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369 Possible Causes for Pigment Clumping, Retinal Pigmentation

  • Thioridazine

    Atrophy and disorganization of the photoreceptor outer segments appeared to be the initial degenerative event, followed by loss of the retinal pigment epithelium and choriocapillaris[ncbi.nlm.nih.gov] The ocular fundus examination revealed areas of retinal pigment epithelium (RPE) clumping as well as generalized atrophy of the RPE and choroid.[ncbi.nlm.nih.gov] Nummular areas of retinal pigment epithelial atrophy separated by relatively intact pigment epithelium are found in the midretinal periphery, with sparing of central vision[ncbi.nlm.nih.gov]

  • Kearns Sayre Syndrome

    The triad of progressive external ophthalmoplegia, atypical retinal pigmentation and cardiac conduction defects characterizes Kearns-Sayre syndrome (KSS), which is most often[ncbi.nlm.nih.gov] Fundus showed a waxy pale disc with marked attenuation of arterioles and pigment clumps at the periphery.[ijo.in] Kearns-Sayre syndrome (KSS) is characterized by external ophthalmoplegia, retinal pigmentation and cardiac conduction defects due to mitochondrial DNA (mtDNA) deletions.[ncbi.nlm.nih.gov]

  • Usher Syndrome Type I

    clumping.[jamanetwork.com] […] pigmentosa (pigment deposits on fundoscopy and a flat or diminished electroretinogram).[orpha.net] Pigmentation OU Granular Macula OU CDH23 22.8 (5) 20/54 (33.6, 9) 3487.9 (37.0, 7) 1.49 (36.7, 8) 4/9 patients 8/9 patients 5/9 patients MYO7A 20.5 (10) 20/35 (23.3, 15)[iovs.arvojournals.org]

  • Nephronophthisis

    Retinal pigment changes in these cases may be absent or minimal although arteriolar narrowing is usually seen.[disorders.eyes.arizona.edu] The clinical picture has been: normal disos and retinal vessels, fine pigment clumping in the equatorial region."[healio.com] There was no reference to retinal pigmentation, which was a finding of the recent examinations.[academic.oup.com]

  • Retinitis Pigmentosa with Situs Inversus

    Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone[uniprot.org] Retinal vessels were attenuated, and there were few scattered pigment clumping in the periphery of each eye.[aaopt.org] UniProtKB/Swiss-Prot : 75 Retinitis pigmentosa with or without situs inversus: A disorder characterized by variable association of retinitis pigmentosa with situs inversus[malacards.org]

  • Amblyopia

    Visual loss from diffuse choroidal hemangioma may result from chronic serous retinal detachments causing retinal pigment epithelial, photoreceptor or cystoid degeneration,[ncbi.nlm.nih.gov] Fundus examination did not reveal any abnormalities in the right eye, but narrow retinal vessels, optic disc pallor, and peripheral retinal pigment clumping was found in the[ncbi.nlm.nih.gov] CT was measured perpendicularly (from the outer edge of the hyper-reflective retinal pigment epithelium to the inner sclera) at the fovea, and 1.5-mm temporal, 3.0-mm temporal[ncbi.nlm.nih.gov]

  • Proliferative Vitreoretinopathy

    We sought to study the changes in retinal pigment epithelial cells when cell line-derived retinal pigment epithelial cells are cultured in the presence of pathological vitreous[ncbi.nlm.nih.gov] clumps or clusters on the retina Wrinkling of inner retina, retinal stiffness associated with decreased mobility of the vitreous Full thickness, fixed folds which may be[dro.hs.columbia.edu] Table 2: Classification of Proliferative Vitreoretinopathy, 1991 Grade Features A Vitreous haze, vitreous pigment clumps, pigment clusters on inferior retina B Wrinkling of[webeye.ophth.uiowa.edu]

  • Choroiditis

    Multifocal choroiditis is an inflammatory disorder affecting the outer photoreceptors, ellipsoid layer, retinal pigment epithelium, and choroid; and areas of acute inflammation[ncbi.nlm.nih.gov] clumping in chronic lesions Electrophysiologic studies are normal.[dro.hs.columbia.edu] Acute lesions appeared as nodular collections under the retinal pigment epithelium.[ncbi.nlm.nih.gov]

  • Nephronophthisis

    Retinal pigment changes in these cases may be absent or minimal although arteriolar narrowing is usually seen.[disorders.eyes.arizona.edu] There was no reference to retinal pigmentation, which was a finding of the recent examinations.[academic.oup.com] The fundus, more easily seen in OD, was typical of retinitis pigmentosa, with optic disc atrophy, attenuation of vessels, and bonecorpuscle-like pigmentation in the periphery[healio.com]

  • Serpiginous Choroiditis

    The serpiginous lesions were characterized by loss of retinal pigment epithelium and the photoreceptor cell layer.[ncbi.nlm.nih.gov] clumping in chronic lesions Electrophysiologic studies are normal.[dro.hs.columbia.edu] One patient showed combined detachment of the retinal pigment epithelium and serous detachment of the retina, while the other showed thickening of the retinal pigment epithelium[ncbi.nlm.nih.gov]

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