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826 Possible Causes for Platelet Count Abnormal

  • Chronic Immune Thrombocytopenic Purpura

    Abnormal platelet distribution involves an enlarged spleen and is most commonly due to congestive splenomegaly although other disorders such as lymphoma, Gaucher's disease[] Platelet transfusions may be used in severe bleeding together with a very low count. Sometimes the body may compensate by making abnormally large platelets.[] The role of platelets and the way in which the results of platelet counts can help to identify symptoms of abnormal bleeding are also explained.[]

  • Follicular Lymphoma

    When physicians use rituximab to treat high-risk patients, the platelet count should be closely monitored to avoid possible adverse events.[] Coagulation abnormality, which mimicked disseminated intravascular coagulation, also appeared.[]

  • Essential Thrombocythemia

    Since platelet counts are so high, the spleen can experience thrombotic episodes which eventually results in splenic atrophy.[] Even though the platelet count is elevated for a short time (or even indefinitely after splenectomy), secondary thrombocytosis does not typically lead to abnormal blood clotting[] Platelets derived from the abnormal megakaryocytes are activated, which, along with the elevated platelet count, contributes to the likelihood of forming blood clots.[]

  • Chronic Myelomonocytic Leukemia

    In the only model that took karyotype into account, bone marrow blasts 10%, leukocyte count 13 10(9) L(-1), hemoglobin 10 g/dL, platelet count 100 10(9) L(-1), and presence[] Leukemia specialists at Rush may recommend one or more of the following tests: Blood tests to check for high monocyte count and low red blood cell and platelet count Tests[] Univariate analysis identified low hemoglobin level; low platelet count; high white blood cell, monocyte, and lymphocyte counts; presence of circulating immature myeloid cells[]

  • B Acute Lymphoblastic Leukemia

    PLoS One. 2016 Aug 18;11(8):e0161539. doi: 10.1371/journal.pone.0161539. eCollection 2016. Edwards H 1, 2 , Rubenstein M 3 , Dombkowski AA 4, 5 , Caldwell JT 6, 7 , Chu R 3, 5 , Xavier AC 8 , Thummel R 9 , Neely M 10 , Matherly LH 1, 2, 11 , Ge Y 1, 2 , Taub JW 2, 3, 5 . Author information 1 Department of Oncology, Wayne State[…][]

  • Promyelocytic Leukemia

    The standard of practice is to prophylactically transfuse platelets, plasma and cryoprecipitate to mitigate abnormal platelet counts, PT/PTT and fibrinogen levels.[] Serious bleeding abnormalities due to the low platelet count and clotting factors are much more frequent in patients with APML compared with ‘standard’ AML.[] Patients with APL invariably have abnormal laboratory hemostasis tests.[]

  • Hairy Cell Leukemia

    1%), and a platelet (PLT) count of 17 x 10(9)/L.[] She had splenomegaly and lymphocytosis (lymphocyte count of 11.6 10 9 /l), with remarkably abnormal appearing morphology. Her hemoglobin and platelet counts were normal.[] It is likely the result of producing slightly abnormal platelets in the overstressed bone marrow tissue.[]

  • Congenital Acquired Immune Deficiency Syndrome

    Congenital acquired immune deficiency syndrome occurs due to mother-to-child transmission of HIV in utero, during delivery or breast-feeding. Depending on various factors, around 5-50% of children born to HIV mothers are infected. The diagnosis is made by a combination of clinical and immunological criteria, while[…][]

  • Atypical Hemolytic Uremic Syndrome

    , ECG abnormalities, and clinical laboratory test abnormalities TMA Response [ Time Frame: 26 weeks ] Complete TMA response defined as normalization of platelet count, normalization[] Eculizumab has stabilized hematological abnormalities (i.e. reduced acute hemolysis and normalized platelet counts) and stabilized renal disease and can reverse acute kidney[] An increased platelet count is anticipated after the second or third daily treatment, and often the platelet count reaches normal in 1 week.[]

  • ALK+ Histiocytosis

    Total leukocyte count was 12,080 with differential count showing 45% neutrophils, 37% lymphocytes, 15% monocytes and 3% eosinophils. Platelet count was normal.[] Skeleton X-ray survey revealed no abnormality.[]

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