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1 Possible Causes for Poor Response to the C5 Inhibitor Eculizumab

  • Poor Response to Eculizumab

    BACKGROUND: Eculizumab is a humanized monoclonal antibody that targets complement protein C5 and inhibits terminal complement-mediated hemolysis associated with paroxysmal nocturnal hemoglobinuria (PNH). The molecular basis for the poor response to eculizumab in a small population of Japanese patients is unclear.[…][]

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