Poikilocytosis: Causes & Reasons

Possible Causes for Poikilocytosis

Teardrop poikilocytosis on peripheral smear. Leukoerythroblastic blood picture; giant abnormal platelets. [accessmedicine.mhmedical.com]

Primary melofibrosis (Agnogenic myeloid metaplasia-AMM) is a chronic myeloproliferative disease characterized by splenomegaly, a leukoerythroblastic blood picture, teardrop poikilocytosis [ncbi.nlm.nih.gov]

First two patients have massive splenomegaly, leukoerythroblastic blood picture with tear drop poikilocytosis but no cytopenias. [omicsonline.org]

Thalassemia

A blood smear with target cells and poikilocytosis provides additional certainty. [lecturio.com]

This blood smear from an individual with thalassemia shows small (microcytic), pale (hypochromic), variously-shaped (poikilocytosis) red blood cells. [mountsinai.org]

Beginning in the first year of life the PBS shows severe anisocytosis and poikilocytosis, targets, elliptocytes, teardrops, and NRBCs. [med-ed.virginia.edu]

Congenital Dyserythropoietic Anemia Type 1B

The peripheral blood smear examination revealed varying degrees of anisocytosis, poikilocytosis, hypochromia and tear drop cells. [indianpediatrics.net]

Leukoerythroblastic Anemia

RBC morphology may show extreme variation (anisocytosis and poikilocytosis) in size and shape. The white blood cell count may vary. [msdmanuals.com]

RBC morphology may show extreme variation (anisocytosis and poikilocytosis) in size and shape. The WBC count may vary. [merckmanuals.com]

Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of red blood cell and white blood cell precursors. [msdmanuals.com]

Normocytic Normochromic Anemia

There is anisocytosis, poikilocytosis. There are pencil cells (elliptical RBCs). [labpedia.net]

The peripheral smear can also reveal variation in RBC shape (poikilocytosis) and size (anisocytosis). [merckmanuals.com]

Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors. [msdmanuals.com]

Erythrocyte Membrane Abnormality

[…] spectrin deficiency another mutant spectrum which causes problems with horizontal interaction of membrane proteins PBS of hereditary pyropiklocytosis eliptocytes severe poikilocytosis [quizlet.com]

Severe hemolysis, bizarre poikilocytosis, and RBC fragmentation are the hallmarks of hereditary pyropoikilocytosis, a rare autosomal recessive disease. [med-ed.virginia.edu]

Peripheral blood smears showed elliptocytosis and poikilocytosis in 10 patients (eight ALL and two CML) ( Figure 1 and Table 1 ). [nature.com]

Myelophthisis

RBC morphology may show extreme variation (anisocytosis and poikilocytosis) in size and shape. The WBC count may vary. [merck.com]

In addition, anisocytosis, poikilocytosis, and polychromasia can be seen. [emedicine.medscape.com]

Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors. [merck.com]

Red Blood Cell Disorder

[…] pyropoikilocytosis HFE hereditary haemochromatosis I Iron deficiency L Latent iron deficiency M McLeod syndrome Methemoglobinemia Microcytosis Myomatous erythrocytosis syndrome P Poikilocytosis [en.wikipedia.org]

Applicable To Abnormal red-cell morphology NOS Abnormal red-cell volume NOS Anisocytosis Poikilocytosis The following code(s) above R71.8 contain annotation back-references [icd10data.com]

Tables Size Variations in Red Blood Cells Anisocytosis Reference Table Variations in Hemoglobin Content Hemoglobin Content Reference Table Shape Variations in Red Blood Cells Poikilocytosis [medialabinc.net]

Pyruvate Kinase Deficiency

Embden-Meyerhof pathway Erythrocytes (mature red blood cells) completely depend on glucose as a source of energy. Glucose is usually catabolized to pyruvate and lactate in the Embden-Meyerhof pathway, which is the major anaerobic glycolytic pathway. In the process, adenosine triphosphate (ATP), which is essential[…] [emedicine.medscape.com]

Hypochromic Microcytic Anemia with Iron Overload Type 2

Images hosted on other servers: Bone marrow smear: RARS with thrombocythemia Fig 1: peripheral blood shows dual population of microcytic and normocytic red cells with marked poikilocytosis [pathologyoutlines.com]

Red Blood Cell Abnormalities in Morphology: Poikilocytosis- Variation in RBC shape : Poikilocytosis: Variations in RBC shape and morphology Anisocytosis : Variation in RBC [hematologylearning.weebly.com]

[…] sideroblastic anemia frequently demonstrates a "dimorphic" RBC population [microcytic and macrocytic RBCs (increased RDW)], basophilic stippling, ovalocytes, and other evidence of poikilocytosis [med-ed.virginia.edu]

Hereditary Elliptocytosis

[…] with neonatal poikilocytosis hereditary spherocytic elliptocytosis hereditary pyropoikilocytosis [gpnotebook.co.uk]

In these three patients the blood smear showed pronounced elliptocytosis, poikilocytosis and a few small red cell fragments instead of the mild elliptocytosis observed in [ncbi.nlm.nih.gov]

The red blood cells showed marked poikilocytosis and fragmentation. [ncbi.nlm.nih.gov]

Idiopathic Refractory Anemia

Red cell precursors may be megaloblastic, with anisocytosis (abnormal variation in red blood cell [RBC] size) and poikilocytosis (abnormal variation in RBC shape). [encyclopedia.lubopitko-bg.com]

The peripheral blood smear review that was consequently performed revealed a poikilocytosis with the presence of target cells and stomatocytes. [sysmex-europe.com]

Toxic Hemolytic Anemia

RDW is increased due to anisocytosis and poikilocytosis. Unlike other normochromic and normocytic anemias. [labpedia.net]

Red cells may contain Heinz bodies and the cells may be fragmented showing anisocytosis and poikilocytosis. Serum bilirubin is elevated. [flipper.diff.org]

[…] occurs 24 to 48 hours after exposure and is characterized by diminished hemoglobin and hematocrit, increase in reticulocyte count, increase in total bilirubin, anisocytosis, poikilocytosis [path.upmc.edu]

Hemoglobin Lepore-Beta-Thalassemia Syndrome

Anisocytosis and poikilocytosis, and target cells, are present on peripheral smear. Diagnosis? Definition Term A patient has microcytic hypochromic anemia. [flashcardmachine.com]

Homo form in African Americans. α-Thalassemia - 2 gene del: Lab finding [trait] M/H Poikilocytosis target cells RDW normal Hb H [some] Hb Bart's 5-15% in cord blood α-Thalassemia [studyblue.com]

See mild to moderate poikilocytosis. In more severe cases, see marked number of target cells and elliptocytes. [slideplayer.com]

Acquired Sideroblastic Anemia

[…] distinct accelerated variant of agnogenic myeloid metaplasia that is characterized by marked anemia, peripheral blood myeloblastosis and normoblastosis, a lack of teardrop poikilocytosis [ncbi.nlm.nih.gov]

Red cell precursors may be megaloblastic, with anisocytosis (abnormal variation in red blood cell [RBC] size) and poikilocytosis (abnormal variation in RBC shape). [encyclopedia.lubopitko-bg.com]

Congenital Heinz Body Hemolytic Anemia

The stained peripheral blood smear shows anisocytosis, poikilocytosis, basophilic stippling, polychromasia and, sometimes, hypochromia. [mayomedicallaboratories.com]

Normochromic, normocytic mild to moderate anemia Many target cells, folded cells, cells with hgb C crystals, and occasional sickle cells Slight to marked anisocytosis and poikilocytosis [slideplayer.com]

Hereditary Cryohydrocytosis with Reduced Stomatin

The latter include (i) the disorders of the red cell mechanics: hereditary spherocytosis, hereditary elliptocytosis and poikilocytosis, and (ii) the disorders of the passive [scipers.com]

Normal-appearing RBCs, along with polychromasia and varying degrees of anisocytosis and poikilocytosis, are present. [doctorlib.info]

در حالت دوم شامل (من) اختلالات مکانیک سلول های قرمز: اسفروسیتوز ارثی، الیپتوسیتوز و poikilocytosis، و (ب) اختلالات از شار منفعل کاتیون در سراسر غشاء است: stomacytoses و شرایط [scipers.com]

Megaloblastic Anemia

In five of the eight episodes, erythropoiesis was not megaloblastic and there was insufficient anisocytosis or poikilocytosis to suggest an underlying vitamin deficiency state [jamanetwork.com]

The smear shows macro-ovalocytosis, anisocytosis, and poikilocytosis. The RBC distribution width (RDW) is high. [merckmanuals.com]

Diagnosis is usually based on a CBC and peripheral smear, which usually shows a macrocytic anemia with anisocytosis and poikilocytosis, large oval RBCs (macro-ovalocytes), [merckmanuals.com]

Hemoglobin E Disease

[…] of homozygous hemoglobin C disease: target cells (arrows), microspherocytes (arrowheads), rod-shaped cells containing hemoglobin C crystals (asterisk), anisocytosis, and poikilocytosis [nejm.org]

Anisocytosis, poikilocytosis, and target cells were present in almost all cases. [jscisociety.com]

The morphology of the erythrocytes showed severe hypochromia, anisoschisto-and poikilocytosis, film suggestive of thalassemia. [jpma.org.pk]

Hemoglobin Bart's Disease

The Wright-stained blood smear on the left shows a microcytic, hypochromic anemia with poikilocytosis. [brown.edu]

Hematology and Clinical Presentation: There is a microcytic, hemolytic anemia with usually marked poikilocytosis. [hemoglobins.bio-rad.com]

This tetramer is somewhat unstable, and can precipitate as Heinz bodies (hemoglobin inclusions in RBC's) or lead to increased RBC poikilocytosis (abnormally shaped RBC's). [health.auckland.ac.nz]

Refractory Megaloblastic Anemia

[…] also atrophic glossitis, atrophic gastritis, neurologic disorders Histology Peripheral blood: normochromic macrocytic anemia, often pancytopenia, significant anisocytosis, poikilocytosis [atlases.muni.cz]

Morphology Peripheral smear ( Figure ) RBCs - Macrocytic anemia, ovulocytosis - Poikilocytosis if anemia is severe. - Normo / hyperchromasia - Increased polychromatophilic [sites.google.com]

Posthemorrhagic Anaemia of the Newborn

Poikilocytosis (irregular shape) and ... [5minuteconsult.com]

The microcythemia, an anisocytosis, a poikilocytosis are observed. Iron level in blood serum is reduced against the increased iron-binding ability of serum. [infomeds.net]

[영문] Red blood cell size variation (anisocytosis), along with poikilocytosis, have long been recognized as morphologic hallmarks of some amemias. [ir.ymlib.yonsei.ac.kr]

Chronic Acquired Pure Red Cell Aplasia

Histology: Peripheral blood: hypochromic microcytic anemia, anisocytosis, polychromasia is absent, poikilocytosis. [atlases.muni.cz]

Yes (seen in peripheral smear) There is moderate to severe poikilocytosis in renal disease showing what kinds of shapes... 1)Echinocytes 2)Schistocytes 3)Spherocytes Are WBCs [quizlet.com]

[…] mean corpuscular haemoblobin- 27.8 pg, mean corpuscular haemoblobin concentration- 32.7%, red cell distribution width- 16.6, peripheral blood smear showed anisocytosis, poikilocytosis [ijmstrust.in]

Congenital Hemolytic Anemia

Aniso- and poikilocytosis were marked on a stained smear, and there were many small hyperchromatic cells of irregular shape. [ncbi.nlm.nih.gov]

[…] hypersplenism) Consideration to make for splenectomy All lobes should be removed RBC morphology in Congenital Hemolytic Anemia Hypochromic Microcytic Anisocytosis (size) Poikilocytosis [brainscape.com]

PBS initially showed severe poikilocytosis that could be explained by some degree of stress erythropoiesis. [casesjournal.biomedcentral.com]

Traumatic Hemolytic Anemia

RDW is increased due to anisocytosis and poikilocytosis. Unlike other normochromic and normocytic anemias. [labpedia.net]

Blood film: moderate poikilocytosis, schistocytosis, and polychromasia may be present (see Table 20–1 ). [mhmedical.com]

RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis) and shape (poikilocytosis [labtestsonline.org]

Paroxysmal Cold Hemoglobinuria

[…] cramps Back pain Intermittent episodes of hemoglobinuria Typical laboratory findings Elevated bilirubin level Decreased hemoglobin Polychromatophilia, nucleated RBCs, and poikilocytosis [labce.com]

Other morphological abnormalities may be observed in the red blood cells such as poikilocytosis, polychromasia, spherocytosis, and nucleated erythrocytes. [symptoma.com]

The peripheral blood smear exhibits spherocytosis, polychromasia, nucleated red blood cells (RBCs), anisocytosis, poikilocytosis, and sometimes erythrophagocytosis by neutrophils [emedicine.com]

Microcytic Anemia

[…] hypochormic microcytic anemia condition Hypochormic as central pallor zone increased in most red cells Microcytic as cells are smaller than normal Anisocytosis (variation in size) Poikilocytosis [medical-labs.net]

There is also increased anisocytosis (variation in RBC size) and poikilocytosis (variation in RBC shape). [library.med.utah.edu]

[…] blood cell morphology showed striking (3+) anisocytosis, polychromasia, and basophilic stippling (Figures 4, 5), as well as moderate (2+) hypochromia, microcytosis, and poikilocytosis [path.upmc.edu]

Hereditary Orotic Aciduria without Megaloblastic Anemia

Poikilocytosis and anisocytosis are common due to ineffective erythropoiesis. [ncbi.nlm.nih.gov]

[citation needed] Anisocytosis (increased variation in RBC size) and poikilocytosis (abnormally shaped RBCs). Macrocytes (larger than normal RBCs) are present. [en.wikipedia.org]

Poikilocytosis MedGen UID: 67451 •Concept ID: C0221281 • Finding An increase in the number of abnormally shaped red blood cells. [ncbi.nlm.nih.gov]

Southeast Asian Ovalocytosis

As opposed to neonatal poikilocytosis, the hemolytic anemia in HPP is lifelong. [emedicine.medscape.com]

Examination of the blood smear revealed anisocytosis and poikilocytosis, without spherocytes but with ovalocytes and macro-ovalocytes, some of them with more than 1 ridge [imagebank.hematology.org]

[…] symptom free until second half of 1st year of life due to Hb F undergo periods of pain termed crises Sickle cell disease peripheral smear Normocytic/normochromic, marked poikilocytosis [quizlet.com]

Woronets Trait

Anemia Anemia of inadequate production, Hypochromic anemia, Anisocytosis, Poikilocytosis, Macrothrombocy... [mousephenotype.org]

OMIM:603529 Anemia, Congenital Dyserythropoietic, Type Ib Anemia of inadequate production, Splenomegaly, Anemia, Anisocytosis, Poikilocytosis, Reticulocyto... [mousephenotype.org]

OMIM:300908 Congenital Dyserythropoietic Anemia Type Iii Increased mean corpuscular volume, Anisocytosis, Poikilocytosis, Anemia, Abnormal erythrocyte mor... [mousephenotype.org]