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298 Possible Causes for Pathological Fracture, Skin Discoloration

  • Kaposi Sarcoma

    skin lesion on both legs, initially considered as chronic vein insufficiency.[] […] female of Greek ethnicity, with no history of HIV infection or immunosuppression, presented to the Surgical Out-patient Department of our Center, with complaints of extensive discolored[]

  • Infectious Mononucleosis

    CT is best utilized for skull fracture and intracranial bleeding, whereas MRI may be ordered for prolonged symptoms, worsening symptoms or other suspected structural pathology[] Skin discoloration and icterus is sometime seen in patients with hepatosplenomegaly, and is slightly more common in elderly individuals.[] skin.[]

  • Diabetic Gangrene

    fracture, joint dislocation and fragmentation of articular cartilage Diabetic neuropathy is the most common cause.[] Bullae and the bluish skin discoloration are classic findings of gas gangrene and were noted have begun to show at the time of presentation of this case (Figures 1 and 2 )[] Gas gangrene is marked by a high fever, brownish pus *, gas bubbles under the skin, skin discoloration, and a foul odor.[]

  • Gaucher Disease

    fractures, and pyogenic osteomyelitis.[] […] of the skin due to diminished oxygen), and low blood pressure.[] BMD was low in 11 patients (50%); neither BMD nor HSA were associated with pathological fractures.[]

  • Maffucci Syndrome

    Pathological fractures can arise in affected metaphyses and diaphyses of the long bones and are common (26%).[] Figure 1: Multiple bluish and hyperpigmented nodules on (a) dorsal aspect and (b) ulnar aspect of the right forearm and hand, (c) note the violaceous discoloration underneath[] These tumors commonly lead to pathological fractures of bones, and although most of the tumors are benign, there is a 15-20% incidence of malignancy.[]

  • Multiple Myeloma

    Bottom Line: Among patients with myeloma, bisphosphonates were associated with lower rates of pathological fractures and skeletal-related events compared with placebo or no[] Symptoms associated with thrombocytopenia include abnormal bleeding episodes that often result in purplish discoloration of the skin resulting from bleeding (hemorrhaging)[] fracture.[]

  • Secondary Hyperparathyroidism

    PHPT must always be evaluated in patients with clinical histories of nephrolithiasis, nephrocalcinosis, osseous pain, subperiosteal resorption, and pathologic fractures, as[] Signs and symptoms of chronic kidney disease may be seen in patients who have the condition, which includes bruising and skin discoloration, pruritus, pericardial rub, edema[] Clinical features are due to: Excessive calcium resorption from bone: Osteopenia and osteoporosis, presenting as bone pain and pathological fractures.[]

  • Thalassemia

    Erythroid hyperplasia can result in typical structural bone abnormalities with marrow hyperplasia, bone thinning, maxillary hyperplasia, and pathologic fractures.[] Signs and symptoms vary but may include mild to severe anemia, paleness, fatigue, yellow discoloration of skin ( jaundice ), and bone problems. [2] Beta thalassemia is caused[] Pathologic fractures, especially in long bones and vertebrae, can result.[]

  • Osteogenesis Imperfecta

    These cases present with several pathologic fractures in the body during autopsies.[] […] teeth Curved spine, called scoliosis Feeling very tired Skin that is easily hurt Hearing loss that starts in early adulthood Can’t stand warm temperatures Loose joints Short[] Malabsorption syndromes: celiac disease, pancreatitis, Malignancy (lymphoma,leukemia, multiple myeloma). pathologic fractures, osteolytic bone lesions, hematologic and immune[]

  • Metastatic Adenocarcinoma of the Breast

    Local examination showed skin discoloration and 2 x2 cm lump in left upper outer quadrant. There was no discharge per nipple or enlarged lymph nodes.[]

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