Phosphate Decreased: Causes & Reasons

Possible Causes for Phosphate Decreased

The decreased levels of serum phosphate show decreased absorption or increased renal wasting of phosphate, while the elevated serum alkaline phosphatase levels suggest an [jisppd.com]

Decreased intestinal calcium and phosphate absorption also occurs. [msdmanuals.com]

elevated alkaline phosphatase, decreased PTH 4 Elevated serum phosphate, elevated alkaline phosphatase, elevated PTH 5 Elevated serum phosphate, decreased alkaline phosphatase [orthobullets.com]

X-Linked Hypophosphatemia

[…] tubular cells and inhibit 1a-hydroxylase, resulting in decreased intestinal absorption of calcium and phosphate (see also ADHR). [iofbonehealth.org]

XLH-associated mutations in phosphate-regulating endopeptidase (PHEX) result in elevated serum FGF23, decreased renal phosphate reabsorption, and low serum concentrations [ncbi.nlm.nih.gov]

Decreased intestinal calcium and phosphate absorption also occurs. [merckmanuals.com]

Hereditary Hypophosphatemic Rickets with Hypercalciuria

Hereditary hypophosphatemic rickets with hypercalciuria is a rare autosomal recessive disorder (OMIM #241530), characterized by decreased renal phosphate reabsorption that [ncbi.nlm.nih.gov]

The initial serum biochemistry in our clinic confirmed the previous biochemical alterations and showed decreased tubular reabsorption of phosphate (TRP) and high circulating [ojrd.biomedcentral.com]

FGF23 is known to act on the kidney to cause increased phosphate excretion and decreased alpha-1 hydroxylase activity. [boneandspine.com]

Acquired Fanconi Syndrome

[…] expression of apical tubular transporters including sodium glucose co-transporter, sodium phosphate co-transporter, uric acid transporter 1, and a decrease of Na(+)/K(+)- [ncbi.nlm.nih.gov]

In addition, they had the generalized dysfunction of the renal proximal tubules presenting decreased tubular reabsorption of phosphate (%TRP), increased fractional excretion [ncbi.nlm.nih.gov]

The tubular reabsorption of phosphate (%TRP) was decreased, although the fractional excretion of uric acid (FEUA) was increased, indicating disturbed proximal tubular reabsorption [bmcnephrol.biomedcentral.com]

Osteomalacia

He had multiple stress fractures, low serum phosphate, decreased renal tubular reabsorption of phosphate, and normal PTH and FGF23, indicating adult onset hypophosphatemic [ncbi.nlm.nih.gov]

Decreased or normal Decreased or normal Elevated Elevated Urinary phosphate wasting Decreased Normal Elevated or normal Normal Proximal (type II) renal tubular acidosis Decreased [step2.medbullets.com]

The calculated TRP (tubular reabsorption of phosphate) was decreased and the FGF23 increased. [ncbi.nlm.nih.gov]

Respiratory Alkalosis

[…] concentration (delta[PO4]p, +0.14 mmol/liter, P less than 0.005) associated with increased fractional excretion of Ca++ (+0.5%, P less than 0.005), decreased phosphate clearance [ncbi.nlm.nih.gov]

In the placebo group, fractional excretion of phosphate (FEPi) decreased from 24.1% +/- 3.4% in NV to 19.2% +/- 2.6% in RA. [ncbi.nlm.nih.gov]

decrease in free phosphate in both the cells and the extracellular fluid. [alpfmedical.info]

Hereditary Fructose Intolerance

In patients with HFI (n = 5) ingestion of small amounts of fructose was followed by an increase in sugar phosphates and decrease in inorganic phosphate (Pi) in the liver that [ncbi.nlm.nih.gov]

(Pi) are significantly decreased. [namrata.co]

[…] rate of fructose phosphorylation by fructokinase is so high (almost an order of magnitude greater than that of glucokinase), intracellular levels of both ATP and inorganic phosphate [usmle.biochemistryformedics.com]

Hypophosphatemic Nephrolithiasis - Osteoporosis Type 2

VAR_024765 147 - 147 V -> M (in NPHLOP1; causes hypophosphatemic osteoporosis; results in lower phosphate current, decreases affinity for phosphate and decreases phosphate [slc.bioparadigms.org]

[…] current, decreases affinity for phosphate and decreases phosphate uptake compared to wild-type; shows a dominant-negative effect. [uniprot.org]

[…] and decreases phosphate uptake compared to wild-type; shows a dominant-negative effect. [web.expasy.org]

Rickets

phosphate resorption. [ncbi.nlm.nih.gov]

Review Topic QID: 932 2 increased phosphate level 3 decreased alkaline phosphatase level 4 increased vitamin D level 5 increased parathyroid hormone level ML 1 Select Answer [orthobullets.com]

Autosomal Recessive Hypophosphatemic Rickets Type 2

Biochemically affected individuals have hypophosphatemia (low serum phosphate) due to decreased renal tubular reabsorption, phosphaturia (high urine phosphate) and decreased [exeterlaboratory.com]

Decreased intestinal calcium and phosphate absorption also occurs. [msdmanuals.com]

Hypophosphatemic Rickets and Hyperparathyroidism

Decreased intestinal calcium and phosphate absorption also occurs. [msdmanuals.com]

Acute Alcohol Intoxication

The loss of electrolytes such as phosphate, potassium and magnesium can result in cardiac dysrhythmia. [emsworld.com]

Acute alcohol ingestion can result in a decreased cardiac output in nonalcoholic patients with preexisting cardiac disease. This may be clinically significant. [emsworld.com]

Glycogen Storage Disease Type 1

decreased (0.36 +/- 0.08 vs. -0.43 +/- 0.17 arbitrary units; P < 0.01). [ncbi.nlm.nih.gov]

[…] the pentose phosphate pathway. [en.wikipedia.org]

[…] glucose-6-phosphate. 3. increased affinity of the enzyme for ATP and P i. [themedicalbiochemistrypage.org]

Proximal Renal Tubular Acidosis

Generalized aminoaciduria and decreased tubular reabsorption of phosphate were also present. [ncbi.nlm.nih.gov]

[…] modestly, and ( c ) urinary excretion of titratable acid increased briskly with diuresis of infused phosphate, although urinary pH changed little. [doi.org]

There may be increased or normal excretion of calcium, citrate, or phosphate in urine, while there may be decreased or normal excretion of NH 4 + in the urine. [lecturio.com]

Malnutrition

Carbohydrate metabolism that occurs during treatment stimulates insulin release, which drives phosphate into cells. [merckmanuals.com]

Treatment decreases extracellular potassium and magnesium. Depletion of potassium or magnesium may cause arrhythmias. [merckmanuals.com]

Vitamin D-Dependent Rickets Type 1B

Review Topic QID: 932 2 increased phosphate level 3 decreased alkaline phosphatase level 4 increased vitamin D level 5 increased parathyroid hormone level ML 1 Select Answer [orthobullets.com]

Diabetic Ketoacidosis

Phosphate concentration decreases with insulin therapy. [care.diabetesjournals.org]

Phosphate Despite whole-body phosphate deficits in DKA that average 1.0 mmol/kg body wt, serum phosphate is often normal or increased at presentation. [care.diabetesjournals.org]

Prospective randomized studies have failed to show any beneficial effect of phosphate replacement on the clinical outcome in DKA ( 46, 67 ), and overzealous phosphate therapy [care.diabetesjournals.org]

Primary Hyperparathyroidism

In detail, PTH synthesis is stimulated by decreased serum calcium levels and elevated phosphate concentrations. [symptoma.com]

Depending on the etiology, the serum calcium may be elevated and phosphate may be decreased. [en.wikibooks.org]

Hence, an increased plasma PTH leads to increased renal phosphate excretion5 with decreased plasma phosphate levels. [touchendocrinology.com]

Parathyroid Adenoma

decreased see hyperparathyroidism Technetium-99m-sestamibi radionuclide scan localizes mass Treatment Surgical adenoma excision hungry bones syndrome increased bone breakdown [medbullets.com]

The parathyroid glands produce PTH which regulates calcium and phosphate homeostasis. [medical-case-reports.imedpub.com]

[…] of the effect of dietary phosphate. [doi.org]

Bronchial Asthma

[…] serum levels of potassium, magnesium, and phosphate. [ncbi.nlm.nih.gov]

GAPDH, glyceraldehyde 3-phosphate dehydrogenase; PPARγ, peroxisome proliferator-activated receptor gamma. [ncbi.nlm.nih.gov]

[…] prudent to measure electrolytes in patients who have been taking diuretics regularly and in patients with cardiovascular disease because excessive use of β 2 -agonists may decrease [ncbi.nlm.nih.gov]

Gout

Over 80 % are pure uric acid stones, the rest are mixed calcium oxalate stones or calcium phosphate stones. [lecturio.com]

Stones form due to increased uric acid excretion, acidic urine and substances decreasing uric acid solubility. [lecturio.com]

Gram-Negative Septicaemia

ABG, arterial blood gas- increased serum lactate levels indicate tissue hypoperfusion PT/PTT- Fibin and fibrinogen are decreased and prothrombin is increased in the patients [austincc.edu]

Liver and renal function tests- BUN/creatinine, electrolytes, alkaline phosphate, bilirubin, and glucose UA- urinalysis for proteins, ketones, blood, leukocytes Urea nitrogen [austincc.edu]

Celiac Disease

[…] albumin level Malnutrition Elevated calcium level, decreased phosphate level Vitamin D deficiency, secondary hyperparathyroidism Thrombocytosis, leukocytosis General inflammatory [aafp.org]

[…] reaction Coagulopathy Decreased vitamin K absorption Low high-density and low-density lipoprotein cholesterol levels Decreased fat absorption, decreased hepatic lipoprotein [aafp.org]

[…] phosphatase level Osteoporosis, osteomalacia Elevated aspartate transaminase and alanine transaminase levels Minimal elevation common in celiac disease; presumably autoimmune Decreased [aafp.org]

Renal Tubular Acidosis

Without NH 3, the other buffers, primarily phosphate, are overloaded. As a result, the urine pH is acidic. [netscut.templaro.com]

[…] may be normal, due to renal tubular acidosis (RTA) URAEMIC ACIDOSIS Uraemic acidosis results from the loss of functional nephrons involves injury to glomeruli and tubules decreased [lifeinthefastlane.com]

This type of RTA is often part of Fanconi syndrome (in which there is also proximal tubule loss of glucose, calcium, phosphate, other electrolytes, and organic acids). [netscut.templaro.com]

Hypokalemia

Because of hypophosphataemia, phosphate supplementation was given. Lactic acid levels decreased quickly and no cardiac events reoccurred. [njmonline.nl]

Anterior Pituitary Hypofunction

[…] enemas or sodas, etidronate sodium) High Calcium levels Causes of Decreased Intracellular phosphorus shift Alkalosis or recovery from acidosis (COPD, Diabetic ketoacidosis [drkaslow.com]

[…] hypoparathyroidism, excess estrogen, adrenal steroids, growth hormone) Sarcoidosis Liver dysfunction Diabetes Drug induced (calcium containing antacids, excess Vitamin D, phosphate [drkaslow.com]

Renal Tubular Acidosis Type 1

[…] with calcium phosphate stone formation: hypocitraturia, hypercalciuria, and a high urine pH. [cjasn.asnjournals.org]

Hypoaldosteronism (type 4 RTA) Serum bicarbonate mildly decreased(>17meq/L) Hyperkalemia Urine anion gap in metabolic acidosis positive (impaired ammoniagenesis) Urine pH [clinicaladvisor.com]

Total Parenteral Nutrition

phosphate, magnesium, and potassium in serum levels) that may lead to widespread cellular dysfunction. [opentextbc.ca]

[…] in circulating levels of potassium, magnesium, and phosphate. [g-pact.org]

[…] syndrome Refeeding syndrome is caused by rapid refeeding after a period of malnutrition, which leads to metabolic and hormonal changes characterized by electrolyte shifts (decreased [opentextbc.ca]

Wilson Disease

[…] levels 0003109 Hypoparathyroidism Decreased parathyroid hormone secretion 0000829 Joint hypermobility Double-Jointed Flexible joints Increased mobility of joints [ more ] [rarediseases.info.nih.gov]

Hepatic failure Liver failure 0001399 High nonceruloplasmin-bound serum copper 0010838 Hypercalciuria Elevated urine calcium levels 0002150 Hyperphosphaturia High urine phosphate [rarediseases.info.nih.gov]

Nephropathic Cystinosis

[…] reabsorption of phosphate and hypophosphoremia, reduction in bicarbonate reabsorption producing plasma acidosis, and/or hypouricemia. [cjasn.asnjournals.org]

often incomplete, was based on the usual criteria: Hyperaminoaciduria, glycosuria, tubular proteinuria with the presence of β2-microglobulin, renal loss of potassium, decreased [cjasn.asnjournals.org]