Primary Amenorrhea: Causes & Reasons

Possible Causes for Primary Amenorrhea

CASE A 17-year-old nulligravid female presented to the adolescent gynecology clinic for primary amenorrhea. [file.scirp.org]

Keywords : hematocolpos; imperforate hymen; primary amenorrhea. [scielo.mec.pt]

Palabras clave : hematocolpos; imperforate hymen; primary amenorrhea. [scielo.mec.pt]

Kallmann Syndrome

By contrast, our second patient consulted a doctor at 18 years of age, but the etiology of primary amenorrhea was not investigated at the time, and was simply treated as a [elsevier.es]

These females, aged at 20 and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. [ncbi.nlm.nih.gov]

Untreated adult females almost always experience primary amenorrhea with absent, little or normal breast development. [orpha.net]

Vaginal Atresia

The primary presenting signs and symptoms included primary amenorrhea (71.8%), periodic abdominalgia (41.0%), abdominal pain (36.0%), dyspareunia (10.3%), menstrual disorders [ncbi.nlm.nih.gov]

A 16-year-old girl with cyclic hematuria, periodic pelvic pain, and primary amenorrhea. [ncbi.nlm.nih.gov]

Congenital vaginal atresia is a rare malformation classically and clinically pictured as a primary amenorrhea with chronic cyclic pelvic pain. [panafrican-med-journal.com]

Agenesis of Uterus

Patients with pure gonadal dysgenesis/agenesis are often short in stature with primary or secondary amenorrhea. [clinicaladvisor.com]

In case of persistent primary amenorrhea, despite estrogen replacement, this unusual combination should be considered in girls with CHARGE syndrome. [ncbi.nlm.nih.gov]

Here, we report two cases of MRKH syndrome, one in a 20-year-old woman who presented with primary amenorrhea (MRKH Type I) and the other in a 65-year-old woman with primary [mjdrdypu.org]

Imperforate Hymen

A 16-year-old girl presented with primary amenorrhea and had had cyclical abdominal pain for almost a year. [ncbi.nlm.nih.gov]

amenorrhea and had had cyclical abdominal pain for almost a year. [doi.org]

Imperforate hymen in an adolescent usually presents with cyclic abdominal pain or with pelvic mass associated with primary amenorrhea. [ncbi.nlm.nih.gov]

Turner Syndrome

A high thyroid stimulating hormone (TSH) result suggests the primary amenorrhea is due to primary hypothyroidism and should be followed with fT4 analysis. [clinicaladvisor.com]

A 16-year-old female with primary amenorrhea was diagnosed with TS based on karyotype 45,XO. [ncbi.nlm.nih.gov]

A 17-year-old girl was referred to our clinic with short stature and primary amenorrhea. The patient was diagnosed with Turner syndrome and underwent estrogen therapy. [ncbi.nlm.nih.gov]

Ovarian Dysgenesis

Patients with pure gonadal dysgenesis/agenesis are often short in stature with primary or secondary amenorrhea. [clinicaladvisor.com]

We present a case of a 33-year-old woman with Turner syndrome, primary amenorrhea and menopausal hormonal profile in which peritoneal endometriosis (white opacification type [ncbi.nlm.nih.gov]

A healthy non-dysmorphic 23 year-old phenotypic female with primary amenorrhea and infertility presented for reproductive endocrinology evaluation. [ncbi.nlm.nih.gov]

Androgen Insensitivity Syndrome

After birth, differential diagnosis should be performed using other forms of abnormal sexual differentiation of primary amenorrhea. [ncbi.nlm.nih.gov]

We report a case of complete Androgen insensitivity syndrome in a 30 years old woman with primary amenorrhea. [panafrican-med-journal.com]

The symptoms range from phenotypically normal males with impaired spermatogenesis to phenotypically normal women with primary amenorrhea. [ncbi.nlm.nih.gov]

Hypogonadotropic Hypogonadism

She is a 20-year-old tall, eunuchoid female referred for evaluation of primary amenorrhea. Spontaneous thelarche occurred at the age of 15 years. [ncbi.nlm.nih.gov]

The patient was a 19-year-old female who presented the nIHH phenotype with primary amenorrhea, cleft lip and palate, mixed hearing disorders, and skeletal malformations. [ncbi.nlm.nih.gov]

We described a case of singleton pregnancy in a 38-year-old patient, presenting with primary hypogonadotropic amenorrhea and empty sella syndrome, treated with human menopausal [ncbi.nlm.nih.gov]

Cervix Stricture

A rare case of primary amenorrhea. [mjdrdypu.org]

Both conditions often present with primary amenorrhea, shortened vagina, and absent cervix. [acog.org]

Here, we present a case of primary amenorrhea resulting from cervical agenesis in a 38-year-old woman. [mjdrdypu.org]

Ovotesticular Disorder of Sex Development

This time, she was more concerned about clitoromegaly rather than primary amenorrhea. [ijem.in]

We documented a new case of 46,XY true hermaphroditism in an 18-year-old patient, reared as a female at birth, with ambiguous genitalia and primary amenorrhea. [ncbi.nlm.nih.gov]

Primary amenorrhea and virilization in a true hermaphrodite with a rare dicentric Y chromosome. Obstet Gynecol. 1984 Sep. 64(3 Suppl):64S-67S. [Medline]. [emedicine.medscape.com]

Polycystic Ovary Syndrome

The females presented with primary amenorrhea. Both had partial alopecia especially on the temporo-parietal regions of the cranium. [jpma.org.pk]

amenorrhea; thus, this syndrome is unlikely if regular menses occurred for a time after menarche. [msdmanuals.com]

This is a case report of a 42-year-old woman of African descent who presented to our fertility clinic with a 10-year history of primary subfertility and amenorrhea of 6 years [ncbi.nlm.nih.gov]

Prolactinoma

Treatment with a dopamine agonist can be considered as the primary treatment with almost all microadenomas, including patients desiring pregnancy or those with primary amenorrhea [ncbi.nlm.nih.gov]

Hyperprolactinemia is a cause of hypogonadotrophic hypogonadism, which leads to delayed puberty, primary and secondary amenorrhea, gynecomastia and/or galactorrhea. [karger.com]

Such alterations appear in adolescent females as delayed puberty (48% in our experience), primary amenorrhea (14–41%), secondary amenorrhea (29–45%) and oligomenorrhea (up [karger.com]

Adrenogenital Syndrome

This 27-year-old patient, first evaluated at the age of 18, had a masculine figure, abnormal external genitalia, and primary amenorrhea. Clitoridectomy was performed. [journals.lww.com]

Panhypopituitarism

At the age of 15 she was evaluated for primary amenorrhea. [oatext.com]

Prolactin deficiency Women: lactation failure following delivery Men: asymptomatic FSH/LH deficiency Women: primary amenorrhea (delayed puberty), secondary amenorrhea, irregular [amboss.com]

Endocr J 42 : 83 – 88 5 Crottaz B, Uske A, Reymond MJ, Rey F, Temler E, Germond M, Gomez F 1996 Normogonadotropic primary amenorrhea in a growth hormone-deficient woman with [academic.oup.com]

Asherman Syndrome

The two types of amenorrhea are referred to as primary and secondary. [healthline.com]

3 (15%) patients presented with primary infertility. [jpma.org.pk]

Primary amenorrhea is when a teenage girl has reached or passed the age of 16 and still hasn’t had her first period. [healthline.com]

Craniopharyngioma

[…] or secondary amenorrhea, often associated with galactorrhea. [dx.doi.org]

sexual dysfunction was the most common presentation, with 88% of males presenting with impotence or marked decrease in sexual drive, and 82% of females presenting with primary [dx.doi.org]

Hyperprolactinemia

Primary or secondary amenorrhea, absence of menstruation. Headaches and alterations in the field of vision due to tumors. Hirsutism, if there is a hyperandrogenism. [invitra.com]

[…] in women, loss of libido and impotence in men, and in children delayed puberty, galactorrhea, gynecomastia, and primary amenorrhea. [biochemia-medica.com]

In young girls, primary amenorrhea is the consequence of hyperprolactinemia, and depending on the age at which the disorder occurs, it can cause puberty retardation or interruption [em-consulte.com]

Swyer-James Syndrome

Swyer syndrome is a pure gonadal dysgenesis associated with a 46 XY karyotype and primary amenorrhea in a phenotypic female. 28487303 FEMALE Female phenotype with male karyotype [pubcasefinder.dbcls.jp]

Swyer syndrome or pure gonadal dysgenesis 46, XY is a medical condition associated with 46 XY karyotype and primary amenorrhea in a phenotypic female. 25532682 FEMALE Incidental [pubcasefinder.dbcls.jp]

Ovarian Dysgerminoma

Dysgerminoma is the most common malignant ovarian germ‐cell tumor diagnosed in pregnancy 2, and may also be discovered in patients investigated for primary amenorrhea, in [obgyn.onlinelibrary.wiley.com]

Gonadoblastoma

Case 2 was a 15-year-old female presented with lack of pubertal development and primary amenorrhea. [abstracts.eurospe.org]

Case 2 A 19-year-old patient with female phenotype presented with primary amenorrhea. [ams.ac.ir]

This patient presented with primary amenorrhea. [ncbi.nlm.nih.gov]

Cystic Fibrosis

Genetic multisystem disease associated with abnormalities in salt and water transport across epithelial surfaces. Age of onset of symptoms is highly variable; implementation of newborn screening in some countries allows for early detection and treatment. A sweat test is the most conclusive test for diagnosis.[…] [bestpractice.bmj.com]

Pseudohypoparathyroidism

Pseudohypoparathyroidism is a topic covered in the 5-Minute Clinical Consult. To view the entire topic, please sign in or purchase a subscription. 5-Minute Clinical Consult (5MCC) app and website powered by Unbound Medicine helps you diagnose and manage 900+ medical conditions. Exclusive bonus features include[…] [unboundmedicine.com]

Anterior Pituitary Hypofunction

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X-Linked Hypogonadotropic Hypogonadism without Anosmia

Similar observations can be made in girls, where primary amenorrhea is diagnosed in about 90% of cases. Female breast development varies largely. [symptoma.com]

Kallmann Syndrome Type 4

Amenorrhea Definition The absence of menstrual periods is called amenorrhea. Primary amenorrhea is the failure to start having a period by the age of 16. [medical-dictionary.thefreedictionary.com]

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

Adult females have little or no breast development along witth primary amenorrhea. [ijdvl.com]

Kallmann Syndrome Type 3

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

CHH is revealed in the majority of female teenagers and women by primary amenorrhea [ 1, 2, 3, 4, 5, 6 ]. [em-consulte.com]

At age of 15 she had primary amenorrhea thus she was referred for an endocrine check-up. [umbalk.org]

Hypogonadotropic Hypogonadism Type 8

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

amenorrhea Associated Genes KISS1R (Withdrawn symbols: AXOR12, GPR54, HOT7T175 ) Mouse Orthologs Kiss1r (Withdrawn symbols: Gpr54 ) Source OMIM:614837 (names, synonyms, disease [mousephenotype.org]

Adult females have little or no breast development along witth primary amenorrhea. [ijdvl.com]

Hypogonadotropic Hypogonadism Type 21

Normal MRI indicates a hypothalamic cause of amenorrhea. 3 Differential Diagnosis of Primary Amenorrhea Causes of primary amenorrhea should be evaluated in the context of [aafp.org]

amenorrhea with hypogonadotropic hypogonadism following pulsatile gonadotropin-releasing hormone (GnRH) treatment using the OmniPod pump versus placebo Primary Amenorrhea [clinicaltrials.gov]

CHH is revealed in the majority of female teenagers and women by primary amenorrhea [ 1, 2, 3, 4, 5, 6 ]. [em-consulte.com]

Female Infertility due to Anovulation

Patients with pure gonadal dysgenesis/agenesis are often short in stature with primary or secondary amenorrhea. [clinicaladvisor.com]

[…] septa present with normal pubertal development and normal uterus/ovaries Evaluation In a patient with primary amenorrhea and an increased FSH, the next step in management [medbullets.com]

Females with a 45,XO karyotype characteristically have short stature, primary amenorrhea, streak gonads, and sexual infantilism. [library.med.utah.edu]