Create issue ticket

118 Possible Causes for Persistent Lactic Acidosis, Seizure

  • Hypoglycemia

    Postoperatively the patient demonstrated both generalized and focal seizure activity.[ncbi.nlm.nih.gov] Severe hypoglycemia eventually lead to glucose deprivation of the central nervous system resulting in hunger; sweating; paresthesia; impaired mental function; seizures; coma[icd9data.com] We present the case of a 61-year-old woman with severe hypoglycemia that induced seizures.[ncbi.nlm.nih.gov]

  • MELAS Syndrome

    MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[ncbi.nlm.nih.gov] After two years without seizures, the non-enhanced hyperintense parieto-temporo-occipital lesion had disappeared, being attributed to consequent seizure control.[ncbi.nlm.nih.gov] There is persistent lactic acidosis. Histologically, there are ragged red fibres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle.[omicsonline.org]

  • Pyridoxine Dependency Syndrome

    Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden.[demosmedical.com] A dramatic reduction in seizure frequency occurred within 72 hours, and the seizures had stopped by the fifth day following pyridoxine adniinistrarion.[dev.docslide.net] seizures.[adc.bmj.com]

  • Leigh's Disease

    All children developed progressive neurological deterioration and persistent metabolic lactic acidosis, which was treated with sodium bicarbonate, and the 1st patient needed[ncbi.nlm.nih.gov] Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.[wikidata.org] The importance of obtaining a blood or cerebrospinal fluid lactate in all infants with unexplained seizures, cortical blindness or apnoea is emphasized.[ncbi.nlm.nih.gov]

  • Maple Syrup Urine Disease Mild Variant

    Between 2 and 6 months of age, persistent lactic acidosis starts to develop. References: MSUD Family Support Group, 2010. MSUD Classifications. [online].[maplesyrupstory.blogspot.com] The condition can then lead to progressive degeneration of brain functions, seizures, coma and death, especially when left untreated.[healthfoxx.com] Development of persistent lactic acidosis occurs between 8 weeks and 6 months of age Followed by progressive neurologic deterioration with - Hypotonia Developmental delay[motherbabyuniversity.com]

  • Infantile Apnea

    CASE SUMMARY: We report a 5-month-old girl with sudden respiratory arrest followed by episodic hyper- and hypo-ventilation, encephalopathy, and persistent lactic acidosis.[ncbi.nlm.nih.gov] Experience in these two infants suggests: 1)There is a subgroup of patients diagnosed as "Near-miss SIDS" who have apnea associated with seizures. 2)Seizure threshold may[nature.com] There have been no previously published cases with infantile spasms that evolved from epileptic apnea as partial seizures.[ncbi.nlm.nih.gov]

  • Alpers Syndrome

    acidosis, and strokelike episodes syndrome (MELAS) during recurrent status epilepticus ( 14 ).[ajnr.org] Herein we present a case of a 17-year-old male with a progressive 8-month course of severe headaches, multiple stroke-like episodes with visual deficits, and seizures that[ncbi.nlm.nih.gov] Children present with seizures in half of the cases. Seizures may be focal, generalized or myoclonic.[symptoma.com]

  • Hereditary Fructose Intolerance

    Clinical description HFI usually presents in infancy at the time of weaning (when fructose is added to the diet), manifesting with hypoglycemia, lactic acidosis, ketosis with[orpha.net] Herein we report on a case of hereditary fructose intolerance with initial presentation of episodic unconsciousness, seizure, hypoglycemia, hepatomegaly, and abnormal liver[ncbi.nlm.nih.gov] He presented with episodic unconsciousness, seizures, hypoglycemia, hepatomegaly and abnormal liver function.[ncbi.nlm.nih.gov]

  • Methylmalonic Acidemia

    After hemodialysis and clearance of toxic metabolites, severe lactic acidosis persisted with multiorgan failure.[ncbi.nlm.nih.gov] At 9 months of age, he developed brief tonic seizures, which showed polyspike bursts under EEG. His psychomotor development continued to deteriorate.[ncbi.nlm.nih.gov] The seizure types included partial seizure (n 21), generalized tonic-clonic seizure (n 5), tonic seizure (n 3), myoclonic seizure (n 3), and epileptic spasms (n 2).[ncbi.nlm.nih.gov]

  • Hyperglycemia

    Laboratory findings revealed significant lactic acidosis, hyperuricemia, hyperglycemia, elevated liver enzyme level, and hyperlipidemia.[ncbi.nlm.nih.gov] Among such seizures, reflex seizures are rare, and most of them are movement-induced focal seizures.[ncbi.nlm.nih.gov] Nonketotic hyperglycemia often causes seizures.[ncbi.nlm.nih.gov]

Further symptoms

Similar symptoms