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118 Possible Causes for Persistent Lactic Acidosis, Seizure

  • Hypoglycemia

    Postoperatively the patient demonstrated both generalized and focal seizure activity.[] Severe hypoglycemia eventually lead to glucose deprivation of the central nervous system resulting in hunger; sweating; paresthesia; impaired mental function; seizures; coma[] We present the case of a 61-year-old woman with severe hypoglycemia that induced seizures.[]

  • MELAS Syndrome

    MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[] After two years without seizures, the non-enhanced hyperintense parieto-temporo-occipital lesion had disappeared, being attributed to consequent seizure control.[] There is persistent lactic acidosis. Histologically, there are ragged red fibres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle.[]

  • Pyridoxine Dependency Syndrome

    Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden.[] A dramatic reduction in seizure frequency occurred within 72 hours, and the seizures had stopped by the fifth day following pyridoxine adniinistrarion.[] seizures.[]

  • Leigh's Disease

    All children developed progressive neurological deterioration and persistent metabolic lactic acidosis, which was treated with sodium bicarbonate, and the 1st patient needed[] Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.[] The importance of obtaining a blood or cerebrospinal fluid lactate in all infants with unexplained seizures, cortical blindness or apnoea is emphasized.[]

  • Maple Syrup Urine Disease Mild Variant

    Between 2 and 6 months of age, persistent lactic acidosis starts to develop. References: MSUD Family Support Group, 2010. MSUD Classifications. [online].[] The condition can then lead to progressive degeneration of brain functions, seizures, coma and death, especially when left untreated.[] Development of persistent lactic acidosis occurs between 8 weeks and 6 months of age Followed by progressive neurologic deterioration with - Hypotonia Developmental delay[]

  • Infantile Apnea

    CASE SUMMARY: We report a 5-month-old girl with sudden respiratory arrest followed by episodic hyper- and hypo-ventilation, encephalopathy, and persistent lactic acidosis.[] Experience in these two infants suggests: 1)There is a subgroup of patients diagnosed as "Near-miss SIDS" who have apnea associated with seizures. 2)Seizure threshold may[] There have been no previously published cases with infantile spasms that evolved from epileptic apnea as partial seizures.[]

  • Alpers Syndrome

    acidosis, and strokelike episodes syndrome (MELAS) during recurrent status epilepticus ( 14 ).[] Herein we present a case of a 17-year-old male with a progressive 8-month course of severe headaches, multiple stroke-like episodes with visual deficits, and seizures that[] Children present with seizures in half of the cases. Seizures may be focal, generalized or myoclonic.[]

  • Hereditary Fructose Intolerance

    Clinical description HFI usually presents in infancy at the time of weaning (when fructose is added to the diet), manifesting with hypoglycemia, lactic acidosis, ketosis with[] Herein we report on a case of hereditary fructose intolerance with initial presentation of episodic unconsciousness, seizure, hypoglycemia, hepatomegaly, and abnormal liver[] He presented with episodic unconsciousness, seizures, hypoglycemia, hepatomegaly and abnormal liver function.[]

  • Methylmalonic Acidemia

    After hemodialysis and clearance of toxic metabolites, severe lactic acidosis persisted with multiorgan failure.[] At 9 months of age, he developed brief tonic seizures, which showed polyspike bursts under EEG. His psychomotor development continued to deteriorate.[] The seizure types included partial seizure (n 21), generalized tonic-clonic seizure (n 5), tonic seizure (n 3), myoclonic seizure (n 3), and epileptic spasms (n 2).[]

  • Hyperglycemia

    Laboratory findings revealed significant lactic acidosis, hyperuricemia, hyperglycemia, elevated liver enzyme level, and hyperlipidemia.[] Among such seizures, reflex seizures are rare, and most of them are movement-induced focal seizures.[] Nonketotic hyperglycemia often causes seizures.[]

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