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22 Possible Causes for Phenotypic Overlap with Parkinson Disease

  • Dementia with Lewy Bodies

    About this book Introduction This book describes biological and clinical aspects of dementia with Lewy bodies (DLB), one of the most common types of progressive dementia, although in most cases the cause is unknown. The editor has made a major contribution to the understanding of the disease since he first[…][doi.org]

  • Pallidopyramidal Syndrome

    Very recently, a locus was mapped in a single family with an overlapping phenotype, and an FBXO7 gene mutation was nominated as the likely disease cause.[moh-it.pure.elsevier.com] Methods: We performed clinical and genetic studies in two families with early-onset, progressive parkinsonism and pyramidal tract signs.[neurology.org] METHODS:: We performed clinical and genetic studies in two families with early-onset, progressive parkinsonism and pyramidal tract signs.[moh-it.pure.elsevier.com]

  • Parkinson's Disease

    phenotype of essential tremor and Parkinson’s disease (ET-PD) , BMC Neurology , 10.1186/1471-2377-14-54 , 14 , 1 , (2014) .[dx.doi.org] phenotype of essential tremor and Parkinson’s disease (ET-PD), BMC Neurology, 10.1186/1471-2377-14-54, 14, 1, (2014).[oadoi.org] Danguolė Šurkienė, Birutė Vaidelytė, Gabrielė Dambrauskaitė, Andrius Sakalauskas, Antanas Vaitkus and Rymantė Gleiznienė , Ultrasonographic (TCS) and clinical findings in overlapping[dx.doi.org]

  • Drug Dependence

    Challenging the involved phenotype led to the demonstration that other potentially overlapping disorders, such as schizophrenia and Parkinson disease, could also be involved[ncbi.nlm.nih.gov]

  • Upper Motor Neuron Disease

    overlap of Parkinson's disease and ALS.[pn.bmj.com] Parkinsonian features The ALS-Parkinsonian-Dementia complex of Guam (and the similar disorders in the Kii Peninsula of Japan and Papua New Guinea) represent extreme examples of the phenotypic[pn.bmj.com]

  • Juvenile Primary Lateral Sclerosis

    overlap of Parkinson's disease and ALS.[pn.bmj.com] Parkinsonian features The ALS-Parkinsonian-Dementia complex of Guam (and the similar disorders in the Kii Peninsula of Japan and Papua New Guinea) represent extreme examples of the phenotypic[pn.bmj.com]

  • Amyotrophic Lateral Sclerosis

    Abstract Recently, the coiled‑coil‑helix‑coiled‑coil‑helix domain 2 (CHCHD2) gene was identified as a possible causative gene for Parkinson's disease (PD).[ncbi.nlm.nih.gov] […] in clinical phenotypes, pathological features and genetic heredities, and it is still unclear whether CHCHD2 variants could explain these three diseases.[ncbi.nlm.nih.gov] Three other neurodegenerative diseases, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), share significant overlaps with PD[ncbi.nlm.nih.gov]

  • Gaucher Disease

    This clinical spectrum now overlaps with different disorders including Parkinson's disease and other Lewy body disorders, myoclonic epilepsy, and infantile neurodegenerative[ncbi.nlm.nih.gov] Clinical research showed that Gaucher disease manifests with broad phenotypic variation typical of many metabolic disorders, ranging from neonatal lethality to asymptomatic[ncbi.nlm.nih.gov]

  • Addictive Behavior

    Challenging the involved phenotype led to the demonstration that other potentially overlapping disorders, such as schizophrenia and Parkinson disease, could also be involved[ncbi.nlm.nih.gov]

  • Early-Onset Autosomal Dominant Alzheimer Disease

    For the different types of early-onset dementia (such as frontotemporal dementia, prion diseases, and Parkinson’s disease), the phenotypes may be similar especially in the[dovepress.com] Pathological overlap may be possible, which makes the disease diagnosis more difficult. 110 AD is one of the most complex disorders, in which several genes were identified[dovepress.com] […] variants in them, PCR and standard sequencing methods can be performed. 3 However, the mutations in these genes are relatively rare, and there may be similarities between the phenotypes[dovepress.com]

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