both the partial thromboplastin time (PTT) and the Russell viper venom time. The latter is a more sensitive predictor of disease. [health.am]

Antiphospholipid antibodies are associated with an increase in arterial and venous thrombosis despite the prolongation of the activated partial thromboplastin time (1,3). [fetalultrasound.com]

Vitamin K Deficiency

Prothrombin time and partial thromboplastin time were prolonged. Administration of phylloquinone (vitamin K1) resulted in rapid normalization of coagulation. [ncbi.nlm.nih.gov]

All the infants had prolonged prothrombin time (PT) and seven had prolonged activated partial thromboplastin time (APTT), both of which were corrected by the administration [ncbi.nlm.nih.gov]

Treatment with vitamin K should be considered in kidney or combined kidney-pancreas allograft recipients with a prolonged prothrombin or partial thromboplastin time during [ncbi.nlm.nih.gov]

Hereditary Factor I Deficiency

[…] bleeding time (in some people) • prolonged partial thromboplastin time • prolonged prothrombin time Treatments There are no commercially available concentrates of factor [slideshare.net]

Since bleeding time is usually normal, diagnosis is made by a prolonged activated partial thromboplastin time (aPTT) test. [myneighborhoodprimarycare.org]

Screening coagulogram was performed, which showed marked prolongation of prothrombin time (93'/13'), activated partial thromboplastin time (145'/30'), and thrombin time (45 [ehj.eg.net]

Purpura Fulminans

The prothrombin time and partial thromboplastin time were prolonged and the fibrin degradation products were grossly elevated. Blood culture grew group-A streptococci. [westjem.com]

Laboratory investigations documented thrombocytopenia (90×109/L), elevated prothrombin time (17.6 s), prolonged activated partial thromboplastin time (53.5 s) along with elevated [pmj.bmj.com]

Hemophilia A

The partial thromboplastin time is prolonged but the prothrombin time and platelet count are normal; factor VIII and IX assays determine the type and severity of the hemophilia [msdmanuals.com]

normal Platelet count: normal Activated partial thromboplastin time (aPTT): usually prolonged If aPTT prolonged → mixing study If mixing study is positive (or if patient [amboss.com]

Platelet count, prothrombin time (PT), partial thromboplastin time (PTT), factor VIII and IX assays Sometimes von Willebrand factor activity and antigen and multimer composition [msdmanuals.com]

Hemophilia

[…] activated partial thromboplastin time (aPTT).One will find that the factor XI has decreased in the individuals body. [en.wikipedia.org]

AHA should be suspected when a patient with no previous history of bleeding presents with bleeding and an unexplained prolonged activated partial thromboplastin time. [doi.org]

Hemophilic Arthropathy

In patients with hemophilia, prothrombin time and platelet count are normal, and activated partial thromboplastin time is prolonged, denoting a defect in the intrinsic clotting [musculoskeletalkey.com]

In laboratory tests, isolated prolongation of activated partial thromboplastin time (aPTT) can be found, but it is necessary to determine the plasma levels of factor VIII [ncbi.nlm.nih.gov]

normal prothrombin time, normal thrombin time, but prolonged partial thromboplastin time. [en.wikipedia.org]

Von Willebrand Disease

Laboratory studies revealed isolated prolongation of the activated partial thromboplastin time, which corrected in a mixing study. [ncbi.nlm.nih.gov]

One standard test of blood clotting (the prothrombin time [PT]) is usually normal while another standard test (partial thromboplastin time [PTT]) is usually prolonged. [msdmanuals.com]

Passovoy Factor Defect

partial thromboplastin time Causes List for Prolonged partial thromboplastin time Some of the possible causes of Prolonged partial thromboplastin time or similar disorders [familydiagnosis.com]

Prolonged partial thromboplastin time MedGen UID: 66815 • Concept ID: C0240671 • Finding An abnormal laboratory test result in which the partial thromboplastin time is found [ncbi.nlm.nih.gov]

Prolonged partial thromboplastin time MedGen UID: 66815 •Concept ID: C0240671 • Finding Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure [ncbi.nlm.nih.gov]

Portal Cirrhosis

[…] prothrombin time (PT) Prolonged international normalized ratio (INR) Prolonged activated partial thromboplastin time (aPTT) This condition does not respond to Vitamin K because [amboss.com]

[PT], partial thromboplastin time [PTT], international normalized ratio [INR]): Prolonged INR is suggestive of impaired hepatic synthetic function Albumin: hypoalbuminemia [emedicine.medscape.com]

[…] cirrhosis characterized by the presence of jaundice, ascites, variceal hemorrhage, or hepatic encephalopathy Clinical manifestations Hematologic manifestations Coagulopathy ;: Prolonged [amboss.com]

Acquired Factor XIII Deficiency

Posted on January 7, 2016 A physician may order mixing studies when a patient’s prothrombin time (PT), activated partial thromboplastin time, (aPTT) or both PT and aPTT are [kingbiomed.com]

Coagulation studies were normal, with a mildly prolonged activated partial thromboplastin time (aPTT; 44 s, normal value 20–40 s). [anesthesiology.pubs.asahq.org]

prolonged outside the upper limit of the laboratory’s established normal range. [kingbiomed.com]

Systemic Lupus Erythematosus

She was also found to have prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), positive lupus anticoagulant (LA) and low factor II levels. [ncbi.nlm.nih.gov]

A prolonged partial thromboplastin time and the presence of antiphospholipid antibodies are characteristic for antiphospholipid syndrome. [pubs.sciepub.com]

partial-thromboplastin time or Russell's viper–venom time). 17 A family history of coronary artery disease was defined as a first-degree relative who had had a myocardial [dx.doi.org]

Liver Failure

partial thromboplastin time (PTT) become prolonged when plasma coagulation components are diluted to less than 30%, and abnormal bleeding occurs when they are less than 17% [emedicine.medscape.com]

The exception is when an invasive procedure is planned or in the presence of profound coagulopathy (international normalized ratio [INR] >7). [41] Prothrombin time (PT) and [emedicine.medscape.com]

Gaucher Disease

[…] activated partial thromboplastin time, and pyrexia. [medicalnewstoday.com]

partial thromboplastin time. [aetna.com]

Prolongation of both the prothrombin time (PT) and the activated partial thromboplastin time (APTT) in GD patients has prompted the testing of individual coagulation factor [onlinelibrary.wiley.com]

Acute Promyelocytic Leukemia

The pancytopenia also causes abnormal results in other tests, such as a prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), high levels of fibrin [symptoma.com]

activated partial thromboplastin time (39.1 seconds, NR 24 to 34 seconds) and low fibrinogen (1.4 g/L, NR 1.5 to 4.0). [circ.ahajournals.org]

Most patients have a coagulopathy manifested by a prolonged prothrombin time (PT) and partial thromboplastin times (PTT), a low fibrinogen and a very low platelet count. [clinicaladvisor.com]

Acute Myeloid Leukemia

[…] of diagnosis.[ 7 ] This is typically manifested with thrombocytopenia, prolonged prothrombin time, partial thromboplastin time, elevated d-dimers, and hypofibrinogenemia. [northshore.org]

PML that occurs in the presence of the fusion protein.[ 4 - 6 ] Clinical Presentation Clinically, APL is characterized by severe coagulopathy that is often present at the time [cancer.gov]

[…] that occurs in the presence of the fusion protein.[ 4, 5, 6 ] Clinical Presentation Clinically, APL is characterized by severe coagulopathy that is often present at the time [northshore.org]