Poor Growth: Causes & Reasons

Possible Causes for Poor Growth

Patients with NFNS who show poor growth should be evaluated for GHD. [ncbi.nlm.nih.gov]

Growth hormone deficiency is the most common pituitary hormone deficiency and is accompanied by poor overall growth and short stature. [msdmanuals.com]

If children have no other cause of poor growth and their growth hormone levels are low, doctors typically do a stimulation test. [msdmanuals.com]

Methylmalonic Acidemia with Homocystinuria Type cblJ

211 3 0.100 0 CUI: C1837385 Disease: Poor growth Poor growth phenotype Finding 167 0.100 0 CUI: C1848556 Disease: Decreased adenosylcobalamin Decreased adenosylcobalamin [disgenet.org]

Clinical features include feeding difficulties, poor growth, hypotonia, lethargy, anemia, and developmental delay. [malacards.org]

growth Very poor growth phenotype Sign or Symptom 173 10 0.100 0 CUI: C0456070 Disease: Growth delay Growth delay phenotype Pathologic Function 168 1 0.100 0 CUI: C0853697 [disgenet.org]

Familial Dysautonomia

Symptoms vary, and may include insensitivity to pain, unstable blood pressure and body temperature, absence of overflow tears, frequent pneumonia, and poor growth. [familialdysautonomia.org]

They commonly suffer from severe gastrointestinal problems, poor growth, repeated pneumonia, and eye damage caused by the inability to produce tears. [knowyourgenes.org]

growth, and labile blood pressure (episodic hypertension and postural hypotension). [snpedia.com]

Isolated Succinate-CoQ Reductase Deficiency

Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy [genecards.org]

Vitamin D-Dependent Rickets Type 1B

Clinical description The disease manifests within the first year of life with hypotonia, tetany, seizures, muscle weakness, and poor growth. [orpha.net]

Vitamin D-dependent rickets type-1 (VDDR1) is an autosomal recessive disorder characterised by onset of rickets by 2 years of age, accompanied by poor growth and hypotonia [endocrine-abstracts.org]

Lethal Ataxia with Deafness and Optic Atrophy

[…] swallowing Swallowing difficulties Swallowing difficulty [ more ] 0002015 Growth delay Delayed growth Growth deficiency Growth failure Growth retardation Poor growth Retarded [rarediseases.info.nih.gov]

Neurological evaluation at the age 2.5 years showed poor somatic growth (10%ile), microcephaly ( P1 presented since first months with frequent vomiting and marked psychomotor [link.springer.com]

[…] development Lack of language development Lack of speech No speech development No speech or language development Nonverbal [ more ] 0001344 Drooling Dribbling 0002307 Dysphagia Poor [rarediseases.info.nih.gov]

Singleton Merten Syndrome

; Russell-Silver syndrome (RSS) is a rare condition associated with poor growth both .... Do you have more information about symptoms of this disease? ..... [xdlrwffz.gq]

growth and variable phenotypic manifestations, such as facial dysmorphism and congenital heart defects, associated with mosaic aneuploidies resulting from defects in cell [mendelian.co]

Other findings may include neurologic problems, generalized short stature, muscle weakness; poor muscle tone ( hypotonia ); progressive wasting of the muscles ( muscle atrophy [rarediseases.info.nih.gov]

Hardikar Syndrome

Other: failure to thrive poor growth Abdomen Liver: hepatomegaly portal hypertension portal inflammation fibrosis ductal plate malformations more Skin Nails Hair Skin: jaundice [malacards.org]

[…] delay Delayed growth Growth deficiency Growth failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Hearing impairment Deafness Hearing defect [ more ] [rarediseases.info.nih.gov]

[…] mottled pigmentation 31 HP:0001070 28 patent foramen ovale 31 HP:0001655 29 cholangitis 31 HP:0030151 Symptoms via clinical synopsis from OMIM®: 57 (Updated 05-Apr-2021) Growth [malacards.org]

Hereditary Hypophosphatemic Rickets with Hypercalciuria

Hypophosphatemia in children leads to rickets resulting in poor growth and frequently in skeletal deformities. [jcrpe.org]

Lessened parental surveillance, poor taste of phosphate preparations, and lack of convincing demonstration of therapeutic benefits in asymptomatic individuals contribute to [ec.bioscientifica.com]

Therapy in adults Metabolism After the years of burdensome therapy over the ‘pediatric’ period, which is essential to ensure adequate bone matrix mineralization and skeletal growth [ec.bioscientifica.com]

Neonatal-Onset Citrullinemia Type 2

Poor growth may be evident. Head, ears, eyes, nose, and throat (HEENT): Papilledema may be present if cerebral edema and increased intracranial pressure have ensued. [checkorphan.org]

growth poor appetite vomiting headaches learning disabilities behavior problems hyperactivity balance and coordination problems, and spasticity Symptoms of citrullinemia [medicalhomeportal.org]

BY agc1 Δ cells had very poor growth ability with acetate as the unique carbon source, which could be restored after the transformation with the plasmid pYX212-CITRIN but [journals.plos.org]

14q11-q22 Microdeletion Syndrome

We report the clinical and molecular characterization of a female newborn, whose phenotype was characterized by poor growth, dysmorphic facial features, subclinical hypothyroidism [ncbi.nlm.nih.gov]

Patients are characterised by short stature. 14q11–q22 deletion syndrome Common features of patients with 14q11–q22 deletion syndrome are microcephaly, hypotonia, poor growth [nipt-geneplanet.com]

[…] the nervous system Abnormal CNS myelination Global developmental delay Hyperreflexia Hypoplasia of the corpus callosum Inability to walk Intellectual disability, severe Poor [ncbi.nlm.nih.gov]

The most frequent symptoms at onset were poor feeding, hypotonia, lethargy, respiratory and heart failure, accompanied by lactic acidosis, 3-methylglutaconic aciduria and [wwww.unboundmedicine.com]

Symptoms further included: developmental delay (98%), hypotonia (95%), faltering growth (94%), short stature (89%), non-progressive cardiomyopathy (89%), microcephaly (71% [wwww.unboundmedicine.com]

X-Linked Mental Retardation Type 98

Other features may include hypotonia, poor growth, microcephaly, agenesis of the corpus callosum, and seizures. [findzebra.com]

MRX98 patients show delayed psychomotor development, absent or poor speech development, and postnatal growth retardation, often with microcephaly. [cloud-clone.com]

Symptoms INHERITANCE: Autosomal dominant GROWTH: [Height]; Short stature; [Other]; Poor growth HEAD AND NECK: [Head]; Microcephaly; [Face]; Round face ; Prominent forehead [findzebra.com]

Insulin-Like Growth Factor 1 Deficiency

IGF-1 No other underlying disease or causes of poor growth e.g. chronic diseases, poor nutrition When all of these criteria are met, a doctor may diagnose PIGFD. [childgrowthfoundation.org]

Growth hormone deficiency is one of the endocrine (hormonal) disorders that can cause poor growth. [saizenus.com]

This disorder is known as Laron dwarfism and is characterized by abnormal GH receptors, resulting in decreased GH-stimulated production of IGF-1 and poor growth. [britannica.com]

3M Syndrome Type 3

Definition A disorder characterized by poor postnatal growth and distinctive facial features, including triangular facies, frontal bossing, fleshy tipped nose, and fleshy [uniprot.org]

Combined Oxidative Phosphorylation Defect Type 13

Other features include hypotonia, poor growth, lactic acidosis, and failure to thrive. The disorder may be fatal in early childhood. {ECO:0000269 PubMed:23849775}. [genecards.org]

growth, and sensorineural hearing loss. [genome.jp]

Poor head control MedGen UID: 322809 •Concept ID: C1836038 • Finding Difficulty to maintain correct position of the head while standing or sitting. [ncbi.nlm.nih.gov]

Molybdenum Cofactor Deficiency Type B

Poor growth may ensue. Affected individuals are at risk for severe psychomotor retardation, spasticity, and/or hypotonia. [emedicine.medscape.com]

growth Measurement of growth & head circumference At each visit Motor dysfunction Physical medicine, OT/PT assessment of mobility, self-help skills Ectopia lentis Ophthalmology [ncbi.nlm.nih.gov]

Neuropsychological testing using age-appropriate standardized assessment batteries Standardized quality-of-life assessment tools for affected persons & parents/caregivers As needed Poor [ncbi.nlm.nih.gov]

Hyperphosphatasia with Mental Retardation Type 2

Poor growth, microcephaly (1 patient), moderate to severe delayed speech and language development, plagiocephaly (1 patient), coronal synostosis (1 patient), hypertelorism [iofbonehealth.org]

[…] forehead Long palpebral fissure Anophthalmia Short palpebral fissure Microphthalmia High palate Pica Ptosis Mandibular prognathia Cleft palate Cryptorchidism Intrauterine growth [mendelian.co]

[…] alkaline phosphatase Telecanthus Shortening of all distal phalanges of the fingers Prominent nasal bridge Generalized seizures Deeply set eye Synophrys Short nose Strabismus Poor [mendelian.co]

Primary Bile Acid Malabsorption

Patients with liver involvement may have one or more of the following: elevated liver function tests; pale, foul-smelling stools; or poor growth, or failure to thrive, caused [retrophin.com]

The presentation was quite varied in this case series with one family member having liver failure in infancy; however, most patients presented with poor growth and fat soluble [rarediseases.org]

growth; pale, foul-smelling stools; dark urine; enlarged liver or spleen; and liver disease. 5,16,17,18 A patient diagnosed with ZSD may need regular testing of their liver [retrophin.com]

Fanconi Renotubular Syndrome Type 3

Clinical features include poor growth, fatigue, dehydration, polyuria, muscle weakness, and bone pain. [radiopaedia.org]

Transient Infantile Hypertriglyceridemia and Hepatosteatosis

[…] by intellectual disability, poor overall growth, hypotonia, and variable liver dysfunction. [mendelian.co]

A baby girl of Norwegian ancestry was delivered by cesarean section at 36 weeks' gestation (birth weight, 1670 g; length, 42 cm) because of poor fetal growth (Subject III- [nejm.org]

Top matches: Low match GROWTH RETARDATION, INTELLECTUAL DEVELOPMENTAL DISORDER, HYPOTONIA, AND HEPATOPATHY; GRIDHH GRIDHH is an autosomal recessive multisystem disorder characterized [mendelian.co]

Myopathy with Lactic Acidosis and Sideroblastic Anemia Type 2

Poor growth and intermittent vomiting persisted despite serial interventions including gluten-free diet and nasogastric, gastrostomy and (eventually) parenteral feeding. [ncbi.nlm.nih.gov]

Other frequent signs are poor growth, motor incoordination (ataxia) due to cerebellar failure, mental deterioration, deafness, and alterations of cardiac rhythm (Atrio-ventricular [mitopedia.org]

At 10 years he presented with abdominal pain, poor weight gain and lethargy. [ncbi.nlm.nih.gov]

Mitochondrial DNA Depletion Syndrome Type 3 Hepatocerebral

Clinical Synopsis: INHERITANCE: Autosomal recessive GROWTH: [Other]; Poor growth; Failure to thrive HEAD AND NECK: [Head]; Microcephaly (less common); [Eyes]; Nystagmus; Disconjugate [genome.jp]

Symptoms usually start shortly after birth and include vomiting, lack of energy, low blood sugar (hypoglycemia), diarrhea, and poor growth. [natera.com]

Glycogen Storage Disease, Type 4 often causes symptoms in infancy with poor feeding and growth (failure to thrive), an enlarged liver and spleen, enlarged heart, low muscle [natera.com]

Revesz Syndrome

Symptoms of Hoyeraal Hreidarsson syndrome include poor growth of the child during pregnancy, head size that is smaller than expected (microcephaly), the back of the brain [diseaseinfosearch.org]

Analysis of TIN2 protein in Patient 3's skin fibroblasts was not possible because of poor growth of the culture Plasmids TINF2 short isoform cDNA sequence derived from pLPC-N-FH2 [ncbi.nlm.nih.gov]

May be subtle with ridging, flaking, or poor growth, or more diffuse with nearly complete loss of nails Lacy reticular pigmentation of the upper chest and/or neck. [ncbi.nlm.nih.gov]

Lissencephaly 4 with Microcephaly

Infants with ILS may have poor muscle tone (hypotonia) and difficulty feeding, which leads to poor growth overall. [medlineplus.gov]

Case presentation A 1910 g infant was born at 41-weeks gestation to a 19-year-old gravida 1 mother after a pregnancy complicated by hydramnios and poor fetal movement. [nature.com]

In general, life expectancy for individuals with microcephaly is reduced and the prognosis for normal brain function is poor. [blueprintgenetics.com]

Nakajo Syndrome

growth. [altmeyers.org]

Other features included poor overall growth, lymphadenopathy, hepatosplenomegaly, myositis, arthritis/arthralgias, recurrent infections, joint contractures, and lipodystrophy [altmeyers.org]

[…] and edema, purplish eyelids, fever, skin lesions, myositis, arthralgia, joint contractures, increased acute phase reactants, lymphadenopathy, lipodystrophy, and overall poor [altmeyers.org]

Nicolaides-Baraitser Syndrome

Other: failure to thrive intrauterine growth retardation poor growth Genitourinary Internal Genitalia Male: cryptorchidism Head And Neck Face: long philtrum triangular face [malacards.org]

Apart from the craniofacial characteristics, poor growth and feeding, seizures, absent or delayed speech, variable ID, and behavioral disturbances (ex. decreased inhibitions [bmcmedgenomics.biomedcentral.com]

[…] retardation Long philtrum Low anterior hairline Microcephaly Poor speech Prominent interphalangeal joints Sandal gap Seizures Short metacarpal Short metatarsal Short phalanx [dovemed.com]

SIDDT Syndrome

Despite exclusive gastrostomy tube feeding, growth remained poor, and she died suddenly before her first birthday. [pnas.org]

A syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair [nectarmutation.org]

At age 4 weeks, she presented with poor growth, persistent stridor, and episodes of laryngospasm and cyanosis. A barium swallow excluded tracheoesophageal fistula. [pnas.org]

Autosomal Recessive Mental Retardation Type 27

All had delayed psychomotor development with limited speech, dysarthria, and poor somatic growth. [findzebra.com]

There is also limited intellectual development, skin lesions, liver damage, and growth of brittle hair. [biotechnologyforums.com]

[…] retardation, poor vision, dystonic movements, characteristic face, and severe mental retardation. [findzebra.com]

Cerebro-Oculo-Facio-Skeletal Syndrome Type 4

Introduction Cockayne syndrome (CS) is a rare autosomal recessive multisystem disorder characterized by poor growth, neurological abnormality and a short life span ( 1 ). [spandidos-publications.com]

Types [ edit ] CS Type I, the "classic" form, is characterized by normal fetal growth with the onset of abnormalities in the first two years of life. [en.wikipedia.org]

Additionally, atrophy of the central area of the cerebellum found in patients with Cockayne syndrome could also result in the lack of muscle control, particularly involuntary, and poor [en.wikipedia.org]