Poor Growth: Causes & Reasons

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Possible Causes for Poor Growth

Growth Hormone Deficiency

Patients with NFNS who show poor growth should be evaluated for GHD. [ncbi.nlm.nih.gov]

Growth hormone deficiency is the most common pituitary hormone deficiency and is accompanied by poor overall growth and short stature. [merckmanuals.com]

If children have no other cause of poor growth and their growth hormone levels are low, doctors typically do a stimulation test. [merckmanuals.com]

Familial Dysautonomia

They commonly suffer from severe gastrointestinal problems, poor growth, repeated pneumonia, and eye damage caused by the inability to produce tears. [knowyourgenes.org]

growth, and labile blood pressure (episodic hypertension and postural hypotension). [snpedia.com]

Symptoms vary, and may include insensitivity to pain, unstable blood pressure and body temperature, absence of overflow tears, frequent pneumonia, and poor growth. [familialdysautonomia.org]

Methylmalonic Acidemia with Homocystinuria Type cblJ

211 3 0.100 0 CUI: C1837385 Disease: Poor growth Poor growth phenotype Finding 167 0.100 0 CUI: C1848556 Disease: Decreased adenosylcobalamin Decreased adenosylcobalamin [disgenet.org]

Clinical features include feeding difficulties, poor growth, hypotonia, lethargy, anemia, and developmental delay. [malacards.org]

growth Very poor growth phenotype Sign or Symptom 173 10 0.100 0 CUI: C0456070 Disease: Growth delay Growth delay phenotype Pathologic Function 168 1 0.100 0 CUI: C0853697 [disgenet.org]

Isolated Succinate-CoQ Reductase Deficiency

Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy [genecards.org]

Vitamin D-Dependent Rickets Type 1B

Vitamin D-dependent rickets type-1 (VDDR1) is an autosomal recessive disorder characterised by onset of rickets by 2 years of age, accompanied by poor growth and hypotonia [endocrine-abstracts.org]

Clinical description The disease manifests within the first year of life with hypotonia, tetany, seizures, muscle weakness, and poor growth. [orpha.net]

3M Syndrome Type 3

Definition A disorder characterized by poor postnatal growth and distinctive facial features, including triangular facies, frontal bossing, fleshy tipped nose, and fleshy [uniprot.org]

Insulin-Like Growth Factor 1 Deficiency

IGF-1 No other underlying disease or causes of poor growth e.g. chronic diseases, poor nutrition When all of these criteria are met, a doctor may diagnose PIGFD. [childgrowthfoundation.org]

This disorder is known as Laron dwarfism and is characterized by abnormal GH receptors, resulting in decreased GH-stimulated production of IGF-1 and poor growth. [britannica.com]

Growth hormone deficiency is one of the endocrine (hormonal) disorders that can cause poor growth. [saizenus.com]

Lethal Ataxia with Deafness and Optic Atrophy

[…] swallowing Swallowing difficulties Swallowing difficulty [ more ] 0002015 Growth delay Delayed growth Growth deficiency Growth failure Growth retardation Poor growth Retarded [rarediseases.info.nih.gov]

Neurological evaluation at the age 2.5 years showed poor somatic growth (10%ile), microcephaly ( P1 presented since first months with frequent vomiting and marked psychomotor [link.springer.com]

[…] development Lack of language development Lack of speech No speech development No speech or language development Nonverbal [ more ] 0001344 Drooling Dribbling 0002307 Dysphagia Poor [rarediseases.info.nih.gov]

Hardikar Syndrome

Other: failure to thrive poor growth Abdomen Liver: hepatomegaly portal hypertension portal inflammation fibrosis ductal plate malformations more Skin Nails Hair Skin: jaundice [malacards.org]

[…] delay Delayed growth Growth deficiency Growth failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Hearing impairment Deafness Hearing defect [ more ] [rarediseases.info.nih.gov]

[…] mottled pigmentation 31 HP:0001070 28 patent foramen ovale 31 HP:0001655 29 cholangitis 31 HP:0030151 Symptoms via clinical synopsis from OMIM®: 57 (Updated 05-Apr-2021) Growth [malacards.org]

Neonatal-Onset Citrullinemia Type 2

Poor growth may be evident. Head, ears, eyes, nose, and throat (HEENT): Papilledema may be present if cerebral edema and increased intracranial pressure have ensued. [checkorphan.org]

growth poor appetite vomiting headaches learning disabilities behavior problems hyperactivity balance and coordination problems, and spasticity Symptoms of citrullinemia [medicalhomeportal.org]

BY agc1 Δ cells had very poor growth ability with acetate as the unique carbon source, which could be restored after the transformation with the plasmid pYX212-CITRIN but [journals.plos.org]

X-Linked Mental Retardation Type 98

Other features may include hypotonia, poor growth, microcephaly, agenesis of the corpus callosum, and seizures. [findzebra.com]

MRX98 patients show delayed psychomotor development, absent or poor speech development, and postnatal growth retardation, often with microcephaly. [cloud-clone.com]

Symptoms INHERITANCE: Autosomal dominant GROWTH: [Height]; Short stature; [Other]; Poor growth HEAD AND NECK: [Head]; Microcephaly; [Face]; Round face ; Prominent forehead [findzebra.com]

Singleton Merten Syndrome

; Russell-Silver syndrome (RSS) is a rare condition associated with poor growth both .... Do you have more information about symptoms of this disease? ..... [xdlrwffz.gq]

growth and variable phenotypic manifestations, such as facial dysmorphism and congenital heart defects, associated with mosaic aneuploidies resulting from defects in cell [mendelian.co]

Other findings may include neurologic problems, generalized short stature, muscle weakness; poor muscle tone ( hypotonia ); progressive wasting of the muscles ( muscle atrophy [rarediseases.info.nih.gov]

Combined Oxidative Phosphorylation Defect Type 13

Other features include hypotonia, poor growth, lactic acidosis, and failure to thrive. The disorder may be fatal in early childhood. {ECO:0000269 PubMed:23849775}. [genecards.org]

growth, and sensorineural hearing loss. [genome.jp]

MD, Diaz GA, Naidich TP, Rodenburg RJ, Houten SM, Schadt EE Title Novel, compound heterozygous, single-nucleotide variants in MARS2 associated with developmental delay, poor [genome.jp]

14q11-q22 Microdeletion Syndrome

We report the clinical and molecular characterization of a female newborn, whose phenotype was characterized by poor growth, dysmorphic facial features, subclinical hypothyroidism [ncbi.nlm.nih.gov]

The characteristics of persons with this syndrome are poor muscle tone, low growth, incomplete sexual development, cognitive disability, problematic behavior and chronic feeling [nipt.ng]

microcephaly, plagioccephaly, poor head control, triangular facial features, unusual smallness of the upper or lower jaw, an enlarged area between the upper lip and nose [nipt.ng]

Hereditary Hypophosphatemic Rickets with Hypercalciuria

Hypophosphatemia in children leads to rickets resulting in poor growth and frequently in skeletal deformities. [jcrpe.org]

Hyperphosphatasia with Mental Retardation Type 2

Poor growth, microcephaly (1 patient), moderate to severe delayed speech and language development, plagiocephaly (1 patient), coronal synostosis (1 patient), hypertelorism [iofbonehealth.org]

[…] forehead Long palpebral fissure Anophthalmia Short palpebral fissure Microphthalmia High palate Pica Ptosis Mandibular prognathia Cleft palate Cryptorchidism Intrauterine growth [mendelian.co]

[…] alkaline phosphatase Telecanthus Shortening of all distal phalanges of the fingers Prominent nasal bridge Generalized seizures Deeply set eye Synophrys Short nose Strabismus Poor [mendelian.co]

The most frequent symptoms at onset were poor feeding, hypotonia, lethargy, respiratory and heart failure, accompanied by lactic acidosis, 3-methylglutaconic aciduria and [wwww.unboundmedicine.com]

Symptoms further included: developmental delay (98%), hypotonia (95%), faltering growth (94%), short stature (89%), non-progressive cardiomyopathy (89%), microcephaly (71% [wwww.unboundmedicine.com]

Primary Bile Acid Malabsorption

Patients with liver involvement may have one or more of the following: elevated liver function tests; pale, foul-smelling stools; or poor growth, or failure to thrive, caused [retrophin.com]

The presentation was quite varied in this case series with one family member having liver failure in infancy; however, most patients presented with poor growth and fat soluble [rarediseases.org]

growth; pale, foul-smelling stools; dark urine; enlarged liver or spleen; and liver disease. 5,16,17,18 A patient diagnosed with ZSD may need regular testing of their liver [retrophin.com]

Molybdenum Cofactor Deficiency Type B

Poor growth may ensue. Affected individuals are at risk for severe psychomotor retardation, spasticity, and/or hypotonia. [emedicine.medscape.com]

Fanconi Renotubular Syndrome Type 3

Clinical features include poor growth, fatigue, dehydration, polyuria, muscle weakness, and bone pain. [radiopaedia.org]

Transient Infantile Hypertriglyceridemia and Hepatosteatosis

[…] by intellectual disability, poor overall growth, hypotonia, and variable liver dysfunction. [mendelian.co]

A baby girl of Norwegian ancestry was delivered by cesarean section at 36 weeks' gestation (birth weight, 1670 g; length, 42 cm) because of poor fetal growth (Subject III- [nejm.org]

Top matches: Low match GROWTH RETARDATION, INTELLECTUAL DEVELOPMENTAL DISORDER, HYPOTONIA, AND HEPATOPATHY; GRIDHH GRIDHH is an autosomal recessive multisystem disorder characterized [mendelian.co]

Myopathy with Lactic Acidosis and Sideroblastic Anemia Type 2

Poor growth and intermittent vomiting persisted despite serial interventions including gluten-free diet and nasogastric, gastrostomy and (eventually) parenteral feeding. [ncbi.nlm.nih.gov]

Other frequent signs are poor growth, motor incoordination (ataxia) due to cerebellar failure, mental deterioration, deafness, and alterations of cardiac rhythm (Atrio-ventricular [mitopedia.org]

At 10 years he presented with abdominal pain, poor weight gain and lethargy. [ncbi.nlm.nih.gov]

Mitochondrial DNA Depletion Syndrome Type 3 Hepatocerebral

Clinical Synopsis: INHERITANCE: Autosomal recessive GROWTH: [Other]; Poor growth; Failure to thrive HEAD AND NECK: [Head]; Microcephaly (less common); [Eyes]; Nystagmus; Disconjugate [genome.jp]

Symptoms usually start shortly after birth and include vomiting, lack of energy, low blood sugar (hypoglycemia), diarrhea, and poor growth. [natera.com]

Glycogen Storage Disease, Type 4 often causes symptoms in infancy with poor feeding and growth (failure to thrive), an enlarged liver and spleen, enlarged heart, low muscle [natera.com]

Revesz Syndrome

Symptoms of Hoyeraal Hreidarsson syndrome include poor growth of the child during pregnancy, head size that is smaller than expected (microcephaly), the back of the brain [diseaseinfosearch.org]

Analysis of TIN2 protein in Patient 3's skin fibroblasts was not possible because of poor growth of the culture Plasmids TINF2 short isoform cDNA sequence derived from pLPC-N-FH2 [ncbi.nlm.nih.gov]

May be subtle with ridging, flaking, or poor growth, or more diffuse with nearly complete loss of nails Lacy reticular pigmentation of the upper chest and/or neck. [ncbi.nlm.nih.gov]

Lissencephaly 4 with Microcephaly

Infants with ILS may have poor muscle tone (hypotonia) and difficulty feeding, which leads to poor growth overall. [medlineplus.gov]

Case presentation A 1910 g infant was born at 41-weeks gestation to a 19-year-old gravida 1 mother after a pregnancy complicated by hydramnios and poor fetal movement. [nature.com]

In general, life expectancy for individuals with microcephaly is reduced and the prognosis for normal brain function is poor. [blueprintgenetics.com]

Nicolaides-Baraitser Syndrome

Other: failure to thrive intrauterine growth retardation poor growth Genitourinary Internal Genitalia Male: cryptorchidism Head And Neck Face: long philtrum triangular face [malacards.org]

Apart from the craniofacial characteristics, poor growth and feeding, seizures, absent or delayed speech, variable ID, and behavioral disturbances (ex. decreased inhibitions [bmcmedgenomics.biomedcentral.com]

[…] retardation Long philtrum Low anterior hairline Microcephaly Poor speech Prominent interphalangeal joints Sandal gap Seizures Short metacarpal Short metatarsal Short phalanx [dovemed.com]

SIDDT Syndrome

Despite exclusive gastrostomy tube feeding, growth remained poor, and she died suddenly before her first birthday. [pnas.org]

A syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair [nectarmutation.org]

At age 4 weeks, she presented with poor growth, persistent stridor, and episodes of laryngospasm and cyanosis. A barium swallow excluded tracheoesophageal fistula. [pnas.org]

Pontocerebellar Hypoplasia Type 10

Although head size may be normal at birth, for those infants surviving beyond the newborn period, the growth of the head is arrested and progressive microcephaly is noticed [rarediseases.org]

[…] type 6 manifests as early as the first day of life or within the first month of life as infantile encephalopathy, with generalized hypotonia, lethargic, poor sucking and poor [rarediseases.org]

Cerebro-Oculo-Facio-Skeletal Syndrome Type 4

Introduction Cockayne syndrome (CS) is a rare autosomal recessive multisystem disorder characterized by poor growth, neurological abnormality and a short life span ( 1 ). [spandidos-publications.com]

Types [ edit ] CS Type I, the "classic" form, is characterized by normal fetal growth with the onset of abnormalities in the first two years of life. [en.wikipedia.org]

Additionally, atrophy of the central area of the cerebellum found in patients with Cockayne syndrome could also result in the lack of muscle control, particularly involuntary, and poor [en.wikipedia.org]

Autosomal Recessive Mental Retardation Type 27

All had delayed psychomotor development with limited speech, dysarthria, and poor somatic growth. [findzebra.com]

There is also limited intellectual development, skin lesions, liver damage, and growth of brittle hair. [biotechnologyforums.com]

[…] retardation, poor vision, dystonic movements, characteristic face, and severe mental retardation. [findzebra.com]