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84 Possible Causes for Persistent Lactic Acidosis

  • Hypoglycemia

    Endocrine. 2016 Jul;53(1):47-57. doi: 10.1007/s12020-016-0902-0. Epub 2016 Mar 7. Abstract Spontaneous hypoglycemia is a puzzling clinical problem and an important reason for referral to endocrinologists. Several clinical conditions such as insulinomas, non-insulinoma pancreatogenous hypoglycemia syndrome, insulin[…][]

  • Acidosis

    Symptoms of Lactic Acidosis The symptoms of lactic acidosis include: Persistent nausea, vomiting, and abdominal (belly) pain Unexplained tiredness Shortness of breath Rapid[] Lactic acidosis is a rare side effect of the NRTIs, especially Zerit (stavudine, d4T) and Videx (diadanosine, ddI).[]

  • Intermediate Maple Syrup Urine Disease

    Between 2 and 6 months of age, persistent lactic acidosis starts to develop. References: MSUD Family Support Group, 2010. MSUD Classifications. [online].[] Persistent lactic acidosis will be seen to develop between 2 and 6 months of age. back to the Inborn Errors page back to Amino Acid Metabolism page Return to The Medical Biochemistry[] The infants develop a persistent lactic acidosis between 8 weeks and 6 months of age followed by progressive neurologic deterioration with hypotonia, developmental delay,[]

  • Infantile Apnea

    CASE SUMMARY: We report a 5-month-old girl with sudden respiratory arrest followed by episodic hyper- and hypo-ventilation, encephalopathy, and persistent lactic acidosis.[]

  • Cardiomyopathy

    acidosis, severe lactic acidosis, expansion and hypertrophic cardiomyopathy.[] Met452Val) in a female infant who presented with poor sucking at birth, poor activity, hyporeflexia, hypertonia, persistent pulmonary hypertension of newborn (PPHN), metabolic[]

  • Sepsis

    However, in patients with persistently elevated lactate without evidence of inadequate oxygen delivery, type B lactic acidosis should be considered.[] Hypoperfusion abnormalities may include lactic acidosis, oliguria, or an acute alteration in mental status.[] Lactic acidosis in the emergency department and other hospital settings is typically due to tissue hypoxia with sepsis being the most common cause.[]

  • Liver Cirrhosis

    Despite stable hemodynamics, lactic acidosis still persisted, and linezolid therapeutic drug monitoring was ordered.[] In the presence of lactic acidosis and increased inflammatory laboratory findings (elevated C-reactive protein and leukocytosis), a surgical evaluation is mandatory, as bowel[] High linezolid trough concentration (49 mg/L) was found by therapeutic drug monitoring, and linezolid-associated lactic acidosis was highly suspected.[]

  • MELAS Syndrome

    MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[] There is persistent lactic acidosis. Histologically, there are ragged red fibres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle.[] lactic acidosis in individuals with MELAS syndrome).[]

  • Infantile Gastroenteritis

    We conclude that some infants with acute diarrhea may develop severe dehydration and anion-gap acidosis associated with lactic acidemia and renal dysfunction.[] These high-risk infants more often demonstrate severe malnutrition, persistent course of diarrhea, and prolonged hospital stay.[]

  • Lactic Acidosis

    […] interval: 2.5-20.6; P CONCLUSION: In the absence of risk factors associated with persistent lactic acidosis, such as shock or acute kidney or liver injury, continued peri-operative[] lactic acidosis CAUSES (Cohen & Woods classification) Type A – Inadequate Oxygen Delivery anaerobic muscular activity (sprinting, generalised convulsions) tissue hypoperfusion[] Multivariable logistic regression analysis identified the need for vasopressor administration as an independent predictor of lactic acidosis (odds ratio: 7.3, 95% confidence[]

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