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523 Possible Causes for Primary Myelofibrosis, Toxic Effect of Benzene

  • Benzene Poisoning

    The toxic effects of benzene are varied; acute exposure affects the central nervous system, whereas chronic exposure causes damage to the hematopoietic system.[] Reducing Benzene Toxicity Benzene is a very difficult substance to detoxify unless you know what you doing, each person is different in the way they are effected by benzene[] These are reactive chemical species and may contribute to benzene’s effects through different pathways, making the mechanism of toxicity a complex issue.[]

  • Myelodysplasia

    ., vitamin B12, folate, copper), toxic exposures (i.e., benzene, zinc, heavy metals, ethanol), pharmaceutical side effect (i.e., recent chemotherapy, growth factor stimulation[] primary MDS (often RAEB2 ) with fibrosis and therapy related myeloid neoplasms with fibrosis Primary Myelofibrosis, Fibrotic Phase MDS with Fibrosis Post-Polycythemia Vera[] Benzene represents a model for secondary carcinogenesis, in particular, due to its toxic effects on blood and bone marrow.[]

  • Leukemia

    […] description ICD-O3 code Myeloproliferative neoplasms Chronic myelogenous leukaemia, BCR-ABL1 positive 9975/3 Chronic neutrophilic leukaemia 9963/3 Polycythaemia vera 9950/3 Primary[] Table 3 Criteria for polycythemia vera (PV) Table 4 Criteria for essential thrombocythemia (ET) Table 5 Criteria for primary myelofibrosis (PMF) Recently, some authorities[] myelofibrosis 9961/3 Essential thrombocythaemia 9962/3 Chronic eosinophilic leukaemia, NOS 9964/3 Cutaneous mastocytosis 9740/3 Systemic mastocytosis 9741/3 Mast cell leukaemia[]

    Missing: Toxic Effect of Benzene
  • Lymphoma

    Table 3 Criteria for polycythemia vera (PV) Table 4 Criteria for essential thrombocythemia (ET) Table 5 Criteria for primary myelofibrosis (PMF) Recently, some authorities[] myelofibrosis (PMF) or essential thrombocythemia (ET). 11, 27 Therefore, JAK2 V617F is not specific for any single MPN, nor does its absence exclude any MPN.[] […] in BCR-ABL1 –negative MPN is JAK2 V617F. 11, 26 – 28 This mutation is found in more than 90% of patients with polycythemia vera (PV) and in nearly one-half of those with primary[]

    Missing: Toxic Effect of Benzene
  • Bone Metastasis

    Abstract Bone metastasis is the primary cause of death in human prostate cancer. Disseminated from primary tumor and distributed via the bloodstream, a proportion of prostate carcinoma cells eventually reach the skeleton and develop into metastases, requiring adhesion to inner bone surfaces lined by osteoblasts.[…][]

    Missing: Toxic Effect of Benzene
  • Polycythemia Vera

    Megakaryocytic morphology also differed between primary myelofibrosis JAK2 V617F and essential thrombocythemia JAK2 V617F.[] This case report describes the progression of primary myelofibrosis (PMF) to polycythemia vera (PV), and discuss its potential mechanisms.[] Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[]

    Missing: Toxic Effect of Benzene
  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Patel & Srdan Verstovsek Annals of Hematology (2018) Sequential development of chronic myelogenous leukemia and primary myelofibrosis in a patient with history of large B-cell[] CALR-mutated primary myelofibrosis evolving to chronic myeloid leukemia with both CALR mutation and BCR-ABL1 fusion gene.[] "Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations[]

    Missing: Toxic Effect of Benzene
  • Aplastic Anemia

    Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (RBCs, WBCs, and/or platelets). Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[…][]

    Missing: Toxic Effect of Benzene
  • Chronic Myeloid Leukemia

    myelofibrosis (PMF).[] Table 5 2001 WHO criteria for prefibrotic stage primary myelofibrosis Table 6 2001 WHO criteria for fibrotic stage primary myelofibrosis Table 7 Proposed revised WHO criteria[] myelofibrosis, atypical CML, chronic neutrophilic leukemia.[]

    Missing: Toxic Effect of Benzene
  • Gaucher Disease

    Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting[]

    Missing: Toxic Effect of Benzene

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