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34 Possible Causes for Polyclonal Hyperglobulinemia, Splenomegaly

  • Castleman Disease

    Older age ( 40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis. 2017 The Authors.[] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[]

  • Primary Myelofibrosis

    Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly[] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[]

  • Angioimmunoblastic Lymphadenopathy

    A woman 68 years of age had fever, malaise, diffuse lymphadenopathy, splenomegaly followed by abdominal pain, and diarrhea.[] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[] A 13-year-old girl presented with doughy swelling of both hands, a pruritic maculopapular rash, fever, malaise, lymphadenopathy and splenomegaly.[]

  • H Syndrome

    […] septal defect, patent ductus arteriosis, hole in heart, ASD, VSD, PDA, mitral valve prolapse, cardiomegaly, diabetes mellitus, diabetes, hepatosplenomegaly, hepatomegaly, splenomegaly[]

  • Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

    We conclude that in selected patients with marked splenomegaly and ALPS, splenectomy may be considered a treatment option.[] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[] All five children had splenomegaly, cytopenias, and hypertriglyceridemia at presentation; four had lymphadenopathy.[]

  • Pediatric Chronic Granulomatous Disease

    Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, cytopenias, splenomegaly, and hemophagocytosis by macrophages activated by high cytokine levels.[] Polyclonal hyperglobulinemia 3. Elevated acute phase reactants such as ESR or CRP 4. Normal studies of T and B lymphocyte immunity Diagnostic test 1.[] DANGER SIGNS: failure to thrive, inflammatory anemia, thrombocytopenia, splenomegaly, lymphadenopathy, joint swelling/bone pain, dysmorphia, recurrent serious infections,[]

  • Multicentric Castleman's Disease

    Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[] We report the case of a 35 year patient from Nigeria who presented with fever and splenomegaly. The initial diagnosis was Salmonellosis.[]

  • Posthemorrhagic Anaemia of the Newborn

    The infants are pale but have no hepato-splenomegaly or edema.[] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[] (D73.81) primary splenic neutropenia (D73.81) splenitis, splenomegaly in late syphilis (A52.79) splenitis, splenomegaly in tuberculosis (A18.85) splenomegaly NOS (R16.1)[]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    Related phenotypes are splenomegaly and abnormality of metabolism/homeostasis OMIM : 58 Hexokinase deficiency is an autosomal recessive disorder characterized by early-onset[] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[] Chronic icterus, gallstones and splenomegaly are common findings. Etiology Erythrocyte PK deficiency is caused by mutations in the PKLR gene (1q22).[]

  • Autoimmune Pancreatitis

    Therefore, this patient was diagnosed with AIP associated with portal hypertension, systemic lymphadenopathy, and splenomegaly.[] hyperglobulinemia.[] Splenomegaly was not detected at the time of the diagnosis.[]

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