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84 Possible Causes for Persistent Lactic Acidosis

  • Hypoglycemia

    Endocrine. 2016 Jul;53(1):47-57. doi: 10.1007/s12020-016-0902-0. Epub 2016 Mar 7. Abstract Spontaneous hypoglycemia is a puzzling clinical problem and an important reason for referral to endocrinologists. Several clinical conditions such as insulinomas, non-insulinoma pancreatogenous hypoglycemia syndrome, insulin[…][ncbi.nlm.nih.gov]

  • Acidosis

    Symptoms of Lactic Acidosis The symptoms of lactic acidosis include: Persistent nausea, vomiting, and abdominal (belly) pain Unexplained tiredness Shortness of breath Rapid[thebody.com] Lactic acidosis is a rare side effect of the NRTIs, especially Zerit (stavudine, d4T) and Videx (diadanosine, ddI).[thebody.com]

  • Intermediate Maple Syrup Urine Disease

    Between 2 and 6 months of age, persistent lactic acidosis starts to develop. References: MSUD Family Support Group, 2010. MSUD Classifications. [online].[maplesyrupstory.blogspot.com] Persistent lactic acidosis will be seen to develop between 2 and 6 months of age. back to the Inborn Errors page back to Amino Acid Metabolism page Return to The Medical Biochemistry[themedicalbiochemistrypage.org] The infants develop a persistent lactic acidosis between 8 weeks and 6 months of age followed by progressive neurologic deterioration with hypotonia, developmental delay,[wvdhhr.org]

  • Infantile Apnea

    CASE SUMMARY: We report a 5-month-old girl with sudden respiratory arrest followed by episodic hyper- and hypo-ventilation, encephalopathy, and persistent lactic acidosis.[ncbi.nlm.nih.gov]

  • Cardiomyopathy

    acidosis, severe lactic acidosis, expansion and hypertrophic cardiomyopathy.[ncbi.nlm.nih.gov] Met452Val) in a female infant who presented with poor sucking at birth, poor activity, hyporeflexia, hypertonia, persistent pulmonary hypertension of newborn (PPHN), metabolic[ncbi.nlm.nih.gov]

  • Sepsis

    However, in patients with persistently elevated lactate without evidence of inadequate oxygen delivery, type B lactic acidosis should be considered.[ncbi.nlm.nih.gov] Hypoperfusion abnormalities may include lactic acidosis, oliguria, or an acute alteration in mental status.[doi.org] Lactic acidosis in the emergency department and other hospital settings is typically due to tissue hypoxia with sepsis being the most common cause.[ncbi.nlm.nih.gov]

  • Liver Cirrhosis

    Despite stable hemodynamics, lactic acidosis still persisted, and linezolid therapeutic drug monitoring was ordered.[ncbi.nlm.nih.gov] In the presence of lactic acidosis and increased inflammatory laboratory findings (elevated C-reactive protein and leukocytosis), a surgical evaluation is mandatory, as bowel[dx.doi.org] High linezolid trough concentration (49 mg/L) was found by therapeutic drug monitoring, and linezolid-associated lactic acidosis was highly suspected.[ncbi.nlm.nih.gov]

  • MELAS Syndrome

    MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[ncbi.nlm.nih.gov] There is persistent lactic acidosis. Histologically, there are ragged red fibres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle.[omicsonline.org] lactic acidosis in individuals with MELAS syndrome).[emedicine.medscape.com]

  • Infantile Gastroenteritis

    We conclude that some infants with acute diarrhea may develop severe dehydration and anion-gap acidosis associated with lactic acidemia and renal dysfunction.[journals.lww.com] These high-risk infants more often demonstrate severe malnutrition, persistent course of diarrhea, and prolonged hospital stay.[journals.lww.com]

  • Lactic Acidosis

    […] interval: 2.5-20.6; P CONCLUSION: In the absence of risk factors associated with persistent lactic acidosis, such as shock or acute kidney or liver injury, continued peri-operative[ncbi.nlm.nih.gov] lactic acidosis CAUSES (Cohen & Woods classification) Type A – Inadequate Oxygen Delivery anaerobic muscular activity (sprinting, generalised convulsions) tissue hypoperfusion[lifeinthefastlane.com] Multivariable logistic regression analysis identified the need for vasopressor administration as an independent predictor of lactic acidosis (odds ratio: 7.3, 95% confidence[ncbi.nlm.nih.gov]

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