Patient Responsive: Causes & Reasons

Possible Causes for Patient Responsive

Recurrent Small-Cell Carcinoma of the Lung

A response rate of 65% was observed in the intracranial disease of 14 patients with known brain metastases. [ncbi.nlm.nih.gov]

She also highlights the utility of patient derived xenografts to chart patient responses through time, and identify stages of resistance and response. [ecancer.org]

Fifteen of 17 patients (88.2%) had an objective response, with five complete responses (CRs; 29%) and 10 partial responses (PRs; 58.8%). [ncbi.nlm.nih.gov]

Chronic Phase of Chronic Myeloid Leukemia

However, only a small proportion of CP-CML patients subsequently achieve a deep molecular response (DMR) with imatinib. [ncbi.nlm.nih.gov]

At 12 months, 70.8% of patients had achieved a major molecular response. At 24 months, 81% of patients had achieved a major molecular response. [medivizor.com]

[…] achieved a cytogenetic response (major response in 7 patients and complete response in 5 patients). [clincancerres.aacrjournals.org]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Clinical and biologic features also seem to characterize this peculiar type of abrupt disease evolution, which intervenes in patients' response to this drug. [ncbi.nlm.nih.gov]

Cytogenetic responses were evident in 90 patients [45%; complete response in 47 patients (24%) and partial response (Ph 1-34%) in 21 patients (11%)]. [ncbi.nlm.nih.gov]

Responses were rapid, mostly occurring within 6 months, and were higher in patients with suboptimal response to imatinib, with 75% and 50% achieving major cytogenetic response [ncbi.nlm.nih.gov]

Chronic Immune Thrombocytopenic Purpura

Two patients achieved complete response, 4 patients achieved partial response, and OR rate was 46% (6 of 13) after therapy. Seven patients have no response. [ncbi.nlm.nih.gov]

Non-splenectomized patients had a better early response rate than those splenectomized. [ncbi.nlm.nih.gov]

Six of nine nonsplenectomized patients (67%) increased PC, thus avoiding splenectomy; four patients attained a stable complete response (CR). [ncbi.nlm.nih.gov]

Chronic Myeloid Leukemia

Among patients with CML receiving therapy, PCR levels will drop below 0.1%, indicating a strong response to treatment, in approximately one-third. [hematologyandoncology.net]

Advanced-stage CML Allo-SCT should be considered early in patients in CML-AP based on response to TKI therapy. [journals.lww.com]

We present here a chronic myeloid leukemia patient harboring the T315I and E255V BCR-ABL1 mutation successfully achieved deep molecular response with a combined treatment [ncbi.nlm.nih.gov]

Minimally Conscious State

The healthy volunteers imaged during comparable passive language stimulation demonstrated responses similar to the patients' responses. [ncbi.nlm.nih.gov]

The coherence responses significantly correlated with the patients’ baseline CRS-R scores. [tandfonline.com]

Patient's task-related neural responses mirrored the clinical change from a VS to an MCS. [ncbi.nlm.nih.gov]

Carcinoma in Situ of the Bladder

If a patient has a preexisting Th1 immunologic response within the tumor, there is no value in using a therapy intended to create a Th1 immunologic response. [ncbi.nlm.nih.gov]

There were 18 patients who had a complete response following chemotherapy, 11 had a partial response (positive cytology) and 11 failed (persistent carcinoma in situ). [ncbi.nlm.nih.gov]

A total of 19 patients achieved complete response following an initial course of induction therapy and 2 partial responders to initial therapy also achieved complete response [ncbi.nlm.nih.gov]

Lyme Arthritis

OBJECTIVE: To compare the pattern of antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme [ncbi.nlm.nih.gov]

METHODS: CD4+ T cell subsets were enumerated in the peripheral blood (PB) and synovial fluid (SF) of 12 patients with antibiotic-refractory arthritis and 6 patients with antibiotic-responsive [ncbi.nlm.nih.gov]

[…] with patients with antibiotic-responsive arthritis. [ncbi.nlm.nih.gov]

Hairy Cell Leukemia Variant

Of these 4 patients, 1 (25%) achieved a complete response and 2 (50%) partial responses, for an overall response rate of 75%. [ncbi.nlm.nih.gov]

In contrast to HCl-C, the HCl-V response to purine nucleoside analogs (PNA) is limited to partial responses in approximately 50% of patients. [ncbi.nlm.nih.gov]

response rate of 86% was observed in the 28 patients, including a CR rate of 46%. [hairycellleukemia.org]

Hairy Cell Leukemia

In the U.S. trial, 42% of patients achieved a complete response after 12 weeks of treatment while 58% of patients achieved a partial response. [medpagetoday.com]

Patients were evaluated for response at 6 months because data in patients with indolent lymphoma indicated that patients may have delayed responses to rituximab. 10 Response [bloodjournal.hematologylibrary.org]

Disease progression occurred in seven out of 24 U.S. patients or 29% of the group including three patients who had achieved a complete response. [medpagetoday.com]

Mantle Cell Lymphoma

Within each response category, the median progression-free survival was longer for patients given VR-CAP than for those given R-CHOP (complete response/unconfirmed complete [ncbi.nlm.nih.gov]

Patients with relapsed/refractory MCL (n = 370) treated with ibrutinib had an objective response rate (ORR) of 66% (20% complete response; 46% partial response); median duration [ncbi.nlm.nih.gov]

Overall response rate was 26%, and complete response (or complete response unconfirmed) was achieved by 9 patients. Partial response was achieved by 25 patients. [emedicine.medscape.com]

Carotid Sinus Syncope

Twelve patients with a positive response to prolonged head-up tilt testing showed a vasodepressor response and only one patient showed a mixed response. [pmj.bmj.com]

Three patients had syncope during prolonged head-up tilt. Heart rate and blood pressure responses were similar for patients and controls who completed tilt. [ncbi.nlm.nih.gov]

A Medtronic Kappa 700 pacemaker with a rate drop response algorithm was implanted and the patient became asymptomatic. [ncbi.nlm.nih.gov]

Metastatic Renal Cell Carcinoma

Radiologic assessment of tumor response remains a challenge in patients treated with immune checkpoint inhibitors. [ncbi.nlm.nih.gov]

For 37 patients with no or one MSKCC risk factor, response groups defined by Choi, mChoi, MASS, and 10% threshold criteria did not differ in PFS or OS. [ncbi.nlm.nih.gov]

Here, we report the case of a metastatic renal cell carcinoma patient treated with everolimus who presented unexpected prolonged tumor response. [ncbi.nlm.nih.gov]

Waldenstrom Macroglobulinemia

Achievement of response was also an important prognostic factor for subsequent survival in patients with advanced WM. [doi.org]

[…] a partial response, and 11 patients (30%) obtaining a minor response. [emedicine.medscape.com]

Of these patients, 16 (64%) patients achieved a major response and 2 (8%) patients achieved a minor response. One complete remission was observed among major responders. [doi.org]

Idiopathic Achalasia

Neither age, sex, nor duration or severity of symptoms were predictive of patients' responses to treatment. [ncbi.nlm.nih.gov]

In the achalasia patients, MRS induced a variable response: eight patients had simultaneous motor activity during all MRS although onset was delayed compared with SS [median [ncbi.nlm.nih.gov]

Twenty-nine patients had a good response and two had a poor response. [ncbi.nlm.nih.gov]

Blast Phase of Chronic Myeloid Leukemia

There were no complete responses, but one patient had a partial response with a transient return to the chronic phase. [ncbi.nlm.nih.gov]

The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic [ncbi.nlm.nih.gov]

Major cytogenetic responses were attained in 33% (MBP-CML) and 52% (LBP-CML) of patients and complete cytogenetic responses were attained in 26 and 46%, respectively. [ncbi.nlm.nih.gov]

Chronic Active Hepatitis B

We found no significant difference in the response to different types of interferon or to high or low dose regimens, or in the responses of patients with cirrhosis. [ncbi.nlm.nih.gov]

At the end of treatment, IL-2R+ cells were decreased in the group of patients with complete response, unchanged in patients with partial response and increased in patients [ncbi.nlm.nih.gov]

RESULTS: Nine patients had a complete response to treatment with interferon alfa (loss of hepatitis B surface antigen), 26 had a partial response (permanently HBV-DNA negative [ncbi.nlm.nih.gov]

Immune Thrombocytopenic Purpura

RESULTS: Complete remission was achieved in 19 patients (76%), partial remission in 3 patients (12%), and minimal response in none of the patients; 1 patient was considered [ncbi.nlm.nih.gov]

Some response (CR+PR) was initially obtained in 21 patients (91%), with the remaining two exhibiting no response at all. [omicsonline.org]

RESULTS: Four weeks after treatment, only in 6 patients (33/3%) of 18 patients, complete response (Plt > 100,000) were obtained and most patients (67/66%) had no appropriate [ncbi.nlm.nih.gov]

B-Cell Chronic Lymphocytic Leukemia

ORR was 67% in 43 patients; 30% achieved complete response. [ncbi.nlm.nih.gov]

In the FC group, 9 patients had no response, and 5 of these patients died ( P = .006). [dx.doi.org]

Median progression-free survival was 24.4 months, not reached in patients achieving complete response. Median overall survival was 33.6 months. [ncbi.nlm.nih.gov]

Malignant Mixed Mesodermal Tumor

Nevertheless, surgical treatment is paramount for the survival of patients. Response rates to chemotherapy are about 20%. [link.springer.com]

High-Grade B-Cell Lymphoma with MYC - BCL2 - BCL6 Rearrangement

Conclusions : R/R LBCL is responsive to RT, although RR are lower among DHL/THL patients. [e-cancer.fr]

Among patients with relapsed/refractory (R/R) large B-cell lymphoma (LCBL), we compared rates and durability of response between patients with and without DHL/THL. [e-cancer.fr]

Despite similar RT doses (median 35 Gy), radiographic complete response rate was lower among DHL/THL patients: 14.3% vs 64.7% (p=0.01). [e-cancer.fr]

Myeloid and Lymphoid Neoplasms with FGFR1 Abnormalities

[…] will only be evaluated in patients with an objective response of CR or PR. [clinicaltrialsregister.eu]

At the analysis stage, the best objective response will be assigned for each patient as the best response recorded after initiation of study treatment and confirmed at least [clinicaltrialsregister.eu]

Duration of CR (only in patients who achieved a CR), duration of CR+CRi (only in patients who achieved a CR/CRi [leukemia presentation only]), and duration of response (only [clinicaltrialsregister.eu]

NEMO Mutation with Immunodeficiency

This lack of response is notable even in patients with normal total serum immunoglobulin levels. [primaryimmune.org]

Many patients had humoral immunity problems with a complete lack of antibody response against bacteria such as Pneumococcus. [primaryimmune.org]

Innate immune cells from patients with the NEMO syndrome also demonstrate poor responses after stimulation with molecules derived from microbes. [primaryimmune.org]

Thiamine-Responsive Megaloblastic Anemia - Diabetes Mellitus - Sensorineural Deafness

The diagnosis of thiamine responsive megaloblastic anemia in our patient was based on clinical features, the response to thiamine therapy and the absence of the m.3243A>G [latunisiemedicale.com]

Pancytopenia in an adult patient with thiamine-responsive megaloblastic anaemia. Moulin V, Grandoni F, Castioni J, Lu H. Moulin V, et al. [pubmed.ncbi.nlm.nih.gov]

The response to thiamine therapy in 17 patients reported in the litterature showed no improvement of glycemic control in eight of them, partial response with reducing temporally [latunisiemedicale.com]

Ovarian Mesodermal Adenosarcoma

Nevertheless, surgical treatment is paramount for the survival of patients. Response rates to chemotherapy are about 20%. [link.springer.com]

Bladder Lymphoma

Eight (53%) patients achieved complete remission, six (40%) patients partial response and only one (7%) patient had progressive disease. [scienceopen.com]

To study the main clinicobiologic features, response, and outcome of patients with diffuse large B-cell lymphoma (DLBCL) according to the primary site, lymph node, or different [scienceopen.com]

A total of 74 cycles was administered to our patients, with a median number of five cycles per patient. [scienceopen.com]

Aztreonam Allergy

Sixty patients underwent skin testing to antigenic determinants of penicillin and imipenem (8). Twenty of the 60 patients developed IgE-mediated responses to penicillin. [ncbi.nlm.nih.gov]

Of these, 9 developed IgE-mediated responses to imipenem, for an overall cross-reactivity of 45%. [ncbi.nlm.nih.gov]

One case report described an immediate hypersensitivity reaction to imipenem in a patient allergic to penicillin and aztreonam (9). [ncbi.nlm.nih.gov]

Intraepithelial Corneal Neoplasia

Two of the 89 eyes treated (2.25%) had only a partial response to treatment; of these 2 patients, 1 was taking cyclosporine for keratitis sicca. [aianmodena.org]

The tumor size pre- and post-treatment, clinical response, and ocular complications were evaluated. Results: The mean age of the patients was 56 +/- 13.4 years. [pubmed.ncbi.nlm.nih.gov]

Four of the 87 patients with complete response developed a mild allergic papillary conjunctivitis that settled on halving the interferon dose to 0.5 million IU drops and reducing [aianmodena.org]

Pancreatic Ductal Carcinoma

response to treatment. [radiopaedia.org]

Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. [ncbi.nlm.nih.gov]

Preoperative / neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages// PLoS Medicine. 2010. Vol. 7, № 4. [malignanttumors.org]

X-Linked Lymphoproliferative Disease due to SH2D1A Deficiency

Defective anti-polysaccharide response and splenic marginal zone disorganization in ALPS patients. Blood. 2014;124(10):1597-1609. [scielo.org.mx]

Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome. Br J Haematol. 2009;145(1):101. [scielo.org.mx]

Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome. Br J Haematol. 2009;145(1):101-106. [scielo.org.mx]