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20 Possible Causes for Polyclonal Hyperglobulinemia

  • Castleman Disease

    The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[scielo.br] […] most common of these are anemia, fever, diaphoresis, weight loss, night sweating and fatigue. 1,2,9 Patients with M-PCV may have an elevated erythrocyte sedimentation rate, hyperglobulinemia[scielo.br]

  • Central Retinal Vein Occlusion

    Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[ncbi.nlm.nih.gov]

  • Rosai-Dorfman Disease

    hyperglobulinemia.[ncbi.nlm.nih.gov] The typical clinical features of this disease include bilateral painless lymphadenopathy, fever, and polyclonal hyperglobulinemia.[jdrntruhs.org] Although the histopathology is fairly distinctive, the laboratory abnormalities are not; past reports note elevated erythrocyte sedimentation rate, anemia, and polyclonal[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • Multicentric Castleman's Disease

    hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org] Patients with MCD may reveal raised serum C-reactive protein level, polyclonal hyperglobulinemia, anemia of microcytic hypochromic nature, low albumin level, and high cholesterol[lungindia.com] […] cells has been noted to correspond with symptoms during MCD flare. 1 , 6 Laboratory abnormalities could include an elevated acute phase reactants anemia, hypoalbuminemia, polyclonal[pagepress.org]

  • Chronic Active Hepatitis

    hyperglobulinemia.[hepatitiscentral.com] Additionally, some authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal[hepatitiscentral.com]

  • Chronic Active Hepatitis B

    hyperglobulinemia.[hepatitiscentral.com] Additionally, some authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal[hepatitiscentral.com]

  • H Syndrome

    Disease definition H syndrome is a systemic inherited histiocytosis, with characteristic cutaneous findings accompanying systemic manifestations. H syndrome refers to the major clinical findings of hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, and[…][orpha.net]

  • Biliary Cirrhosis

    All forms of PBC: IgM Typical: ALK-P & GGT , ALT/AST PBC with AIH features: ALT/AST , IgG Late phase: thrombocytopenia, polyclonal hyperglobulinemia, and hyperbilirubinemia[slideshare.net]

  • Pyoderma

    Monoclonal or polyclonal hyperglobulinemia may also be associated with PG.[ 3 ] However, the immunological abnormalities associated with PG are not always consistently observed[ncbi.nlm.nih.gov]

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