Philadelphia Chromosome Positive: Causes & Reasons

Possible Causes for Philadelphia Chromosome Positive

chromosome-positive acute myeloid leukemia (Ph+ AML). [ncbi.nlm.nih.gov]

METHODS: Patients with newly diagnosed Philadelphia chromosome-positive CML in chronic phase (CML-CP; N = 112) received nilotinib 300 mg twice daily. [ncbi.nlm.nih.gov]

We report a case of a 72-year-old woman diagnosed with blastic phase of Philadelphia chromosome positive CML treated with IM for 28 months. [ncbi.nlm.nih.gov]

Chronic Phase of Chronic Myeloid Leukemia

Pfizer and Avillion announce positive top-line results for phase 3 BFORE study of Bosulif for first-line treatment of philadelphia chromosome positive chronic myeloid leukemia [oncologynurseadvisor.com]

A Phase II study of STI 571 in adult patients with Philadelphia chromosome positive chronic myeloid leukemia in accelerated phase. [clincancerres.aacrjournals.org]

chromosome positive (Ph+) ALL. [nature.com]

Acute Lymphoblastic Leukemia Type L1

Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med. 2012 Nov 29. 367(22):2075-88. [Medline]. [emedicine.medscape.com]

Philadelphia chromosome–positive ALL The treatment of Philadelphia chromosome–positive childhood ALL during the remission induction, consolidation/intensification, and maintenance [fairview.org]

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006 Jun 15. 354(24):2542-51. [Medline]. [emedicine.medscape.com]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

chromosome-positive CML in chronic phase. [pharmalive.com]

chromosome-positive CML. [healio.com]

The main treatment for Philadelphia chromosome-positive CML is by targeting the abnormality, which is the tyrosine kinase protein. [symptoma.com]

B-Cell Acute Lymphoblastic Leukemia

Abstract Purpose Few therapeutic options are available for patients with Philadelphia chromosome-positive (Ph + ) B-precursor acute lymphoblastic leukemia (ALL) who progress [ncbi.nlm.nih.gov]

[DR:D09325] (Philadelphia chromosome-negative) Inotuzumab ozogamicin [DR:D08933] Imatinib mesylate [DR:D01441] (Philadelphia chromosome positive) Dasatinib [DR:D06414] (Philadelphia [genome.jp]

chromosome-negative) Inotuzumab ozogamicin [DR: D08933 ] Imatinib mesylate [DR: D01441 ] (Philadelphia chromosome positive) Dasatinib [DR: D06414 ] (Philadelphia chromosome [genome.jp]

Precursor-Cell Lymphoblastic Leukemia

Abstract Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) accounts for approximately one-fourth of cases of adult ALL. [ncbi.nlm.nih.gov]

There is currently no clinical standard for induction therapy in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL). [ncbi.nlm.nih.gov]

The outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL) has improved with the use of tyrosine kinase inhibitors, such as imatinib and dasatinib [ncbi.nlm.nih.gov]

Philadelphia Chromosome Negative Chronic Myeloid Leukemia

The current study reports the case of a patient with Philadelphia chromosome-negative (Ph-) non-Hodgkin's lymphoma (NHL) and chronic phase (CP) Philadelphia chromosome-positive [spandidos-publications.com]

@article{Lee1989DetectionOT, title={Detection of two alternative bcr/abl mRNA junctions and minimal residual disease in Philadelphia chromosome positive chronic myelogenous [semanticscholar.org]

English Glivec is indicated for the treatment of adult and paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia [mymemory.translated.net]

Blast Phase of Chronic Myeloid Leukemia

Abstract Molecular abnormalities caused by the hybrid Bcr-Abl gene are causally associated with the development and progression of Philadelphia chromosome-positive (Ph(+)) [ncbi.nlm.nih.gov]

chromosome positive acute lymphoblastic leukemia with primary or acquired resistance to imatinib mesylate. [ichgcp.net]

Considering taking medication to treat myeloid+blast+phase+philadelphia+chromosome+positive+chronic+myelocytic+leukemia? [webmd.com]

Myeloproliferative Disease

Babushok’s examination of the myeloproliferative diseases concludes with an overview of chronic myelogenous leukemia, a Philadelphia chromosome positive disease state. [broadcastmed.com]

Nilotinib (Tasigna): Indicated for the treatment of chronic-phase and accelerated-phase Philadelphia chromosome-positive chronic myelogenous leukemia in adult patients who [emedicine.com]

Chronic MPD Polycythemia vera, agnogenic myeloid metaplasia, primary thrombocythemia, chronic myelogenous leukemia–Philadelphia chromosome positive or negative, chronic monocytic [medical-dictionary.thefreedictionary.com]

Atypical Chronic Myeloid Leukemia

•Partial cytogenetic response: 1 to 35 percent Philadelphia chromosome positive cells present. [caprockhematology.com]

According to the latest WHO classification of tumours of the haematopoietic and lymphoid tissues, CML is typically Philadelphia chromosome positive (Ph+) 1. [afjho.com]

Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med. 2012 Nov 29. 367(22):2075-88. [Medline]. [emedicine.medscape.com]

Acute Leukemia

Chromosomal analysis reveals t(9;22)(q34;q11) translocation. Minor BCR-ABL fusion gene was positive. Philadelphia chromosome-positive mixed phenotype acute leukemia. [ncbi.nlm.nih.gov]

Philadelphia chromosome positive (Ph+) mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia having both myeloid and lymphoid features for which no optimal [ncbi.nlm.nih.gov]

Philadelphia chromosome-positive mixed phenotype acute leukemia (Ph(+)MPAL) is a rare type of acute leukemia having myeloid and lymphoid features. [ncbi.nlm.nih.gov]

T-Cell Acute Lymphoblastic Leukemia

The authors report an unusual presentation of a Philadelphia chromosome-positive acute lymphoblastic leukemia with two unusual features: a bcr-abl fusion mRNA coding for p210 [ncbi.nlm.nih.gov]

Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med. 2012 Nov 29. 367(22):2075-88. [Medline]. [emedicine.medscape.com]

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006 Jun 15. 354(24):2542-51. [Medline]. [emedicine.medscape.com]

Acute Undifferentiated Leukemia

Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia Philadelphia Chromosome Positive [clinicaltrials.gov]

It appears to have a worse prognosis than other MPALs; however, it has not been clarified how the prognosis compares to Philadelphia chromosome-positive acute lymphoblastic [path.upmc.edu]

Leukemia L1 Adult Acute Lymphoblastic Leukemia L1 Childhood Acute Lymphoblastic Leukemia L2 Adult Acute Lymphoblastic Leukemia L2 Childhood Acute Lymphoblastic Leukemia Philadelphia [clinicaltrials.gov]

Acute Myelomonocytic Leukemia

Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med. 2012 Nov 29. 367(22):2075-88. [Medline]. [emedicine.medscape.com]

: A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood 2002, 100 : 1965. [link.springer.com]

Bosulif (bosutinib) was approved by the FDA in 2012 as a treatment for patients with chronic, accelerated or blast phase Philadelphia chromosome positive CML who are resistant [rarediseases.org]

Adult Acute Lymphoblastic Leukemia

Improved Early Event-Free Survival With Imatinib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Children's Oncology Group Study. [scielo.org.pe]

Efficacy and prognostic factors of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. [scielo.org.pe]

Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, [scielo.org.pe]

Acute Lymphoblastic Leukemia

Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med. 2012 Nov 29. 367(22):2075-88. [Medline]. [emedicine.medscape.com]

Five patients underwent a hematopoietic cell transplant (HCT), three of whom (all Philadelphia chromosome-positive) were in first CR after receiving DA-EPOCH. [healio.com]

- The use of tyrosine kinase inhibitors (TKIs) in adult patients with Philadelphia chromosome-positive (Ph+) ALL. [cancercareontario.ca]

Unclassified Chronic Myeloproliferative Disease

[…] and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Resistant or. [documents.mx]

Philadelphia chromosome-positive Essential Thrombocythemia (ET ) Chronic Myelogenous Leukemia (CML) Myelofibrosis (MF) Polycythemia Vera (PV) There are atypical myeloproliferative [cmleukemia.com]

Acute Biphenotypic Leukemia

Kantarjian, MD6 7 3914 Final Report Of Single-Center Study Of Chemotherapy Plus Dasatinib For The Initial Treatment Of Patients With Philadelphia- Chromosome Positive Acute [docplayer.it]

chromosome positive ALL with the advent of the tyrosine kinase inhibitors. [books.google.com]

Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2011;118(25):6521-8. [biomed.papers.upol.cz]

Bilineal Acute Leukemia

chromosome-positive leukemias. [neoplasm.imedpub.com]

Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2011;118(25):6521-8. [biomed.papers.upol.cz]

Philadelphia chromosome-positive mixed phenotype acute leukemia in the imatinib era. Eur J Haematol 2014;93(4):297-301. DOI: 10.1111/ejh.12343. [ Links ] 64. [scielo.org.mx]

Aleukemic Leukemia

Imatinib in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia: current status and evolving concepts. [link.springer.com]

Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics. Ann Intern Med. 2003;138:819–830. CrossRef PubMed Google Scholar 11. [link.springer.com]

This report is the first of a case of aleukemic leukemia cutis preceding Philadelphia-positive biphenotypic leukemia. [link.springer.com]

Lymphatic Neoplasm

8:11-12 Published Date: 11 April 2018 Review Spotlight on ponatinib in the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic [dovepress.com]

chromosome-positive acute lymphoblastic leukemia: patient selection and perspectives [Erratum] Anagnostou T, Litzow MR Blood and Lymphatic Cancer: Targets and Therapy 2018 [dovepress.com]

Blood and Lymphatic Cancer: Targets and Therapy 2018, 8:13-20 Published Date: 18 April 2018 Erratum Spotlight on ponatinib in the treatment of chronic myeloid leukemia and Philadelphia [dovepress.com]

Ovarioleukodystrophy

Treatment Imatinib mesylate (a drug that blocks an abnormal kinase made by Philadelphia chromosome positive CML cells) effectively reduces the number of tumor cells in the [medical-dictionary.thefreedictionary.com]

Subsequent evaluation, including bone marrow aspiration and biopsy with cytogenetic analysis, reveal the Philadelphia chromosome. [medical-dictionary.thefreedictionary.com]

chromosome positive; may occur < age 5 with myelomonocytosis, anemia, thrombocytopenia, lymphadenopathy; WBC count < 50 x 109, ≠ HbF, ≠ muraminidase; adult CML comprises [medical-dictionary.thefreedictionary.com]

Autosomal Recessive Deafness 76

There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. [42v.posterior.us]

We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation [42v.posterior.us]

Lymphoblastic Lymphoma

English Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph-positive ALL). [mymemory.translated.net]

First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive ALL. [cancertherapyadvisor.com]

Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. [jshem.or.jp]

Hematologic Neoplasm

In Philadelphia chromosome-positive chronic myelogenous leukemia, patients possess the BCR-ABL1 fusion gene, which can be detected by conventional cytogenetics the vast majority [cancertherapyadvisor.com]

chromosome-positive (Ph+) hematologic neoplasms. [biorxiv.org]

chromosome–positive (Ph+) ALL. [abstracts.asco.org]

Autosomal Recessive Deafness 88

There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. [1ws.tatter.us]

We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation [1ws.tatter.us]

Tyrosine Kinase 2 Deficiency

Dasatinib crosses the blood–brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. [htct.com.br]

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med, 2006, 354:2542–2551. [accessmedicina.mhmedical.com]

Full Text Introduction Dasatinib is a potent BCR/ABL tyrosine kinase inhibitor (TKI) that has been become widely used in the treatment of Philadelphia chromosome-positive [htct.com.br]

Acute Basophilic Leukemia

chromosome-positive leukemias. [neoplasm.imedpub.com]

The Philadelphia (Ph) chromosome was positive on fluorescence in-situ hybridization (FISH). [austinpublishinggroup.com]

ACUTE BASOPHILIC LEUKEMIA  Primary differentiation is to basophils  May represent trasformation of an undetected Philadelphia chromosome positive CML  Symptoms related [slideshare.net]

Childhood Leukemia

Tasigna is reported to have greater efficacy than Gleevec in Philadelphia-chromosome positive CML. [texasoncology.com]

Philadelphia chromosome–positive ALL The treatment of Philadelphia chromosome –positive childhood ALL during the remission induction, consolidation / intensification, and [cancer.gov]

Children with Philadelphia chromosome-positive ALL usually receive Gleevec ® (imatinib) in the induction regimen. [texasoncology.com]

Autosomal Recessive Deafness 103

There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. [47.somnolent.us]

We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation [47.somnolent.us]