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241 Possible Causes for Poikilocytosis

  • Primary Myelofibrosis

    Primary melofibrosis (Agnogenic myeloid metaplasia-AMM) is a chronic myeloproliferative disease characterized by splenomegaly, a leukoerythroblastic blood picture, teardrop poikilocytosis[] First two patients have massive splenomegaly, leukoerythroblastic blood picture with tear drop poikilocytosis but no cytopenias.[] 91–2). 7–15,262–265 Mean hemoglobin concentration in a series of patients at diagnosis is approximately 9.0 to 12.0 g/dL (range: 4–20 g/dL). 7–15,264,265 Anisocytosis and poikilocytosis[]

  • Thalassemia

    A blood smear with target cells and poikilocytosis provides additional certainty.[] Red blood cell distribution width may be enhanced, and blood films may reveal anisocytosis and poikilocytosis.[] Beginning in the first year of life the PBS shows severe anisocytosis and poikilocytosis, targets, elliptocytes, teardrops, and NRBCs.[]

  • Congenital Dyserythropoietic Anemia Type 1

    The peripheral blood smear examination revealed varying degrees of anisocytosis, poikilocytosis, hypochromia and tear drop cells.[]

  • Hereditary Elliptocytosis

    In these three patients the blood smear showed pronounced elliptocytosis, poikilocytosis and a few small red cell fragments instead of the mild elliptocytosis observed in[] The red blood cells showed marked poikilocytosis and fragmentation.[] We studied a family in which the proband presented with a severe neonatal hemolytic anemia with poikilocytosis.[]

  • Megaloblastic Anemia

    […] also atrophic glossitis, atrophic gastritis, neurologic disorders Histology Peripheral blood: normochromic macrocytic anemia, often pancytopenia, significant anisocytosis, poikilocytosis[] The smear shows macro-ovalocytosis, anisocytosis, and poikilocytosis. The RBC distribution width (RDW) is high.[] Diagnosis is usually based on a CBC and peripheral smear, which usually shows a macrocytic anemia with anisocytosis and poikilocytosis, large oval RBCs (macro-ovalocytes),[]

  • Anemia of Chronic Disease

    Poikilocytosis) is not as pronounced as that found in iron deficiency anemia.[]

  • Sickle Cell Thalassemia Disease

    The most striking laboratory findings are an elevated count of nucleated red blood cells (NRBCs; Table 1 ), along with marked anisocytosis and moderate poikilocytosis (drepanocytes[] Wright-Giemsa stained peripheral blood smear from our patient, a 37-year-old man of half African and half Italian ethnicity, illustrating anisocytosis, thrombocytosis, and poikilocytosis[]

  • Traumatic Hemolytic Anemia

    Blood film: moderate poikilocytosis, schistocytosis, and polychromasia may be present (see Table 20–1 ).[] RDW is increased due to anisocytosis and poikilocytosis. Unlike other normochromic and normocytic anemias.[] RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis) and shape (poikilocytosis[]

  • Retinitis Pigmentosa with Situs Inversus

    Peripheral smear revealed red blood cells with mild degree of anisocytosis, poikilocytosis, polychromasia with hypochromic, macrocytic RBCs, target cells and sickle cells.[]

  • Congenital Hemolytic Anemia

    Aniso- and poikilocytosis were marked on a stained smear, and there were many small hyperchromatic cells of irregular shape.[] […] hypersplenism) Consideration to make for splenectomy All lobes should be removed RBC morphology in Congenital Hemolytic Anemia Hypochromic Microcytic Anisocytosis (size) Poikilocytosis[] PBS initially showed severe poikilocytosis that could be explained by some degree of stress erythropoiesis.[]

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