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6 Possible Causes for Phenotypic Overlap with Frontotemporal Dementia

  • Progressive Supranuclear Palsy

    Frontal dynamic aphasia is characterised by a profound reduction in spontaneous speech despite well-preserved naming, repetition and comprehension. Since Luria (1966, 1970) designated this term, two main forms of dynamic aphasia have been identified: one, a language-specific selection deficit at the level of[…][ncbi.nlm.nih.gov]

  • Pick Disease of The Brain

    Pick's disease is a specific pathology that is one of the causes of frontotemporal lobar degeneration . It is also known as Pick disease and PiD (not to be confused with pelvic inflammatory disease (PID) or Parkinson's disease (PD)). A defining characteristic of the disease is build-up of tau proteins in neurons ,[…][en.wikipedia.org]

  • Dementia

    dementia.[doi.org] There is considerable overlap in the clinical and pathological presentations; for example, Alzheimer's disease pathology may be present in people who have a clinical phenotype[doi.org] […] subtypes of dementia include Alzheimer's disease dementia, vascular dementia, dementia with Lewy bodies (pathological clusters of alpha‐synuclein protein; McKeith 2005 ), and frontotemporal[doi.org]

  • Motor Neuron Disease

    […] supranuclear palsy (PSP), but present with clinical features of motor neuron disease (MND) and/or frontotemporal dementia (FTD).[ncbi.nlm.nih.gov] These two clinical phenotypes have been published independently and as a result, have come to be considered as distinct disease entities.[ncbi.nlm.nih.gov] A number of recent studies have described cases with tau-positive globular oligodendroglial inclusions (GOIs) and such cases have overlapping pathological features with progressive[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    Three other neurodegenerative diseases, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), share significant overlaps with PD[ncbi.nlm.nih.gov] The discovery of TARDBP and FUS enabled recognition that ALS and frontotemporal dementia (FTD) represent overlapping clinical syndromes ( 13, 14, 18, 19 ) and this convergence[doi.org] Genetic and pathological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).[ncbi.nlm.nih.gov]

  • Autosomal Recessive Spastic Paraplegia Type 72

    Recently, large intronic hexanucleotide repeat expansions (GGGGCC) in C9ORF72 have been found to cause frontotemporal dementia (FTD), amyotrophic lateral sclerosis and FTD[nature.com] Owing to the overlapping phenotypes among HSP, amyotrophic lateral sclerosis and FTD with motor neuron disease along with shared pathological findings, we hypothesized that[nature.com] […] sclerosis (ALS) 4, 5 and FTD with motor neuron disease. 6 ALS, FTD and FTD with motor neuron disease are part of the same spectrum of diseases with overlapping phenotypes[nature.com]

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