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31 Possible Causes for Peripheral T Cells Decreased, Pruritic Rash

  • Food Allergy

    It is a blistering skin disorder that manifests clinically with a chronic and intensely pruritic rash with a symmetrical distribution.[emedicine.com] This causes low FOXP3 mRNA levels and markedly decreased protein expression in peripheral blood lymphocytes of affected patients.[ncbi.nlm.nih.gov] […] production of T cells.[synapse.koreamed.org]

  • Psoriasis

    Pruritic urticarial papules and plaques of pregnancy. The rash presentation can vary; two examples are shown above.[aafp.org] Treatment of psoriasis results in a decreased expression of type 1 cytokines by both peripheral blood and lesional T-cells that correlates with clearing of the lesions, as[web.archive.org] Accurate diagnosis of the generalized rash can be difficult because of the nonspecific appearance of many rashes.[web.archive.org]

  • Vitiligo

    However, regulatory T cells from peripheral blood had decreased ability of suppressing CD8 T lymphocytes, suggesting that TREGs' malfunction and an increase in lymphocytes[dx.doi.org] […] of invariant natural killer T cells ( i NKT) in peripheral blood, these are regulatory cells, responsible for the Th1/Th2 immune response balance that are often diminished[dx.doi.org] […] in TREGs in patients with generalized vitiligo, in addition, expressive increases in these two cell types were identified in the perilesional skin of patients.[dx.doi.org]

  • Graft-versus-Host-Disease

    Acute graft-versus-host-disease usually presents within three to four weeks of transplantation with a painful, pruritic rash.[symptoma.com] These cells induce allogeneic T cell death in response to interferon-γ, resulting in regulatory T cell expansion and immunosuppression.[stm.sciencemag.org] […] maculopapular skin rash, often on acral surfaces and pinnae May progress to diffuse eruption on trunk and extremities with oral mucosal stomatitis and ulceration Chronic[pathologyoutlines.com]

  • Exfoliative Dermatitis

    64-year-old man presented with a 3-week history of a diffuse, pruritic rash that had started on his trunk and then spread to his entire cutaneous surface, including the palms[ncbi.nlm.nih.gov] […] or scabies mites • CD4 t cells are decreased in exfoliative dermatitis (in absence of HIV), studied by Griffiths et al. • HIV test – PCR better than ELISA, • Chest X ray done[slideshare.net] We describe a case of a 22-year old woman admitted to our hospital with acute diffuse, pruritic rash associated with crampy abdominal pain, vomiting, diarrhea and fever three[ncbi.nlm.nih.gov]

  • Multicentric Castleman's Disease

    The rash was migratory, non-pruritic, maculopapular, mainly over the chest, abdomen, and extensor aspect of limbs with exacerbation on exposure to cold.[jpgmonline.com] These results show: (1) polyclonal B cell activation in 4/4 patients, (2) decreased T cell colony formation in 3/4 patients, (3) decreased NK activity and NK cell number in[jstage.jst.go.jp] The common characteristics of MWS include: Rashes During Infancy Chronic, recurrent, generally non-pruritic (not itchy) urticaria, which is usually present during early infancy-but[autoinflammatory.org]

  • Sézary Syndrome

    Abstract Sézary syndrome (SS) is a rare and aggressive type of cutaneous T cell lymphoma (CTCL) characterized by an intensely pruritic, exfoliative rash, known as erythroderma[ncbi.nlm.nih.gov] Decreased expression of Fas (APO-1/CD95) on peripheral blood CD4 T lymphocytes in cutaneous T-cell lymphomas . Br. J. Dermatol. 143 , 1205–1210 (2000). 41.[nature.com] Decreased expression of Fas (APO-1/CD95) on peripheral blood CD4 T lymphocytes in cutaneous T-cell lymphomas. Br. J. Dermatol. 143, 1205–1210 (2000). 41.[nature.com]

  • Autoimmune Hepatitis

    The most interesting result was that MGL administration significantly decreased the frequency of CD4 CD25 - CD69 T-cells rather than CD4 CD25 CD69 T-cells in peripheral blood[dovepress.com]

  • Epidermodysplasia Verruciformis

    Flow cytometric immunophenotyping analysis of peripheral blood of the patient showed decreases in total numbers of T lymphocytes, T-helper cells (CD4 T) and T suppressor cells[pubs.sciepub.com] Flowcytometric analysis of peripheral blood demonstrated 50% CD3 cells (normal range 64–85), 16.5% CD4 cells (normal range 34–62), 9.45% CD8 cells (normal range 14–42) with[pubs.sciepub.com]

  • HIV Infection

    rash before diagnosis.[ncbi.nlm.nih.gov] Highly active antiretroviral therapy results in a decrease in CD8 T cell activation and preferential reconstitution of the peripheral CD4 T cell population with memory rather[hivinsite.ucsf.edu] […] viral load presenting with HIV encephalopathy, in a 54-year-old woman who had been treated with 2 years of extended high-dose immunosuppressant therapy for a recalcitrant pruritic[ncbi.nlm.nih.gov]

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