Primary Amenorrhea: Causes & Reasons

Possible Causes for Primary Amenorrhea

CASE A 17-year-old nulligravid female presented to the adolescent gynecology clinic for primary amenorrhea. [file.scirp.org]

Keywords : hematocolpos; imperforate hymen; primary amenorrhea. [scielo.mec.pt]

Palavras-chave : hematocolpos; imperforate hymen; primary amenorrhea. [scielo.mec.pt]

Kallmann Syndrome

These females, aged at 20 and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. [ncbi.nlm.nih.gov]

amenorrhea. [ncbi.nlm.nih.gov]

By contrast, our second patient consulted a doctor at 18 years of age, but the etiology of primary amenorrhea was not investigated at the time, and was simply treated as a [elsevier.es]

Vaginal Atresia

The primary presenting signs and symptoms included primary amenorrhea (71.8%), periodic abdominalgia (41.0%), abdominal pain (36.0%), dyspareunia (10.3%), menstrual disorders [ncbi.nlm.nih.gov]

Congenital vaginal atresia is a rare malformation classically and clinically pictured as a primary amenorrhea with chronic cyclic pelvic pain. [panafrican-med-journal.com]

A 16-year-old girl with cyclic hematuria, periodic pelvic pain, and primary amenorrhea. [ncbi.nlm.nih.gov]

Agenesis of Uterus

Patients with pure gonadal dysgenesis/agenesis are often short in stature with primary or secondary amenorrhea. [clinicaladvisor.com]

In case of persistent primary amenorrhea, despite estrogen replacement, this unusual combination should be considered in girls with CHARGE syndrome. [ncbi.nlm.nih.gov]

Here, we report two cases of MRKH syndrome, one in a 20-year-old woman who presented with primary amenorrhea (MRKH Type I) and the other in a 65-year-old woman with primary [mjdrdypu.org]

Imperforate Hymen

A 16-year-old girl presented with primary amenorrhea and had had cyclical abdominal pain for almost a year. [ncbi.nlm.nih.gov]

amenorrhea and had had cyclical abdominal pain for almost a year. [doi.org]

Primary amenorrhea: patients may never have experienced a menstrual period due to mechanical retention of vaginal secretions by the imperforate hymen. [stepwards.com]

Turner Syndrome

A high thyroid stimulating hormone (TSH) result suggests the primary amenorrhea is due to primary hypothyroidism and should be followed with fT4 analysis. [clinicaladvisor.com]

A 16-year-old female with primary amenorrhea was diagnosed with TS based on karyotype 45,XO. [ncbi.nlm.nih.gov]

A 17-year-old girl was referred to our clinic with short stature and primary amenorrhea. The patient was diagnosed with Turner syndrome and underwent estrogen therapy. [ncbi.nlm.nih.gov]

Ovarian Dysgenesis

Patients with pure gonadal dysgenesis/agenesis are often short in stature with primary or secondary amenorrhea. [clinicaladvisor.com]

We present a case of a 33-year-old woman with Turner syndrome, primary amenorrhea and menopausal hormonal profile in which peritoneal endometriosis (white opacification type [ncbi.nlm.nih.gov]

Definition An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and [uniprot.org]

Androgen Insensitivity Syndrome

After birth, differential diagnosis should be performed using other forms of abnormal sexual differentiation of primary amenorrhea. [ncbi.nlm.nih.gov]

We report a case of complete androgen insensitivity syndrome in a 30 years old woman who presented primary amenorrhea. [ncbi.nlm.nih.gov]

A 24-year-old woman with a normal-appearing vulva and vagina presented to us because of primary amenorrhea. [ncbi.nlm.nih.gov]

Hypogonadotropic Hypogonadism

She is a 20-year-old tall, eunuchoid female referred for evaluation of primary amenorrhea. Spontaneous thelarche occurred at the age of 15 years. [ncbi.nlm.nih.gov]

The patient was a 19-year-old female who presented the nIHH phenotype with primary amenorrhea, cleft lip and palate, mixed hearing disorders, and skeletal malformations. [ncbi.nlm.nih.gov]

At age of 15 she had primary amenorrhea thus she was referred for an endocrine check-up. [umbalk.org]

Cervix Stricture

A rare case of primary amenorrhea. [mjdrdypu.org]

Both conditions often present with primary amenorrhea, shortened vagina, and absent cervix. [acog.org]

Here, we present a case of primary amenorrhea resulting from cervical agenesis in a 38-year-old woman. [mjdrdypu.org]

Ovotesticular Disorder of Sex Development

This time, she was more concerned about clitoromegaly rather than primary amenorrhea. [ijem.in]

We documented a new case of 46,XY true hermaphroditism in an 18-year-old patient, reared as a female at birth, with ambiguous genitalia and primary amenorrhea. [ncbi.nlm.nih.gov]

Primary amenorrhea and virilization in a true hermaphrodite with a rare dicentric Y chromosome. Obstet Gynecol. 1984 Sep. 64(3 Suppl):64S-67S. [Medline]. [emedicine.medscape.com]

Polycystic Ovary Syndrome

The females presented with primary amenorrhea. Both had partial alopecia especially on the temporo-parietal regions of the cranium. [jpma.org.pk]

amenorrhea; thus, this syndrome is unlikely if regular menses occurred for a time after menarche. [msdmanuals.com]

This is a case report of a 42-year-old woman of African descent who presented to our fertility clinic with a 10-year history of primary subfertility and amenorrhea of 6 years [ncbi.nlm.nih.gov]

Prolactinoma

Treatment with a dopamine agonist can be considered as the primary treatment with almost all microadenomas, including patients desiring pregnancy or those with primary amenorrhea [ncbi.nlm.nih.gov]

Hyperprolactinemia is a cause of hypogonadotrophic hypogonadism, which leads to delayed puberty, primary and secondary amenorrhea, gynecomastia and/or galactorrhea. [karger.com]

Such alterations appear in adolescent females as delayed puberty (48% in our experience), primary amenorrhea (14–41%), secondary amenorrhea (29–45%) and oligomenorrhea (up [karger.com]

Adrenogenital Syndrome

This 27-year-old patient, first evaluated at the age of 18, had a masculine figure, abnormal external genitalia, and primary amenorrhea. Clitoridectomy was performed. [journals.lww.com]

Panhypopituitarism

At the age of 15 she was evaluated for primary amenorrhea. [oatext.com]

Prolactin deficiency Women: lactation failure following delivery Men: asymptomatic FSH/LH deficiency Women: primary amenorrhea (delayed puberty), secondary amenorrhea, irregular [amboss.com]

Endocr J 42 : 83 – 88 5 Crottaz B, Uske A, Reymond MJ, Rey F, Temler E, Germond M, Gomez F 1996 Normogonadotropic primary amenorrhea in a growth hormone-deficient woman with [academic.oup.com]

Asherman Syndrome

The two types of amenorrhea are referred to as primary and secondary. [healthline.com]

3 (15%) patients presented with primary infertility. [jpma.org.pk]

Primary amenorrhea is when a teenage girl has reached or passed the age of 16 and still hasn’t had her first period. [healthline.com]

Hyperprolactinemia

Primary or secondary amenorrhea, absence of menstruation. Headaches and alterations in the field of vision due to tumors. Hirsutism, if there is a hyperandrogenism. [invitra.com]

[…] in women, loss of libido and impotence in men, and in children delayed puberty, galactorrhea, gynecomastia, and primary amenorrhea. [biochemia-medica.com]

In young girls, primary amenorrhea is the consequence of hyperprolactinemia, and depending on the age at which the disorder occurs, it can cause puberty retardation or interruption [em-consulte.com]

Craniopharyngioma

[…] or secondary amenorrhea, often associated with galactorrhea. [dx.doi.org]

sexual dysfunction was the most common presentation, with 88% of males presenting with impotence or marked decrease in sexual drive, and 82% of females presenting with primary [dx.doi.org]

Ovarian Dysgerminoma

Dysgerminoma is the most common malignant ovarian germ‐cell tumor diagnosed in pregnancy 2, and may also be discovered in patients investigated for primary amenorrhea, in [obgyn.onlinelibrary.wiley.com]

Gonadoblastoma

This patient presented with primary amenorrhea. [ncbi.nlm.nih.gov]

We present the case of a 36-year-old female with the complaints of primary amenorrhea with a pelvic mass. [jhrsonline.org]

At the age of 17 years, the patient presented primary amenorrhea and was referred to our department. [ncbi.nlm.nih.gov]

Cystic Fibrosis

BACKGROUND: Cystic Fibrosis (CF) is an autosomal recessive genetic disease. Two models for screening CF are normally used: newborn screening and population-based CF carrier screening. In turn, there are three main models of population-based CF carrier screening: prenatal carrier screening, preconception carrier[…] [ncbi.nlm.nih.gov]

Pseudohypoparathyroidism

Overview Practice Essentials Pseudohypoparathyroidism (PHP) is a heterogeneous group of rare endocrine disorders characterized by normal renal function and resistance to the action of parathyroid hormone (PTH), manifesting with hypocalcemia, hyperphosphatemia, and increased serum concentration of PTH. There are[…] [emedicine.com]

Anterior Pituitary Hypofunction

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X-Linked Hypogonadotropic Hypogonadism without Anosmia

Similar observations can be made in girls, where primary amenorrhea is diagnosed in about 90% of cases. Female breast development varies largely. [symptoma.com]

Kallmann Syndrome Type 4

Amenorrhea Definition The absence of menstrual periods is called amenorrhea. Primary amenorrhea is the failure to start having a period by the age of 16. [medical-dictionary.thefreedictionary.com]

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

Adult females have little or no breast development along witth primary amenorrhea. [ijdvl.com]

Swyer-James Syndrome

Swyer-James syndrome, also known as unilateral hyperlucent lung syndrome, refers to the manifestation of postinfectious obliterative bronchiolitis. Most patients do not develop symptoms while the remaining exhibit a productive cough, hemoptysis, exertional dyspnea, and decreased exercise tolerance. The diagnosis is[…] [symptoma.com]

Kallmann Syndrome Type 3

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

CHH is revealed in the majority of female teenagers and women by primary amenorrhea [ 1, 2, 3, 4, 5, 6 ]. [em-consulte.com]

At age of 15 she had primary amenorrhea thus she was referred for an endocrine check-up. [umbalk.org]

Hypogonadotropic Hypogonadism Type 8

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

Adult females have little or no breast development along witth primary amenorrhea. [ijdvl.com]

amenorrhea Associated Genes KISS1R (Withdrawn symbols: AXOR12, GPR54, HOT7T175 ) Mouse Orthologs Kiss1r (Withdrawn symbols: Gpr54 ) Source OMIM:614837 (names, synonyms, disease [mousephenotype.org]

Hypogonadotropic Hypogonadism Type 21

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

amenorrhea with hypogonadotropic hypogonadism following pulsatile gonadotropin-releasing hormone (GnRH) treatment using the OmniPod pump versus placebo Primary Amenorrhea [clinicaltrials.gov]

CHH is revealed in the majority of female teenagers and women by primary amenorrhea [ 1, 2, 3, 4, 5, 6 ]. [em-consulte.com]

Female Infertility due to Anovulation

Patients with pure gonadal dysgenesis/agenesis are often short in stature with primary or secondary amenorrhea. [clinicaladvisor.com]

[…] septa present with normal pubertal development and normal uterus/ovaries Evaluation In a patient with primary amenorrhea and an increased FSH, the next step in management [medbullets.com]

Females with a 45,XO karyotype characteristically have short stature, primary amenorrhea, streak gonads, and sexual infantilism. [library.med.utah.edu]