Poor Responsiveness: Causes & Reasons

Possible Causes for Poor Responsiveness

Thrombophilia due to Activated-Protein C Resistance

A poor APC response may also result from acquired conditions, some of which are clearly involved in the pathogenesis of venous thrombosis. [ncbi.nlm.nih.gov]

Factor V Leiden thrombophilia is characterized by a poor anticoagulant response to activated protein C (APC) and an increased risk for venous thromboembolism (VTE). [ncbi.nlm.nih.gov]

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated [books.google.com]

Classic Progressive Supranuclear Palsy Syndrome

PSP -atrophy of several subcortical areas -severe executive dysfunctions -poor response to drug therapies -downward gaze palsy [quizlet.com]

Poor response to Parkinsonian drugs argues against Parkinson's. Care and treatment Treatment is aimed at controlling symptoms. [alzheimer-europe.org]

Because the CR or ER is sometimes absorbed very little or erratically, a poor response in a patient with PSP might be incorrectly blamed on the fact that the disease is usually [psp.org]

Bovine Actinomycosis

Abstract Actinomycosis, or lumpy jaw, is an important cause of economic losses in livestock because of its widespread occurrence and poor response to the routine clinical [scopemed.org]

Various treatment protocols documented in the literature for the lumpy jaw have sub-satisfactory responses and are expensive for resource poor settings such as Cholistan. [en.engormix.com]

When the response to penicillin is poor, a search should be made for an undrained abscess, although it is more likely that unsatisfactory therapeutic results are due to the [antimicrobe.org]

T-Cell Prolymphocytic Leukemia

It has been associated with an aggressive course, a poor response to conventional chemotherapy and a short median survival. [ncbi.nlm.nih.gov]

Abstract T-cell prolymphocytic leukemia (T-PLL) is a rare aggressive post-thymic malignancy with poor response to conventional treatment and short survival. [ncbi.nlm.nih.gov]

The clinical course is typically aggressive with poor response to conventional chemotherapy and short survival. [ncbi.nlm.nih.gov]

Hairy Cell Leukemia Variant

Hairy cell leukemia variant (HCLv) is a rare B-cell chronic lymphoproliferative disorder with features of the classic HCL but presenting some particularities, a poor response [ncbi.nlm.nih.gov]

Treat Rev 2011;37:3 ) Rearrangement of VH4-34 gene is more common in variant than classic disease, and is associated with poorer survival ( Blood 2009;114:4687 ) Treatment Poor [pathologyoutlines.com]

HCL-V has a poor response to treatment and a shorter survival. [e-immunohistochemistry.info]

Sternal Lymphoma

Our patient also had low ADA in pleural fluid and poor response to ATT, further emphasizing the role of histopathology for diagnosis. [ncbi.nlm.nih.gov]

Previous cases of granulomatous reaction in Hodgkin's lymphoma have been reported in lymph nodes,[6] spleen[5] and bone.[2] Strong clinical suspicion and inadequate response [ncbi.nlm.nih.gov]

NEMO Mutation with Immunodeficiency

Innate immune cells from patients with the NEMO syndrome also demonstrate poor responses after stimulation with molecules derived from microbes. [primaryimmune.org]

This lack of response is notable even in patients with normal total serum immunoglobulin levels. [primaryimmune.org]

Histiocytic Sarcoma

The biologic behavior of HS is typically aggressive with a poor response to therapy. [latunisiemedicale.com]

Poor Response to Eculizumab

RESULTS: Of 345 Japanese patients with PNH who received eculizumab, 11 patients had a poor response. [ncbi.nlm.nih.gov]

The 11 patients with a poor response who had this mutation were identified among 345 Japanese patients who received eculizumab (rate of a poor response, 3.2%). [nejm.org]

Of 345 Japanese patients with PNH who received eculizumab, 11 showed a poor response. [ncbi.nlm.nih.gov]

Primary Coenzyme Q10 Deficiency Type 5

Contraer todo Desplegar todo Antecedentes Las enfermedades cardiovasculares (EC) son la causa número uno de muerte y discapacidad en todo el mundo y las intervenciones de salud pública se centran en los factores de riesgo modificables como el régimen dietético. La coenzima Q10 (CoQ10) es un antioxidante que el[…] [cochranelibrary.com]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 1

Moreover, this herpesvirus has been found in almost all patients with ENKL and persists in studies in people with poor response to treatment (3-5). [revistas.unal.edu.co]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 2

Moreover, this herpesvirus has been found in almost all patients with ENKL and persists in studies in people with poor response to treatment (3-5). [revistas.unal.edu.co]

Bleomycine-Resistant Testicular Cancer

These may represent markers that predict poor clinical outcome and response to cisplatin. [pesquisa.bvsalud.org]

Childhood Parosteal Osteogenic Sarcoma

Comparison of MAPIE versus MAP in Patiens with a poor response to preperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): and open-label, international [es.studenta.com]

Chronic Polyneuropathy

Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg. Neurology 2014; 82: 879-886 30 Miura Y, Devaux JJ, Fukami Y et al. [thieme-connect.com]

Hereditary Factor II Deficiency

- Dahlback B, Carlsson M, Svensson PJ: Familial thrombophilia dueto a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein [revistascientificas.una.py]

Mediastinal Angiosarcoma

These tumors are very aggressive and have a poor response to treatment modalities including surgical resection, chemotherapy, and radiation. [ncbi.nlm.nih.gov]

Consequently, they carry a poor prognosis. Due to the rarity of these tumors, no standard chemotherapy or radiation protocol exists. [ncbi.nlm.nih.gov]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 4

Moreover, this herpesvirus has been found in almost all patients with ENKL and persists in studies in people with poor response to treatment (3-5). [revistas.unal.edu.co]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 3

Moreover, this herpesvirus has been found in almost all patients with ENKL and persists in studies in people with poor response to treatment (3-5). [revistas.unal.edu.co]

Isocyanate-Induced Asthma

response to inhaled corticosteroids. [link.springer.com]

Scholar Green RH, Brightling CE, Woltmann G et al (2002) Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor [link.springer.com]

Immunodeficiency Type 37

(IIb C) Several genetically definable primary immunodeficiencies have been associated with poor polysaccharide antibody responses, and vaccination with pneumococcal polysaccharide [es.slideshare.net]

[…] patients with diabetes mellitus include defective phagocytosis and macrophage chemotaxis in vitro, T-cell anergy demonstrated by delayed hypersensitivity skin tests, and poor [es.slideshare.net]

(Ib A) A protective (normal or adequate) response to each pneumococcal serotype is defined as a titer equal to or greater than 1.3 mg/mL antibody. [es.slideshare.net]

Hemidystonia

The most common drugs used in the treatment were anticholinergics and benzodiazepines, with poor responses in the generalized forms. [pubmed.ncbi.nlm.nih.gov]

Meanwhile, the generalized forms of dystonia show poor response to the therapies utilized. Similar articles [Medical aspects of the medical treatment in dystonia]. [pubmed.ncbi.nlm.nih.gov]

Askin's Tumor

Considering his poor response, the protocol was changed to cyclophosphamide, vincristine, and dactinomycin (CVD) [6]. [hindawi.com]

Poor prognostic indicators were age >18 years, poor response to induction chemotherapy, and presence of pleural effusion. [ncbi.nlm.nih.gov]

However, poor response to antibiotics, any associated alarming features and relatively poor general condition of the patient should hint towards more sinister underlying pathology [hindawi.com]

C1Q Nephropathy

A poor response to steroid therapy was described in ClqN. Thus it was worthwhile to differentiate it from lupus nephritis, that is responsive to steroids. [bases.bireme.br]

Patients with nephrotic syndrome and C1q nephropathy, particularly those with FSGS, often show a poor response to corticosteroid treatment. [ncbi.nlm.nih.gov]

response to corticosteroid therapy, whereas patients presenting with asymptomatic urinary abnormalities maintained normal renal function. 3, 4, 8, 9 Additional studies are [ncbi.nlm.nih.gov]

Acute Erythremia

Pure erythroleukemia is a very uncommon subtype of leukemia associated with a very poor response and survival to current available therapeutic agents. [ncbi.nlm.nih.gov]

Neonatal Ovarian Cyst

Exclusion criteria Nine studies excluded women with an evidence of poor response. [cochranelibrary.com]

With regard to poor responders, only one of the included studies used poor response to ovarian stimulation as an inclusion criterion in 120 women (Kim 2011). [cochranelibrary.com]

2012; Hauzman 2013), and one study defined poor response as more than three unsuccessful controlled ovarian stimulation cycles or a history of low or no ovarian response [cochranelibrary.com]

Botryoid Vaginal Rhabdomyosarcoma

[…] prognostic factors include:[10] Metastatic disease at presentation Poor response to chemotherapy Diagnosis Symptoms Sarcoma botryoides may be initially asymptomatic. [wikidoc.org]

The presence of distant metastasis at the diagnosis, quality of surgery and poor response to preoperative chemotherapy are strongly associated with poor prognosis (Table 1 [heighpubs.org]

Metastatic disease at presentation and poor response to chemotherapy are strongly associated with poor prognosis [4]. [jmedicalcasereports.biomedcentral.com]

Inclusion Body Myopathy Type 3

Barohn R J, Amato A A, Sahenk Z, Kissel J T, Mendell J R.Inclusion Body Myositis: Explanation for Poor Response toImmunosuppressive Therapy. Neurology. 1995;45:1302–04. [revistas.unimilitar.edu.co]

Pyruvate Carboxylase Deficiency Type A

Ophthalmologic examination may reveal poor visual tracking, grossly disconjugate eye movements, poor pupillary response, and/or blindness. [emedicine.medscape.com]

[…] loss of motor milestones, poor muscle tone, new-onset seizures, periods of incoordination (i.e., ataxia), abnormal eye movements, poor response to visual stimuli, and episodic [ncbi.nlm.nih.gov]

[…] acquisition or loss of motor milestones, new-onset seizures, episodic incoordination, abnormal eye movements, and poor response to visual stimuli are signs of poor neurologic [emedicine.medscape.com]

KCNQ2-Related Disorders

Nevertheless, it is notable that in the early stage he presented several electroclinical features resembling epileptic encephalopathy including hypotonia, poor response to [stdjhs.scienceandtechnology.com.vn]

On the other hand, the suspicion of KCNQ2 -EE is mainly based on absence of structural lesions in the brain, severe abnormality on EEG background activity, poor response to [stdjhs.scienceandtechnology.com.vn]