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496 Possible Causes for Periventricular White Matter Lesions

  • Vitamin B12 Deficiency

    Vitamin B 12 status has been associated with severity of white-matter lesions, especially periventricular in some, 97 but not all studies. 98 The partial reversal of white-matter[] lesions has been documented with cobalamin treatment, 32, 91 emphasizing the importance of early detection and treatment of vitamin B 12 deficiency.[] The disease process ranges from subclinical metabolic changes, to clinical symptoms, to irreversible structural damage, such as periventricular white-matter lesions.[]

  • Autosomal Recessive Spastic Paraplegia Type 54

    Brain MRI shows a thin corpus callosum and periventricular white matter lesions.[] Further neurological manifestations can be identified through brain MRI, such as thinning of corpus callosum and periventricular white matter lesions.[]

  • Binswanger Disease

    white matter lesions are associated with severe arteriosclerosis of the small penetrating arteries which are thickened, lipohyalinised, stenotic, or even occluded.[] white matter lesions in the elderly.[] white matter.[]

  • Susac Syndrome

    A new cerebral MRI showed multiple small T2-weighted lesions involving corpus callosum and periventricular white matter lesions, with enhancement after gadolinium injection[] Again shown were multiple periventricular white matter lesions of high signal intensity on T2-weighted and FLAIR sequences (Figs. 1G , 1H , 1I , 1J ).[] Again shown were multiple periventricular white matter lesions of high signal intensity on T2-weighted and FLAIR sequences (Figs. 1G, 1H, 1I, 1J ).[]

  • Periventricular Leukomalacia

    white matter lesions.[] Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology, 22 pp. 106–132.[] Periventricular leukomalacia is an ischemic lesion in periventricular white matter of premature infants. Hemorrhage into the ischemic area occurs in up to 25% of cases.[]

  • Multisystemic Smooth Muscle Dysfunction Syndrome

    white matter lesions.[] Patients had cerebrovascular disease characterized by small vessel disease (hyperintense periventricular white matter lesions; 95%), intracranial artery stenosis (77%), ischemic[] matter lesions, congenital mydriasis, hypotonic bladder, intestinal malrotation and hypoperistalsis and pulmonary hypertension associated vascular changes.[]

  • Paraparesis

    white matter lesions, corpus callosum, brainstem, cerebellar, spinal cord, optic nerve) Management: MDT approach, high dose iv steroid acutely, symptom management eg. antispasmodics[] Brain involvement in TSP was suggested by magnetic resonance imaging (MRI) studies revealing subcortical and periventricular white matter lesions 4,5 .[] […] potentials are reduced (slow conduction in optic nerve) CSF: increased protein, increased lymphocytes, unmatched oligoclonal bands MRI: active inflammation, hyperintense on T2 (periventricular[]

  • Orthostatic Hypotension

    Persons with orthostatic intolerance are reported to have more MRI abnormalities called periventricular white matter lesions (Kruit et al, 2013).[]

  • Febrile Infection-Related Epilepsy Syndrome

    The higher grade of periventricular white matter lesions suggested poorer neurological outcomes.[] Focal abnormal signal changes over the periventricular white matter suggested the more extensive lesions would be associated with a poorer clinical outcome.[]

  • Vascular Dementia

    matter lacunes, or extensive periventricular white matter lesions, or combinations thereof.[] CT and MRI may show Bilateral multiple infarcts in the dominant hemisphere and limbic structures Multiple lacunar strokes Periventricular white-matter lesions extending into[] matter lacunes 5 1 5.9 Extensive periventricular white matter lesions 26 1 30.6 Combinations thereof 6 1 7.1 3.[]

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