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54 Possible Causes for Polychromasia in Peripheral Blood Smear, Splenomegaly

  • Congenital Dyserythropoietic Anemia Type 1

    Our patient is a Taiwanese child who presented to us at 8. years of age with severe hemolytic anemia, splenomegaly, elevated fetal hemoglobin (HbF), iron overload, and dyserythropoiesis[einstein.pure.elsevier.com] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[unboundmedicine.com] Individuals with CDAII show progressive splenomegaly, gallstones and iron overload potentially with liver cirrhosis or cardiac failure.[f1000.com]

  • Paroxysmal Cold Hemoglobinuria

    Signs Splenomegaly Hepatomegaly Transient Jaundice Pale fingers, toes, and tip of nose VI.[fpnotebook.com] Tests include complete blood count (CBC) and peripheral smear.[emedicine.com] Typically there was a sudden onset of pallor and malaise; jaundice, splenomegaly and hepatomegaly were found in about half the subjects.[doi.org]

  • Autoimmune Hemolytic Anemia

    Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] The diagnosis of HLH after SOT is especially difficult, as several of the diagnostic criteria, including fever, splenomegaly, and cytopenias, are nonspecific and can be seen[ncbi.nlm.nih.gov]

  • Hemoglobin SC Disease

    We report here our experience with an adult patient with severe SC disease who developed symptomatic splenomegaly requiring splenectomy while being treated with hydroxyurea[ncbi.nlm.nih.gov] Sickle and target cells, polychromasia, and sometimes Howell–Jolly bodies are detected on peripheral blood smears. Results of sickle cell solubility tests are positive.[clinchem.aaccjnls.org] Acute splenic sequestration, a well recognized complication of the various sickle cell syndromes, is characterized by increasing splenomegaly and a sudden fall in hemoglobin[ncbi.nlm.nih.gov]

  • Erythropoietic Porphyria

    Clinical manifestations can range from mild to severe and include erythrodontia, reddish-colored urine, and hemolytic anemia that can be mild or severe and may result in splenomegaly[ncbi.nlm.nih.gov] A peripheral blood smear showed poikilocytosis, polychromasia, tear-drop cells, and normoblasts.[bloodjournal.org] The consequences of chronic haemolysis are splenomegaly, reactive erythroid hyperplasia, erythrodontia, bone fragility, extreme photosensitivity and photomutilation.[ncbi.nlm.nih.gov]

  • Pyruvate Kinase Deficiency

    Significant hyperbilirubinaemia, anemia, and splenomegaly are common features in patients with severe haemolysis due to pyruvate kinase (PK) deficiency.[ncbi.nlm.nih.gov] Peripheral blood smear showed polychromasia, anisocytosis, tear drop cells, fragmented eyrtrocytes, and target cells.[ncbi.nlm.nih.gov] She is doing well with mild splenomegaly.[ncbi.nlm.nih.gov]

  • Myelofibrosis

    Several gene mutations were found to be associated with significant splenomegaly in MF.[ncbi.nlm.nih.gov] The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[mpncanada.com] No reduction in splenomegaly was seen [ 23 ].[jhoonline.biomedcentral.com]

  • Severe Congenital Hypochromic Anemia with Ringed Sideroblasts

    This is a rare finding in CDA. 2 Case A full-term male Saudi infant presented after delivery with pallor, splenomegaly (6 cm below left costal margin) and a systolic murmur[annsaudimed.net] Peripheral blood smear examination showed marked anisopoikilocytosis with moderate microcytic hypochromic cells and dimorphic blood picture [Figure 1] a, moderate polychromasia[jahjournal.org] Lymphadenopathy, splenomegaly. Once case of fatal adrenal hemmorhage. [89] Joints bones muscles cartilage: Hypotonia (generalized or tructal) with increasing severity.[autoinflammatory-search.org]

  • Secondary Myelofibrosis

    Due to symptomatic splenomegaly, despite first-line treatment, the patients underwent splenic irradiation.[ncbi.nlm.nih.gov] The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[mpncanada.com] These findings are rare and myeloid metaplasia with striking extramedullary hematopoiesis causing massive splenomegaly and mimicking agnogenic myeloid metaplasia is seldom[ncbi.nlm.nih.gov]

  • Congenital Hemolytic Anemia

    Children with massive splenomegaly had similar outcomes compared with children without massive splenomegaly.[ncbi.nlm.nih.gov] Laboratory The review of the peripheral blood smear revealed no evidence of the schistocytes or fragmented red cells.[medcraveonline.com] blood smear of Congenital Hemolytic Anemia Describe the extent of central pallor of a normal RBC T/F: There is increased reticulocytosis and polychromasia in Congenital Hemolytic[brainscape.com]

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