Premature Coronary Artery Disease: Causes & Reasons

Possible Causes for Premature Coronary Artery Disease

We have documented here a clinical variant of TD in a Japanese patient who manifested corneal lipidosis and premature coronary artery disease as well as an almost complete [ncbi.nlm.nih.gov]

coronary artery disease (CAD). [ncbi.nlm.nih.gov]

Issues on cholesterol: diet, statins and genetics Genetic lipoprotein disorders are frequently seen in patients with premature coronary artery disease (CAD). [news-medical.net]

Hypercholesterolemia

Elevated levels of LDL-C cause an increased risk for premature coronary artery disease, which can result in myocardial infarction. [questdiagnostics.com]

Clinical manifestations may vary but often include markedly premature coronary artery disease, supravalvular aortic stenosis due to aortic root atheroma, and cutaneous manifestations [centerwatch.com]

* coronary artery disease 2 Patient with premature* cerebral or peripheral vascular disease 1 Physical examination Tendinous xanthomata 6 Arcus cornealis prior to age 45 years [mdcalc.com]

Familial Hypercholesterolemia Type 1

artery disease. [ncbi.nlm.nih.gov]

PURPOSE OF REVIEW: Familial hypercholesterolemia, represents one of the most extreme clinical entities associated with premature coronary artery disease (CAD). [ncbi.nlm.nih.gov]

None of the parents had been treated with statins at the time of diagnosis, and 10 (12.7%) had premature coronary artery disease. [ncbi.nlm.nih.gov]

Heterozygous Familial Hypercholesterolemia

Familial hypercholesterolaemia (FH) is a relatively common inherited cause of premature coronary artery disease. [racgp.org.au]

present in up to 1 in 200 people, in which there is a life-long burden of high LDL cholesterol levels leading to increased risk of premature coronary artery disease and [globenewswire.com]

[…] atherosclerosis Coronary artery disease [bmcpediatr.biomedcentral.com]

Familial Hypercholesterolemia

Untreated FH accelerates atherosclerosis and predisposes individuals to premature coronary artery disease (CAD) in adulthood. [ncbi.nlm.nih.gov]

None of the parents had been treated with statins at the time of diagnosis, and 10 (12.7%) had premature coronary artery disease. [ncbi.nlm.nih.gov]

PURPOSE OF REVIEW: Familial hypercholesterolemia, represents one of the most extreme clinical entities associated with premature coronary artery disease (CAD). [ncbi.nlm.nih.gov]

Familial Hyperlipidemia

* coronary artery disease 2 Patient with premature* cerebral or peripheral vascular disease 1 Physical examination Tendinous xanthomata 6 Arcus cornealis prior to age 45 years [mdcalc.com]

Familial hypercholesterolaemia (FH) is a relatively common inherited cause of premature coronary artery disease. [racgp.org.au]

In patients with premature coronary artery disease, the prevalence of FH is much higher. [knowledge.statpearls.com]

Homozygous Familial Hypercholesterolemia

Homozygous familial hypercholesterolemia is a rare cause of premature coronary artery disease. [ncbi.nlm.nih.gov]

This mutation can lead to increased serum LDL, and subsequently to premature coronary artery disease. [ncbi.nlm.nih.gov]

Homozygous familial hypercholesterolemia is an important risk factor for atherosclerosis and premature coronary artery disease in children and young adults. [ncbi.nlm.nih.gov]

Hyperlipoproteinemia Type 3

Personal or family history of premature coronary artery disease 3. Carrier testing for known familial mutations 4. Characteristic findings such as xanthomas 5. [asperbio.com]

High levels of these remnants, called β-VLDL, promote lipid deposition in tuberous xanthomas, atherosclerosis, premature coronary artery disease, and early myocardial infarction [ncbi.nlm.nih.gov]

Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke. [medicowesome.com]

Hypoalphalipoproteinemia

Abstract Hypoalphalipoproteinemia (HA) is a common finding in patients with premature coronary artery disease. [ncbi.nlm.nih.gov]

Abstract Decreased plasma high-density-lipoprotein (HDL) cholesterol and apolipoprotein A-I levels have been associated with premature coronary artery disease. [nejm.org]

Pharmacotherapy selected according to the dyslipidemia that accompanies the HDL-C disorder is indicated for subjects who manifest premature coronary artery disease or who [ncbi.nlm.nih.gov]

Combined Hyperlipidemia

Familial combined hyperlipidemia is a complex genetic disorder conferring a high risk of premature coronary artery disease, characterized by high serum cholesterol and/or [ncbi.nlm.nih.gov]

DESIGN NARRATIVE: Attention is focused on the molecular, genetic and pathophysiological basis of the inherited dyslipoproteinemias associated with premature coronary artery [clinicaltrials.gov]

coronary artery disease. [heart.bmj.com]

Familial Combined Hyperlipidemia

Abstract Familial combined hyperlipidemia (FCHL), with a marked elevation of apolipoprotein B (apoB), is estimated to cause 10-20% of premature coronary artery disease. [ncbi.nlm.nih.gov]

coronary artery disease. [nyu.pure.elsevier.com]

Familial combined hyperlipidemia is the most common genetic hyperlipidemia and is responsible for premature coronary artery disease. [ncbi.nlm.nih.gov]

Hyperlipoproteinemia Type 4

The prognosis remains uncertain, however, because of predisposition to premature coronary artery disease. [checkorphan.org]

Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke. [medicowesome.com]

The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease. J Clin Lipidol 2012; 6(1):81. [labtestsonline.it]

Hyperlipoproteinemia

coronary artery disease. [ncbi.nlm.nih.gov]

Hyperlipoproteinemia is suspected in patients presenting with the clinical features associated with dyslipidemia, those with a positive family history of premature coronary [symptoma.com]

[…] hypothyroidism at diagnosis requiring thyroxine replacement, palmar xanthomas requiring surgical removal, splenomegaly requiring splenectomy, 18 episodes of pancreatitis and premature [ncbi.nlm.nih.gov]

Hyperlipoproteinemia Type 5

Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke. [medicowesome.com]

The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease. J Clin Lipidol 2012; 6(1):81. [labtestsonline.it]

Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation 1992;85:2025–33. 4. [bjcardio.co.uk]

Multisystemic Smooth Muscle Dysfunction Syndrome

Disease: ( OMIM: 102620 611788 613834 614042 ) Note=ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery [rbcc.hegelab.org]

Involvement in disease : DISEASE: Note=ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery disease [sinobiological.com]

Note=ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery disease (CAD), premature ischemic strokes and [genecards.org]

Hyperlipoproteinemia Type 1

Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke. [medicowesome.com]

[…] stenosis 0004950 Premature coronary artery atherosclerosis Premature coronary artery disease 0005181 Renal steatosis Fatty kidney 0000799 Showing of 21 | Last updated: 3/ [rarediseases.info.nih.gov]

Familial Partial Lipodystrophy

Premature coronary artery disease was present in 31% of subjects. [ncbi.nlm.nih.gov]

The latter is known to result in premature coronary artery disease. [circ.ahajournals.org]

coronary artery disease. [dermnetnz.org]

Chylomicronemia Syndrome

Familial hepatic lipase deficiency (MIM 151670) is a rare autosomal recessive disorder characterized by moderate hypertriglyceridemia and premature coronary artery disease [ommbid.mhmedical.com]

coronary artery disease. [f1000research.com]

APOE p.Leu167del-Related Lipid Disorders

The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease. J Clin Lipidol 2012; 6(1):81. [labtestsonline.it]

Apolipoprotein A-I Deficiency

Apolipoprotein A-I(Zavalla) (Leu159→Pro): HDL cholesterol deficiency in a kindred associated with premature coronary artery disease. [jhu.pure.elsevier.com]

coronary artery disease. [ncbi.nlm.nih.gov]

To further define the linkage of the Apo A-I gene polymorphism to genetic high density lipoprotein (HDL) deficiency and premature coronary artery disease. [clinicaltrials.gov]

Hyperlipidemia due to Hepatic Triglyceride Lipase Deficiency

coronary artery atherosclerosis Premature coronary artery disease 0005181 Percent of people who have these symptoms is not available through HPO Autosomal recessive inheritance [rarediseases.info.nih.gov]

[…] concentration High blood HDL level 0012184 80%-99% of people have these symptoms Eruptive xanthomas 0001013 30%-79% of people have these symptoms Angina pectoris 0001681 Premature [rarediseases.info.nih.gov]

Sitosterolemia

ABCG5 ABCG8 Ascites Cryptogenic cirrhosis Idiopathic cirrhosis Macrothrombocytopenia Phytosterolemia Plant sterols Premature coronary artery disease Sitosterolemia Cite this [mayoclinic.pure.elsevier.com]

coronary artery disease. [knightdxlabs.ohsu.edu]

artery disease (summary by {2:Berge et al., 2000}). [diseaseinfosearch.org]

Hyperlipidemia

coronary artery disease. [dx.doi.org]

Major complications include recurrent pancreatitis, peripheral vascular disease and premature coronary artery disease. [ncbi.nlm.nih.gov]

Familial Hypercholesterolemia Type 2

The resultant hypercholesterolemia leads to premature coronary artery disease and atherosclerotic plaque formation. [themedicalbiochemistrypage.org]

Patients develop highly progressive atherosclerosis that can lead to premature cardiovascular disease (stroke, coronary and peripheral artery disease. [orpha.net]

Prognosis Patients with hyperlipidemia are at extremely high risk of developing premature coronary artery disease (CAD) (30%). [27] If the disease is inadequately managed, [emedicine.medscape.com]

Lipodystrophy

The latter is known to result in premature coronary artery disease. [circ.ahajournals.org]

coronary artery disease. [epainassist.com]

[…] lipodystrophy is associated with metabolic syndrome ( syndrome X) including hypertension, insulin resistance, diabetes and severe hypertriglyceridemia resulting in pancreatitis and premature [dermnetnz.org]

Acquired Partial Lipodystrophy

‘Patients with lipodystrophy often display the same metabolic features that are expected in obese people: type 2 diabetes, premature coronary artery disease, stroke and non-alcoholic [endocrinology.org]

coronary artery disease. [dermnetnz.org]

[…] lilpodystrophy is associated with metabolic syndrome ( syndrome X) including hypertension, insulin resistance, diabetes and severe hypertriglyceridemia resulting in pancreatitis and premature [dermnetnz.org]

Autosomal Dominant Coronary Artery Disease 1

Untreated FH results in premature coronary artery disease (typically fourth decade in men, up to 10 years later in women). [genomicseducation.hee.nhs.uk]

Family history of premature coronary heart disease and coronary artery calcification: Multi-Ethnic Study o Atherosclerosis (MESA). [jpgmonline.com]

[…] myocardial infarction and coronary artery disease. [genecards.org]

Familial Apolipoprotein C-II Deficiency

A genetic HDL deficiency, familial hypoalphalipoproteinemia, appears to be fairly common in patients with premature coronary artery disease. [clinicaltrials.gov]

Decreased plasma concentrations of HDL cholesterol and Apo A-I have been associated with premature coronary artery disease due to atherosclerosis in our society. [clinicaltrials.gov]

Kounis Syndrome

We report the case of an HIV-negative 39-year-old man with no coronary risk factors or family history of premature coronary artery disease, who developed Kounis syndrome after [samj.org.za]

[…] risk factors or family history of premature coronary artery disease, who developed Kounis syndrome after the administration of fluoroquinolone for dysuria. [read.qxmd.com]

[…] to the number of potential instigating factors and its relatively infrequent documentation in the literature.We report the case of an HIV-negative 39-year-old man with no coronary [read.qxmd.com]

Fish-Eye Disease

The impact of this mutation on HDL levels and HDL subclass distribution may be related to the premature coronary artery disease observed in the male probands. [ncbi.nlm.nih.gov]

A 53-year-old man with a severely reduced HDL cholesterol level, dense corneal opacities, normal renal function, and premature coronary artery disease was investigated together [ncbi.nlm.nih.gov]

The impact of this mutation on HDL levels and HDL subclass distribution may be related to the premature coronary artery disease observed in the male probands. Images. [jci.org]