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107 Possible Causes for Postnatal Macrocephaly

  • Russell-Silver Syndrome

    Silver-Russell syndrome is a clinically and genetically heterogeneous disorder, characterized by prenatal and postnatal growth restriction, relative macrocephaly, body asymmetry[ncbi.nlm.nih.gov] We describe a 10-year-old Taiwanese RSS girl with prenatal and postnatal growth retardation, relative macrocephaly, a triangular face, frontal bossing, and mild fifth finger[ncbi.nlm.nih.gov] Russell-Silver Syndrome (RSS) is a genetically determined condition characterized by severe intrauterine and postnatal growth retardation; relative macrocephaly; a small,[ncbi.nlm.nih.gov]

  • Hepatoblastoma

    […] overgrowth, distinctive craniofacial features, macrocephaly, and organomegaly.[ncbi.nlm.nih.gov] […] syndrome is a rare overgrowth syndrome caused by the GPC3 mutation at Xq26 and is clinically characterized by multiple congenital abnormalities, intellectual disability, pre/postnatal[ncbi.nlm.nih.gov]

  • Sotos Syndrome

    , macrocephaly, developmental delay, and resembling that of Sotos syndrome, rather than the recently reported syndrome of reciprocal duplication.[ncbi.nlm.nih.gov] All presented normal growth at birth but postnatal overgrowth. Two patients with NSD1 and FGFR4 gene deletions presented congenital heart anomalies.[ncbi.nlm.nih.gov] Sotos syndrome is an autosomal dominant condition characterized by pre- and postnatal overgrowth (tall stature and macrocephaly), a typical facial appearance, advanced bone[ncbi.nlm.nih.gov]

  • Autistic Disorder

    But macrocephaly is not observed at birth, consistent with imaging data showing postnatal growth acceleration.[ncbi.nlm.nih.gov] Brain Overgrowth and Macrocephaly The findings of early postnatal brain “overgrowth” in ASD followed by normalization or relative growth arrest in childhood are intriguing[ncbi.nlm.nih.gov] In addition, macrocephaly or head circumference above the ninety-eighth percentile is observed in 20% of autistic children in mid-childhood ( 34 ), and macrocephaly itself[ncbi.nlm.nih.gov]

  • Macrocephaly - Intellectual Disability - Autism Syndrome

    Subsequently, Stevenson et al. [1997: Lancet 349:1744-1745] emphasized the association of progressive postnatal macrocephaly with autism, and they suggested that this might[ncbi.nlm.nih.gov] macrocephaly in the context of autosomal dominant familial macrocephaly.[ncbi.nlm.nih.gov] Genet 41:115-124] reported a new syndrome associated with marked obesity, occasional delayed bone age, distinctive facial anomalies, mental retardation, and progressive postnatal[ncbi.nlm.nih.gov]

  • Breast Hypertrophy

    , including progressive macrocephaly, seizures, and premature death.[pnas.org] Selective inactivation of Pten in postnatal granule neurons of the cerebellum and dentate gyrus in mouse causes cell-autonomous hypertrophy as well as more complex phenotypes[pnas.org]

  • Nephroblastoma

    SGBS is characterized by pre- and postnatal macrosomia, distinctive craniofacies (including macrocephaly, coarse facial features, macrostomia, macroglossia, palatal abnormalities[doi.org]

  • Mental Retardation

    Neurologic and physical abnormalities: Prevalence of ID is increased among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal[emedicine.com] […] and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly[emedicine.com]

  • Coxa Valga

    Sotos syndrome 2 MedGen UID: 766574 • Concept ID: C3553660 • Disease or Syndrome A multiple congenital anomalies syndrome characterised by moderate postnatal overgrowth, macrocephaly[ncbi.nlm.nih.gov]

  • Macrocephaly

    Their most common presentation is macrocephaly, hydrocephalus, stillbirth, or diagnosis by pre- or postnatal imaging.[ncbi.nlm.nih.gov] OBJECTIVES: To compare the outcomes of fetuses with apparently isolated macrocephaly and those with associated findings, and to compare prenatal findings with postnatal diagnoses[ncbi.nlm.nih.gov] The patient presented typical congenital findings in utero, although the syndrome was diagnosed postnatally.[ncbi.nlm.nih.gov]

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