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5,346 Possible Causes for phosphates

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  • Tumor Lysis Syndrome

    The serum phosphate reduced to normal levels within 24-48 hrs of initiation of sevelamer hydrochloride.[ncbi.nlm.nih.gov] Treatment of hyperphosphatemia reduces dietary phosphate intake and includes phosphate binders such as aluminum hydroxide and aluminum carbonate.[ncbi.nlm.nih.gov] The pathophysiology involves massive tumor cell lysis resulting in the release of large amounts of potassium, phosphate, and uric acid.[ncbi.nlm.nih.gov]

  • Tumoral Calcinosis

    Medical treatments are targeted toward decreasing intestinal phosphate absorption or increasing phosphate excretion; however, results have been variable and generally limited[ncbi.nlm.nih.gov] […] the phosphate regulator protein FGF23, impairing its ability inhibit reabsorption of filtered phosphate in the kidneys.[ncbi.nlm.nih.gov] The patient was treated with withdrawal of vitamin D therapy, strict control of serum phosphate levels with noncalcemic phosphate binders, and subtotal parathyroidectomy.[ncbi.nlm.nih.gov]

  • Hyperphosphatemia

    A low phosphate diet, an efficient dialysis removal of phosphate load, and the administration of phosphate binders are the main recommended steps to control hyperphosphatemia[ncbi.nlm.nih.gov] She was treated conservatively with oral phosphate binders and made an uneventful recovery.[ncbi.nlm.nih.gov] The authors described a patient with HP due to a phosphate-binding immunoglobulin (Ig).[ncbi.nlm.nih.gov]

  • Vitamin D Deficiency

    In stage 1 VDDR, urinary amino acid and phosphate excretion are normal with minimal or no findings of rickets on radiographs.[ncbi.nlm.nih.gov] Serum calcium, phosphate, PTH, LIC, cardiac T2 * , and LVEF were not different between the groups with or without Vitamin D deficiency.[ncbi.nlm.nih.gov] […] here presented for evaluation of bowing of his lower extremities, and was ultimately diagnosed with X-linked hypophosphatemic rickets, a disorder caused by renal wasting of phosphate[ncbi.nlm.nih.gov]

  • Hereditary Fructose Intolerance

    The radioactive fructose-1-phosphate compound was prepared from [U-14C]fructose by use of partly purified fructokinase (EC 2.7.1.4).[ncbi.nlm.nih.gov] It was found that fructose 1-phosphate is a potent competitive inhibitor (Ki congruent to 40 microM) of phosphomannose isomerase (EC 5.3.1.8), the first enzyme of the N-glycosylation[ncbi.nlm.nih.gov] Fructose-1 -phosphate (F-1-P), the initial reaction product of administered fructose, accumulates intracellularly behind this enzymatic defect 4, much as galactose-1-phosphate[nature.com]

  • Nephrocalcinosis

    In vitro studies showed that the p.Arg495His mutation resulted in decreased phosphate uptake when compared to wild-type SLC34A1.[ncbi.nlm.nih.gov] In this study, we wanted to elucidate whether the histopathological appearance of calcium phosphate deposits provides information about possible etiology.[ncbi.nlm.nih.gov] We found the increased phosphate dose administered for treatment to play a role in nephrocalcinosis development.[ncbi.nlm.nih.gov]

  • Carbamoyl Phosphate Synthetase Deficiency

    Mutations in the CPS1 gene cause carbamoyl phosphate synthetase I deficiency. The CPS1 gene provides instructions for making the enzyme carbamoyl phosphate synthetase I.[ghr.nlm.nih.gov] […] carbamoyl phosphate.[symptoma.com] Title Other Names: Hyperammonemia due to carbamoyl phosphate synthetase 1 deficiency; CPS 1 deficiency; Carbamyl phosphate synthetase (CPS) deficiency Categories: This disease[rarediseases.info.nih.gov]

  • Calciphylaxis

    We report on a 21-month-old girl with end-stage renal disease with severe calcium-phosphate imbalance.[ncbi.nlm.nih.gov] Conservative principles for management include normalization of calcium phosphate levels and local wound care. Penectomy may not impact survival.[ncbi.nlm.nih.gov] (8.2 versus 5.7 mg/dl; p 0.001), calcium phosphate product (81.5 versus 52.9; p 0.0004), parathyroid hormone (1496 versus 138 pg/ml; p 0.0001), and alkaline phosphatase levels[ncbi.nlm.nih.gov]

  • Pulmonary Alveolar Microlithiasis

    Inactivating mutations in SLC34A2, which encodes the NPT2b sodium-dependent phosphate cotransporter, has been proposed as a cause of PAM.[ncbi.nlm.nih.gov] Whole-lung EDTA can reduce the burden of stones in the lungs, and a low-phosphate diet prevents stone formation.[doi.org] PAM has been reported to arise from inactivating mutations in SLC34A2, encoding a sodium-dependent phosphate co-transporter essential for phosphate transport in the lungs[ncbi.nlm.nih.gov]

  • Disorder of Fructose Metabolism

    The two triose phosphates, Dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, may be degraded by glycolysis or may be substrates for aldolase and hence gluconeogenesis[usmle.biochemistryformedics.com] -1-phosphate.[fpnotebook.com] Gal actose 1 phosphate is converted to Glu cose 1 phosphate by Galactose 1 phosphate U ridyl transferase (the letter U ).[medicowesome.com]

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