Patient Responsive: Causes & Reasons

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Possible Causes for Patient Responsive

Recurrent Small-Cell Carcinoma of the Lung

A response rate of 65% was observed in the intracranial disease of 14 patients with known brain metastases. [ncbi.nlm.nih.gov]

Fifteen of 17 patients (88.2%) had an objective response, with five complete responses (CRs; 29%) and 10 partial responses (PRs; 58.8%). [ncbi.nlm.nih.gov]

She also highlights the utility of patient derived xenografts to chart patient responses through time, and identify stages of resistance and response. [ecancer.org]

Chronic Phase of Chronic Myeloid Leukemia

However, only a small proportion of CP-CML patients subsequently achieve a deep molecular response (DMR) with imatinib. [ncbi.nlm.nih.gov]

At 12 months, 70.8% of patients had achieved a major molecular response. At 24 months, 81% of patients had achieved a major molecular response. [medivizor.com]

[…] achieved a cytogenetic response (major response in 7 patients and complete response in 5 patients). [clincancerres.aacrjournals.org]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Clinical and biologic features also seem to characterize this peculiar type of abrupt disease evolution, which intervenes in patients' response to this drug. [ncbi.nlm.nih.gov]

Responses were rapid, mostly occurring within 6 months, and were higher in patients with suboptimal response to imatinib, with 75% and 50% achieving major cytogenetic response [ncbi.nlm.nih.gov]

Cytogenetic responses were evident in 90 patients [45%; complete response in 47 patients (24%) and partial response (Ph 1-34%) in 21 patients (11%)]. [ncbi.nlm.nih.gov]

Chronic Immune Thrombocytopenic Purpura

Two patients achieved complete response, 4 patients achieved partial response, and OR rate was 46% (6 of 13) after therapy. Seven patients have no response. [ncbi.nlm.nih.gov]

Non-splenectomized patients had a better early response rate than those splenectomized. [ncbi.nlm.nih.gov]

The remaining four patients showed no platelet response and subsequently underwent splenectomy. [ncbi.nlm.nih.gov]

Chronic Myeloid Leukemia

We present here a chronic myeloid leukemia patient harboring the T315I and E255V BCR-ABL1 mutation successfully achieved deep molecular response with a combined treatment [ncbi.nlm.nih.gov]

Among patients with CML receiving therapy, PCR levels will drop below 0.1%, indicating a strong response to treatment, in approximately one-third. [hematologyandoncology.net]

The complete response rate is lower, at 7-34% of patients. [emedicine.medscape.com]

Minimally Conscious State

The healthy volunteers imaged during comparable passive language stimulation demonstrated responses similar to the patients' responses. [ncbi.nlm.nih.gov]

Patient's task-related neural responses mirrored the clinical change from a VS to an MCS. [ncbi.nlm.nih.gov]

The coherence responses significantly correlated with the patients’ baseline CRS-R scores. [tandfonline.com]

Lyme Arthritis

OBJECTIVE: To compare the pattern of antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme [ncbi.nlm.nih.gov]

METHODS: CD4+ T cell subsets were enumerated in the peripheral blood (PB) and synovial fluid (SF) of 12 patients with antibiotic-refractory arthritis and 6 patients with antibiotic-responsive [ncbi.nlm.nih.gov]

[…] with patients with antibiotic-responsive arthritis. [ncbi.nlm.nih.gov]

Carcinoma in Situ of the Bladder

If a patient has a preexisting Th1 immunologic response within the tumor, there is no value in using a therapy intended to create a Th1 immunologic response. [ncbi.nlm.nih.gov]

There were 18 patients who had a complete response following chemotherapy, 11 had a partial response (positive cytology) and 11 failed (persistent carcinoma in situ). [ncbi.nlm.nih.gov]

A total of 19 patients achieved complete response following an initial course of induction therapy and 2 partial responders to initial therapy also achieved complete response [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Patients were evaluated for response at 6 months because data in patients with indolent lymphoma indicated that patients may have delayed responses to rituximab. 10 Response [bloodjournal.hematologylibrary.org]

In the U.S. trial, 42% of patients achieved a complete response after 12 weeks of treatment while 58% of patients achieved a partial response. [medpagetoday.com]

Of the 2 relapsed patients, 1 had achieved a complete response to rituximab. [bloodjournal.hematologylibrary.org]

Mantle Cell Lymphoma

Within each response category, the median progression-free survival was longer for patients given VR-CAP than for those given R-CHOP (complete response/unconfirmed complete [ncbi.nlm.nih.gov]

Overall response rate to lenalidomide-based therapy was similar for patients with relapsed/progressive disease after previous response to ibrutinib (i.e., ≥PR) versus ibrutinib-refractory [ncbi.nlm.nih.gov]

Overall response rate was 26%, and complete response (or complete response unconfirmed) was achieved by 9 patients. Partial response was achieved by 25 patients. [emedicine.medscape.com]

Hairy Cell Leukemia Variant

Of these 4 patients, 1 (25%) achieved a complete response and 2 (50%) partial responses, for an overall response rate of 75%. [ncbi.nlm.nih.gov]

In contrast to HCl-C, the HCl-V response to purine nucleoside analogs (PNA) is limited to partial responses in approximately 50% of patients. [ncbi.nlm.nih.gov]

response rate of 86% was observed in the 28 patients, including a CR rate of 46%. [hairycellleukemia.org]

Bednar Tumor

response to irinotecan-based therapies. 2017;76. doi:10.1016/j.ejca.2017.02.003 Robin G, Sato Y, Desplancq D, Rochel N, Weiss E, Martineau P Restricted diversity of antigen [ircm.fr]

F, Vie N, Selves J, Emile J, Roger P, Gongora C, Robert J, Tubiana-Mathieu N, Ychou M, Martineau P Molecular subtypes of metastatic colorectal cancer are associated with patient [ircm.fr]

Thiamine-Responsive Megaloblastic Anemia - Diabetes Mellitus - Sensorineural Deafness

The diagnosis of thiamine responsive megaloblastic anemia in our patient was based on clinical features, the response to thiamine therapy and the absence of the m.3243A>G [latunisiemedicale.com]

The response to thiamine therapy in 17 patients reported in the litterature showed no improvement of glycemic control in eight of them, partial response with reducing temporally [latunisiemedicale.com]

Respiratory chain activities should be determined in this patient and in others thiamine responsive megaloblastic anemia patients and correlations between genotype, biochemistry [latunisiemedicale.com]

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

12 patients. [pubmed.ncbi.nlm.nih.gov]

[…] a favourable initial response to high dose glucocorticosteroids. [pubmed.ncbi.nlm.nih.gov]

[…] with pontine perivascular enhancement responsive to steroids' (CLIPPERS). [pubmed.ncbi.nlm.nih.gov]

Segmental Glomerulosclerosis

The overall kidney survival seems to be more favorable in younger patients, white patients, and patients with initial response to corticosteroid [24]. [latunisiemedicale.com]

Cyclophosphamide was given to 6 patients: 3 had no response to cyclosporine, 2 had ciclo toxicity, and one had steroid dependency. [latunisiemedicale.com]

Three patients received renal transplantation without recurrence. Chronic renal failure was significantly associated with non-response to cyclosporin A (p = 0.021). [latunisiemedicale.com]

Metastatic Renal Cell Carcinoma

Radiologic assessment of tumor response remains a challenge in patients treated with immune checkpoint inhibitors. [ncbi.nlm.nih.gov]

For 37 patients with no or one MSKCC risk factor, response groups defined by Choi, mChoi, MASS, and 10% threshold criteria did not differ in PFS or OS. [ncbi.nlm.nih.gov]

Here, we report the case of a metastatic renal cell carcinoma patient treated with everolimus who presented unexpected prolonged tumor response. [ncbi.nlm.nih.gov]

Chronic Diarrhea with Villous Atrophy

Giardiasis, responsible for diarrhea and malabsorption, should always be looked for, because immune competent patients are not spared. [link.springer.com]

Chez le patient infecté pour le VIH, le degré d’immunodépression doit être important pour être responsable d’une diarrhée infectieuse opportuniste. [link.springer.com]

Quel que soit le statut immunitaire du patient, la giardiase peut être responsable d’une diarrhée et d’une malabsorption. Elle doit être systématiquement recherchée. [link.springer.com]

Carotid Sinus Syncope

Three patients had syncope during prolonged head-up tilt. Heart rate and blood pressure responses were similar for patients and controls who completed tilt. [ncbi.nlm.nih.gov]

Twelve patients with a positive response to prolonged head-up tilt testing showed a vasodepressor response and only one patient showed a mixed response. [pmj.bmj.com]

A Medtronic Kappa 700 pacemaker with a rate drop response algorithm was implanted and the patient became asymptomatic. [ncbi.nlm.nih.gov]

Joubert Syndrome Type 10

Electroretinogram was performed in three patients and its response was extinct. [scielo.br]

Tent-shaped upper lip was observed in the younger patients (cases 3 and 4). MRI disclosed the typical molar tooth sign in all patients (Figure). [scielo.br]

In patients 4 and 5, abdominal ultrasound disclosed increased renal echogenicity, suggestive of parenquimatous nephropathy. [scielo.br]

Joubert Syndrome Type 5

Electroretinogram was performed in three patients and its response was extinct. [scielo.br]

Tent-shaped upper lip was observed in the younger patients (cases 3 and 4). MRI disclosed the typical molar tooth sign in all patients (Figure). [scielo.br]

In patients 4 and 5, abdominal ultrasound disclosed increased renal echogenicity, suggestive of parenquimatous nephropathy. [scielo.br]

Aztreonam Allergy

Sixty patients underwent skin testing to antigenic determinants of penicillin and imipenem (8). Twenty of the 60 patients developed IgE-mediated responses to penicillin. [ncbi.nlm.nih.gov]

Of these, 9 developed IgE-mediated responses to imipenem, for an overall cross-reactivity of 45%. [ncbi.nlm.nih.gov]

One case report described an immediate hypersensitivity reaction to imipenem in a patient allergic to penicillin and aztreonam (9). [ncbi.nlm.nih.gov]

B-Cell Chronic Lymphocytic Leukemia

ORR was 67% in 43 patients; 30% achieved complete response. [ncbi.nlm.nih.gov]

The overall response rate was 33% (95% confidence interval: 4-78) (1/6 patient each achieved complete response and partial response, respectively) and 3/6 patients had stable [ncbi.nlm.nih.gov]

Response to treatment and treatment outcome All patients enrolled on this trial were evaluable for response. [dx.doi.org]

Small-Intestine Neuroendocrine Tumor

Caplin M, Pavel M, Cwikla J, et al (2013) A randomized, double-blind, placebo-Controlled study of Lanreotide Antiproliferative Response in patients with gastroenteropancreatic [link.springer.com]

Kulke MH, Hornick JL, Frauenhoffer C, et al (2009) O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine [link.springer.com]

Poor Response to Eculizumab

Pharmacodynamic Analysis of Eculizumab in 2 Patients with a Poor Response and in 27 Patients with a Good Response in the AEGIS Study. [nejm.org]

[…] with good response to eculizumab and 1 healthy patient). [2minutemedicine.com]

RESULTS: Of 345 Japanese patients with PNH who received eculizumab, 11 patients had a poor response. [ncbi.nlm.nih.gov]

Prostate Leiomyosarcoma

For CRC patients – the biggest subgroup – radiological response was 2 PR, 7 SD, and 2 PD, with a median survival of 11.5 months. [publikationen.ub.uni-frankfurt.de]

Radiological tumor response, survival, and clinical response (in pelvis and pancreas only) were retrospectively analyzed. [publikationen.ub.uni-frankfurt.de]

Materials and methods: TACP of the pelvis was performed in 24 patients. [publikationen.ub.uni-frankfurt.de]

Liver Leiomyosarcoma

For CRC patients – the biggest subgroup – radiological response was 2 PR, 7 SD, and 2 PD, with a median survival of 11.5 months. [publikationen.ub.uni-frankfurt.de]

Radiological tumor response, survival, and clinical response (in pelvis and pancreas only) were retrospectively analyzed. [publikationen.ub.uni-frankfurt.de]

Materials and methods: TACP of the pelvis was performed in 24 patients. [publikationen.ub.uni-frankfurt.de]

Blast Phase of Chronic Myeloid Leukemia

There were no complete responses, but one patient had a partial response with a transient return to the chronic phase. [ncbi.nlm.nih.gov]

The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic [ncbi.nlm.nih.gov]

Major cytogenetic responses were attained in 33% (MBP-CML) and 52% (LBP-CML) of patients and complete cytogenetic responses were attained in 26 and 46%, respectively. [ncbi.nlm.nih.gov]

Hereditary Spherocytosis Type 1

We describe a patient 45 years old, with hereditary spherocytosis with masses of mediastinal paravertebral extramedullary hematopoietic tissue, with a favorable response to [pesquisa.bvsalud.org]

[…] with asymptomatic hereditry spherocytosis Artículo en Español | LILACS | ID: lil-699429 Biblioteca responsable: AR392.1 RESUMEN ABSTRACT RESUMEN En diversas patologías con [pesquisa.bvsalud.org]

[…] en paciente con esferocitosis hereditaria asintomática Hematopoyesis extramedular en paciente con esferocitosis hereditaria asintomática / Extramedullary hematopoiesis in patients [pesquisa.bvsalud.org]

Idiopathic Achalasia

Neither age, sex, nor duration or severity of symptoms were predictive of patients' responses to treatment. [ncbi.nlm.nih.gov]

In the achalasia patients, MRS induced a variable response: eight patients had simultaneous motor activity during all MRS although onset was delayed compared with SS [median [ncbi.nlm.nih.gov]

Twenty-nine patients had a good response and two had a poor response. [ncbi.nlm.nih.gov]

Chronic Leukemia

[…] close monitoring of patient's adherence is critical to achieving optimal responses. [jnccn.org]

Rituximab plus chlorambucil in patients with CD20-positive B-cell chronic lymphocytic leukemia (CLL): final response analysis of an open-label phase II study (Abstract) Blood [ncbi.nlm.nih.gov]

[…] and CLL3X–reduced-intensity HSC transplantation in poor-risk patients) failed to show any adverse impact of NOTCH1 or SF3B1 mutations on response rate, PFS, or OS after multivariate [bloodjournal.org]