Polyuria: Causes & Reasons

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Possible Causes for Polyuria

Diabetes Mellitus

The patient was admitted due to polyuria and weight loss in the past few days. The initial blood glucose level was 1167mg/dL. [ncbi.nlm.nih.gov]

Nine weeks after initiation, he developed fatigue and polyuria with blood glucose 336 mg/dL, c-peptide 0.6 ng/mL, A1C8.2% and GAD antibodies 28.4 U/mL (normal, <1 U/mL). [ncbi.nlm.nih.gov]

[…] to diagnose polyuria are:[4] Treatment[edit] Depending on the cause of the polyuria, the adequate treatment should be afforded. [en.wikipedia.org]

Diabetes Mellitus Type 1

Diabetic Ketoacidosis also has polyuria, polydipsia, fruity death and neurological symptoms COMPLICATION OF DIABETES MELLITUS Diabetic patients who do no manage their glucose [youtube.com]

[…] to diagnose polyuria are:[4] Treatment[edit] Depending on the cause of the polyuria, the adequate treatment should be afforded. [en.wikipedia.org]

Patients most often present with a few days or weeks of polyuria, polydipsia, weight loss, and weakness. Some patients may present with diabetic ketoacidosis. [us.bestpractice.bmj.com]

Diabetic Ketoacidosis

The patient was treated without dialysis and was cured after a polyuria period of 2 months after the oliguric period. [oadoi.org]

Results: In a 26-year-old woman with a 3-day history of malaise, polyuria, nausea, and vomiting, severe hypoxia and rales developed, and intubation and mechanical ventilation [oadoi.org]

Drug-Induced Hypokalemia

A vasopressin-resistant polyuria and urinary acidification and concentration defects are the principal renal manifestations. [jamanetwork.com]

Acute proximal tubule dysfunction was evident by virtue of polyuria, renal salt wasting, and hypophosphatemia. [jpgmonline.com]

The administration of both has been shown to cause a metabolic alkalosis and hypokalemia with polyuria. [karger.com]

Psychogenic Polydipsia

We present a patient who presented with a new onset of polyuria and polydipsia after sustaining a TBI. [ncbi.nlm.nih.gov]

Abstract Psychogenic polydipsia (PPD), a clinical disorder characterized by polyuria and polydipsia, is a common occurrence in inpatients with psychiatric disorders. [ncbi.nlm.nih.gov]

The case of a 17 year-old female with psychogenic polydipsia is reported; 13 out of 18 members of her maternal family were known to have had polydipsia and polyuria, but only [ncbi.nlm.nih.gov]

Diabetes Insipidus

A 7-month-old infant presented polyuria-polydipsia syndrome with poor weight gain. [ncbi.nlm.nih.gov]

In follow-up she reported excellent control of polyuria and significant functional improvement. [ncbi.nlm.nih.gov]

Introduction The determination of a specific diagnosis in patients with polyuria and low plasma osmolality (i.e., hypotonic polyuria) is a frequent problem in clinical practice [doi.org]

Hypercalcemia

She had nausea, vomiting, leg pain, polyuria, polydipsia, and muscle weakness. At the time of relapse, the ionized calcium level was 1.99 mmol/L. [ncbi.nlm.nih.gov]

[…] describe a woman who had hypercalcemia associated with elevated serum concentrations of parathyroid hormone-related protein during pregnancy and lactation.Lethargy, thirst, polyuria [nejm.org]

58-year-old male with a past medical history of CML diagnosed six years earlier, presented to the emergency department with one week of acute confusion, disorientation, polyuria [ncbi.nlm.nih.gov]

Nephrocalcinosis

The index case, a 9-year-old girl, presented with severe growth retardation, polyuria and polydipsia, while her brothers, 11 and 7 years old, were disclosed during family [ncbi.nlm.nih.gov]

Thorough history was taken for polyuria, polydipsia and hypocalcemia symptoms, as well as clinical examination with stress on anthropometric measurements and radiological [ncbi.nlm.nih.gov]

Two children from a consanguineous family of Chinese Han origin demonstrated manifestations of rickets, polyuria, polydipsia, hematuria and failure to thrive. [ncbi.nlm.nih.gov]

Diabetic Ketotic Coma

extreme acidosis (pH Signs and Symptoms – many gastric symptoms, probably protective against further ingestion of glucose osmotic diuresis (from hyperglycemia) causes polyuria [d3jonline.tripod.com]

Hyperglycaemia will lead to polyuria, dehydration, weight loss, polydipsia and thirst. [diapedia.org]

The initial symptoms of DKA include anorexia, nausea, vomiting, polyuria, and thirst. Abdominal pain, altered mental function, or frank coma may ensue. [accessmedicine.mhmedical.com]

Hypokalemia

Last time we reviewed the proposed mechanisms by which hypercalcaemia can induce polyuria. [renalfellow.org]

Genitourinary Polyuria or sexual dysfunction. [2] Medical Management (current best evidence) Severe hypokalmeia levels that cause ECG changes such as T-wave flattening or [physio-pedia.com]

Therefore, potassium deficiency may lead to concentrating defects via this pathway, leading to polyuria. [renalfellow.org]

Hypokalemic Nephropathy

Hypokalemia can lead to a renal concentrating defect leading to polyuria and polydipsia- DI 2. [nephronpower.com]

Overview If left untreated, hypokalemia may present as nausea, vomiting that progresses to develop ileus, muscle cramps, rhabdomyolysis and polyuria leading to dehydration [wikidoc.org]

On the mechanism of polyuria in potassium depletion. J Clin Invest. 1977;60(3):620–625. Torres V, Young W, Offord K, Hattery, RR. [symbiosisonlinepublishing.com]

Conn Syndrome

[…] pri·mar·y al·dos·ter·on·ism an adrenocortical disorder caused by excessive secretion of aldosterone and characterized by headaches, nocturia, polyuria, fatigue, hypertension [medical-dictionary.thefreedictionary.com]

The authors report on a 5-year-old girl who had symptoms of polyuria, polydipsia, and fatigue, and for whom the diagnosis of hyperaldosteronemia was suggested by a low serum [ncbi.nlm.nih.gov]

It is often symptomless, but may present with symptoms of hypokalaemia – such as muscle weakness, fatigue, polyuria, cramps. 2/3 are due to a solitary mineralocorticoid producing [almostadoctor.co.uk]

Renal Tubular Acidosis

Despite polyuria, both patients developed resistant hyperkalemia that needed further hemodialysis. [ncbi.nlm.nih.gov]

[…] outdated tetracyclines, aminoglycosides Heavy metal poisoning (e.g., lead, cadmium, mercury ) Clinical features Vitamin D -resistant rickets / osteomalacia Stunted growth Polyuria [amboss.com]

Clinical Manifestations In children the clinical spectrum is nonspecific including anorexia, failure to thrive, vomiting and dehydration, constipation, polyuria, and polydipsia [renaltube.com]

Central Diabetes Insipidus

However, persistent polyuria can cause not only patient discomfort, including polyuria and polydipsia, but also volume depletion that can produce allograft dysfunction. [ncbi.nlm.nih.gov]

Polyuria, renal concentrating defects and generally elevated ADH levels, a form of nephrogenic diabetes insipidus (NDI) is often implicated. [ncbi.nlm.nih.gov]

Hypovolemia is usually presumed to be secondary to blood loss and polyuria resulting from a diuretic phase of acute renal failure. [ncbi.nlm.nih.gov]

Wolfram Syndrome

Although the Wolfram syndrome is rare, it should be considered in diabetic patients with unexplained optic atrophy and hearing loss or with polyuria and polydipsia in the [ncbi.nlm.nih.gov]

This syndrome should be considered in young diabetic patients with unexplained visual loss or with polyuria and polydipsia in the presence of adequate blood sugar control. [ncbi.nlm.nih.gov]

Persistent hypernatremia, iposmolar polyuria and high plasma osmolality suggested DI, confirmed by a normal urine concentration after vasopressin test. [ncbi.nlm.nih.gov]

Bartter Syndrome

After birth he displayed extreme polyuria, severe renal sodium and chloride loss, and marked hypercalciuria. [link.springer.com]

Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt [medical-dictionary.thefreedictionary.com]

The follow-up for a period of 6 years showed a surprising evolution: he has no hypokalemic alkalosis, no polyuria, and no hypercalciuria; growth and development are within [link.springer.com]

Hypercalcemia of Malignancy

Those with moderate hypercalcemia (12 to 14 mg/d) can develop polydipsia, polyuria, clinical dehydration, muscle weakness, and changes in mental status. [advancedpractitioner.com]

A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria. N Engl J Med 1981; 305: 1539-46. ‎ [books.google.ro]

The administration of both has been shown to cause a metabolic alkalosis and hypokalemia with polyuria. [karger.com]

Fanconi Renotubular Syndrome

We discuss in this article the atypical electrolytes losses found in our patient, as well as the possible mechanisms of severe polyuria. [ncbi.nlm.nih.gov]

The presenting symptoms are polyuria, polydipsia, and dehydration. [accessanesthesiology.mhmedical.com]

Differential diagnosis Other causes of polyuria and polydipsia - eg, diabetes mellitus, diabetes insipidus. Other causes of rickets and osteomalacia. [patient.info]

Cystinosis

At follow-up, the polyuria and hyponatremia were found to persist. [ncbi.nlm.nih.gov]

A 9-month-old boy was referred to our department for evaluation of polyuria and polydipsia. [ncbi.nlm.nih.gov]

The history of muscle weakness, failure to thrive, polydipsia, and polyuria prompted subsequent clinical and laboratory evaluations, leading to the correct diagnosis of cystinosis [ncbi.nlm.nih.gov]

Froehlich Syndrome

Polyuria and polydipsia are the result of DI. [accesspediatrics.mhmedical.com]

Obesity Growth retardation and retarded sexual development, atrophy or hypoplasia of the gonads, and altered secondary sex characteristics, Headaches Problems with vision polyuria [en.wikipedia.org]

Headaches, retarded growth and sexual development; mental retardation, visual troubles; polyuria; polydipsia. [whonamedit.com]

Nephrogenic Diabetes Insipidus

Polyuria will continue as long as the patient is able to drink. [en.wikipedia.org]

A 7-year-old boy presented with short stature and severe intellectual disability other than polyuria and polydipsia. The karyotype was normal. [ncbi.nlm.nih.gov]

Li+ promotes polyuria mainly counteracting the intracellular vasopressin signaling. [ncbi.nlm.nih.gov]

Diabetes Mellitus Type 2

[…] to diagnose polyuria are:[4] Treatment[edit] Depending on the cause of the polyuria, the adequate treatment should be afforded. [en.wikipedia.org]

Clinical case: A 61-year-old smoker, diagnosed with LCH 9 years ago with pulmonary and hepatic involvement, without treatment, who consulted for asthenia, unquantifiable polyuria [endocrine-abstracts.org]

Symptoms include excessive excretion of urine (polyuria), thirst (polydipsia), constant hunger, weight loss, vision changes and fatigue. [power2dm.eu]

Nephronophthisis Type 1

[…] nephronophthisis [ nef″ron-of´thĭ-sis ] wasting disease of the kidney substance. familial juvenile nephronophthisis a progressive hereditary kidney disease marked by anemia, polyuria [medical-dictionary.thefreedictionary.com]

AIMS: Nephronophthisis (NPHP) is an autosomal recessive cystic disease of the kidney with main characteristic features of polyuria/polydipsia, mild or absent proteinuria, [ncbi.nlm.nih.gov]

Therapy with potassium chloride resulted in reduction of polyuria, increased rate of growth, and arrest of progression of renal insufficiency. [pediatrics.aappublications.org]

Medullary Cystic Kidney Disease

The first sign of MCKD is polyuria; later, the clinical findings relate to renal insufficiency. Originally, NPH and MCKD were considered separate entities. [ncbi.nlm.nih.gov]

Features of both disorders include the following: A vasopressin (ADH)-resistant urine-concentrating defect that leads to polyuria and polydipsia Sodium wasting severe enough [merckmanuals.com]

We postulate that mutation of UMOD disrupts the tertiary structure of UMOD and is responsible for the clinical changes of interstitial renal disease, polyuria, and hyperuricaemia [ncbi.nlm.nih.gov]

Oculocerebrorenal Syndrome

Clinical problems typically include polyuria, acidosis, hypophosphatemia with rickets and eventually end stage renal disease. [ncbi.nlm.nih.gov]

[…] proteinuria, aminoaciduria, bicarbonate wasting and renal tubular acidosis, phosphaturia with hypophosphatemia and renal rickets, hypercalciuria, sodium and potassium wasting, and polyuria [ncbi.nlm.nih.gov]

Proteinuria, polyuria, as well as bicarbonate, sodium and potassium wasting with tubular acidosis are all part of the urinary profile. [disorders.eyes.arizona.edu]

Hypomagnesemia

In this report, we present a seven-year-old girl with polyuria and polydipsia. [ncbi.nlm.nih.gov]

[…] calcium at the level of ascending limb of loop of Henle, characterized by hypomagnesemia, hypercalciuria and nephrocalcinosis, known as "Manz syndrome," who presented with polyuria [ncbi.nlm.nih.gov]

In this report, we presented a 12-year-old girl with rickets, polyuria, and polydipsia. [ncbi.nlm.nih.gov]

Idiopathic Hypercalciuria

These children were checked for polyuria, concentrating defects, and their fluid intake. [sjkdt.org]

Hypercalcaemia: polyuria and polydipsia, nausea and vomiting. May cause hypertension. [patient.info]

[…] were similar to control subjects.4 To our knowledgethere is only one previous case report from India byRakesh Lodha et al,6 a fourteen year old girl with failureto thrive, polyuria [japi.org]

Vitamin D Toxicity

These are the conditions that are followed by polydipsia and polyuria which are conditions of excessive thirst and urine experienced by the body. [findhomeremedy.com]

Ten cases of hypercalcemia due to vitamin D intoxication are presented with features of vomiting, polyuria, polydipsia, encephalopathy and renal dysfunction. [ncbi.nlm.nih.gov]

Hypertension, loss of appetite and weight loss Hypercalcuric symptoms, such as polyuria and renal calculi Long-term toxicity, including increases in mortality from all causes [news-medical.net]

Hyperparathyroidism

Polyuria can occur with renal failure. Cardiac arrhythmias can occur and even coma. [smartypance.com]

[…] associated with hypercalcemia include: Weak muscles and fatigue Depression Nausea Loss of appetite Constipation and abdominal pain Feeling thirsty and frequent urination (polyuria [news-medical.net]

The symptoms of hyperparathyroidism are related to hypercalcaemia and include General weakness; lethargy; muscle weakness Polyuria and polydipsia Anorexia, vomiting, abdominal [diapedia.org]

Water Intoxication

Also, we present a diagnostic algorithm for polydipsia and polyuria before death. [ncbi.nlm.nih.gov]

Epidemiological surveys have used staff reports and polyuria measures to identify polydipsic patients. [ncbi.nlm.nih.gov]

Three hours postadmission she developed polyuria. Follow-up urinalysis at this point was consistent with water intoxication. [ncbi.nlm.nih.gov]