Postnatal Growth Retardation: Causes & Reasons

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Possible Causes for Postnatal Growth Retardation

Dubowitz Syndrome

Dubowitz syndrome is a rare autosomal recessive disorder characterized by intrauterine and postnatal growth retardation, microcephaly, moderate mental retardation, typical [ncbi.nlm.nih.gov]

Abstract We report the psychological status of ten people with the Dubowitz syndrome, an autosomal recessive condition characterized by intrauterine and postnatal growth retardation [ncbi.nlm.nih.gov]

A 2-year-old Japanese male whose clinical features included intrauterine and postnatal growth retardation, mild mental retardation, microcephaly and characteristic facial [ncbi.nlm.nih.gov]

Sanjad-Sakati Syndrome

growth retardation History and etymology First definitively described by Sanjad et al in 1991. [radiopaedia.org]

It is characterized by congenital hypoparathyroidism, severe prenatal and postnatal growth retardation, dysmorphic features, as well as mild to severe mental retardation. [ingentaconnect.com]

It is characterized by congenital hypoparathyroidism, severe prenatal and postnatal growth retardation, and distinct facial dysmorphism. [ncbi.nlm.nih.gov]

Rubinstein-Taybi Syndrome

The Rubinstein-Taybi syndrome (RTS; OMIM 180849) is a well-defined mental retardation/multiple congenital anomalies (MR/MCA) syndrome characterized by postnatal growth retardation [ncbi.nlm.nih.gov]

Rubinstein-Taybi syndrome is a rare autosomal dominant congenital disorder characterized by postnatal growth retardation, psychomotor developmental delay, skeletal anomalies [ncbi.nlm.nih.gov]

RSTS is characterized by typical facial features, microcephaly, broad thumbs and first toes, intellectual disability, and postnatal growth retardation. [ncbi.nlm.nih.gov]

Donohue Syndrome

growth retardation, exaggerated hyperglycemia with hyperinsulinism and dysmorphic abnormalities.We present a case of DS owing to the rarity of this syndrome (1 case… CONTINUE [semanticscholar.org]

growth retardation, exaggerated hyperglycemia with hyperinsulinism and dysmorphic abnormalities.We present a case of DS owing to the rarity of this syndrome (1 case in every [ncbi.nlm.nih.gov]

DS is characterized by pre- and postnatal growth retardation with failure to thrive, lipoatrophy, muscle wasting, acanthosis nigricans, hypertrichosis, and dysmorphic features [ncbi.nlm.nih.gov]

Oculopalatoskeletal Syndrome

[…] abnormality Postnatal growth retardation IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information [ncbi.nlm.nih.gov]

growth retardation, Growth delay, Glaucoma, Short 5th finger, Short foot, Underdeveloped supraorbital ridges, Hydronephrosis, Highly arched eyebrow, Hypertelorism, Radioulnar [fdna.health]

failure, lip/palate cleft(s), and urogenital anomalies. [genome.jp]

Cerebro-Costo-Mandibular Syndrome

Intrauterine and postnatal growth retardation are common. Familial cases are rare and the mode of transmission is uncertain. [ncbi.nlm.nih.gov]

Postnatal growth retardation and microcephaly are common findings ( 4 ). [ncbi.nlm.nih.gov]

growth retardation Growth delay as children 0008897 Renal cyst Kidney cyst 0000107 Rib gap 0030280 Scoliosis Abnormal curving of the spine 0002650 Short humerus Short long [rarediseases.info.nih.gov]

Warburg Micro Syndrome 3

growth retardation, cataract, microcornea, atonic pupils, optic atrophy, profound mental retardation, hypotonic spastic diplegia, polymicrogyria, hypoplasia of the corpus [bio2rdf.org]

growth retardation ; Postnatal microcephaly ; Scrotal hypoplasia ; Seizures ; Shallow anterior chamber ; Short nose ; Spastic tetraplegia ; Ventriculomegaly Associated Genes [mousephenotype.org]

Warburg Micro syndrome 2 and Martsolf syndrome are clinically overlapping conditions characterized by variable clinical signs counting postnatal growth retardation, cataract [tandfonline.com]

Chromosome 19q13.11 Deletion Syndrome

growth retardation Growth delay as children 0008897 Ptosis Drooping upper eyelid 0000508 Recurrent infections Frequent infections Frequent, severe infections Increased frequency [rarediseases.info.nih.gov]

There are very few cases reported with this deletion, but clinically this condition seems to be recognizable by pre and postnatal growth retardation, microcephaly, developmental [link.springer.com]

Abstract Developmental delay/intellectual disabilities, speech disturbance, pre- and postnatal growth retardation, microcephaly, signs of ectodermal dysplasia, and genital [nature.com]

Genee-Wiedemann Syndrome

growth retardation ; Pyloric stenosis ; Radioulnar synostosis ; Short thumb ; Supernumerary nipple ; Supernumerary vertebrae ; Syndactyly Associated Genes DHODH Mouse Orthologs [mousephenotype.org]

failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Low-set ears Low set ears Lowset ears [ more ] 0000369 Micropenis Short penis Small penis [ more ] [rarediseases.info.nih.gov]

growth retardation Camptodactyly of finger Micropenis Hypoplasia of the corpus callosum Edema Milia Enlarged cochlear aqueduct Abnormality of the kidney Abnormal lacrimal [mendelian.co]

IMAGE Syndrome

growth retardation Growth delay as children 0008897 Prominent forehead Pronounced forehead Protruding forehead [ more ] 0011220 Short nose Decreased length of nose Shortened [rarediseases.info.nih.gov]

For example the 3-M syndrome is characterized [ 11 - 14 ] by prenatal- and postnatal growth retardation, peculiar facial features (relatively large head, frontal bossing, [omicsonline.org]

growth retardation with normal head circumference. 3-M syndrome is characterized by severe pre- and postnatal growth retardation (final height 5-6 SD below the mean), distinctive [ncbi.nlm.nih.gov]

Malpuech Syndrome

Similarly, the four related patients reported by Al Gazali et al. [1994] with prenatal and postnatal growth retardation, anterior segment defects of the eye have distinctive [onlinelibrary.wiley.com]

Similarly, the fourrelated patients reported by Al Gazali et al. [1994] withprenatal and postnatal growth retardation, anterior segmentdefects of the eye have distinctive [documents.tips]

Symptoms INHERITANCE: Autosomal dominant GROWTH: [Height]; Short stature; [Weight]; Low birth weight; [Other]; Postnatal growth retardation HEAD AND NECK: [Head]; Microcephaly [findzebra.com]

Acrocallosal Syndrome

Postnatal onset of growth retardation is proposed as an additional manifestation of ACS. [ncbi.nlm.nih.gov]

growth retardation Growth delay as children 0008897 Prominent forehead Pronounced forehead Protruding forehead [ more ] 0011220 Pulmonary valve defects 0005148 Rectovaginal [rarediseases.info.nih.gov]

failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Inguinal hernia 0000023 Preauricular skin tag 0000384 Prominent occiput Prominent back of the skull [rarediseases.info.nih.gov]

Cockayne Syndrome

In its classical form (Cockayne syndrome type I or type A) it is characterized by loss of adipose tissue and severe postnatal growth retardation, starting in the first year [scielo.br]

Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly [icd10data.com]

Mental retardation, neurological deterioration, growth failure, ocular changes and cutaneous sensitivity are the major features to be considered for the diagnosis of CS. [scielo.br]

Filippi Syndrome

We report on a child with Filippi syndrome who shows syndactyly of fingers, severe postnatal growth retardation, postnatal microcephaly, and moderate to severe mental retardation [hindawi.com]

syndactyly of the fingers and toes, microcephaly, pre and postnatal growth retardation, and unusual facies. [malacards.org]

Syndactyly type 1 with microcephaly and intellectual disability Description Filippi syndrome is a rare autosomal-recessive disorder characterized by mild to severe mental retardation [genome.jp]

Short Stature - Optic Atrophy - Pelger-Huët Anomaly Syndrome

growth retardation, facial dysmorphism with senile face, small hands and feet, normal intelligence, abnormal nuclear shape in neutrophil granulocytes (Pelger-Huet anomaly [malacards.org]

Disease: ( OMIM: 608025 614800 ) Short stature, optic nerve atrophy, and Pelger-Huet anomaly (SOPH) [MIM:614800]: An autosomal recessive syndrome characterized by severe postnatal [rbcc.hegelab.org]

Definition An autosomal recessive syndrome characterized by severe postnatal growth retardation, facial dysmorphism with senile face, small hands and feet, normal intelligence [uniprot.org]

Ehlers-Danlos Syndrome Spondylodysplastic Type 3

Clinical features include postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar [uniprot.org]

Clinical features included postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar [rprotein.com]

Chromosome 16q22 Deletion Syndrome

growth retardation Short palpebral fissure • • • References Source: GTR (NCBI/NIH): ncbi.nlm.nih.gov/ gtr/ conditions/ C3281152/ Source: Human Phenotype Ontology • • • Note [familydiagnosis.com]

[…] severe growth retardation. [mendelian.co]

Global developmental delay Failure to thrive Small for gestational age Frontal bossing Poor suck Wormian bones Sporadic Depressed nasal bridge Wide intermamillary distance Postnatal [familydiagnosis.com]

Congenital Disorder of Glycosylation Type 2A

growth retardation Growth delay as children 0008897 Prominent nasal bridge Elevated nasal bridge High nasal bridge Prominent bridge of nose Prominent nasal root Protruding [rarediseases.info.nih.gov]

Affected infants often experience seizures, postnatal growth retardation, and microcephaly, a term used to describe head circumference that is smaller than would be expected [rarediseases.org]

Osteopenia 0000938 Pectus excavatum Funnel chest 0000767 Pes planus Flat feet Flat foot [ more ] 0001763 Posteriorly rotated ears Ears rotated toward back of head 0000358 Postnatal [rarediseases.info.nih.gov]

Recombinant Chromosome 8 Syndrome

growth retardation Growth delay as children 0008897 Postnatal microcephaly 0005484 Pulmonic stenosis Narrowing of pulmonic valve 0001642 Strabismus Cross-eyed Squint Squint [rarediseases.info.nih.gov]

failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Hydronephrosis 0000126 Hypertonia 0001276 Infra-orbital crease Crease in skin under the eye Groove [rarediseases.info.nih.gov]

[…] deficiency Underdevelopment of midface [ more ] 0011800 Muscular hypotonia Low or weak muscle tone 0001252 Posteriorly rotated ears Ears rotated toward back of head 0000358 Postnatal [rarediseases.info.nih.gov]

Coffin-Siris Syndrome

Clin-Dysmorphol. 2000 Jan; 9(1): 15-9 Kirel,-B; Kural,-N; Yakut,-A; Adapinar,-B Triplets with growth failure, microcephaly, mental retardation, nail hypoplasia and corpus [malattierare.regione.veneto.it]

Turk-J-Pediatr. 2000 Apr-Jun; 42(2): 171-6 Ounap,-K; Justus,-I; Lipping-Sitska,-M Two sisters with growth failure, microcephaly, peculiar facies and apical dystrophy: the [malattierare.regione.veneto.it]

Glycogen Storage Disease Type 6

growth retardation Growth delay as children 0008897 Showing of 11 | Last updated: 5/1/2019 GSD6 is caused by changes or mutations in the PYGL gene. [rarediseases.info.nih.gov]

Children born with GSD I typically exhibit growth failure, chronic hunger, fatigue, irritability, an enlarged liver, and a swollen abdomen. [liverfoundation.org]

The child with myopathy and growth failure should receive a high protein diet. [clinicaladvisor.com]

Dyggve-Melchior-Clausen Syndrome

growth retardation Sloping forehead Spinal canal stenosis Occasionally present symptoms in 5-29% of the cases: Attention deficit hyperactivity disorder Autism Shoulder dislocation [dovemed.com]

growth retardation Growth delay as children 0008897 Scoliosis 0002650 Short neck Decreased length of neck 0000470 Sloping forehead Inclined forehead Receding forehead [ more [rarediseases.info.nih.gov]

The clinical history begins at two years when after a normal postnatal development, parents noticed delay in growth and deformity in both knees but there was no mental retardation [omicsonline.org]

Autosomal Recessive Mental Retardation Type 5

growth retardation, including microcephaly; and (3) CNS dysfunction, including mild-to-moderate mental retardation, delay in motor development, hyperactivity, and attention [emedicine.medscape.com]

Postnatal microcephaly and growth deficiency with mental retardation and early hypotonia are typical features. The mental retardation may be severe. [disorders.eyes.arizona.edu]

[…] used heavily during pregnancy, alcohol causes abnormalities in 3 main categories: (1) dysmorphic features, which originate in the period of organogenesis; (2) prenatal and postnatal [emedicine.medscape.com]

Mandibuloacral Dysostosis

October 24, 2017 Mandibuloacral dysplasia (MAD) is a uncommon autosomal recessive disorder seen as a postnatal growth retardation, craniofacial anomalies, skeletal malformations [dna-pk.info]

growth retardation. [updoc.site]

Patient 1 exhibited typical phenotype of MADA, showing the initial symptoms in the first year of life, and postnatal growth retardation, hair loss, joint stiffness, lipodystrophy [bmcpediatr.biomedcentral.com]

Marden-Walker Syndrome

growth retardation, mutilple joint contractures and a distinct facies. [cags.org.ae]

growth retardation Growth delay as children 0008897 Primitive reflex 0002476 Pulmonary hypoplasia Small lung Underdeveloped lung [ more ] 0002089 Renal hypoplasia Small kidneys [rarediseases.info.nih.gov]

Clinical aspects Prenatal and severe postnatal growth deficiency; moderate-to-severe mental retardation with hypotonia; microcephaly with fixed facial expression and blepharophimosis [accesspediatrics.mhmedical.com]

Anophthalmia or Microphthalmia - Esophageal Atresia Syndrome

growth retardation Growth delay as children 0008897 Rib fusion Fused ribs 0000902 Sensorineural hearing impairment 0000407 Short stature Decreased body height Small stature [rarediseases.info.nih.gov]

Several other associated anomalies have been described including developmental anomalies of the central nervous system, cardiac defects, vertebral anomalies, growth failure [orpha.net]

failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Hemivertebrae Missing part of vertebrae 0002937 Holoprosencephaly 0001360 Hydrocephalus Too much cerebrospinal [rarediseases.info.nih.gov]

Coats Plus Syndrome

We recently described 9 cases highlighting the core clinical features of this condition which are: pre- and postnatal growth retardation, bilateral retinal telangiectasia [doi.org]

We describe the phenotype of a patient with severe growth failure where whole exome sequencing (WES) revealed compound heterozygosity for two mutations in the CTC1 gene. [abstracts.eurospe.org]

failure. [research.manchester.ac.uk]

Carnevale Krajewska Fischetto Syndrome

Similarly, the fourrelated patients reported by Al Gazali et al. [1994] withprenatal and postnatal growth retardation, anterior segmentdefects of the eye have distinctive [documents.tips]

failure, lip/palate cleft(s), and urogenital anomalies. [genome.jp]

Malpuech G, Demeocq F, Palcoux JB, Vanlieferinghen P タイトル A previously undescribed autosomal recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome with growth [genome.jp]

CHARGE Syndrome

failure may be a primary feature of CHARGE syndrome of unknown etiology, 21 or it may be caused by suboptimal nutritional intake secondary to feeding difficulties or, in [nursingcenter.com]

Oliveira, Hypothalamic abnormalities: Growth failure due to defects of the GHRH receptor, Growth Hormone & IGF Research, (2017). [doi.org]

Polyendocrine - Polyneuropathy Syndrome

growth retardation Abnormal pyramidal sign Hypoglycemia Intellectual disability, moderate Cerebellar hypoplasia Diabetes mellitus And 10 more phenotypes. [mendelian.co]

growth retardation Hypoglycemia Hypothyroidism Diabetes mellitus Cerebellar hypoplasia Growth delay Hearing impairment Limb joint contracture Limb ataxia Increased CSF lactate [mendelian.co]

Symptoms INHERITANCE: Autosomal recessive GROWTH: [Height]; Short stature; [Other]; Postnatal growth retardation HEAD AND NECK: [Head]; Partial frontal alopecia; [Ears]; Progressive [findzebra.com]