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2,026 Possible Causes for Predisposition to UV Induced Malignancies, Premature Graying of the Hair, Vitiligo

  • Vitiligo

    In addition to white patches, vitiligo can cause premature graying of the hair.[cbsnews.com] vitiligo.[niams.nih.gov] In some families, premature graying of the hair results from an autoimmune loss of melanocytes in the hair follicles.[nytimes.com]

    Missing: Predisposition to UV Induced Malignancies
  • Pernicious Anemia

    The case presented here is a woman who had a restoration of fertility after initiation of vitamin B12 treatment for vitiligo-associated pernicious anemia.[ncbi.nlm.nih.gov] Vitiligo is an acquired disease characterized by depigmentation of the skin due to destruction of melanocytes.[ncbi.nlm.nih.gov] A patient with a 46-year history of vitiligo who also presented rheumatoid arthritis and pernicious anemia is described.[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Rothmund Thomson Syndrome

    graying of hair Early graying Premature graying Premature greying Premature hair graying [ more ] 0002216 Ptosis Drooping upper eyelid 0000508 Pyloric stenosis 0002021 Reduced[rarediseases.info.nih.gov] Idiopathic Guttate Hypomelanosis Laugier-Hunziker Syndrome Lentigo Melasma Ocular Manifestations of Albinism Pigmented Lesions of the Eyelid Postinflammatory Hyperpigmentation Vitiligo[dokterairlangga.com] […] of hair, alopecia, scleroderma-like skin changes Skin ulcers (4th decade) Cancer predisposition Premature appearance of features associated w/normal aging Normal development[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Klein-Waardenburg Syndrome

    graying of the hair (by age 30) Waardenburg syndrome type 2 is defined as having all the features of type 1 except dystopia canthorum. 77% of individuals with type 2 have[verywell.com] It consists of a white forelock, vitiligo, partial or total heterochromic irides, hyperplastic broad high nasal root, lateral displacement of the medial canthi and lacrimal[whonamedit.com] […] topical areas, which causes depigmentation of the total skin to match the white patches of vitiligo.[pinterest.de]

    Missing: Predisposition to UV Induced Malignancies
  • Alopecia Areata

    A cis -acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nature Genet. 40, 1004–1009 (2008) 22. Akar, A. et al.[doi.org] Vitiligo and alopecia areata are common autoimmune diseases of the skin.[ncbi.nlm.nih.gov] Vitiligo and alopecia areata are two cutaneous diseases believed to be primarily autoimmune in pathogenesis.[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Uveomeningoencephalitic Syndrome

    Vogt-Koyanagi syndrome - bilateral uveitis with iritis and glaucoma, premature graying of the hair, alopecia, vitiligo, and dysacusia.[medical-dictionary.thefreedictionary.com] Cytokines: the yin and yang of vitiligo pathogenesis.[bioportfolio.com] Alopecia, premature graying of hair, and vitiligo are also observed.[accessanesthesiology.mhmedical.com]

    Missing: Predisposition to UV Induced Malignancies
  • Autosomal Recessive Spastic Paraplegia Type 23

    SPG23 is an autosomal recessive form characterized by childhood-onset of gait difficulties and pigmentary abnormalities, including premature graying of the hair and vitiligo-like[ghr.nlm.nih.gov] […] graying-characteristic facies syndrome spastic paraplegia 23 SPASTIC PARAPLEGIA 23; SPG23 Autosomal recessive spastic paraplegia type 23 Spastic Paraparesis, Vitiligo, Premature[wikidata.org] graying of hair, and characteristic facies (i.e. thin with ''sharp'' features).[rarediseases.info.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Thyroiditis

    graying of hair, pernicious anemia, connective tissue disorders (eg, rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome ), celiac disease, and type 2 polyglandular[msdmanuals.com] KEYWORDS: Autoimmune thyroiditis; CCL2; CXCL10; Chemokines; Vitiligo[ncbi.nlm.nih.gov] Vitiligo and overt thyroid diseases: a nationwide population-based study in Korea. J Am Acad Dermatol. 2017 May. 76 (5):871-8. [Medline].[emedicine.com]

    Missing: Predisposition to UV Induced Malignancies
  • Homocystinuria

    Hypopigmentation and premature graying of the hair are also common.[advbiores.net] […] signs of homocystinuria include: Hypopigmentation due to inhibition of tyrosinase Fair and thin hair Thin, translucent skin Hyperhidrosis Dry skin with tendency to eczema Vitiligo[dermnetnz.org] Is there a relationship between homocysteine and vitiligo? A pilot study. Br J Dermatol. 2008 Sep. 159(3):720-4. [Medline]. Tallur KK, Johnson DA, Kirk JM, et al.[emedicine.com]

    Missing: Predisposition to UV Induced Malignancies
  • Piebaldism

    Hypoplastic nasal alae Affected first‐degree relative Premature gray hair ( 30 y of age)dd Defined by graying before 30 years of age. a Requires 2 major criteria or 1 major[onlinelibrary.wiley.com] BACKGROUND: Refractory and stable defects of vitiligo and piebaldism may be unresponsive to medical therapy.[ncbi.nlm.nih.gov] (n 33), generalized vitiligo (n 33), mixed vitiligo (n 6), halo naevi (n 11), piebaldism (n 3) and naevus depigmentosus (n 1).[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies

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