Polyneuropathy: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Polyneuropathy

Churg-Strauss Syndrome

[…] clinical and electrophysiological data, 10 (91%) patients demonstrated notable asymmetric involvement, whereas 1 patient presented with a length-dependent symmetrical axonal polyneuropathy [ncbi.nlm.nih.gov]

Further tests verified pulmonary infiltrates, paranasal sinusitis, extravascular eosinophils on histopathologic sample of skin tissue, and polyneuropathy. [ncbi.nlm.nih.gov]

Mono- or polyneuropathy : Development of mononeuropathy, multiple mononeuropathies, or polyneuropathy (glove/ stocking distribution) attributable to systemic vasculitis. [medicalcriteria.com]

Acute Hepatic Porphyria

Chronic neuropathic pain Depression (increased risk of suicide) The 5 P's of acute intermittent porphyria: Painful abdomen, Polyneuropathy, Psychologic disturbances, Port [amboss.com]

5% have recurrence Presentation Symptoms often nonspecific and vague primary symptoms (5 P’s) severe abdominal pain without tenderness on palpation neurological symptoms polyneuropathy [step1.medbullets.com]

For example, the polyneuropathy of acute porphyria may be misidentified as Guillain-Barré syndrome. [ncbi.nlm.nih.gov]

Hereditary ATTR Amyloidosis

Initial presentation of hATTR amyloidosis with polyneuropathy is typically peripheral and autonomic polyneuropathy.2,3,4 Although the rate of disease progression is variable [fcneurology.net]

Familial amyloid polyneuropathy Other names FAP Familial amyloid polyneuropathy has an autosomal dominant pattern of inheritance. [en.wikipedia.org]

Initial presentation of hATTR amyloidosis with polyneuropathy is typically peripheral and autonomic polyneuropathy.2-4 Although the rate of disease progression is variable [neurologyadvisor.com]

Delta Aminolevulinate Dehydrase Deficiency

[…] neuropathies, the book contains chapterson common and rare forms including mononeuropathy in the upper and lower extremities, mononeuritismultiplex, diffuse and symmetric polyneuropathies [books.google.com]

The 5 P's: Painful abdomen, Polyneuropathy, Psychologic disturbances, Purple pee, Precipitated by triggers like drugs Erythropoietic porphyrias Congenital erythropoietic porphyria [amboss.com]

Key words Hepatic porphyria Porphobilinogen synthase deficiency Acute abdominal and neurologic manifestations Persistent motoric polyneuropathy Persistent δ-aminolevulinic [doi.org]

Erythropoietic Protoporphyria

A mild polyneuropathy of the lower limbs had been diagnosed several years ago. [ncbi.nlm.nih.gov]

In addition to polyneuropathy, our patient also experienced photosensitivity. [anesthesiology.pubs.asahq.org]

His OLT was uneventful, and he developed neither polyneuropathy nor exacerbation of photosensitivity. [ncbi.nlm.nih.gov]

Neurosarcoidosis

Anti-ganglioside antibodies have been reported in various peripheral neuropathies, including Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy [ncbi.nlm.nih.gov]

Symmetric sarcoid polyneuropathy: Analysis of sural nerve biopsy. Neurology 1981;31:1212-23. 14. Hunninghake GW, Gilbert S, Pueringer R, et al. [neurologyindia.com]

Symmetric sarcoid polyneuropathy: analysis of a sural nerve biopsy. Neurology. 1981 Oct. 31(10):1217-23. [Medline]. [emedicine.com]

Gaucher Disease

Among them, 10.7% were diagnosed with sensory motor axonal polyneuropathy at baseline using standardized electrophysiological assessment. [content.sciendo.com]

Patients with type I Gaucher's disease by polyneuropathy status, total (000s) Table 9. [giikorea.co.kr]

it was concluded that both prevalence and incidence of polyneuropathy in type 1 GD patients are greater than for the general population. [content.sciendo.com]

Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome

Other signs may include seizures, developmental delays, polyneuropathy, episodic confusion, gait disturbance, learning disabilities, a below-average intelligent quotient [emedicine.medscape.com]

Neuropathy

Motor Sensory Hereditary Pain Small Fiber Large Fiber Large and Small Fiber Neuronopathy Autonomic Many polyneuropathies have both motor and sensory involvement. [neuromuscular.wustl.edu]

There is a need for additional prospective studies to define more exact guidelines for the evaluation of polyneuropathy. [oadoi.org]

Asymmetric Bulbar Cranial Nerve Involvement Proximal Motor Sensory Upper Extremity Many polyneuropathies are: Symmetric Most prominent Distally & in Legs. [neuromuscular.wustl.edu]

Peripheral Neuropathy

Motor Sensory Hereditary Pain Small Fiber Large Fiber Large and Small Fiber Neuronopathy Autonomic Many polyneuropathies have both motor and sensory involvement. [neuromuscular.wustl.edu]

There is a need for additional prospective studies to define more exact guidelines for the evaluation of polyneuropathy. [dx.doi.org]

Asymmetric Bulbar Cranial Nerve Involvement Proximal Motor Sensory Upper Extremity Many polyneuropathies are: Symmetric Most prominent Distally & in Legs. [neuromuscular.wustl.edu]

Polyneuropathy

(disorder) Polyneuropathy unspecified Polyneuropathy unspecified (disorder) Polyneuropathy, unspecified (disorder) symmetrical polyneuropathy edit English polyneuropathy [wikidata.org]

Polyneuropathy Micrograph showing peripheral neuropathy (vasculitis).Polyneuropathy is peripheral neuropathy occurring in the same area on both sides of the body. [en.wikipedia.org]

Acute symmetrical polyneuropathy (eg, Guillain-Barré syndrome) is uncommon. Sensory polyneuropathy In sensory polyneuropathy, usually, the feet are affected first. [patient.info]

Median Neuropathy

[…] diabetic polyneuropathy but without median neuropathy (n=36). [endocrinologyadvisor.com]

not uncommon for patients with polyneuropathy to have slowing at entrapment sites w/o symptoms--diagnosis is median neuropathy at wrist superimposed on polyneuropathy w/ [quizlet.com]

(n=71); patients with median neuropathy but without diabetic polyneuropathy (n=25); patients with median neuropathy and diabetic polyneuropathy (n=55); and patients with [endocrinologyadvisor.com]

Entrapment Neuropathy

Polyneuropathy was diagnosed in 45 subjects (70%). [ncbi.nlm.nih.gov]

This entrapment neuropathy remains poorly diagnosed and it might be misleading when performing a diagnostic EMG-ENG examination for suspected polyneuropathy or lumbosacral [ncbi.nlm.nih.gov]

Of the many patterns of peripheral nerve disorders in diabetes mellitus (DM), isolated clinical involvement of single nerves, though less common than distal symmetric polyneuropathy [mayoclinic.pure.elsevier.com]

Diabetic Autonomic Neuropathy

Diabetic polyneuropathy and Diabetic autonomic neuropathy Hi Coders, Can Diabetic Neuropathy and Diabetic Autonomic Neuropathy both be reported together? [aapc.com]

Key words Electronmicroscopy Diabetes mellitus Autonomic polyneuropathy Gut This is a preview of subscription content, log in to check access. [link.springer.com]

Diabetic neuropathies can be classified as generalized polyneuropathies and mononeuropathies. [jstage.jst.go.jp]

Ischemic Peripheral Neuropathy

Ulnar nerve motor conduction study in a mixed axonal and demyelinating polyneuropathy. [anesthesiology.pubs.asahq.org]

They may be present as mononeuropathies, polyneuropathies, autonomic neuropathies, or polyneuropathies associated with autonomic neuropathies. [clinicaladvisor.com]

Overlapping mononeuritis multiplex is a common presentation, but distal symmetric polyneuropathy and monomelic neuropathy patterns can be seen. [ncbi.nlm.nih.gov]

Diabetic Polyneuropathy

Electromyoneurography is indispensable in the diagnosis of diabetic polyneuropathy. [ncbi.nlm.nih.gov]

Abstract Diabetic polyneuropathy (DPN) has several forms of clinical presentation. [ncbi.nlm.nih.gov]

Diabetic polyneuropathy is primarily symmetric sensory neuropathy, initially affecting distal lower extremities. [ncbi.nlm.nih.gov]

Diabetic Neuropathy

Abstract The presentations of chronic inflammatory demyelinating polyneuropathy (CIDP) overlap with those of diabetic peripheral neuropathy (DPN). [ncbi.nlm.nih.gov]

In Bangladeshi patients, there was no statistically significant difference in the subgroup of patients with polyneuropathy in comparison to those without polyneuropathy. [ncbi.nlm.nih.gov]

Said G et al. (1992) Severe early-onset polyneuropathy in insulin-dependent diabetes mellitus. [nature.com]

Distal Spinal Muscular Atrophy Type 5

Neurophysiology TTR – FAP : NCV studies consistent with an axonal polyneuropathy ± CTS, sometimes with a demyelinating polyneuropathy [ 6 ]. EMG: denervation. [neupsykey.com]

Evaluation and treatment of suspected polyneuropathy (eg, multifocal mononeuropathy). [jaoa.org]

Polyneuropathy Polyneuropathy is a common condition. It is not always easy to determine its cause. [dartmouth.edu]

CANOMAD Syndrome

[…] later by mild polyneuropathy. [neuroweb.us]

We present a case of a 65-year-old woman with clinical and electrophysiological features of chronic sensory polyneuropathy and diplopia. [meta.org]

Treatment with intravenous immunoglobulins resulted in an improvement of the patient's diplopia and polyneuropathy. [portal.findresearcher.sdu.dk]

Chronic Inflammatory Demyelinating Polyneuropathy

(CIDP) for over a decade but was ultimately found to have sarcoid polyneuropathy. [ncbi.nlm.nih.gov]

Pulse cyclophosphamide therapy in chronic inflammatory demyelinating polyneuropathy. [doi.org]

[…] diagnosis of chronic inflammatory demyelinating polyneuropathy needs further investigations. [en.wikipedia.org]

Multifocal Motor Neuropathy

Intravenous immunoglobulin [IVIg], plasma exchange [PE], and corticosteroids are efficacious treatment in chronic inflammatory demyelinating polyneuropathy [CIDP]. [ncbi.nlm.nih.gov]

Childhood chronic inflammatory demyelinating polyneuropathy. Europ J Paediatr Neurol. 1998;2:169-77. Comi G, et al. [rarediseases.org]

Transfusion}, year={2016}, volume={56 10}, pages={ 2443-2448 } } BACKGROUND Intravenous immunoglobulin (IVIG) is recommended treatment for chronic inflammatory demyelinating polyneuropathy [semanticscholar.org]

Guillain-Barré Syndrome

The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barré syndrome and multiple mononeuropathy via Sjögren's syndrome. [ncbi.nlm.nih.gov]

Schofield, Pathophysiology inferred from electrodiagnostic nerve tests and classification of polyneuropathies. [dx.doi.org]

A patient with xerostomia and xerophthalmia due to Sjögren's syndrome presented with acute motor-dominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies [ncbi.nlm.nih.gov]

Acute Pandysautonomia

IVIg for apparently autoimmune small-fiber polyneuropathy: first analysis of efficacy and safety. [karger.com]

The serial electrophysiologic studies revealed progressive periphear axonal polyneuropathy. [jkna.org]

The Guillain-Barre syndrome (GBS) or Landry-Guillain-Barre-Strohl syndrome, also known as post-infectious polyneuropathy or acute idiopathic polyneuritis, is an acute acquired [books.google.com]

Miller-Fisher Syndrome

Acute inflammatory demyelinating polyneuropathy (AIDP) AIDP accounts for about 90% of childhood GBS in the developed world. [cancertherapyadvisor.com]

polyneuropathy. [einstein.pure.elsevier.com]

[…] presenting as acute urinary retention 0 We present the case of a 16 year old boy in acute urinary retention secondary to an inflammatory polyneuropathy; likely the Miller [bjuinternational.com]

Alcoholic Neuropathy

Alcoholic polyneuropathy is very similar to other axonal degenerative polyneuropathies and therefore can be difficult to diagnose. [en.wikipedia.org]

Alcoholic polyneuropathy is a common disorder, characterized by nonspecific clinical, electromyographic, and pathologic features. [ncbi.nlm.nih.gov]

Distribution of symptoms in the different polyneuropathy groups: relationship between polyneuropathy and symptoms. P < 0.001. Fig. 3. [dx.doi.org]

Amyloidosis

Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening [web.archive.org]

KEYWORDS: amyloid polyneuropathy; domino liver transplantation; myocardial amyloidosis; tafamidis; transthyretin [ncbi.nlm.nih.gov]

20 Apr, 2016 Complete 18-Month Data from Ongoing Phase 2 OLE Study with Patisiran in Development for the Treatment of Hereditary TTR-Mediated Amyloidosis with Polyneuropathy [alnylam.com]

Familial Amyloid Polyneuropathy

Familial Amyloidotic Polyneuropathy World Transplant Registry. www.fapwtr.org. [karger.com]

Late-onset familial amyloidotic polyneuropathy with Bence Jones proteinuria and cardiomyopathy. [ruralneuropractice.com]

Abstract Familial amyloid polyneuropathies (FAPs) are a group of life-threatening multisystem disorders transmitted as an autosomal dominant trait. [ncbi.nlm.nih.gov]

Bickerstaff Brainstem Encephalitis

Therefore, identifying critical illness polyneuropathy for patients with respiratory muscle paralysis and tracheal extubation difficulties at early stages is clinically important [ncbi.nlm.nih.gov]

We report a rare case of childhood BBE with elevated anti-GM1 antibodies in the serum, who had specific clinical symptoms such as a cranial polyneuropathy presenting as ophthalmoplegia [kjp.or.kr]

EMG was consistent with an acute demyelinating polyneuropathy. [neurology.org]

POEMS Syndrome

Nerve conduction study showed severe sensorimotor polyneuropathy. Serum immunofixation showed lambda light chain restricted monoclonal gammopathy. [ncbi.nlm.nih.gov]

The POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome and osteosclerotic myeloma (polyneuropathy and sclerotic bone lesions [nejm.org]

Key words Myeloma Osteosclerosis Polyneuropathy M protein Haemangioma This is a preview of subscription content, log in to check access. [link.springer.com]

Long QT Syndrome 2

BAG3-related myopathy, polyneuropathy and cardiomyopathy with long QT syndrome Kostera-Pruszczyk A, Suszek M, Ploski R, et al. [myobase.org]