Patient Responsive: Causes & Reasons

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Possible Causes for Patient Responsive

Recurrent Small-Cell Carcinoma of the Lung

A response rate of 65% was observed in the intracranial disease of 14 patients with known brain metastases. [ncbi.nlm.nih.gov]

Fifteen of 17 patients (88.2%) had an objective response, with five complete responses (CRs; 29%) and 10 partial responses (PRs; 58.8%). [ncbi.nlm.nih.gov]

She also highlights the utility of patient derived xenografts to chart patient responses through time, and identify stages of resistance and response. [ecancer.org]

Chronic Phase of Chronic Myeloid Leukemia

At 12 months, 70.8% of patients had achieved a major molecular response. At 24 months, 81% of patients had achieved a major molecular response. [medivizor.com]

[…] achieved a cytogenetic response (major response in 7 patients and complete response in 5 patients). [clincancerres.aacrjournals.org]

We recommend additional studies to investigate patient immunogenetic profiles and their potential role in complete response to therapy. [ncbi.nlm.nih.gov]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Clinical and biologic features also seem to characterize this peculiar type of abrupt disease evolution, which intervenes in patients' response to this drug. [ncbi.nlm.nih.gov]

Responses were rapid, mostly occurring within 6 months, and were higher in patients with suboptimal response to imatinib, with 75% and 50% achieving major cytogenetic response [ncbi.nlm.nih.gov]

Cytogenetic responses were evident in 90 patients [45%; complete response in 47 patients (24%) and partial response (Ph 1-34%) in 21 patients (11%)]. [ncbi.nlm.nih.gov]

Chronic Immune Thrombocytopenic Purpura

Two patients achieved complete response, 4 patients achieved partial response, and OR rate was 46% (6 of 13) after therapy. Seven patients have no response. [ncbi.nlm.nih.gov]

Non-splenectomized patients had a better early response rate than those splenectomized. [ncbi.nlm.nih.gov]

The remaining four patients showed no platelet response and subsequently underwent splenectomy. [ncbi.nlm.nih.gov]

Chronic Myeloid Leukemia

Among patients with CML receiving therapy, PCR levels will drop below 0.1%, indicating a strong response to treatment, in approximately one-third. [hematologyandoncology.net]

The complete response rate is lower, at 7-34% of patients. [emedicine.medscape.com]

[…] than did patients without a complete cytogenetic response (P<0.001). [ncbi.nlm.nih.gov]

Minimally Conscious State

The healthy volunteers imaged during comparable passive language stimulation demonstrated responses similar to the patients' responses. [ncbi.nlm.nih.gov]

Patient's task-related neural responses mirrored the clinical change from a VS to an MCS. [ncbi.nlm.nih.gov]

Accuracy for simple orientation yes/no questions remains challenging for responsive patients in early recovery from traumatic brain injury. [ncbi.nlm.nih.gov]

Carcinoma in Situ of the Bladder

There were 18 patients who had a complete response following chemotherapy, 11 had a partial response (positive cytology) and 11 failed (persistent carcinoma in situ). [ncbi.nlm.nih.gov]

A total of 19 patients achieved complete response following an initial course of induction therapy and 2 partial responders to initial therapy also achieved complete response [ncbi.nlm.nih.gov]

If a patient has a preexisting Th1 immunologic response within the tumor, there is no value in using a therapy intended to create a Th1 immunologic response. [ncbi.nlm.nih.gov]

Mantle Cell Lymphoma

Overall response rate to lenalidomide-based therapy was similar for patients with relapsed/progressive disease after previous response to ibrutinib (i.e., ≥PR) versus ibrutinib-refractory [ncbi.nlm.nih.gov]

Overall response rate was 26%, and complete response (or complete response unconfirmed) was achieved by 9 patients. Partial response was achieved by 25 patients. [emedicine.medscape.com]

Median time from last dose of ibrutinib to the start of lenalidomide was 1.3 weeks (range, 0.1-21.7); 45% of patients had partial responses or better to prior ibrutinib. [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Patients were evaluated for response at 6 months because data in patients with indolent lymphoma indicated that patients may have delayed responses to rituximab. 10 Response [bloodjournal.hematologylibrary.org]

In the U.S. trial, 42% of patients achieved a complete response after 12 weeks of treatment while 58% of patients achieved a partial response. [medpagetoday.com]

Of the 2 relapsed patients, 1 had achieved a complete response to rituximab. [bloodjournal.hematologylibrary.org]

Hairy Cell Leukemia Variant

Of these 4 patients, 1 (25%) achieved a complete response and 2 (50%) partial responses, for an overall response rate of 75%. [ncbi.nlm.nih.gov]

In contrast to HCl-C, the HCl-V response to purine nucleoside analogs (PNA) is limited to partial responses in approximately 50% of patients. [ncbi.nlm.nih.gov]

response rate of 86% was observed in the 28 patients, including a CR rate of 46%. [hairycellleukemia.org]

Lyme Arthritis

[…] with patients with antibiotic-responsive arthritis. [ncbi.nlm.nih.gov]

The patient's response to treatment with a 2-week course of ceftriaxone was dramatic. [ncbi.nlm.nih.gov]

OBJECTIVE: To compare the pattern of antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme [ncbi.nlm.nih.gov]

Carotid Sinus Syncope

Three patients had syncope during prolonged head-up tilt. Heart rate and blood pressure responses were similar for patients and controls who completed tilt. [ncbi.nlm.nih.gov]

Twelve patients with a positive response to prolonged head-up tilt testing showed a vasodepressor response and only one patient showed a mixed response. [pmj.bmj.com]

A Medtronic Kappa 700 pacemaker with a rate drop response algorithm was implanted and the patient became asymptomatic. [ncbi.nlm.nih.gov]

B-Cell Chronic Lymphocytic Leukemia

ORR was 67% in 43 patients; 30% achieved complete response. [ncbi.nlm.nih.gov]

The overall response rate was 33% (95% confidence interval: 4-78) (1/6 patient each achieved complete response and partial response, respectively) and 3/6 patients had stable [ncbi.nlm.nih.gov]

Response to treatment and treatment outcome All patients enrolled on this trial were evaluable for response. [dx.doi.org]

Metastatic Renal Cell Carcinoma

Radiologic assessment of tumor response remains a challenge in patients treated with immune checkpoint inhibitors. [ncbi.nlm.nih.gov]

One patient has had a continuing partial response for 58 months with cytokine-intolerant metastatic renal cell carcinoma and the other patient has had continuing stable disease [ncbi.nlm.nih.gov]

Here we present 3 patients with mRCC treated with sunitinib for at least one year, resulting in a partial response, followed by a stable disease for several years. [ncbi.nlm.nih.gov]

Blast Phase of Chronic Myeloid Leukemia

There were no complete responses, but one patient had a partial response with a transient return to the chronic phase. [ncbi.nlm.nih.gov]

The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic [ncbi.nlm.nih.gov]

Major cytogenetic responses were attained in 33% (MBP-CML) and 52% (LBP-CML) of patients and complete cytogenetic responses were attained in 26 and 46%, respectively. [ncbi.nlm.nih.gov]

Immune Thrombocytopenic Purpura

RESULTS: Complete remission was achieved in 19 patients (76%), partial remission in 3 patients (12%), and minimal response in none of the patients; 1 patient was considered [ncbi.nlm.nih.gov]

The arrows and overlying numbers represent patients changing response. Patients who required alternative treatment were classified as having no response. [haematologica.org]

Five patients (ns. 1,2,7,9,and 10) had a complete response (platelet counts in normal range), one patient (n. 5) had a partial response (platelet counts between 80 and 150 [haematologica.org]

Waldenstrom Macroglobulinemia

[…] a partial response, and 11 patients (30%) obtaining a minor response. [emedicine.medscape.com]

Of these patients, 16 (64%) patients achieved a major response and 2 (8%) patients achieved a minor response. One complete remission was observed among major responders. [doi.org]

The overall response rate in this study was 70%, with 44% of patients achieving a major response and 28% of patients achieved a minor response. [doi.org]

Idiopathic Achalasia

Neither age, sex, nor duration or severity of symptoms were predictive of patients' responses to treatment. [ncbi.nlm.nih.gov]

In the achalasia patients, MRS induced a variable response: eight patients had simultaneous motor activity during all MRS although onset was delayed compared with SS [median [ncbi.nlm.nih.gov]

Twenty-nine patients had a good response and two had a poor response. [ncbi.nlm.nih.gov]

Chronic Lymphocytic Leukemia

In the FC group, 9 patients had no response, and 5 of these patients died ( P = .006). [dx.doi.org]

Patients with complete response (CR) or partial response (PR) after an induction phase were randomized into a maintenance arm with rituximab or an observational arm. [ncbi.nlm.nih.gov]

Baseline characteristics of eligible patients according to treatment Response to treatment Response data were available for 164 patients from each treatment arm. [dx.doi.org]

Myeloma Kidney

[…] achieved an anticancer response. 25% of patients achieved a complete disappearance of cancer (complete response). 15% of patients achieved disease stabilization or a minimal [news.cancerconnect.com]

’s response to initial treatment. [myelomabeacon.org]

response. [news.cancerconnect.com]

Chronic Hepatitis C

response in patients who were treated with peginterferon/ribavirin. [ncbi.nlm.nih.gov]

Therapy will be continued for at least 12 weeks, and patients with an early viral response will continue for a full 48 weeks. [clinicaltrials.gov]

In the 100 patients who also took ribavirin the response rate was 97%. 4 For the 419 patients infected with genotype 1b the response rate was 99% without ribavirin and 99.5% [nps.org.au]

Red Cell Aplasia

Patient Characteristics and Response to Therapy Table. [annals.org]

Abstract To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia [ncbi.nlm.nih.gov]

Among the 96 patients in whom the 12 months response to IVIg treatment was available, hemoglobin correction was achieved in 45 patients while persistant anemia was noticed [acrabstracts.org]

Primary Mediastinal Large B-Cell Lymphoma

Involved-field RT plays an important role in inducing negative results on (67)Ga scintigraphy/positron emission tomography in patients responsive to chemotherapy. [ncbi.nlm.nih.gov]

At the end of their scheduled treatment, 82 patients (83.7%) had a complete and 6 a partial response (6.1%). [ncbi.nlm.nih.gov]

The objective response rate was 48% (7 complete responses; 33%) among 21 patients in KEYNOTE-013 and 45% (7 complete responses; 13%) among 53 patients in KEYNOTE-170. [ascopubs.org]

Primary Amyloidosis

Indeed, NYHA class improvement was accompanied by NT-proBNP response in all patients. [doi.org]

Among evaluable patients, 94% had a hematologic response and 44% a hematologic complete response, including all five patients who had not responded to prior high dose dexamethasone-based [doi.org]

High-dose dexamethasone provides a rapid response time in patients with AL. [doi.org]

Myelodysplasia

Of 10 patients with a 5q31.1 deletion, 9 had a cytogenetic response after 8 weeks, whereas 1 patient had a response at 16 weeks. [doi.org]

12 patients with a response; 10 of these 12 patients had a 5q31.1 deletion ( Figure 2 ). [doi.org]

Of these 10 patients, 9 had del(5)(q31.1) and 1 had t(1;22)(q21p11.2). All cytogenetic responses occurred in patients who also had a hematologic response. [doi.org]

Bednar Tumor

response to irinotecan-based therapies. 2017;76. doi:10.1016/j.ejca.2017.02.003 Robin G, Sato Y, Desplancq D, Rochel N, Weiss E, Martineau P Restricted diversity of antigen [ircm.fr]

F, Vie N, Selves J, Emile J, Roger P, Gongora C, Robert J, Tubiana-Mathieu N, Ychou M, Martineau P Molecular subtypes of metastatic colorectal cancer are associated with patient [ircm.fr]

Thiamine-Responsive Megaloblastic Anemia - Diabetes Mellitus - Sensorineural Deafness

The diagnosis of thiamine responsive megaloblastic anemia in our patient was based on clinical features, the response to thiamine therapy and the absence of the m.3243A>G [latunisiemedicale.com]

The response to thiamine therapy in 17 patients reported in the litterature showed no improvement of glycemic control in eight of them, partial response with reducing temporally [latunisiemedicale.com]

Respiratory chain activities should be determined in this patient and in others thiamine responsive megaloblastic anemia patients and correlations between genotype, biochemistry [latunisiemedicale.com]

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

12 patients. [pubmed.ncbi.nlm.nih.gov]

[…] a favourable initial response to high dose glucocorticosteroids. [pubmed.ncbi.nlm.nih.gov]

[…] with pontine perivascular enhancement responsive to steroids' (CLIPPERS). [pubmed.ncbi.nlm.nih.gov]

Segmental Glomerulosclerosis

The overall kidney survival seems to be more favorable in younger patients, white patients, and patients with initial response to corticosteroid [24]. [latunisiemedicale.com]

Cyclophosphamide was given to 6 patients: 3 had no response to cyclosporine, 2 had ciclo toxicity, and one had steroid dependency. [latunisiemedicale.com]

Three patients received renal transplantation without recurrence. Chronic renal failure was significantly associated with non-response to cyclosporin A (p = 0.021). [latunisiemedicale.com]

Aggressive Systemic Mastocytosis

During therapy, two of the five patients showed a major response defined by complete resolution of C-Finding(s), one a partial response (partial regression of C-Findings), [ncbi.nlm.nih.gov]

In the current article, we propose surrogate markers and treatment response criteria for patients with ASM. [ncbi.nlm.nih.gov]

When the patient was treated with cyclosporin and low-dose methylprednisolone, he showed a good response. [ncbi.nlm.nih.gov]