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28 Possible Causes for Patient Appears Acutely Ill, Tryptophan Increased

  • Urinary Tract Infection

    IDO expression is increased during Escherichia coli urinary tract infection (UTI).[ncbi.nlm.nih.gov] The kynurenine-to-tryptophan (K/T) ratio is used as a surrogate for biological IDO enzyme activity.[ncbi.nlm.nih.gov] BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) catalyzes the first step of tryptophan (Trp) catabolism, yielding kynurenine (Kyn) metabolites.[ncbi.nlm.nih.gov]

  • Toxoplasmosis

    At least some of these effects, possibly mediated by increased dopamine and decreased tryptophan, are products of manipulation activity by Toxoplasma aiming to increase the[ncbi.nlm.nih.gov] tryptophan levels in all brain regions ( Dunn, 2006 ) or alternatively there are only proximate effects on serotonin in the specific area surrounding the cysts.[doi.org] Irritability rather than depression during interferon treatment is linked to increased tryptophan catabolism.[ncbi.nlm.nih.gov]

  • Eosinophilia Myalgia Syndrome

    The risk of developing EMS increases with larger doses of tryptophan and increasing age.[en.wikipedia.org] On the 14th day of prednisolone treatment (40 mg daily), L-kynurenine was declined to 8.1 mumol/L and, concomitantly, L-tryptophan level increased to the normal range (51.0[ncbi.nlm.nih.gov] L-tryptophan increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin.[rxlist.com]

  • Acute Hepatic Porphyria

    These findings suggest that increased tryptophan and 5-hydroxytryptamine in the nervous system may be responsible for the neurologic dysfunctions observed in humans with acute[science.sciencemag.org] Decreased activity of the heme-dependent protein tryptophan pyrrolase in the liver supposedly increases central and systemic tryptophan levels due to decreased tryptophan[emedicine.medscape.com] Acute hepatic heme depletion in porphyric rats was found to impair hepatic tryptophan pyrrolase activity which, in turn, elevated tryptophan and 5-hydroxytryptamine turnover[science.sciencemag.org]

  • Drug Hypersensitivity

    The peptides were radiolabeled and tested for binding in increasing concentrations of abacavir.[pnas.org] […] when the C-terminal P9 residue is switched to a tryptophan (pep-W), and that this effect is not observed for control HLA alleles.[pnas.org] As a control, pep-W with a C-terminal tryptophan was expected to be able to bind HLA-B*57:01 readily in the presence or absence of abacavir.[pnas.org]

  • Acute Cor Pulmonale

    […] incidence of pulmonary hypertension.17 Additionally, ingestion of contaminated rapeseed oil, L-tryptophan, amphetamines, and cocaine are associated with IPAH.16 Other conditions[what-when-how.com] […] associated with IPAH.16 In the 1960s and again in the 1990s, ingestion of appetite suppressants such as aminorex, fenfluramine, and dexfenfluramine were associated with an increased[what-when-how.com]

  • Biliary Tract Infection

    Several variants of this gene have been implicated in the increased risk of bile duct cancer, including a substitution of arginine for tryptophan at position 194 (R194W),[cco.amegroups.com] […] which was associated with an increased risk of bile duct cancer (OR: 1.9; 95% CI: 1.1–3.5, P 0.03), and a substitution of arginine for histidine (R280H) variant, which was[cco.amegroups.com]

  • Acute Intermittent Porphyria

    […] is an imbalance in the kynurenine metabolic pathway in AIP patients, with an increase of the kynurenine/tryptophan ratio in urine and a reduction of the kynurenic acid/kynurenine[ncbi.nlm.nih.gov] Decreased activity of the heme-dependent protein tryptophan pyrrolase in the liver supposedly increases central and systemic tryptophan levels due to decreased tryptophan[emedicine.medscape.com] RESULTS: Significant differences were found in the tryptophan-kynurenine metabolic pathway.[ncbi.nlm.nih.gov]

  • Porphyria

    Decreased activity of the heme-dependent protein tryptophan pyrrolase in the liver supposedly increases central and systemic tryptophan levels due to decreased tryptophan[emedicine.medscape.com] Increased central 5-hydroxytryptamine levels may cause cognitive changes.[emedicine.medscape.com]

  • Sepsis-associated Encephalopathy

    […] disturb neurotransmitter synthesis  Increased serum levels of phenylalanine, ammonia, and tryptophan with influence on procalcitonin and IL-6 levels contributing to SE development[slideshare.net] Appearance Acutely altered mental status Edema Looks ill Vital signs Abnormal body temperature: hypothermia, 100.4 F/38.3 C Hypotension: systolic BP or mean arterial pressure[atrainceu.com] Aromatic amino acids (AAA)  Normally restricted by BBB  Increased in SE patients and correlate with severity of encephalopathy  May act as false neurotransmitter and/or[slideshare.net]

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