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30 Possible Causes for Patient Appears Chronically Ill, Progressive Polyneuropathy

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    Lipodystrophies are a group of heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. Lipodystrophy associated metabolic abnormalities include insulin resistance, that often lead to diabetes mellitus and its complications,[…][ncbi.nlm.nih.gov]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[ncbi.nlm.nih.gov] […] in months; LFU, last follow-up; DADS, distal acquired demyelinating symmetric neuropathy; CIDP, chronic inflammatory demyelinating polyneuropathy; SMM, smoldering multiple[doi.org]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[web.archive.org] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) also may be associated with Waldenström macroglobulinemia.[emedicine.medscape.com]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Patients usually present with familial amyloid polyneuropathy, with progressive peripheral and autonomic neuropathy; involvement of the heart or kidneys is variable.[doi.org] Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis.[circ.ahajournals.org]

  • Myeloma-associated Amyloidosis

    The peripheral neuropathy of MGUS is classically bilateral, peripheral and sensory with electrophysiologic studies showing a demyelinating pattern; and in patients with progressive[hematology.org] […] relationship between MGUS and peripheral neuropathy is supported by association of peripheral neuropathy with other plasma cell dyscrasias including WM, MM, AL amyloid and POEMS (polyneuropathy[hematology.org]

  • Diabetic Nephropathy

    […] from microalbuminuria to macroalbuminuria, the proportion of individuals with peripheral symmetric polyneuropathy increased progressively in our patients (67-85%) (p 0.001[sjkdt.org] Ann N Y Acad Sci 1084 : 89 –117, 2006 Skundric DS, Lisak RP: Role of neuropoietic cytokines in development and progression of diabetic polyneuropathy: From glucose metabolism[doi.org] In fact majority of the patients from CKD stages II to V (74-100%) had peripheral symmetric polyneuropathy.[sjkdt.org]

  • Addison's Disease

    This disease is milder and progresses more slowly than adrenoleukodystrophy.[pedclerk.bsd.uchicago.edu] Adrenomyeloneuropathy begins in adolescence or early adulthood with weakness, spasticity, and distal polyneuropathy.[pedclerk.bsd.uchicago.edu] Adrenoleukodystrophy begins in infancy or childhood with weakness and spasticity and progresses to dementia, blindness and quadriparesis.[pedclerk.bsd.uchicago.edu]

  • Spinal Pachymeningitis

    Idiopathic hypertrophic cranial pachymeningitis causing progressive polyneuropathies in a child. Eur J Paediatr Neurol 2008; 12: 144-7.[medigraphic.com]

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