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55 Possible Causes for Peripheral Retinal Pigment Epithelium Atrophy

  • Hyper IgD Syndrome

    Hyper-IgD syndrome (HIDS) is a hereditary autoinflammatory disorder caused by mutations in the mevalonate kinase gene. HIDS is also referred to as hyperimmunoglobulinemia D and periodic fever syndrome and is to be understood as part of the broad phenotypic spectrum associated with mevalonate kinase deficiency. In[…][symptoma.com]

  • Vitreoretinochoroidopathy

    Ophthalmic Genet. 2016;37(1):81-5. doi: 10.3109/13816810.2014.889171. Epub 2014 Feb 24. Abstract Autosomal dominant vitreoretinochoroidopathy (ADVIRC) is a rare inherited ocular disease associated with distinct mutations in the BEST1 gene. Typically, patients have only mild visual impairment, and rarely do patients have[…][ncbi.nlm.nih.gov]

  • Retinitis Pigmentosa

    pigment epithelium Loss of rods causes early night blindness and restricted visual fields (bilateral loss of peripheral vision) Loss of cones affects central visual acuity[pathologyoutlines.com] Retinal atrophy causes constriction of retinal vessels, optic nerve head atrophy and accumulation of retinal pigment around blood vessels Microscopic (histologic) description[pathologyoutlines.com] […] inflammatory Common (incidence of 1/3600) with variable inheritance or as part of Refsum disease Usually causes loss of rods and cones to apoptosis and focal proliferation of retinal[pathologyoutlines.com]

  • Myopic Macular Degeneration

    PM is characterized by excessive axial length (³26 mm) with secondary degenerative changes of the sclera, choroid, Bruch's membrane, retinal pigment epithelium (RPE), and[retina3000.it] These changes are concentrated in the mid-peripheral fundus and in the macular area.[retina3000.it] The most common posterior pole changes include posterior staphyloma, optic nerve crescents, chorioretinal atrophy, lacquer cracks, and the development of choroidal neovascularization[retina3000.it]

  • Sarcoidosis

    pigment epithelium.[ncbi.nlm.nih.gov] Optic disc and peripapillary atrophy with abnormal vessels (optociliary shunts) of the optic nerve head in a patient with juvenile onset sarcoidosis.[ncbi.nlm.nih.gov] Peripheral area of capillary non-perfusion with impeding development of the neovascular membrane in ocular sarcoidosis. Late phase fluorescein angiogram.[ncbi.nlm.nih.gov]

  • Vitreous Hemorrhage

    Retinal pigment epithelium atrophy and pigment clumping may occur.[disorders.eyes.arizona.edu] Peripheral schisis is evident in about 50% of patients with large bullous cavities that may resolve spontaneously leaving a pigmented demarcation line.[disorders.eyes.arizona.edu] Other retinal findings are white retinal flecks, exudative retinopathy with retinal detachment, perivascular sheathing and dendritiform vessels in the periphery.[disorders.eyes.arizona.edu]

  • Leber Congenital Amaurosis Typ 14

    OMIM : 57 Autosomal recessive childhood-onset severe retinal dystrophy is a heterogeneous group of disorders affecting rod and cone photoreceptors simultaneously. The most severe cases are termed Leber congenital amaurosis, whereas the less aggressive forms are usually considered juvenile retinitis pigmentosa[…][malacards.org]

  • Pseudoxanthoma Elasticum

    A peripheral examination showed atrophy of the retinal pigment epithelium outside the arcade with pigment migration at the level of the retina, a sign of photoreceptor loss[iovs.arvojournals.org] […] coherence tomography: note the presence of crystals in the inner retinal layers. ( f ) Case 2: healthy optic discs, narrow blood vessels, angioid streaks, and bilateral pigmented[iovs.arvojournals.org]

  • Jalili Syndrome

    […] mottling, peripheral deep white dot deposits or retinal pigment epithelium (RPE) alterations in the inferonasal retina, decreased foveal and retinal thickness, attenuation[scitechnoljournals.wordpress.com] […] deposits or retinal pigment epithelium (RPE) alterations in the inferonasal retina; decreased foveal and retinal thickness; attenuation of retinal lamination; hyperreflectivity[en.wikipedia.org] […] dot deposits or retinal pigment epithelium (RPE) alterations in the inferonasal retina; decreased foveal and retinal thickness; attenuation of retinal lamination; hyperreflectivity[ipfs.io]

  • Wagner Disease

    Montage color fundus photos of the right (A) and left (B) eyes show vascular attenuation, perivascular and peripheral retinal pigment epithelium atrophy, and pigment clumping[healio.com] Peripheral retinal pigment epithelium degeneration in equatorial location may be present.[nature.com] Fundus autofluorescence of the right (C) and left eyes (D) show perivascular and peripheral hypoautofluorescence and peripapillary and macular hyperautofluorescence.[healio.com]

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