Pigmented-tumor: Causes & Reasons

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Possible Causes for pigmented tumor

Malignant Neoplasm of the Skin

Telangiectasias and a pearly, rolled border in dark skin or in a pigmented tumor may be difficult to discern. [ncbi.nlm.nih.gov]

Melanoma is a malignant tumor that originates in melanocytes, the cells that produce the pigment melanin which colors our skin, hair and eyes. [theskincancercenter.org]

with up to 60-75 percent of tumors arising on the palms, soles, mucous membranes and nail regions. 25 Basal cell carcinoma (BCC) is the most common cancer in Caucasians, [web.archive.org]

Basal Cell Carcinoma

Reflected-light microscopy is a non-invasive method for investigating skin tumors, which is used especially for early detection and diagnostic assessment of pigmented tumors [ims.uniklinik-freiburg.de]

The original tumors were not noted to be pigmented. [doi.org]

Furthermore, large blue-gray ovoid nests have been defined as pigmented ovoid or elongated areas, larger than globules, and not intimately connected to the pigmented tumor [hindawi.com]

Tendon Sheath Giant Cell Tumor

The main purpose of this study is to gather information about the investigational drug pexidartinib, which may help to treat tumors of pigmented villonodular synovitis (PVNS [clinicaltrials.gov]

Pigmented villonodular synovitis (diffuse tenosynovial giant cell tumor). [humpath.com]

Register Giant Cell Tumor of Tendon Sheath and Pigmented Villonodular Synovitis: An Ultrastructural Study - 24 Hours access EUR 36.00 GBP 28.00 USD 45.00 Rental This article [academic.oup.com]

Pigmented Villonodular Synovitis

[…] villonodular synovitis Diffuse pigmented villonodular synovitis TSGCT Tenosynovial giant cell tumors Diffuse-type giant cell tumor Statements Pigmented villonodular synovitis [wikidata.org]

Intra- and extra-articular giant cell tumor of tendon sheath (GCTTS) and pigmented villonodular synovitis (PVNS) are histologically similar, usually benign tumors that can [ncbi.nlm.nih.gov]

Giant cell tumor of Tenosynovium villous tenosynovitis Diffuse-type GCT Tenosynovial giant cell tumor TGCT Localized pigmented villonodular synovitis Diffuse pigmented villonodular [wikidata.org]

Iris Melanoma

There is evidence that diffusely infiltrating, heavily pigmented tumors, and tumors whose cell nuclei show prominent nucleoli are those most likely to metastasize. [jamanetwork.com]

A pigmented tumor measuring 3 1 mm was seen in the left eye in the inferonasal part of the iris and the anterior chamber angle, beginning in the ciliary body and iris root [jamanetwork.com]

Fundoscopy AFIP images Ciliary body tumor Orange pigment Vessels over tumor are out of focus Gross description Small uveal melanomas may be difficult to distinguish from [pathologyoutlines.com]

Carney Complex

Melanotic schwannoma is a rare form of pigmented neural tumor commonly arising from the posterior spinal nerves and ganglia. [ncbi.nlm.nih.gov]

[…] neoplasia syndrome involving skin and cardiac myxomas, pigmented skin lesions and endocrine tumors. [ncbi.nlm.nih.gov]

Carney Complex (CNC) is a multiple neoplasia syndrome characterized by skin tumors and pigmented lesions, myxomas, and various endocrine tumors. [ncbi.nlm.nih.gov]

Malignant Choroidal Melanoma

These risk factors are critical to judging the malignant potential of a small, pigmented choroidal tumor. [willseye.org]

We reported a 52-year-old male who had a pigmented tumor protruding from choroid of his right eye. [e-tjo.org]

This pigment is a dark-colored, light-absorbing particle. A melanoma is a tumor which arises from these cells. [news-medical.net]

Ciliary Body Melanoma

A 59-year-old woman had a sectorial pigmented iris tumor in her right eye and was found to have secondary glaucoma unresponsive to medical therapy. [ncbi.nlm.nih.gov]

Gonioscopy confirmed angle infiltration by pigmented tumor between 1 and 2 o'clock. [retinalphysician.com]

Fundoscopy AFIP images Ciliary body tumor Orange pigment Vessels over tumor are out of focus Gross description Small uveal melanomas may be difficult to distinguish from a [pathologyoutlines.com]

Blue Nevus

Microscopic examination showed a proliferation of pigmented tumor cells within the submucosa. [jomfp.in]

Over the past 3 months he had developed bluish pigmented tumor over the tip of the nose [Figure - 2] and multiple bluish black nodules over the thigh. [ijdvl.com]

Figure 2 Figure 2: Biphasic pattern of pigmented and non-pigmented tumor cells. Figure 3 Figure 3: Tumor cells in bundles permeating along hair follicle. [ispub.com]

Primary Pigmented Nodular Adrenocortical Disease

pigmented nodular adrenocortical disease (PPNAD). [ncbi.nlm.nih.gov]

cardiac myxomas, and endocrine tumors or be isolated (i). [ncbi.nlm.nih.gov]

Lentigines, blue, junctional or compound nevi Primary pigmented nodular adrenocortical disease testicular tumor large cell calcifying Sertoli cell tumors, often bilateral [medical-dictionary.thefreedictionary.com]

Gingivitis

Villonodular Synovitis or Giant Cell Tumor of the Tendon Sheath Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo 36 Multicentre Canadian Study to Measure the [malacards.org]

Size of MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Completed NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo 43 A Prospective Double-Blinded Clinical [malacards.org]

Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium 42 A Phase II Randomized, Double -Blind, Placebo Controlled Study to Assess Safety, Tolerability and Effect on Tumor [malacards.org]

Rosacea

Figure 16 Pigmented BCC. Dark nodule (resulting from melanin deposition) at the alar of the nose. Small ulceration at the center. Figure 17 Scar-like morphea-like BCC. [doi.org]

A biopsy can be necessary to differentiate fibrous papules from benign adnexal tumors or basal cell carcinomas (BCCs) that sometimes closely resemble its "pearly" appearance [doi.org]

Histopathologically, a clear cell fibrous, hypercellular fibrous, inflammatory fibrous, pigmented fibrous, pleiomorphic fibrous papule and epithelioid variant can be distinguished [doi.org]

Lentigo Maligna Melanoma

In one of the patients, histopathology of the pigmented tumor on the left middle toe was a Pagetoid (superficial spreading) melanoma in situ, and the subungual granulomatous [ncbi.nlm.nih.gov]

It is a slow-growing, pigmented tumor evolving from a premalignant lesion on the exposed cutaneous surface of an elderly patient. [ncbi.nlm.nih.gov]

Dermatofibrosarcoma Protuberans

Pigmented dermatofibrosarcoma protuberans (Bednar tumor: a pathologic, ultrastructural, and immunohistochemical study). [scielo.br]

In addition to the classical form characterized by a storiform pattern of tumor cells, pigmented (Bednar's tumor) and myxoid variants can be observed. [ncbi.nlm.nih.gov]

Original Article A Case of Pigmented Dermatofibrosarcoma Protuberans (Bednar Tumor) Corresponding Author Department of Dermatology, Iwate Medical University, School of Medicine [onlinelibrary.wiley.com]

Actinic Keratosis

Spreading pigmented actinic keratosis is a rarely reported premalignant, pigmented, epidermal tumor that can be difficult to distinguish clinically from other benign and malignant [ncbi.nlm.nih.gov]

[…] skin tumors. 9 The use of dermoscopy can also assist with the diagnosis of non-pigmented or “pink” tumors (lesions) with the emphasis on blood vessel morphology and pattern [podiatrytoday.com]

David Weedon, Tumors of the epidermis, Weedon's Skin Pathology, 10.1016/B978-0-7020-3485-5.00032-2, (667-708.e49), (2010). David J. [doi.org]

Ganglion Cyst

The differential diagnosis of intraosseous ganglion includes unicameral bone cyst, chondromyxoid fibroma, Brodie's abscess, giant-cell tumor, fibrous dysplasia and pigmented [spandidos-publications.com]

fibrous dysplasia and pigmented villonodular synovitis. [spandidos-publications.com]

Our patient underwent an open biopsy, and the pathological examination revealed a benign tumor. [spandidos-publications.com]

Third Trimester Pregnancy

This is an example of pigmented dermatofibrosarcoma protuberans (Bednar tumor). [pathologyoutlines.com]

Introduction Overview dermatofibrosarcoma protuberans is a rare low-grade fibrogenic cutaneous sarcoma that occurs in early to midadult life variants include Bednar tumor [orthobullets.com]

Dermatofibro-sarcoma Protuberans (Bednar Tumor) Tweets by @WebPathology Slide Index Brain Breast Head & Neck Mediastinum Peritoneum Genitourinary Lymph Node/Spleen Hematopathology [webpathology.com]

Primary Malignant Melanoma of the Conjunctiva

Majority of the patients had a pigmented tumor (n 33; 79%). [tandfonline.com]

External photograph shows the pigmented tumor “melanoma” in the conjunctiva. By Paul T. [eyecancer.com]

Microscopic examination revealed normal dura with copious melanin and a heavily pigmented tumor (Fig. 5). [doctiktak.com]

Dermatitis

DFSP' or 'Bednar tumor.' [ncbi.nlm.nih.gov]

[…] pattern and align perpendicular around the vessels in central locations.[8‐11] A rare type of DFSP is characterized by dendritic cells that contain melanin and is known as 'pigmented [ncbi.nlm.nih.gov]

Choroid Hemangioma

Pigmentary changes have also been reported on the surface of the tumor or as a ring of pigmentation around the edge of the tumor. 6 There may be accumulation of lipofuscin [clinicalgate.com]

Right: blood filled, dilated, thin walled vessels Degeneration of retinal pigment epithelium and early cystoid edema of retina overlying vascular tumor Back to top [pathologyoutlines.com]

Nevus Benign pigmented or nonpigmented mass on the eye surface. This is the most common tumor of the conjunctiva. Detection occurs in children and young adults. [isoo.org]

Fibroma

Abstract Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing [ncbi.nlm.nih.gov]

Frozen section showed a benign spindle cell neoplasm with hemosiderin pigments. On gross examination, the tumor measured 3.5 cm 2.3 cm 1.9 cm and weighed 16.5 g. [dovepress.com]

[…] a localized manifestation of pigmented villonodular synovitis that is less hyalinized and more cellular, and with histiocytes and monocytes as well as multinucleated giant [humpath.com]

Eye Neoplasm

Choroidal nevus is typically a pigmented tumor of the blood vessel layer (choroid) beneath the retina. [eyecancer.com]

Lymphoma of the conjunctiva Melanoma and PAM with atypia Pigmented conjunctival tumors Pingueculum Pterygium Squamous carcinoma and intraepithelial neoplasia of the conjunctiva [en.wikipedia.org]

The natural history of these tumors has been characterized as presenting with multiple tumors or non-pigmented skip areas. [eyecancer.com]

Sunburn

Chronic sun exposure may lead to premature aging, severe wrinkling, pigmented skin lesion development (moles), and various malignant (cancerous) skin tumors. [emedicinehealth.com]

Chronic sun exposure may lead to premature aging, severe wrinkling, pigmented skin lesion development ( moles ), and various malignant (cancerous) skin tumors. [emedicinehealth.com]

Often a very rapidly growing tumor. [en.wikipedia.org]

Hypogonadism

Primary hypogonadism Secondary hypogonadism Genetic: Klinefelter’s syndrome (common) Congenital: anorchia Kallman Syndrome Pituitary gland tumor 8. [slideshare.net]

Erectile dysfunction • Small testis • lack scrotal pigmentation • Small penis ( 8 cm long in adults). • Loss of pubic hair • axillary hair • terminal hair growth along the [slideshare.net]

Oral Candidiasis

and pigmented lesions such as oral melanotic macules. [hivinsite.ucsf.edu]

Differential Diagnosis KS must be distinguished from vascular lesions such as hematomas, hemangiomas, other vascular tumors, pyogenic granulomas, bacillary angiomatosis,(69 [hivinsite.ucsf.edu]

Primary Malignant Melanoma of the Cervix

Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. [hindawi.com]

The tumor was carefully dissected and was then removed with cautery under microscope. [e-fjs.org]

Numerous tumor cells had a large amount of melanin pigment in the cytoplasm (Fig. 3). [academic.oup.com]

Familial Adenomatous Polyposis

(locally invasive tumors that grow aggressively and can be life threatening), congenital hypertrophy of retinal pigment (CHRPE) Dental abnormalities An increased risk of [stanfordhealthcare.org]

[…] epithelium without osteoma, dental abnormalities and desmoid tumors. [ncbi.nlm.nih.gov]

FAP may present some extraintestinal manifestations such as osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), desmoid tumors [orpha.net]

Cholelithiasis

Treatment • Medical therapy- • GALL STONE DISSOLUTION • Ursodeoxycholic acid (UDCA) – with a functioning Gall bladder with stone less than 10 mm • 10-15 mg/kg/day • Pigment [slideshare.net]

[…] of radio-opaque shadow on x-ray • Renal stone • Calcified 12th rib tip • Phlebolith • Faecolith • Calcified lymph node • Renal cell Ca - calcification • Calcified Adrenal tumor [slideshare.net]

Balanitis

Benign tumors of the eyelid include a variety of nonpigmented and pigmented epidermal tumors (arising from squamous or melanocytic cells), adnexal tumors ( Chap. 4), and stromal [scinapse.io]

tumors ( Chap. 5). [scinapse.io]

Important to note is that not all clinically pigmented lesions are melanocytic, since squamous cells can pick up melanin pigment, thus giving a pigmented appearance to a lesion [scinapse.io]

Medulloepithelioma

We do not believe that the tumor arose from the pigment epithelium because pigment epithelial tumors do not produce hyaluronic acid, which was present in our patient's tumor [jamanetwork.com]

Tumor with irregular surface filling the chamber angle. [atlasophthalmology.net]

[…] of brown pigment represents melanosomes in epithelial and stromal cells of the iris (I). ( G ) An iridocyclectomy specimen contains both well-differentiated (WDT) and poorly [iovs.arvojournals.org]