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764 Possible Causes for Pediatric Disorder, T Cell Activation Increased

  • Acne Vulgaris

    PPARα increases activity of activator protein 1 (AP-1) and NF-κB, thereby leading to the recruitment of inflammatory T cells.[en.wikipedia.org] Tollefson, Endocrine disorders and hormonal therapy for adolescent acne, Current Opinion in Pediatrics, 10.1097/MOP.0000000000000515, 29, 4, (455-465), (2017).[doi.org] Consensus statement on management of intersex disorders. J Pediatr Urol 2006 ; 2: 148 62 Google Scholar Crossref Medline 55. Hughes, IA.[doi.org]

  • Food Allergy

    Memory T cells are increased in frequency and have distinct activation requirements and cell-surface proteins that distinguish them from armed effector T cells 10-25.[ncbi.nlm.nih.gov] BACKGROUND/AIMS: We evaluated our 16-year single-center experience of pediatric post-transplant lymphoproliferative disorder (PTLD) cases who underwent liver transplantation[ncbi.nlm.nih.gov] Boyce, Joshua Avram, MD Clinical Interests Asthma Eosinophilic disorders Pediatric lung disease Food allergy Allergies Pulmonology Board Certifications Pediatric Pulmonology[massgeneral.org]

  • Allergic Rhinitis

    We found that IL-1R8 expression was very low on dendritic cells (DCs) and resting CD4 T cells but increased strongly on CD4 T cells following T cell activation.[ncbi.nlm.nih.gov] Abstract The studies of T-regulatory (Treg) cells in the pediatric allergic disorders, especially allergic rhinitis (AR), are very few and still far from being elucidated.[ncbi.nlm.nih.gov] Apply the latest treatment options in pediatric care with new chapters on pediatric sleep disorders, pediatric infectious disease, and evaluation and management of the infant[books.google.com]

  • Infectious Mononucleosis

    The persistent activation of T cells in our patient may have increased the likelihood of development of uncontrolled T-cell lymphoproliferative disease.[dx.doi.org] […] optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder.[ncbi.nlm.nih.gov] Katz, Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders), Principles and Practice of Pediatric Infectious Diseases, 10.1016/B978-0-323-40181-4.00208-5, ([oadoi.org]

  • Allergic Asthma

    It is associated with increased IgE, mast cell activation, airway hyperresponsiveness (AHR), mucus overproduction and remodeling of the airways.[ncbi.nlm.nih.gov] Previously, this pathological trait has been associated with T helper type 2 (Th2) cells.[ncbi.nlm.nih.gov]

  • Klinefelter Syndrome

    It has been hypothesized that testosterone protects males from autoimmune phenomena; therefore, hypogonadal males are prone to defects in T-cell activity that lead to autoimmune[glowm.com] disorders, resulting in a rise in the diagnosis and early referral to the pediatric endocrinologist.[ncbi.nlm.nih.gov] […] systemic lupus erythematosus, 63 , 64 , 65 ankylosing spondylitis, 66 and Sjögren’s syndrome, characterized by keratoconjunctivitis, dry mouth, and arthritis, 65 occur with increased[glowm.com]

  • Infantile Colic

    […] boosted with repeated exposure to allergen, increasing activation of allergen-specific T cells and production of IgE.[ncbi.nlm.nih.gov] For Rome III, there was an increase from 1 to 2 pediatric working teams.[ncbi.nlm.nih.gov] JAMA Pediatr 167(10):977–8 CrossRef PubMed Google Scholar 5.[link.springer.com]

  • Zinc Deficiency

    Reduction in intracellular free zinc increases surface expression of major histocompatibility complex class II molecules, which is important for the activation of CD4 T cells[ncbi.nlm.nih.gov] Anxiety in Children In our practice, in addition to zinc deficiency, we often see yeast issues and gut issues in our pediatric patients with general anxiety disorder.[mensahmedical.com] […] hyperactivity disorder EFA — essential fatty acids EPD — enzyme-potentiated desensitization IGg — immunoglobulin G LC — long chain PUFA — polyunsaturated fatty acids Accepted[doi.org]

  • Hepatoblastoma

    Epidermal growth factor receptor RNA and protein and increased levels of activated epidermal growth factor receptor and Stat3 were observed in the transgenic livers.[ncbi.nlm.nih.gov] […] phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders[clinicaltrials.ucsf.edu] Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.[ncbi.nlm.nih.gov]

  • Rotavirus Infection

    Moreover, the excessive increase of T cells producing IFN-gamma (IFN-gamma) was found, which plays an important role in the protection against viral infection.[ncbi.nlm.nih.gov] The primary or secondary activation of immune system by rotavirus may influence structural integrity and vascular permeability, which may play a triggering role in protein-loosing[ncbi.nlm.nih.gov]

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