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58 Possible Causes for Primary Amenorrhea, Thick Facial Skin, Weight Gain

  • Polycystic Ovary Syndrome

    Cessation of VPA administration led to reduced weight gain and restored menstruation.[] […] of thick, darker, velvety skin.[] amenorrhea; thus, this syndrome is unlikely if regular menses occurred for a time after menarche.[]

  • Acromegaly

    We report the case of a 43 years old patient initially diagnosed with acromegaly accompanied by weight gain and acral enlargement.[] The facial aspect is characteristic and includes a widened and thickened nose, prominent cheekbones, forehead bulges, thick lips and marked facial lines.[] gain Surgery to remove the pituitary tumor that is causing this condition often corrects the abnormal GH.[]

  • Prolactinoma

    Only two patients complained of recent weight gain at the initial consultation.[] Skin thickness and consistency was normal, without streaks. The patient was thick-skinned with normal distribution of skin thickness.[] Treatment with a dopamine agonist can be considered as the primary treatment with almost all microadenomas, including patients desiring pregnancy or those with primary amenorrhea[]

  • Virilization

    She gained 10 kg of body weight over the previous 2 years. Her past medical history was significant for mitral valve prolapse with no limitation of physical activity.[] Low level (common): Thick, dark facial hair in the beard or mustache area Increase in body hair Oily skin or acne Irregular menstrual periods Moderate level (uncommon): Male-pattern[] The patient was admitted because of primary amenorrhea and signs of virilization at puberty. The chromosome analysis showed a 46, XY karyotype.[]

  • Hypothyroidism

    Symptoms include weight gain, constipation, dry skin, and sensitivity to the cold.[] […] expression, dementia or frank psychosis (myxedema madness) Dermatologic manifestations: Facial puffiness; myxedema; sparse, coarse and dry hair; coarse, dry, scaly and thick[] A syndrome of primary hypothyroidism, amenorrhea and galactorrhea. J Clin Endocrinol Metab 1968; 28: 591.[]

  • Woodhouse Sakati Syndrome

    […] patches of thick, darker, velvety skin .[] Case report; In a 52-year-old woman from a consanguine pedigree we observed mental retardation, short stature, alopecia with absence of eyebrows, hypogonadism, primary amenorrhea[] She had a primary amenorrhea and alopecia. She had the same dysmorphic facial characteristics as her sister.[]

  • Growth Hormone Deficiency

    gain.[] However, a nice side benefit is that growth hormone also increases the thickness of the skin.[] A Japanese senior high school girl aged 18 years and 5 months with growth hormone deficiency was referred for primary amenorrhea.[]

  • Secondary Hypothyroidism

    Total weight gain at this point is 50 pounds, I exercise, and eat a disgustingly healthy diet.[] […] speech 91 Eyelid edema 90 Cold sensation 89 Decreased sweating 89 Cold skin 83 Thick tongue 82 Facial edema 79 Coarse hair 76 Skin pallor 67 Forgetfulness 66 Constipation[] A case study of a 15 year old girl who was diagnosed with a rare triad of primary amenorrhea, hypothyroidism, and Addison disease : An Unusual Cause of Primary Amenorrhea[]

  • Achard Thiers Syndrome

    Pregnancy causes weight gain and increases levels of estogen and placental hormones, which antagonize insulin. some medications such as thiazide diuretics, adrenal corticosteroids[] The hair itself is sometimes not particularly thick, but the roots are very large which cause a noticeable shadow under the skin.[] .), and signs of hyperandrogenism on the other (hirsutism, especially on the head and neck; menstrual changes such as oligomenorrhea and amenorrhea, clitoral enlargement,[]

  • Hyperpituitarism

    If the adrenocorticotropic hormone (ACTH) is involved, patient present with symptoms of excessive glucocorticoid secretion: hypertension, hirsutism, weight gain, acne, fatigability[] Serious physiological symptoms also may appear, such as increased sweating, thick and coarse oily skin, and chronic sinus congestion.[] […] secondary amenorrhea Galactorrhea Gynecomastia Cushing disease may include the following (see images below): A 16-year-old boy with Cushing disease.[]

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